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UniProtKB - Q5T197 (DCST1_HUMAN)

Protein

E3 ubiquitin-protein ligase DCST1

Gene

DCST1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.1 Publication EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri646 – 685RING-type; degeneratePROSITE-ProRule annotationAdd BLAST40

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin protein ligase activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processImmunity, Innate immunity, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase DCST1Curated (EC:2.3.2.271 Publication)
Alternative name(s):
DC-STAMP domain-containing protein 1
RING-type E3 ubiquitin transferaseCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCST1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000163357.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:26539 DCST1

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5T197

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 48CytoplasmicSequence analysisAdd BLAST48
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 79ExtracellularSequence analysis10
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 115CytoplasmicSequence analysisAdd BLAST15
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Topological domaini137 – 372ExtracellularSequence analysisAdd BLAST236
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 463CytoplasmicSequence analysisAdd BLAST70
Transmembranei464 – 484HelicalSequence analysisAdd BLAST21
Topological domaini485 – 553ExtracellularSequence analysisAdd BLAST69
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21
Topological domaini575 – 706CytoplasmicSequence analysisAdd BLAST132

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000163357

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672005

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DCST1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74756229

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002788241 – 706E3 ubiquitin-protein ligase DCST1Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi525N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5T197

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5T197

PeptideAtlas

More...PeptideAtlasi		Q5T197

PRoteomics IDEntifications database

More...PRIDEi		Q5T197

ProteomicsDB human proteome resource

More...ProteomicsDBi		64248
64249 [Q5T197-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5T197

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5T197

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by IFNB1.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000163357 Expressed in 77 organ(s), highest expression level in skin of abdomen

CleanEx database of gene expression profiles

More...CleanExi		HS_DCST1

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5T197 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5T197 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA060314

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with STAT2; the interaction results in STAT2 'Lys-48'-linked ubiquitination leading to its proteasomal degradation.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		127192, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q5T197, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q5T197

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri646 – 685RING-type; degeneratePROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3726 Eukaryota
ENOG410ZWQR LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153269

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000112180

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG081422

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5T197

KEGG Orthology (KO)

More...KOi		K22375

Identification of Orthologs from Complete Genome Data

More...OMAi		LMAKPFT

Database of Orthologous Groups

More...OrthoDBi		572860at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5T197

TreeFam database of animal gene trees

More...TreeFami		TF318254

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012858 DC_STAMP-like
IPR001841 Znf_RING

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07782 DC_STAMP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T197-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDIKHHQNGT RGQRRKQPHT TVQRLLTWGL PVSCSWFLWR QPGEFPVTAL 
        60         70         80         90        100
LLGAGAGGLL AIGLFQLLVN PMNIYEEQKI MFLYSLVGLG AMGWGTSPHI 
       110        120        130        140        150
RCASLLLVPK MLGKEGRLFV LGYALAAIYV GPVANLRHNL NNVIASLGCT 
       160        170        180        190        200
VELQINNTRA AWRISTAPLR AMFKDLLSSK ELLRAETRNI SATFEDLDAQ 
       210        220        230        240        250
VNSETGYTPE DTMDSGETAQ GREARQAPAS RLHLSTQKMY ELKTKLRCSY 
       260        270        280        290        300
VVNQAILSCR RWFDRKHEQC MKHIWVPLLT HLLCLPMKFK FFCGIAKVME 
       310        320        330        340        350
VWCRNRIPVE GNFGQTYDSL NQSIRGLDGE FSANIDFKEE KQAGVLGLNT 
       360        370        380        390        400
SWERVSTEVR DYVYRQEARL EWALGLLHVL LSCTFLLVLH ASFSYMDSYN 
       410        420        430        440        450
HDIRFDNIYI STYFCQIDDR RKKLGKRTLL PLRKAEEKTV IFPCKPTIQA 
       460        470        480        490        500
SEMSNVVREL LETLPILLLL VVLCGLDWAL YSIFDTIRHH SFLQYSFRSS 
       510        520        530        540        550
HKLEVKVGGD SMLARLLRKT IGALNTSSET VMESNNMPCL PQPVGLDARA 
       560        570        580        590        600
YWRAAVPIGL LVCLCLLQAF GYRLRRVIAA FYFPKREKKR ILFLYNDLLK 
       610        620        630        640        650
KRAAFTKLRR AAILRRERQQ KAPRHPLADI LHRGCPLLRR WLCRRCVVCQ 
       660        670        680        690        700
APETPESYVC RTLDCEAVYC WSCWDDMRQR CPVCTPREEL SSSAFSDSND 

DTAYAG
Length:706
Mass (Da):80,712
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFAE1ADED291F846C
GO
Isoform 2 (identifier: Q5T197-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     624-664: RHPLADILHR...PESYVCRTLD → VFTEPQFLPL...SGVGLRCQRA
     665-706: Missing.

Note: No experimental confirmation available.
Show »
Length:664
Mass (Da):75,737
Checksum:iABE64344EFF240D5
GO
Isoform 3 (identifier: Q5T197-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     63-87: Missing.

Note: No experimental confirmation available.
Show »
Length:681
Mass (Da):77,726
Checksum:i1C5D9CE64FE91D70
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PJX3E9PJX3_HUMAN
E3 ubiquitin-protein ligase DCST1
DCST1
528Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti467L → P in BAB71440 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056859158T → I. Corresponds to variant dbSNP:rs9427170Ensembl.1
Natural variantiVAR_030868512M → L2 PublicationsCorresponds to variant dbSNP:rs11264300Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04561963 – 87Missing in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_023406624 – 664RHPLA…CRTLD → VFTEPQFLPLKNGKTGEICK ACSLEISLEWWSGVGLRCQR A in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_023407665 – 706Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK057347 mRNA Translation: BAB71440.1
AK301876 mRNA Translation: BAG63312.1
AL451085 Genomic DNA No translation available.
BC064844 mRNA Translation: AAH64844.1
AF314227 Genomic DNA Translation: AAS46286.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1083.1 [Q5T197-1]
CCDS44235.1 [Q5T197-3]

NCBI Reference Sequences

More...RefSeqi		NP_001137159.1, NM_001143687.2 [Q5T197-3]
NP_689707.2, NM_152494.3 [Q5T197-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.567717

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000295542; ENSP00000295542; ENSG00000163357 [Q5T197-1]
ENST00000368419; ENSP00000357404; ENSG00000163357 [Q5T197-2]
ENST00000423025; ENSP00000387369; ENSG00000163357 [Q5T197-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		149095

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:149095

UCSC genome browser

More...UCSCi		uc001fgn.3 human [Q5T197-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057347 mRNA Translation: BAB71440.1
AK301876 mRNA Translation: BAG63312.1
AL451085 Genomic DNA No translation available.
BC064844 mRNA Translation: AAH64844.1
AF314227 Genomic DNA Translation: AAS46286.1
CCDSiCCDS1083.1 [Q5T197-1]
CCDS44235.1 [Q5T197-3]
RefSeqiNP_001137159.1, NM_001143687.2 [Q5T197-3]
NP_689707.2, NM_152494.3 [Q5T197-1]
UniGeneiHs.567717

3D structure databases

ProteinModelPortaliQ5T197
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127192, 3 interactors
IntActiQ5T197, 1 interactor

PTM databases

iPTMnetiQ5T197
PhosphoSitePlusiQ5T197

Polymorphism and mutation databases

BioMutaiDCST1
DMDMi74756229

Proteomic databases

jPOSTiQ5T197
PaxDbiQ5T197
PeptideAtlasiQ5T197
PRIDEiQ5T197
ProteomicsDBi64248
64249 [Q5T197-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295542; ENSP00000295542; ENSG00000163357 [Q5T197-1]
ENST00000368419; ENSP00000357404; ENSG00000163357 [Q5T197-2]
ENST00000423025; ENSP00000387369; ENSG00000163357 [Q5T197-3]
GeneIDi149095
KEGGihsa:149095
UCSCiuc001fgn.3 human [Q5T197-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		149095
EuPathDBiHostDB:ENSG00000163357.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		DCST1
HGNCiHGNC:26539 DCST1
HPAiHPA060314
neXtProtiNX_Q5T197
OpenTargetsiENSG00000163357
PharmGKBiPA142672005

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3726 Eukaryota
ENOG410ZWQR LUCA
GeneTreeiENSGT00940000153269
HOGENOMiHOG000112180
HOVERGENiHBG081422
InParanoidiQ5T197
KOiK22375
OMAiLMAKPFT
OrthoDBi572860at2759
PhylomeDBiQ5T197
TreeFamiTF318254

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		149095

Protein Ontology

More...PROi		PR:Q5T197

Gene expression databases

BgeeiENSG00000163357 Expressed in 77 organ(s), highest expression level in skin of abdomen
CleanExiHS_DCST1
ExpressionAtlasiQ5T197 baseline and differential
GenevisibleiQ5T197 HS

Family and domain databases

InterProiView protein in InterPro
IPR012858 DC_STAMP-like
IPR001841 Znf_RING
PfamiView protein in Pfam
PF07782 DC_STAMP, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCST1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T197
Secondary accession number(s): B4DXA0
, E9PHV3, Q5T198, Q6P1W6, Q71S70, Q96M70
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 21, 2004
Last modified: January 16, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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