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Protein

Tumor protein p63-regulated gene 1-like protein

Gene

TPRG1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein p63-regulated gene 1-like protein
Alternative name(s):
Mossy fiber terminal-associated vertebrate-specific presynaptic protein
Protein FAM79A
Gene namesi
Name:TPRG1L
Synonyms:FAM79A, MOVER
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158109.14
HGNCiHGNC:27007 TPRG1L
MIMi611460 gene
neXtProtiNX_Q5T0D9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000158109
PharmGKBiPA162406855

Polymorphism and mutation databases

BioMutaiTPRG1L
DMDMi74744290

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002691861 – 272Tumor protein p63-regulated gene 1-like proteinAdd BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Modified residuei14PhosphoserineBy similarity1
Modified residuei40PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated. Phosphorylation promotes association with synaptic vesicle membranes.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T0D9
MaxQBiQ5T0D9
PaxDbiQ5T0D9
PeptideAtlasiQ5T0D9
PRIDEiQ5T0D9
ProteomicsDBi64154
64155 [Q5T0D9-2]

PTM databases

iPTMnetiQ5T0D9
PhosphoSitePlusiQ5T0D9

Expressioni

Gene expression databases

BgeeiENSG00000158109
CleanExiHS_TPRG1L
GenevisibleiQ5T0D9 HS

Organism-specific databases

HPAiCAB079051
HPA063163

Interactioni

Subunit structurei

Forms homomultimers. Multimerization appears to be important for presynaptic targeting. Interacts with BSN.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ5T0D9, 1 interactor
STRINGi9606.ENSP00000367595

Structurei

3D structure databases

ProteinModelPortaliQ5T0D9
SMRiQ5T0D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 238hSac2PROSITE-ProRule annotationAdd BLAST174

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 97Important for homomultimer formation and localization to presynaptic regionsBy similarityAdd BLAST40
Regioni186 – 272Important for homomultimer formationBy similarityAdd BLAST87

Sequence similaritiesi

Belongs to the TPRG1 family.Curated

Phylogenomic databases

eggNOGiENOG410IEMY Eukaryota
ENOG4110AQ3 LUCA
GeneTreeiENSGT00390000001652
HOGENOMiHOG000273911
HOVERGENiHBG056028
InParanoidiQ5T0D9
OMAiYTTFIEH
OrthoDBiEOG091G0KQD
PhylomeDBiQ5T0D9
TreeFamiTF333472

Family and domain databases

InterProiView protein in InterPro
IPR034753 hSac2
IPR022158 Inositol_phosphatase
PfamiView protein in Pfam
PF12456 hSac2, 1 hit
PROSITEiView protein in PROSITE
PS51791 HSAC2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T0D9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLQLRDSVDS AGTSPTAVLA AGEEVGAGGG PGGGRPGAGT PLRQTLWPLS
60 70 80 90 100
IHDPTRRARV KEYFVFRPGS IEQAVEEIRV VVRPVEDGEI QGVWLLTEVD
110 120 130 140 150
HWNNEKERLV LVTEQSLLIC KYDFISLQCQ QVVRIALNAV DTISYGEFQF
160 170 180 190 200
PPKSLNKREG FGIRIQWDKQ SRPSFINRWN PWSTNVPYAT FTEHPMAGAD
210 220 230 240 250
EKTASLCQLE SFKALLIQAV KKAQKESPLP GQANGVLILE RPLLIETYVG
260 270
LMSFINNEAK LGYSMTRGKI GF
Length:272
Mass (Da):30,212
Last modified:December 21, 2004 - v1
Checksum:i3324B992F460E83C
GO
Isoform 2 (identifier: Q5T0D9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-157: Missing.

Note: No experimental confirmation available.
Show »
Length:213
Mass (Da):23,347
Checksum:i40E7F8F4606984D2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02201999 – 157Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289919 mRNA Translation: BAF82608.1
AL513320 Genomic DNA No translation available.
BC019034 mRNA Translation: AAH19034.1
CCDSiCCDS47.1 [Q5T0D9-1]
RefSeqiNP_877429.2, NM_182752.3 [Q5T0D9-1]
UniGeneiHs.20529

Genome annotation databases

EnsembliENST00000344579; ENSP00000339714; ENSG00000158109 [Q5T0D9-2]
ENST00000378344; ENSP00000367595; ENSG00000158109 [Q5T0D9-1]
GeneIDi127262
KEGGihsa:127262
UCSCiuc001akm.4 human [Q5T0D9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTPRGL_HUMAN
AccessioniPrimary (citable) accession number: Q5T0D9
Secondary accession number(s): A8K1K4, Q8WV04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 21, 2004
Last modified: June 20, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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