UniProtKB - Q5T0N5 (FBP1L_HUMAN)
Formin-binding protein 1-like
FNBP1L
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 165 | Mediates end-to-end attachment of dimersBy similarity | 1 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- GTPase binding Source: UniProtKB
- lipid binding Source: UniProtKB-KW
GO - Biological processi
- autophagy Source: UniProtKB-KW
- cilium assembly Source: MGI
- clathrin-dependent endocytosis Source: BHF-UCL
- membrane invagination Source: BHF-UCL
- membrane organization Source: Reactome
- plasma membrane tubulation Source: BHF-UCL
- positive regulation of filopodium assembly Source: BHF-UCL
- signal transduction Source: InterPro
- vesicle budding from membrane Source: BHF-UCL
- vesicle organization Source: BHF-UCL
- vesicle transport along actin filament Source: BHF-UCL
Keywordsi
Biological process | Autophagy, Endocytosis |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q5T0N5 |
Reactomei | R-HSA-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Formin-binding protein 1-likeAlternative name(s): Transducer of Cdc42-dependent actin assembly protein 1 Short name: Toca-1 |
Gene namesi | Name:FNBP1L Synonyms:C1orf39, TOCA1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20851, FNBP1L |
MIMi | 608848, gene |
neXtProti | NX_Q5T0N5 |
VEuPathDBi | HostDB:ENSG00000137942.16 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Cytoskeleton
- cytoskeleton By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Other locations
- cell cortex By similarity
- Cytoplasmic vesicle By similarity
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cell cortex Source: UniProtKB-SubCell
- cytoplasm Source: MGI
- cytoplasmic vesicle Source: BHF-UCL
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 441 – 443 | MGD → IST: Impairs interaction with CDC42 and reduces CDC42-induced actin assembly. 1 Publication | 3 | |
Mutagenesisi | 576 | W → K: Impairs interaction with WASL and reduces CDC42-induced actin assembly. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 54874 |
OpenTargetsi | ENSG00000137942 |
PharmGKBi | PA128394675 |
Miscellaneous databases
Pharosi | Q5T0N5, Tbio |
Genetic variation databases
BioMutai | FNBP1L |
DMDMi | 118572313 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000261434 | 1 – 605 | Formin-binding protein 1-likeAdd BLAST | 605 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 295 | PhosphoserineCombined sources | 1 | |
Modified residuei | 488 | PhosphoserineCombined sources | 1 | |
Modified residuei | 501 | PhosphoserineCombined sources | 1 | |
Modified residuei | 505 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q5T0N5 |
jPOSTi | Q5T0N5 |
MassIVEi | Q5T0N5 |
MaxQBi | Q5T0N5 |
PaxDbi | Q5T0N5 |
PeptideAtlasi | Q5T0N5 |
PRIDEi | Q5T0N5 |
ProteomicsDBi | 64183 [Q5T0N5-1] 64184 [Q5T0N5-2] 64185 [Q5T0N5-3] 64186 [Q5T0N5-4] 64187 [Q5T0N5-5] |
PTM databases
iPTMneti | Q5T0N5 |
MetOSitei | Q5T0N5 |
PhosphoSitePlusi | Q5T0N5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137942, Expressed in forebrain and 238 other tissues |
ExpressionAtlasi | Q5T0N5, baseline and differential |
Genevisiblei | Q5T0N5, HS |
Organism-specific databases
HPAi | ENSG00000137942, Low tissue specificity |
Interactioni
Subunit structurei
Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures (By similarity).
Interacts with GTP-bound CDC42 (PubMed:15260990).
Interacts with DAAM1, DIAPH1, DIAPH2, DNM1, DNM2 and WASL/N-WASP (PubMed:16326391, PubMed:16630611, PubMed:16418535).
Interacts with ATG3 (PubMed:19342671).
Interacts (via SH3 domain) with ABI1, WASF2, CDC42 and WIPF1 (PubMed:19798448).
By similarity6 PublicationsBinary interactionsi
Hide detailsQ5T0N5
With | #Exp. | IntAct |
---|---|---|
ADAM8 [P78325] | 2 | EBI-714058,EBI-2625954 |
DAAM1 [Q9Y4D1] | 2 | EBI-714058,EBI-2817289 |
Isoform 3 [Q5T0N5-3]
With | #Exp. | IntAct |
---|---|---|
espF(U) [Q8X482] from Escherichia coli O157:H7. | 3 | EBI-4403262,EBI-22229752 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 120222, 29 interactors |
IntActi | Q5T0N5, 21 interactors |
MINTi | Q5T0N5 |
STRINGi | 9606.ENSP00000271234 |
Miscellaneous databases
RNActi | Q5T0N5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 263 | F-BARPROSITE-ProRule annotationAdd BLAST | 263 | |
Domaini | 397 – 474 | REM-1PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 538 – 599 | SH3PROSITE-ProRule annotationAdd BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 245 – 535 | Interaction with CDC42Add BLAST | 291 | |
Regioni | 522 – 605 | Interaction with DNM11 PublicationAdd BLAST | 84 | |
Regioni | 541 – 605 | Interaction with DAAM1, DIAPH1 and DIAPH21 PublicationAdd BLAST | 65 | |
Regioni | 541 – 597 | Interaction with DNM2 and WASL1 PublicationAdd BLAST | 57 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 66 – 258 | By similarityAdd BLAST | 193 | |
Coiled coili | 392 – 484 | By similarityAdd BLAST | 93 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coil, SH3 domainPhylogenomic databases
eggNOGi | KOG3565, Eukaryota |
GeneTreei | ENSGT00950000183047 |
HOGENOMi | CLU_023320_0_1_1 |
InParanoidi | Q5T0N5 |
OMAi | FGKKPKX |
PhylomeDBi | Q5T0N5 |
TreeFami | TF351162 |
Family and domain databases
CDDi | cd07675, F-BAR_FNBP1L, 1 hit cd12072, SH3_FNBP1L, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR030116, FNBP1L IPR035494, FNBP1L_F-BAR IPR035493, FNBP1L_SH3 IPR011072, HR1_rho-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR15735:SF14, PTHR15735:SF14, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF00018, SH3_1, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS51860, REM_1, 1 hit PS50002, SH3, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSWGTELWDQ FDSLDKHTQW GIDFLERYAK FVKERIEIEQ NYAKQLRNLV
60 70 80 90 100
KKYCPKRSSK DEEPRFTSCV AFFNILNELN DYAGQREVVA EEMAHRVYGE
110 120 130 140 150
LMRYAHDLKT ERKMHLQEGR KAQQYLDMCW KQMDNSKKKF ERECREAEKA
160 170 180 190 200
QQSYERLDND TNATKADVEK AKQQLNLRTH MADENKNEYA AQLQNFNGEQ
210 220 230 240 250
HKHFYVVIPQ IYKQLQEMDE RRTIKLSECY RGFADSERKV IPIISKCLEG
260 270 280 290 300
MILAAKSVDE RRDSQMVVDS FKSGFEPPGD FPFEDYSQHI YRTISDGTIS
310 320 330 340 350
ASKQESGKMD AKTTVGKAKG KLWLFGKKPK PQSPPLTPTS LFTSSTPNGS
360 370 380 390 400
QFLTFSIEPV HYCMNEIKTG KPRIPSFRSL KRGWSVKMGP ALEDFSHLPP
410 420 430 440 450
EQRRKKLQQR IDELNRELQK ESDQKDALNK MKDVYEKNPQ MGDPGSLQPK
460 470 480 490 500
LAETMNNIDR LRMEIHKNEA WLSEVEGKTG GRGDRRHSSD INHLVTQGRE
510 520 530 540 550
SPEGSYTDDA NQEVRGPPQQ HGHHNEFDDE FEDDDPLPAI GHCKAIYPFD
560 570 580 590 600
GHNEGTLAMK EGEVLYIIEE DKGDGWTRAR RQNGEEGYVP TSYIDVTLEK
NSKGS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A075B6Q2 | A0A075B6Q2_HUMAN | Formin-binding protein 1-like | FNBP1L | 451 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021709 | 331 – 388 | Missing in isoform 3 and isoform 4. 3 PublicationsAdd BLAST | 58 | |
Alternative sequenceiVSP_021710 | 384 – 388 | Missing in isoform 2 and isoform 5. Curated | 5 | |
Alternative sequenceiVSP_021711 | 605 | S → AVTYI in isoform 4 and isoform 5. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY514449 mRNA Translation: AAR98814.1 AC095034 Genomic DNA No translation available. AL109613 Genomic DNA No translation available. AL512651 Genomic DNA No translation available. BC062477 mRNA Translation: AAH62477.1 BC074891 mRNA Translation: AAH74891.1 BC074892 mRNA Translation: AAH74892.1 AK000282 mRNA Translation: BAA91051.1 Different initiation. |
CCDSi | CCDS53343.1 [Q5T0N5-1] CCDS53344.1 [Q5T0N5-4] CCDS60192.1 [Q5T0N5-3] |
RefSeqi | NP_001020119.1, NM_001024948.2 [Q5T0N5-4] NP_001157945.1, NM_001164473.2 [Q5T0N5-1] NP_060207.2, NM_017737.4 [Q5T0N5-3] |
Genome annotation databases
Ensembli | ENST00000260506; ENSP00000260506; ENSG00000137942 [Q5T0N5-4] ENST00000271234; ENSP00000271234; ENSG00000137942 [Q5T0N5-1] ENST00000370253; ENSP00000359275; ENSG00000137942 [Q5T0N5-3] |
GeneIDi | 54874 |
KEGGi | hsa:54874 |
UCSCi | uc001dpv.4, human [Q5T0N5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY514449 mRNA Translation: AAR98814.1 AC095034 Genomic DNA No translation available. AL109613 Genomic DNA No translation available. AL512651 Genomic DNA No translation available. BC062477 mRNA Translation: AAH62477.1 BC074891 mRNA Translation: AAH74891.1 BC074892 mRNA Translation: AAH74892.1 AK000282 mRNA Translation: BAA91051.1 Different initiation. |
CCDSi | CCDS53343.1 [Q5T0N5-1] CCDS53344.1 [Q5T0N5-4] CCDS60192.1 [Q5T0N5-3] |
RefSeqi | NP_001020119.1, NM_001024948.2 [Q5T0N5-4] NP_001157945.1, NM_001164473.2 [Q5T0N5-1] NP_060207.2, NM_017737.4 [Q5T0N5-3] |
3D structure databases
SMRi | Q5T0N5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120222, 29 interactors |
IntActi | Q5T0N5, 21 interactors |
MINTi | Q5T0N5 |
STRINGi | 9606.ENSP00000271234 |
PTM databases
iPTMneti | Q5T0N5 |
MetOSitei | Q5T0N5 |
PhosphoSitePlusi | Q5T0N5 |
Genetic variation databases
BioMutai | FNBP1L |
DMDMi | 118572313 |
Proteomic databases
EPDi | Q5T0N5 |
jPOSTi | Q5T0N5 |
MassIVEi | Q5T0N5 |
MaxQBi | Q5T0N5 |
PaxDbi | Q5T0N5 |
PeptideAtlasi | Q5T0N5 |
PRIDEi | Q5T0N5 |
ProteomicsDBi | 64183 [Q5T0N5-1] 64184 [Q5T0N5-2] 64185 [Q5T0N5-3] 64186 [Q5T0N5-4] 64187 [Q5T0N5-5] |
Protocols and materials databases
Antibodypediai | 33658, 165 antibodies |
Genome annotation databases
Ensembli | ENST00000260506; ENSP00000260506; ENSG00000137942 [Q5T0N5-4] ENST00000271234; ENSP00000271234; ENSG00000137942 [Q5T0N5-1] ENST00000370253; ENSP00000359275; ENSG00000137942 [Q5T0N5-3] |
GeneIDi | 54874 |
KEGGi | hsa:54874 |
UCSCi | uc001dpv.4, human [Q5T0N5-1] |
Organism-specific databases
CTDi | 54874 |
DisGeNETi | 54874 |
GeneCardsi | FNBP1L |
HGNCi | HGNC:20851, FNBP1L |
HPAi | ENSG00000137942, Low tissue specificity |
MIMi | 608848, gene |
neXtProti | NX_Q5T0N5 |
OpenTargetsi | ENSG00000137942 |
PharmGKBi | PA128394675 |
VEuPathDBi | HostDB:ENSG00000137942.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3565, Eukaryota |
GeneTreei | ENSGT00950000183047 |
HOGENOMi | CLU_023320_0_1_1 |
InParanoidi | Q5T0N5 |
OMAi | FGKKPKX |
PhylomeDBi | Q5T0N5 |
TreeFami | TF351162 |
Enzyme and pathway databases
PathwayCommonsi | Q5T0N5 |
Reactomei | R-HSA-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
BioGRID-ORCSi | 54874, 1 hit in 994 CRISPR screens |
ChiTaRSi | FNBP1L, human |
GeneWikii | FNBP1L |
GenomeRNAii | 54874 |
Pharosi | Q5T0N5, Tbio |
PROi | PR:Q5T0N5 |
RNActi | Q5T0N5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137942, Expressed in forebrain and 238 other tissues |
ExpressionAtlasi | Q5T0N5, baseline and differential |
Genevisiblei | Q5T0N5, HS |
Family and domain databases
CDDi | cd07675, F-BAR_FNBP1L, 1 hit cd12072, SH3_FNBP1L, 1 hit |
Gene3Di | 1.20.1270.60, 1 hit |
InterProi | View protein in InterPro IPR027267, AH/BAR_dom_sf IPR031160, F_BAR IPR001060, FCH_dom IPR030116, FNBP1L IPR035494, FNBP1L_F-BAR IPR035493, FNBP1L_SH3 IPR011072, HR1_rho-bd IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
PANTHERi | PTHR15735:SF14, PTHR15735:SF14, 1 hit |
Pfami | View protein in Pfam PF00611, FCH, 1 hit PF00018, SH3_1, 1 hit |
SMARTi | View protein in SMART SM00055, FCH, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF103657, SSF103657, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51741, F_BAR, 1 hit PS51860, REM_1, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBP1L_HUMAN | |
Accessioni | Q5T0N5Primary (citable) accession number: Q5T0N5 Secondary accession number(s): J3QSS4 Q9NXG1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | July 9, 2014 | |
Last modified: | April 7, 2021 | |
This is version 155 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families