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Protein

Putative hydroxypyruvate isomerase

Gene

HYI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde).By similarity

Catalytic activityi

Hydroxypyruvate = 2-hydroxy-3-oxopropanoate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei150Proton donor/acceptorBy similarity1
Active sitei249Proton donor/acceptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative hydroxypyruvate isomerase (EC:5.3.1.22)
Alternative name(s):
Endothelial cell apoptosis protein E-CE1
Gene namesi
Name:HYI
ORF Names:HT036, SB156
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000178922.16
HGNCiHGNC:26948 HYI
neXtProtiNX_Q5T013

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178922
PharmGKBiPA142671668

Polymorphism and mutation databases

BioMutaiHYI
DMDMi152125829

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002892411 – 277Putative hydroxypyruvate isomeraseAdd BLAST277

Proteomic databases

EPDiQ5T013
MaxQBiQ5T013
PaxDbiQ5T013
PeptideAtlasiQ5T013
PRIDEiQ5T013
ProteomicsDBi64113
64114 [Q5T013-2]
64115 [Q5T013-3]
64116 [Q5T013-4]

PTM databases

iPTMnetiQ5T013
PhosphoSitePlusiQ5T013

Expressioni

Inductioni

Up-regulated by exposure to 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) after which is found in the culture medium of amniotic epithelial cells.1 Publication

Gene expression databases

BgeeiENSG00000178922 Expressed in 206 organ(s), highest expression level in body of pancreas
CleanExiHS_HYI
ExpressionAtlasiQ5T013 baseline and differential
GenevisibleiQ5T013 HS

Organism-specific databases

HPAiHPA040092

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123621, 13 interactors
IntActiQ5T013, 3 interactors
STRINGi9606.ENSP00000361502

Structurei

3D structure databases

ProteinModelPortaliQ5T013
SMRiQ5T013
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hyi family.Curated

Phylogenomic databases

eggNOGiKOG4518 Eukaryota
COG3622 LUCA
GeneTreeiENSGT00390000005462
HOVERGENiHBG056845
InParanoidiQ5T013
KOiK01816
PhylomeDBiQ5T013
TreeFamiTF312858

Family and domain databases

InterProiView protein in InterPro
IPR026040 HyI-like
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PIRSFiPIRSF006241 HyI, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T013-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPLRFSANL SWLFPELSGL PARVRAAGSS GFEAVEVAWP YAETPEALAR
60 70 80 90 100
AAREAGLRLV LINTPPGDQE KGEMGLGAVP GRQAAFREGL EQAVRYAKAL
110 120 130 140 150
GCPRIHLMAG RVPQGADRIA VKAEMEAVFL ENLRHAAGVL AQEDLVGLLE
160 170 180 190 200
PINTRITDPQ YFLDTPQQAA AILQKVGRPN LQLQMDIFHW QIMDGNLTGN
210 220 230 240 250
IREFLPIVGH VQVAQVPGRG EPSSPGELNF PYLFQLLEDE GYKGFVGCEY
260 270
QPRGDTVEGL SWLRSYWDRR GHPEAGQ
Length:277
Mass (Da):30,406
Last modified:May 29, 2007 - v2
Checksum:i79D5072A8717B4F7
GO
Isoform 2 (identifier: Q5T013-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     248-277: Missing.

Show »
Length:174
Mass (Da):19,084
Checksum:iD04A820535AB1705
GO
Isoform 3 (identifier: Q5T013-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-277: Missing.

Show »
Length:247
Mass (Da):26,874
Checksum:iDA0485BAB2BB5724
GO
Isoform 4 (identifier: Q5T013-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Show »
Length:204
Mass (Da):22,616
Checksum:i80BF040C3520EBD7
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6UJY1F6UJY1_HUMAN
Putative hydroxypyruvate isomerase
HYI
302Annotation score:
E7EWH8E7EWH8_HUMAN
Putative hydroxypyruvate isomerase
HYI
276Annotation score:
A0A0A0MTR5A0A0A0MTR5_HUMAN
Putative hydroxypyruvate isomerase
HYI
272Annotation score:
J9JIE9J9JIE9_HUMAN
Putative hydroxypyruvate isomerase
HYI
238Annotation score:
H0YB70H0YB70_HUMAN
Putative hydroxypyruvate isomerase
HYI
186Annotation score:
F6UJY9F6UJY9_HUMAN
Putative hydroxypyruvate isomerase
HYI
213Annotation score:
H0YB18H0YB18_HUMAN
Putative hydroxypyruvate isomerase
HYI
161Annotation score:

Sequence cautioni

The sequence AAH06140 differs from that shown. Reason: Frameshift at position 271.Curated
The sequence AAH19041 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAV84474 differs from that shown. Reason: Frameshift at positions 215, 228, 232 and 238.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18S → P in AAV84474 (Ref. 1) Curated1
Sequence conflicti18S → P in AAK67642 (Ref. 3) Curated1
Sequence conflicti18S → P in AAH19041 (Ref. 5) Curated1
Sequence conflicti224S → KP in AAV84474 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032611239D → N1 PublicationCorresponds to variant dbSNP:rs17850049Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0259861 – 73Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_025987248 – 277Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY775560 mRNA Translation: AAV84474.1 Frameshift.
AF284750 mRNA Translation: AAG59852.1
AF284751 mRNA Translation: AAG59853.1
AY037165 mRNA Translation: AAK67642.1
AL583862 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07090.1
CH471059 Genomic DNA Translation: EAX07091.1
CH471059 Genomic DNA Translation: EAX07093.1
CH471059 Genomic DNA Translation: EAX07094.1
BC006140 mRNA Translation: AAH06140.1 Sequence problems.
BC019041 mRNA Translation: AAH19041.1 Different initiation.
CCDSiCCDS488.2 [Q5T013-3]
CCDS53309.1 [Q5T013-1]
RefSeqiNP_001177809.1, NM_001190880.2 [Q5T013-1]
NP_001230455.1, NM_001243526.1
NP_112484.3, NM_031207.5 [Q5T013-3]
UniGeneiHs.709864

Genome annotation databases

EnsembliENST00000372425; ENSP00000361502; ENSG00000178922 [Q5T013-1]
ENST00000372432; ENSP00000361509; ENSG00000178922 [Q5T013-3]
GeneIDi81888
KEGGihsa:81888
UCSCiuc001cjn.4 human [Q5T013-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY775560 mRNA Translation: AAV84474.1 Frameshift.
AF284750 mRNA Translation: AAG59852.1
AF284751 mRNA Translation: AAG59853.1
AY037165 mRNA Translation: AAK67642.1
AL583862 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07090.1
CH471059 Genomic DNA Translation: EAX07091.1
CH471059 Genomic DNA Translation: EAX07093.1
CH471059 Genomic DNA Translation: EAX07094.1
BC006140 mRNA Translation: AAH06140.1 Sequence problems.
BC019041 mRNA Translation: AAH19041.1 Different initiation.
CCDSiCCDS488.2 [Q5T013-3]
CCDS53309.1 [Q5T013-1]
RefSeqiNP_001177809.1, NM_001190880.2 [Q5T013-1]
NP_001230455.1, NM_001243526.1
NP_112484.3, NM_031207.5 [Q5T013-3]
UniGeneiHs.709864

3D structure databases

ProteinModelPortaliQ5T013
SMRiQ5T013
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123621, 13 interactors
IntActiQ5T013, 3 interactors
STRINGi9606.ENSP00000361502

PTM databases

iPTMnetiQ5T013
PhosphoSitePlusiQ5T013

Polymorphism and mutation databases

BioMutaiHYI
DMDMi152125829

Proteomic databases

EPDiQ5T013
MaxQBiQ5T013
PaxDbiQ5T013
PeptideAtlasiQ5T013
PRIDEiQ5T013
ProteomicsDBi64113
64114 [Q5T013-2]
64115 [Q5T013-3]
64116 [Q5T013-4]

Protocols and materials databases

DNASUi81888
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372425; ENSP00000361502; ENSG00000178922 [Q5T013-1]
ENST00000372432; ENSP00000361509; ENSG00000178922 [Q5T013-3]
GeneIDi81888
KEGGihsa:81888
UCSCiuc001cjn.4 human [Q5T013-1]

Organism-specific databases

CTDi81888
EuPathDBiHostDB:ENSG00000178922.16
GeneCardsiHYI
HGNCiHGNC:26948 HYI
HPAiHPA040092
neXtProtiNX_Q5T013
OpenTargetsiENSG00000178922
PharmGKBiPA142671668
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4518 Eukaryota
COG3622 LUCA
GeneTreeiENSGT00390000005462
HOVERGENiHBG056845
InParanoidiQ5T013
KOiK01816
PhylomeDBiQ5T013
TreeFamiTF312858

Miscellaneous databases

GenomeRNAii81888
PROiPR:Q5T013

Gene expression databases

BgeeiENSG00000178922 Expressed in 206 organ(s), highest expression level in body of pancreas
CleanExiHS_HYI
ExpressionAtlasiQ5T013 baseline and differential
GenevisibleiQ5T013 HS

Family and domain databases

InterProiView protein in InterPro
IPR026040 HyI-like
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PIRSFiPIRSF006241 HyI, 1 hit
SUPFAMiSSF51658 SSF51658, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHYI_HUMAN
AccessioniPrimary (citable) accession number: Q5T013
Secondary accession number(s): D3DPX4
, D3DPX5, Q5Q9A2, Q7Z778, Q96S83, Q9BZR3, Q9BZR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 7, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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