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Protein

Spermatogenesis-associated protein 46

Gene

SPATA46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Play a role in spermiogenesis and fertilization.By similarity

GO - Biological processi

Keywordsi

Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 461 Publication
Gene namesi
Name:SPATA46Imported
Synonyms:C1orf111
ORF Names:HSD20
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000171722.11
HGNCiHGNC:27648 SPATA46
MIMi617257 gene
neXtProtiNX_Q5T0L3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171722
PharmGKBiPA142672495

Polymorphism and mutation databases

BioMutaiC1orf111
DMDMi317373467

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002794581 – 261Spermatogenesis-associated protein 46Add BLAST261

Proteomic databases

PaxDbiQ5T0L3
PRIDEiQ5T0L3
ProteomicsDBi64178

PTM databases

PhosphoSitePlusiQ5T0L3

Expressioni

Tissue specificityi

Testis-specific (PubMed:27488028).1 Publication

Gene expression databases

BgeeiENSG00000171722 Expressed in 76 organ(s), highest expression level in right testis
CleanExiHS_C1orf111
ExpressionAtlasiQ5T0L3 baseline and differential
GenevisibleiQ5T0L3 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPMSQ930623EBI-750105,EBI-740322

Protein-protein interaction databases

BioGridi129933, 11 interactors
IntActiQ5T0L3, 7 interactors
STRINGi9606.ENSP00000356912

Structurei

3D structure databases

ProteinModelPortaliQ5T0L3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 144Poly-Ser5

Phylogenomic databases

eggNOGiENOG410IKWE Eukaryota
ENOG4111ADC LUCA
GeneTreeiENSGT00390000007598
HOGENOMiHOG000111243
HOVERGENiHBG080965
InParanoidiQ5T0L3
OMAiNGYKCAA
OrthoDBiEOG091G1ATE
PhylomeDBiQ5T0L3
TreeFamiTF337124

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5T0L3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENFSLLSIS GPPISSSALS AFPDIMFSRA TSLPDIAKTA VPTEASSPAQ
60 70 80 90 100
ALPPQYQSII VRQGIQNTAL SPDCSLGDTQ HGEKLRRNCT IYRPWFSPYS
110 120 130 140 150
YFVCADKESQ LEAYDFPEVQ QDEGKWDNCL SEDMAENICS SSSSPENTCP
160 170 180 190 200
REATKKSRHG LDSITSQDIL MASRWHPAQQ NGYKCVACCR MYPTLDFLKS
210 220 230 240 250
HIKRGFREGF SCKVYYRKLK ALWSKEQKAR LGDRLSSGSC QAFNSPAEHL
260
RQIGGEAYLC L
Length:261
Mass (Da):29,150
Last modified:January 11, 2011 - v3
Checksum:iCB3CD34987BD2AD0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYQ4V9GYQ4_HUMAN
Spermatogenesis-associated protein ...
SPATA46
40Annotation score:

Sequence cautioni

The sequence AAP20051 differs from that shown. Reason: Frameshift at position 224.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03090469A → V2 PublicationsCorresponds to variant dbSNP:rs164181Ensembl.1
Natural variantiVAR_030905217R → H1 PublicationCorresponds to variant dbSNP:rs17853130Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512785 Genomic DNA No translation available.
BC032957 mRNA Translation: AAH32957.1
AY248900 mRNA Translation: AAP20051.1 Frameshift.
CCDSiCCDS1238.1
RefSeqiNP_872387.2, NM_182581.3
UniGeneiHs.97784

Genome annotation databases

EnsembliENST00000367935; ENSP00000356912; ENSG00000171722
GeneIDi284680
KEGGihsa:284680
UCSCiuc001gbx.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL512785 Genomic DNA No translation available.
BC032957 mRNA Translation: AAH32957.1
AY248900 mRNA Translation: AAP20051.1 Frameshift.
CCDSiCCDS1238.1
RefSeqiNP_872387.2, NM_182581.3
UniGeneiHs.97784

3D structure databases

ProteinModelPortaliQ5T0L3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129933, 11 interactors
IntActiQ5T0L3, 7 interactors
STRINGi9606.ENSP00000356912

PTM databases

PhosphoSitePlusiQ5T0L3

Polymorphism and mutation databases

BioMutaiC1orf111
DMDMi317373467

Proteomic databases

PaxDbiQ5T0L3
PRIDEiQ5T0L3
ProteomicsDBi64178

Protocols and materials databases

DNASUi284680
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367935; ENSP00000356912; ENSG00000171722
GeneIDi284680
KEGGihsa:284680
UCSCiuc001gbx.3 human

Organism-specific databases

CTDi284680
EuPathDBiHostDB:ENSG00000171722.11
GeneCardsiSPATA46
HGNCiHGNC:27648 SPATA46
MIMi617257 gene
neXtProtiNX_Q5T0L3
OpenTargetsiENSG00000171722
PharmGKBiPA142672495
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKWE Eukaryota
ENOG4111ADC LUCA
GeneTreeiENSGT00390000007598
HOGENOMiHOG000111243
HOVERGENiHBG080965
InParanoidiQ5T0L3
OMAiNGYKCAA
OrthoDBiEOG091G1ATE
PhylomeDBiQ5T0L3
TreeFamiTF337124

Miscellaneous databases

ChiTaRSiC1orf111 human
GenomeRNAii284680
PROiPR:Q5T0L3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171722 Expressed in 76 organ(s), highest expression level in right testis
CleanExiHS_C1orf111
ExpressionAtlasiQ5T0L3 baseline and differential
GenevisibleiQ5T0L3 HS

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiSPT46_HUMAN
AccessioniPrimary (citable) accession number: Q5T0L3
Secondary accession number(s): Q6X961, Q8NEC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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