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Entry version 144 (12 Aug 2020)
Sequence version 2 (11 Sep 2007)
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Protein

FK506-binding protein 15

Gene

FKBP15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processEndocytosis, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5T1M5

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q5T1M5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FK506-binding protein 15
Short name:
FKBP-15
Alternative name(s):
133 kDa FK506-binding protein
Short name:
133 kDa FKBP
Short name:
FKBP-133
WASP- and FKBP-like protein
Short name:
WAFL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FKBP15
Synonyms:KIAA0674
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000119321.8

Human Gene Nomenclature Database

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HGNCi
HGNC:23397, FKBP15

Online Mendelian Inheritance in Man (OMIM)

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MIMi
617398, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T1M5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23307

Open Targets

More...
OpenTargetsi
ENSG00000119321

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162388608

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T1M5, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FKBP15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158563913

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002995561 – 1219FK506-binding protein 15Add BLAST1219

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei92N6-acetyllysineCombined sources1
Modified residuei307PhosphoserineBy similarity1
Modified residuei311PhosphoserineBy similarity1
Modified residuei326PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Modified residuei346PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei619PhosphoserineBy similarity1
Modified residuei939PhosphoserineCombined sources1
Modified residuei940PhosphoserineCombined sources1
Modified residuei941PhosphoserineCombined sources1
Modified residuei956PhosphoserineCombined sources1
Modified residuei979PhosphoserineCombined sources1
Modified residuei1024PhosphoserineCombined sources1
Modified residuei1056PhosphoserineBy similarity1
Modified residuei1061PhosphoserineCombined sources1
Modified residuei1065PhosphoserineCombined sources1
Modified residuei1097PhosphoserineCombined sources1
Modified residuei1099PhosphothreonineCombined sources1
Modified residuei1114PhosphoserineCombined sources1
Modified residuei1158PhosphoserineCombined sources1
Modified residuei1161PhosphoserineCombined sources1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1164PhosphoserineCombined sources1
Modified residuei1195PhosphoserineCombined sources1
Modified residuei1203PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T1M5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5T1M5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5T1M5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T1M5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T1M5

PeptideAtlas

More...
PeptideAtlasi
Q5T1M5

PRoteomics IDEntifications database

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PRIDEi
Q5T1M5

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
64271 [Q5T1M5-1]
64272 [Q5T1M5-2]
64273 [Q5T1M5-3]

PTM databases

CarbonylDB database of protein carbonylation sites

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CarbonylDBi
Q5T1M5

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q5T1M5

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q5T1M5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T1M5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000119321, Expressed in monocyte and 246 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5T1M5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5T1M5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000119321, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with WIP and actin (PubMed:19121306).

Interacts with TBC1D23 (PubMed:29084197).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116899, 51 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q5T1M5

Protein interaction database and analysis system

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IntActi
Q5T1M5, 31 interactors

Molecular INTeraction database

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MINTi
Q5T1M5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000238256

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5T1M5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5T1M5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini197 – 290PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni72 – 169Important for function in growth cone organizationBy similarityAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili522 – 789Sequence analysisAdd BLAST268
Coiled coili818 – 878Sequence analysisAdd BLAST61
Coiled coili925 – 951Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1208 – 1216Poly-Asp9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity.By similarity
The central coiled-coil region is responsible for association with early endosomes.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0552, Eukaryota
KOG4725, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000064286

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007194_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5T1M5

KEGG Orthology (KO)

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KOi
K17478

Database of Orthologous Groups

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OrthoDBi
936280at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T1M5

TreeFam database of animal gene trees

More...
TreeFami
TF328592

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001179, PPIase_FKBP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00254, FKBP_C, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50059, FKBP_PPIASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5T1M5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFGAGDEDDT DFLSPSGGAR LASLFGLDQA AAGHGNEFFQ YTAPKQPKKG
60 70 80 90 100
QGTAATGNQA TPKTAPATMS TPTILVATAV HAYRYTNGQY VKQGKFGAAV
110 120 130 140 150
LGNHTAREYR ILLYISQQQP VTVARIHVNF ELMVRPNNYS TFYDDQRQNW
160 170 180 190 200
SIMFESEKAA VEFNKQVCIA KCNSTSSLDA VLSQDLIVAD GPAVEVGDSL
210 220 230 240 250
EVAYTGWLFQ NHVLGQVFDS TANKDKLLRL KLGSGKVIKG WEDGMLGMKK
260 270 280 290 300
GGKRLLIVPP ACAVGSEGVI GWTQATDSIL VFEVEVRRVK FARDSGSDGH
310 320 330 340 350
SVSSRDSAAP SPIPGADNLS ADPVVSPPTS IPFKSGEPAL RTKSNSLSEQ
360 370 380 390 400
LAINTSPDAV KAKLISRMAK MGQPMLPILP PQLDSNDSEI EDVNTLQGGG
410 420 430 440 450
QPVVTPSVQP SLHPAHPALP QMTSQAPQPS VTGLQAPSAA LMQVSSLDSH
460 470 480 490 500
SAVSGNAQSF QPYAGMQAYA YPQASAVTSQ LQPVRPLYPA PLSQPPHFQG
510 520 530 540 550
SGDMASFLMT EARQHNTEIR MAVSKVADKM DHLMTKVEEL QKHSAGNSML
560 570 580 590 600
IPSMSVTMET SMIMSNIQRI IQENERLKQE ILEKSNRIEE QNDKISELIE
610 620 630 640 650
RNQRYVEQSN LMMEKRNNSL QTATENTQAR VLHAEQEKAK VTEELAAATA
660 670 680 690 700
QVSHLQLKMT AHQKKETELQ MQLTESLKET DLLRGQLTKV QAKLSELQET
710 720 730 740 750
SEQAQSKFKS EKQNRKQLEL KVTSLEEELT DLRVEKESLE KNLSERKKKS
760 770 780 790 800
AQERSQAEEE IDEIRKSYQE ELDKLRQLLK KTRVSTDQAA AEQLSLVQAE
810 820 830 840 850
LQTQWEAKCE HLLASAKDEH LQQYQEVCAQ RDAYQQKLVQ LQEKCLALQA
860 870 880 890 900
QITALTKQNE QHIKELEKNK SQMSGVEAAA SDPSEKVKKI MNQVFQSLRR
910 920 930 940 950
EFELEESYNG RTILGTIMNT IKMVTLQLLN QQEQEKEESS SEEEEEKAEE
960 970 980 990 1000
RPRRPSQEQS ASASSGQPQA PLNRERPESP MVPSEQVVEE AVPLPPQALT
1010 1020 1030 1040 1050
TSQDGHRRKG DSEAEALSEI KDGSLPPELS CIPSHRVLGP PTSIPPEPLG
1060 1070 1080 1090 1100
PVSMDSECEE SLAASPMAAK PDNPSGKVCV REVAPDGPLQ ESSTRLSLTS
1110 1120 1130 1140 1150
DPEEGDPLAL GPESPGEPQP PQLKKDDVTS STGPHKELSS TEAGSTVAGA
1160 1170 1180 1190 1200
ALRPSHHSQR SSLSGDEEDE LFKGATLKAL RPKAQPEEED EDEVSMKGRP
1210
PPTPLFGDDD DDDDIDWLG
Length:1,219
Mass (Da):133,630
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86563D82B540B51D
GO
Isoform 2 (identifier: Q5T1M5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     629-638: Missing.

Show »
Length:1,209
Mass (Da):132,467
Checksum:iAD3F9C4AA1FD65A6
GO
Isoform 3 (identifier: Q5T1M5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     462-472: PYAGMQAYAYP → VTFYNRINYIL
     473-1219: Missing.

Show »
Length:472
Mass (Da):50,330
Checksum:i2112364B487D6E69
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH09609 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA31649 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034851106A → T. Corresponds to variant dbSNP:rs1133618Ensembl.1
Natural variantiVAR_034852413H → Q2 PublicationsCorresponds to variant dbSNP:rs10435864Ensembl.1
Natural variantiVAR_034853434L → F. Corresponds to variant dbSNP:rs10465129Ensembl.1
Natural variantiVAR_061543847A → S. Corresponds to variant dbSNP:rs1128116Ensembl.1
Natural variantiVAR_061544993P → T. Corresponds to variant dbSNP:rs57348436Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027756462 – 472PYAGMQAYAYP → VTFYNRINYIL in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_027757473 – 1219Missing in isoform 3. 1 PublicationAdd BLAST747
Alternative sequenceiVSP_027758629 – 638Missing in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB014574 mRNA Translation: BAA31649.1 Different initiation.
AL449105 Genomic DNA No translation available.
AL449305 Genomic DNA No translation available.
BC009609 mRNA Translation: AAH09609.1 Different initiation.
BC077732 mRNA Translation: AAH77732.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS48007.1 [Q5T1M5-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00363

NCBI Reference Sequences

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RefSeqi
NP_056073.1, NM_015258.1 [Q5T1M5-1]
XP_006717081.1, XM_006717018.2 [Q5T1M5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000238256; ENSP00000238256; ENSG00000119321 [Q5T1M5-1]
ENST00000414250; ENSP00000415733; ENSG00000119321 [Q5T1M5-3]
ENST00000446284; ENSP00000416158; ENSG00000119321 [Q5T1M5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23307

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23307

UCSC genome browser

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UCSCi
uc004bgs.3, human [Q5T1M5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014574 mRNA Translation: BAA31649.1 Different initiation.
AL449105 Genomic DNA No translation available.
AL449305 Genomic DNA No translation available.
BC009609 mRNA Translation: AAH09609.1 Different initiation.
BC077732 mRNA Translation: AAH77732.1
CCDSiCCDS48007.1 [Q5T1M5-1]
PIRiT00363
RefSeqiNP_056073.1, NM_015258.1 [Q5T1M5-1]
XP_006717081.1, XM_006717018.2 [Q5T1M5-2]

3D structure databases

SMRiQ5T1M5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116899, 51 interactors
CORUMiQ5T1M5
IntActiQ5T1M5, 31 interactors
MINTiQ5T1M5
STRINGi9606.ENSP00000238256

PTM databases

CarbonylDBiQ5T1M5
iPTMnetiQ5T1M5
MetOSiteiQ5T1M5
PhosphoSitePlusiQ5T1M5

Polymorphism and mutation databases

BioMutaiFKBP15
DMDMi158563913

Proteomic databases

EPDiQ5T1M5
jPOSTiQ5T1M5
MassIVEiQ5T1M5
MaxQBiQ5T1M5
PaxDbiQ5T1M5
PeptideAtlasiQ5T1M5
PRIDEiQ5T1M5
ProteomicsDBi64271 [Q5T1M5-1]
64272 [Q5T1M5-2]
64273 [Q5T1M5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1961, 90 antibodies

The DNASU plasmid repository

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DNASUi
23307

Genome annotation databases

EnsembliENST00000238256; ENSP00000238256; ENSG00000119321 [Q5T1M5-1]
ENST00000414250; ENSP00000415733; ENSG00000119321 [Q5T1M5-3]
ENST00000446284; ENSP00000416158; ENSG00000119321 [Q5T1M5-1]
GeneIDi23307
KEGGihsa:23307
UCSCiuc004bgs.3, human [Q5T1M5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23307
DisGeNETi23307
EuPathDBiHostDB:ENSG00000119321.8

GeneCards: human genes, protein and diseases

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GeneCardsi
FKBP15
HGNCiHGNC:23397, FKBP15
HPAiENSG00000119321, Low tissue specificity
MIMi617398, gene
neXtProtiNX_Q5T1M5
OpenTargetsiENSG00000119321
PharmGKBiPA162388608

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0552, Eukaryota
KOG4725, Eukaryota
GeneTreeiENSGT00530000064286
HOGENOMiCLU_007194_1_0_1
InParanoidiQ5T1M5
KOiK17478
OrthoDBi936280at2759
PhylomeDBiQ5T1M5
TreeFamiTF328592

Enzyme and pathway databases

PathwayCommonsiQ5T1M5
SIGNORiQ5T1M5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23307, 6 hits in 850 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FKBP15, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23307
PharosiQ5T1M5, Tdark

Protein Ontology

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PROi
PR:Q5T1M5
RNActiQ5T1M5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000119321, Expressed in monocyte and 246 other tissues
ExpressionAtlasiQ5T1M5, baseline and differential
GenevisibleiQ5T1M5, HS

Family and domain databases

InterProiView protein in InterPro
IPR001179, PPIase_FKBP_dom
PfamiView protein in Pfam
PF00254, FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059, FKBP_PPIASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFKB15_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T1M5
Secondary accession number(s): Q05DK8
, Q5T1M2, Q6DD85, Q9Y4D0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: August 12, 2020
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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