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Protein

UBX domain-containing protein 11

Gene

UBXN11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity).By similarity

GO - Molecular functioni

  • ubiquitin binding Source: GO_Central

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
UBX domain-containing protein 11
Alternative name(s):
Colorectal tumor-associated antigen COA-1
Socius
UBX domain-containing protein 5
Gene namesi
Name:UBXN11
Synonyms:SOC, UBXD5
ORF Names:PP2243
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158062.20
HGNCiHGNC:30600 UBXN11
MIMi609151 gene
neXtProtiNX_Q5T124

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

DisGeNETi91544
OpenTargetsiENSG00000158062
PharmGKBiPA162408338

Polymorphism and mutation databases

BioMutaiUBXN11
DMDMi146325810

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849211 – 520UBX domain-containing protein 11Add BLAST520

Proteomic databases

PaxDbiQ5T124
PeptideAtlasiQ5T124
PRIDEiQ5T124
ProteomicsDBi64223
64224 [Q5T124-2]
64225 [Q5T124-3]
64226 [Q5T124-4]
64227 [Q5T124-5]
64228 [Q5T124-6]
64229 [Q5T124-7]
64230 [Q5T124-8]

PTM databases

iPTMnetiQ5T124
PhosphoSitePlusiQ5T124

Expressioni

Gene expression databases

BgeeiENSG00000158062 Expressed in 166 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ5T124 baseline and differential
GenevisibleiQ5T124 HS

Organism-specific databases

HPAiHPA028600
HPA031357

Interactioni

Subunit structurei

Interacts with GNA12, GNA13, RND1, RND2 AND RND3.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124844, 44 interactors
IntActiQ5T124, 32 interactors
MINTiQ5T124
STRINGi9606.ENSP00000363338

Structurei

3D structure databases

ProteinModelPortaliQ5T124
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini230 – 294SEPPROSITE-ProRule annotationAdd BLAST65
Domaini392 – 469UBXPROSITE-ProRule annotationAdd BLAST78
Repeati487 – 49418
Repeati495 – 50228
Repeati503 – 51038

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni487 – 5103 X 8 AA tandem repeats of P-G-P-G-P-G-P-SAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili76 – 149Sequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi483 – 519Pro-richAdd BLAST37

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG2086 Eukaryota
ENOG410YGXU LUCA
GeneTreeiENSGT00390000010180
HOVERGENiHBG105985
InParanoidiQ5T124
OMAiQDLMDGY
OrthoDBiEOG091G02X6
PhylomeDBiQ5T124
TreeFamiTF329799

Family and domain databases

Gene3Di3.30.420.210, 1 hit
InterProiView protein in InterPro
IPR036241 NSFL1C_SEP_dom_sf
IPR012989 SEP_domain
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF08059 SEP, 1 hit
PF00789 UBX, 1 hit
SUPFAMiSSF102848 SSF102848, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51399 SEP, 1 hit
PS50033 UBX, 1 hit

Sequences (8+)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T124-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSPLASLSK TRKVPLPSEP MNPGRRGIRI YGDEDEVDML SDGCGSEEKI
60 70 80 90 100
SVPSCYGGIG APVSRQVPAS HDSELMAFMT RKLWDLEQQV KAQTDEILSK
110 120 130 140 150
DQKIAALEDL VQTLRPHPAE ATLQRQEELE TMCVQLQRQV REMERFLSDY
160 170 180 190 200
GLQWVGEPMD QEDSESKTVS EHGERDWMTA KKFWKPGDSL APPEVDFDRL
210 220 230 240 250
LASLQDLSEL VVEGDTQVTP VPGGARLRTL EPIPLKLYRN GIMMFDGPFQ
260 270 280 290 300
PFYDPSTQRC LRDILDGFFP SELQRLYPNG VPFKVSDLRN QVYLEDGLDP
310 320 330 340 350
FPGEGRVVGR QLMHKALDRV EEHPGSRMTA EKFLNRLPKF VIRQGEVIDI
360 370 380 390 400
RGPIRDTLQN CCPLPARIQE IVVETPTLAA ERERSQESPN TPAPPLSMLR
410 420 430 440 450
IKSENGEQAF LLMMQPDNTI GDVRALLAQA RVMDASAFEI FSTFPPTLYQ
460 470 480 490 500
DDTLTLQAAG LVPKAALLLR ARRAPKSSLK FSPGPCPGPG PGPSPGPGPG
510 520
PSPGPGPGPS PCPGPSPSPQ
Length:520
Mass (Da):57,373
Last modified:May 1, 2007 - v2
Checksum:i8642DB07C023276E
GO
Isoform 2 (identifier: Q5T124-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-66: Missing.

Show »
Length:487
Mass (Da):53,976
Checksum:i6EC6574FF3D44CE8
GO
Isoform 3 (identifier: Q5T124-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-186: Missing.

Show »
Length:400
Mass (Da):43,272
Checksum:i7E9912421BC64AA9
GO
Isoform 4 (identifier: Q5T124-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Note: No experimental confirmation available.
Show »
Length:482
Mass (Da):53,192
Checksum:i6D512E3805F8F560
GO
Isoform 5 (identifier: Q5T124-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.

Show »
Length:208
Mass (Da):22,191
Checksum:i17B2577621F2E843
GO
Isoform 6 (identifier: Q5T124-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-324: SDLRNQVYLE...KALDRVEEHP → ISCSSNHTFG...SRCTPWGTPV
     325-520: Missing.

Show »
Length:324
Mass (Da):36,302
Checksum:i992910E8E88948D5
GO
Isoform 7 (identifier: Q5T124-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-66: Missing.
     286-324: SDLRNQVYLE...KALDRVEEHP → ISCSSNHTFG...SRCTPWGTPV
     325-520: Missing.

Show »
Length:291
Mass (Da):32,904
Checksum:i23B621EC61D566EA
GO
Isoform 8 (identifier: Q5T124-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Show »
Length:445
Mass (Da):49,445
Checksum:iBBAC87DB55A1A377
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R8K8X6R8K8_HUMAN
UBX domain-containing protein 11
UBXN11
247Annotation score:
Q5T130Q5T130_HUMAN
UBX domain-containing protein 11
UBXN11
185Annotation score:
Q5T118Q5T118_HUMAN
UBX domain-containing protein 11
UBXN11
115Annotation score:
X6RDK7X6RDK7_HUMAN
UBX domain-containing protein 11
UBXN11
148Annotation score:
X6RDY0X6RDY0_HUMAN
UBX domain-containing protein 11
UBXN11
134Annotation score:
X6RIY5X6RIY5_HUMAN
UBX domain-containing protein 11
UBXN11
207Annotation score:
X6R8M6X6R8M6_HUMAN
UBX domain-containing protein 11
UBXN11
277Annotation score:

Sequence cautioni

The sequence AAM74202 differs from that shown. Reason: Frameshift at position 190.Curated
The sequence AAQ15261 differs from that shown. Reason: Frameshift at position 390.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19E → G in CAH56155 (Ref. 2) Curated1
Sequence conflicti103K → M in BAC05024 (PubMed:14702039).Curated1
Sequence conflicti240N → D in BAC05024 (PubMed:14702039).Curated1
Sequence conflicti320V → L in AAQ15261 (PubMed:15498874).Curated1
Sequence conflicti388S → L in AAM74202 (Ref. 2) Curated1
Sequence conflicti418N → D in BAC04307 (PubMed:17974005).Curated1

Polymorphismi

The number of repeats is polymorphic and varies from 1 to 4.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031860165E → G. Corresponds to variant dbSNP:rs6695966Ensembl.1
Natural variantiVAR_031861312L → R2 PublicationsCorresponds to variant dbSNP:rs4332350Ensembl.1
Natural variantiVAR_031862474A → V1 Publication1
Natural variantiVAR_031863486C → CPGPGPGPS1 Publication1
Natural variantiVAR_031864487 – 494Missing 2 Publications8
Natural variantiVAR_031865488 – 502Missing . Add BLAST15
Natural variantiVAR_052690509P → S2 PublicationsCorresponds to variant dbSNP:rs1134584Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0247711 – 312Missing in isoform 5. 1 PublicationAdd BLAST312
Alternative sequenceiVSP_0247721 – 75Missing in isoform 8. 2 PublicationsAdd BLAST75
Alternative sequenceiVSP_0247731 – 38Missing in isoform 4. CuratedAdd BLAST38
Alternative sequenceiVSP_02477434 – 66Missing in isoform 2 and isoform 7. 3 PublicationsAdd BLAST33
Alternative sequenceiVSP_02477567 – 186Missing in isoform 3. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_024776286 – 324SDLRN…VEEHP → ISCSSNHTFGDFEGSGDTQP PQTPPILRGSRCTPWGTPV in isoform 6 and isoform 7. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_024777325 – 520Missing in isoform 6 and isoform 7. 2 PublicationsAdd BLAST196

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521017 mRNA Translation: AAM74201.1
AF521018 mRNA Translation: AAM74202.1 Frameshift.
AF520989 mRNA Translation: AAM76060.1
CR749413 mRNA Translation: CAH18255.1
BX648412 mRNA Translation: CAH56155.1
AK093258 mRNA Translation: BAC04112.1
AK094198 mRNA Translation: BAC04307.1
AK097368 mRNA Translation: BAC05024.1
AF370425 mRNA Translation: AAQ15261.1 Frameshift.
AL451139 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07823.1
CH471059 Genomic DNA Translation: EAX07826.1
BC038106 mRNA Translation: AAH38106.1
CCDSiCCDS41286.1 [Q5T124-2]
CCDS41287.1 [Q5T124-3]
CCDS41288.1 [Q5T124-1]
RefSeqiNP_001070730.1, NM_001077262.1 [Q5T124-3]
NP_663320.2, NM_145345.2 [Q5T124-2]
NP_892120.2, NM_183008.2 [Q5T124-1]
UniGeneiHs.145061

Genome annotation databases

EnsembliENST00000314675; ENSP00000324721; ENSG00000158062 [Q5T124-3]
ENST00000357089; ENSP00000349601; ENSG00000158062 [Q5T124-2]
ENST00000374217; ENSP00000363334; ENSG00000158062 [Q5T124-2]
ENST00000374221; ENSP00000363338; ENSG00000158062 [Q5T124-1]
ENST00000374222; ENSP00000363339; ENSG00000158062 [Q5T124-1]
GeneIDi91544
KEGGihsa:91544
UCSCiuc001blw.4 human [Q5T124-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF521017 mRNA Translation: AAM74201.1
AF521018 mRNA Translation: AAM74202.1 Frameshift.
AF520989 mRNA Translation: AAM76060.1
CR749413 mRNA Translation: CAH18255.1
BX648412 mRNA Translation: CAH56155.1
AK093258 mRNA Translation: BAC04112.1
AK094198 mRNA Translation: BAC04307.1
AK097368 mRNA Translation: BAC05024.1
AF370425 mRNA Translation: AAQ15261.1 Frameshift.
AL451139 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07823.1
CH471059 Genomic DNA Translation: EAX07826.1
BC038106 mRNA Translation: AAH38106.1
CCDSiCCDS41286.1 [Q5T124-2]
CCDS41287.1 [Q5T124-3]
CCDS41288.1 [Q5T124-1]
RefSeqiNP_001070730.1, NM_001077262.1 [Q5T124-3]
NP_663320.2, NM_145345.2 [Q5T124-2]
NP_892120.2, NM_183008.2 [Q5T124-1]
UniGeneiHs.145061

3D structure databases

ProteinModelPortaliQ5T124
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124844, 44 interactors
IntActiQ5T124, 32 interactors
MINTiQ5T124
STRINGi9606.ENSP00000363338

PTM databases

iPTMnetiQ5T124
PhosphoSitePlusiQ5T124

Polymorphism and mutation databases

BioMutaiUBXN11
DMDMi146325810

Proteomic databases

PaxDbiQ5T124
PeptideAtlasiQ5T124
PRIDEiQ5T124
ProteomicsDBi64223
64224 [Q5T124-2]
64225 [Q5T124-3]
64226 [Q5T124-4]
64227 [Q5T124-5]
64228 [Q5T124-6]
64229 [Q5T124-7]
64230 [Q5T124-8]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314675; ENSP00000324721; ENSG00000158062 [Q5T124-3]
ENST00000357089; ENSP00000349601; ENSG00000158062 [Q5T124-2]
ENST00000374217; ENSP00000363334; ENSG00000158062 [Q5T124-2]
ENST00000374221; ENSP00000363338; ENSG00000158062 [Q5T124-1]
ENST00000374222; ENSP00000363339; ENSG00000158062 [Q5T124-1]
GeneIDi91544
KEGGihsa:91544
UCSCiuc001blw.4 human [Q5T124-1]

Organism-specific databases

CTDi91544
DisGeNETi91544
EuPathDBiHostDB:ENSG00000158062.20
GeneCardsiUBXN11
HGNCiHGNC:30600 UBXN11
HPAiHPA028600
HPA031357
MIMi609151 gene
neXtProtiNX_Q5T124
OpenTargetsiENSG00000158062
PharmGKBiPA162408338
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2086 Eukaryota
ENOG410YGXU LUCA
GeneTreeiENSGT00390000010180
HOVERGENiHBG105985
InParanoidiQ5T124
OMAiQDLMDGY
OrthoDBiEOG091G02X6
PhylomeDBiQ5T124
TreeFamiTF329799

Miscellaneous databases

ChiTaRSiUBXN11 human
GeneWikiiUBXD5
GenomeRNAii91544
PROiPR:Q5T124
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158062 Expressed in 166 organ(s), highest expression level in right uterine tube
ExpressionAtlasiQ5T124 baseline and differential
GenevisibleiQ5T124 HS

Family and domain databases

Gene3Di3.30.420.210, 1 hit
InterProiView protein in InterPro
IPR036241 NSFL1C_SEP_dom_sf
IPR012989 SEP_domain
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF08059 SEP, 1 hit
PF00789 UBX, 1 hit
SUPFAMiSSF102848 SSF102848, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS51399 SEP, 1 hit
PS50033 UBX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBX11_HUMAN
AccessioniPrimary (citable) accession number: Q5T124
Secondary accession number(s): D3DPK6
, Q5T117, Q5T120, Q5T125, Q5T126, Q5T129, Q5T131, Q5T133, Q63HM6, Q71RB3, Q8IY27, Q8N1L6, Q8N9M4, Q8NA18, Q8NFE3, Q8NFE4, Q8NFE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: November 7, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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