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Protein

FRAS1-related extracellular matrix protein 2

Gene

FREM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
FRAS1-related extracellular matrix protein 2
Alternative name(s):
ECM3 homolog
Gene namesi
Name:FREM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000150893.10
HGNCiHGNC:25396 FREM2
MIMi608945 gene
neXtProtiNX_Q5SZK8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini47 – 3113ExtracellularSequence analysisAdd BLAST3067
Transmembranei3114 – 3134HelicalSequence analysisAdd BLAST21
Topological domaini3135 – 3169CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Fraser syndrome 2 (FRASRS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Fraser syndrome, an autosomal recessive disorder characterized by cryptophthalmos, cutaneous syndactyly, and urogenital abnormalities including renal agenesis or hypoplasia. Additional features include abnormalities of the larynx, ear malformations, and facial abnormalities.
See also OMIM:617666
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0232011972E → K in FRASRS2; may impair calcium-binding in the 2nd Calx-beta domain. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi341640
MalaCardsiFREM2
MIMi617666 phenotype
Orphaneti2052 Fraser syndrome
93100 Renal agenesis, unilateral
PharmGKBiPA134930862

Polymorphism and mutation databases

BioMutaiFREM2
DMDMi73620903

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 46Sequence analysisAdd BLAST46
ChainiPRO_000001012447 – 3169FRAS1-related extracellular matrix protein 2Add BLAST3123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi358N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1369N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1584N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1741N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ5SZK8
MaxQBiQ5SZK8
PaxDbiQ5SZK8
PeptideAtlasiQ5SZK8
PRIDEiQ5SZK8
ProteomicsDBi64078
64079 [Q5SZK8-2]

PTM databases

iPTMnetiQ5SZK8
PhosphoSitePlusiQ5SZK8

Expressioni

Gene expression databases

BgeeiENSG00000150893 Expressed in 115 organ(s), highest expression level in adrenal tissue
CleanExiHS_FREM2
GenevisibleiQ5SZK8 HS

Organism-specific databases

HPAiHPA028831

Interactioni

Protein-protein interaction databases

BioGridi131147, 45 interactors
CORUMiQ5SZK8
STRINGi9606.ENSP00000280481

Structurei

3D structure databases

ProteinModelPortaliQ5SZK8
SMRiQ5SZK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati319 – 413CSPG 1PROSITE-ProRule annotationAdd BLAST95
Repeati438 – 537CSPG 2PROSITE-ProRule annotationAdd BLAST100
Repeati560 – 675CSPG 3PROSITE-ProRule annotationAdd BLAST116
Repeati700 – 807CSPG 4PROSITE-ProRule annotationAdd BLAST108
Repeati828 – 919CSPG 5PROSITE-ProRule annotationAdd BLAST92
Repeati945 – 1037CSPG 6PROSITE-ProRule annotationAdd BLAST93
Repeati1066 – 1168CSPG 7PROSITE-ProRule annotationAdd BLAST103
Repeati1189 – 1282CSPG 8PROSITE-ProRule annotationAdd BLAST94
Repeati1303 – 1399CSPG 9PROSITE-ProRule annotationAdd BLAST97
Repeati1420 – 1512CSPG 10PROSITE-ProRule annotationAdd BLAST93
Repeati1532 – 1621CSPG 11PROSITE-ProRule annotationAdd BLAST90
Repeati1655 – 1752CSPG 12PROSITE-ProRule annotationAdd BLAST98
Domaini1759 – 1858Calx-beta 1Add BLAST100
Domaini1871 – 1982Calx-beta 2Add BLAST112
Domaini1997 – 2103Calx-beta 3Add BLAST107
Domaini2118 – 2220Calx-beta 4Add BLAST103
Domaini2238 – 2342Calx-beta 5Add BLAST105

Domaini

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

Sequence similaritiesi

Belongs to the FRAS1 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1306 Eukaryota
KOG2090 Eukaryota
KOG3597 Eukaryota
ENOG410YBR4 LUCA
HOVERGENiHBG081537
InParanoidiQ5SZK8
OrthoDBiEOG091G02YT
PhylomeDBiQ5SZK8
TreeFamiTF316876

Family and domain databases

Gene3Di2.60.40.2030, 5 hits
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR039005 CSPG_rpt
PfamiView protein in Pfam
PF03160 Calx-beta, 5 hits
SMARTiView protein in SMART
SM00237 Calx_beta, 5 hits
SUPFAMiSSF141072 SSF141072, 5 hits
PROSITEiView protein in PROSITE
PS51854 CSPG, 12 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5SZK8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MHSAGTPGLS SRRTGNSTSF QPGPPPPPRL LLLLLLLLSL VSRVPAQPAA
60 70 80 90 100
FGRALLSPGL AGAAGVPAEE AIVLANRGLR VPFGREVWLD PLHDLVLQVQ
110 120 130 140 150
PGDRCAVSVL DNDALAQRPG RLSPKRFPCD FGPGEVRYSH LGARSPSRDR
160 170 180 190 200
VRLQLRYDAP GGAVVLPLVL EVEVVFTQLE VVTRNLPLVV EELLGTSNAL
210 220 230 240 250
DARSLEFAFQ PETEECRVGI LSGLGALPRY GELLHYPQVP GGAREGGAPE
260 270 280 290 300
TLLMDCKAFQ ELGVRYRHTA ASRSPNRDWI PMVVELRSRG APVGSPALKR
310 320 330 340 350
EHFQVLVRIR GGAENTAPKP SFVAMMMMEV DQFVLTALTP DMLAAEDAES
360 370 380 390 400
PSDLLIFNLT SPFQPGQGYL VSTDDRSLPL SSFTQRDLRL LKIAYQPPSE
410 420 430 440 450
DSDQERLFEL ELEVVDLEGA ASDPFAFMVV VKPMNTMAPV VTRNTGLILY
460 470 480 490 500
EGQSRPLTGP AGSGPQNLVI SDEDDLEAVR LEVVAGLRHG HLVILGASSG
510 520 530 540 550
SSAPKSFTVA ELAAGQVVYQ HDDRDGSLSD NLVLRMVDGG GRHQVQFLFP
560 570 580 590 600
ITLVPVDDQP PVLNANTGLT LAEGETVPIL PLSLSATDMD SDDSLLLFVL
610 620 630 640 650
ESPFLTTGHL LLRQTHPPHE KQELLRGLWR KEGAFYERTV TEWQQQDITE
660 670 680 690 700
GRLFYRHSGP HSPGPVTDQF TFRVQDNHDP PNQSGLQRFV IRIHPVDRLP
710 720 730 740 750
PELGSGCPLR MVVQESQLTP LRKKWLRYTD LDTDDRELRY TVTQSPTDTD
760 770 780 790 800
ENHLPAPLGT LVLTDNPSVV VTHFTQAQIN HHKIAYRPPG QELGVATRVA
810 820 830 840 850
QFQFQVEDRA GNVAPGTFTL YLHPVDNQPP EILNTGFTIQ EKGHHILSET
860 870 880 890 900
ELHVNDVDTD VAHISFTLTQ APKHGHMRVS GQILHVGGLF HLEDIKQGRV
910 920 930 940 950
SYAHNGDKSL TDSCSLEVSD RHHVVPITLR VNVRPVDDEV PILSHPTGTL
960 970 980 990 1000
ESYLDVLENG ATEITANVIK GTNEETDDLM LTFLLEDPPL YGEILVNGIP
1010 1020 1030 1040 1050
AEQFTQRDIL EGSVVYTHTS GEIGLLPKAD SFNLSLSDMS QEWRIGGNTI
1060 1070 1080 1090 1100
QGVTIWVTIL PVDSQAPEIF VGEQLIVMEG DKSVITSVHI SAEDVDSLND
1110 1120 1130 1140 1150
DILCTIVIQP TSGYVENISP APGSEKSRAG IAISAFNLKD LRQGHINYVQ
1160 1170 1180 1190 1200
SVHKGVEPVE DRFVFRCSDG INFSERQFFP IVIIPTNDEQ PEMFMREFMV
1210 1220 1230 1240 1250
MEGMSLVIDT PILNAADADV PLDDLTFTIT QFPTHGHIMN QLINGTVLVE
1260 1270 1280 1290 1300
SFTLDQIIES SSIIYEHDDS ETQEDSFVIK LTDGKHSVEK TVLIIVIPVD
1310 1320 1330 1340 1350
DETPRMTINN GLEIEIGDTK IINNKILMAT DLDSEDKSLV YIIRYGPGHG
1360 1370 1380 1390 1400
LLQRRKPTGA FENITLGMNF TQDEVDRNLI QYVHLGQEGI RDLIKFDVTD
1410 1420 1430 1440 1450
GINPLIDRYF YVSIGSIDIV FPDVISKGVS LKEGGKVTLT TDLLSTSDLN
1460 1470 1480 1490 1500
SPDENLVFTI TRAPMRGHLE CTDQPGVSIT SFTQLQLAGN KIYYIHTADD
1510 1520 1530 1540 1550
EVKMDSFEFQ VTDGRNPVFR TFRISISDVD NKKPVVTIHK LVVSESENKL
1560 1570 1580 1590 1600
ITPFELTVED RDTPDKLLKF TITQVPIHGH LLFNNTRPVM VFTKQDLNEN
1610 1620 1630 1640 1650
LISYKHDGTE SSEDSFSFTV TDGTHTDFYV FPDTVFETRR PQVMKIQVLA
1660 1670 1680 1690 1700
VDNSVPQIAV NKGASTLRTL ATGHLGFMIT SKILKVEDRD SLHISLRFIV
1710 1720 1730 1740 1750
TEAPQHGYLL NLDKGNHSIT QFTQADIDDM KICYVLREGA NATSDMFYFA
1760 1770 1780 1790 1800
VEDGGGNKLT YQNFRLNWAW ISFEKEYYLV NEDSKFLDVV LKRRGYLGET
1810 1820 1830 1840 1850
SFISIGTRDR TAEKDKDFKG KAQKQVQFNP GQTRATWRVR ILSDGEHEQS
1860 1870 1880 1890 1900
ETFQVVLSEP VLAALEFPTV ATVEIVDPGD EPTVFIPQSK YSVEEDVGEL
1910 1920 1930 1940 1950
FIPIRRSGDV SQELMVVCYT QQGTATGTVP TSVLSYSDYI SRPEDHTSVV
1960 1970 1980 1990 2000
RFDKDEREKL CRIVIIDDSL YEEEETFHVL LSMPMGGRIG SEFPGAQVTI
2010 2020 2030 2040 2050
VPDKDDEPIF YFGDVEYSVD ESAGYVEVQV WRTGTDLSKS SSVTVRSRKT
2060 2070 2080 2090 2100
DPPSADAGTD YVGISRNLDF APGVNMQPVR VVILDDLGQP ALEGIEKFEL
2110 2120 2130 2140 2150
VLRMPMNAAL GEPSKATVSI NDSVSDLPKM QFKERIYTGS ESDGQIVTMI
2160 2170 2180 2190 2200
HRTGDVQYRS SVRCYTRQGS AQVMMDFEER PNTDTSIITF LPGETEKPCI
2210 2220 2230 2240 2250
LELMDDVLYE EVEELRLVLG TPQSNSPFGA AVGEQNETLI RIRDDADKTV
2260 2270 2280 2290 2300
IKFGETKFSV TEPKEPGESV VIRIPVIRQG DTSKVSIVRV HTKDGSATSG
2310 2320 2330 2340 2350
EDYHPVSEEI EFKEGETQHV VEIEVTFDGV REMREAFTVH LKPDENMIAE
2360 2370 2380 2390 2400
MQLTKAIVYI EEMSSMADVT FPSVPQIVSL LMYDDTSKAK ESAEPMSGYP
2410 2420 2430 2440 2450
VICITACNPK YSDYDKTGSI CASENINDTL TRYRWLISAP AGPDGVTSPM
2460 2470 2480 2490 2500
REVDFDTFFT SSKMVTLDSI YFQPGSRVQC AARAVNTNGD EGLELMSPIV
2510 2520 2530 2540 2550
TISREEGLCQ PRVPGVVGAE PFSAKLRYTG PEDADYTNLI KLTVTMPHID
2560 2570 2580 2590 2600
GMLPVISTRE LSNFELTLSP DGTRVGNHKC SNLLDYTEVK THYGFLTDAT
2610 2620 2630 2640 2650
KNPEIIGETY PYQYSLSIRG STTLRFYRNL NLEACLWEFV SYYDMSELLA
2660 2670 2680 2690 2700
DCGGTIGTDG QVLNLVQSYV TLRVPLYVSY VFHSPVGVGG WQHFDLKSEL
2710 2720 2730 2740 2750
RLTFVYDTAI LWNDGIGSPP EAELQGSLYP TSMRIGDEGR LAVHFKTEAQ
2760 2770 2780 2790 2800
FHGLFVLSHP ASFTSSVIMS ADHPGLTFSL RLIRSEPTYN QPVQQWSFVS
2810 2820 2830 2840 2850
DFAVRDYSGT YTVKLVPCTA PSHQEYRLPV TCNPREPVTF DLDIRFQQVS
2860 2870 2880 2890 2900
DPVAAEFSLN TQMYLLSKKS LWLSDGSMGF GQESDVAFAE GDIIYGRVMV
2910 2920 2930 2940 2950
DPVQNLGDSF YCSIEKVFLC TGADGYVPKY SPMNAEYGCL ADSPSLLYRF
2960 2970 2980 2990 3000
KIVDKAQPET QATSFGNVLF NAKLAVDDPE AILLVNQPGS DGFKVDSTPL
3010 3020 3030 3040 3050
FQVALGREWY IHTIYTVRSK DNANRGIGKR SVEYHSLVSQ GKPQSTTKSR
3060 3070 3080 3090 3100
KKREIRSTPS LAWEIGAENS RGTNIQHIAL DRTKRQIPHG RAPPDGILPW
3110 3120 3130 3140 3150
ELNSPSSAVS LVTVVGGTTV GLLTICLTVI AVLMCRGKES FRGKDAPKGS
3160
SSSEPMVPPQ SHHNDSSEV
Length:3,169
Mass (Da):351,157
Last modified:August 16, 2005 - v2
Checksum:i4000FC02963417F7
GO
Isoform 2 (identifier: Q5SZK8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2663-2667: LNLVQ → QIYNI
     2668-3169: Missing.

Note: No experimental confirmation available.
Show »
Length:2,667
Mass (Da):295,845
Checksum:i9AD8ABD80F89E9F8
GO

Sequence cautioni

The sequence BAC87040 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2030V → A in CAD98088 (PubMed:14702039).Curated1
Sequence conflicti2112E → K in BAC87040 (PubMed:17974005).Curated1
Sequence conflicti2116A → T in BAC87040 (PubMed:17974005).Curated1
Sequence conflicti2359Y → H in CAD98088 (PubMed:14702039).Curated1
Sequence conflicti2508L → P in BAC87040 (PubMed:17974005).Curated1
Sequence conflicti2638E → K in BAC87040 (PubMed:17974005).Curated1
Sequence conflicti2682F → I in CAD98088 (PubMed:14702039).Curated1
Sequence conflicti2777T → S in CAI46253 (PubMed:14702039).Curated1
Sequence conflicti2786E → G in CAD98036 (PubMed:14702039).Curated1
Sequence conflicti2968V → I in CAD98088 (PubMed:14702039).Curated1
Sequence conflicti2968V → I in CAE45813 (PubMed:14702039).Curated1
Sequence conflicti3081D → G in CAD98088 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061174722R → K. Corresponds to variant dbSNP:rs58363253EnsemblClinVar.1
Natural variantiVAR_061175745S → P. Corresponds to variant dbSNP:rs2496423Ensembl.1
Natural variantiVAR_033933770V → M. Corresponds to variant dbSNP:rs7327915EnsemblClinVar.1
Natural variantiVAR_033934868L → V. Corresponds to variant dbSNP:rs7329939EnsemblClinVar.1
Natural variantiVAR_0339351039M → K. Corresponds to variant dbSNP:rs2496424EnsemblClinVar.1
Natural variantiVAR_0375691045I → S. Corresponds to variant dbSNP:rs17058433Ensembl.1
Natural variantiVAR_0339361070F → S. Corresponds to variant dbSNP:rs2496425EnsemblClinVar.1
Natural variantiVAR_0375701668R → H. Corresponds to variant dbSNP:rs1868463EnsemblClinVar.1
Natural variantiVAR_0339371840R → W. Corresponds to variant dbSNP:rs9603422EnsemblClinVar.1
Natural variantiVAR_0232011972E → K in FRASRS2; may impair calcium-binding in the 2nd Calx-beta domain. 1 Publication1
Natural variantiVAR_0232022066R → C1 PublicationCorresponds to variant dbSNP:rs9548505EnsemblClinVar.1
Natural variantiVAR_0232032153T → S1 PublicationCorresponds to variant dbSNP:rs9548506EnsemblClinVar.1
Natural variantiVAR_0232042326T → I2 PublicationsCorresponds to variant dbSNP:rs9548509EnsemblClinVar.1
Natural variantiVAR_0375712962A → V. Corresponds to variant dbSNP:rs7996253EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0150352663 – 2667LNLVQ → QIYNI in isoform 2. 1 Publication5
Alternative sequenceiVSP_0150362668 – 3169Missing in isoform 2. 1 PublicationAdd BLAST502

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC017111 Genomic DNA No translation available.
AL354819 Genomic DNA No translation available.
AL590007 Genomic DNA No translation available.
AK127571 mRNA Translation: BAC87040.1 Different initiation.
BX538150 mRNA Translation: CAD98036.1
BX538304 mRNA Translation: CAD98088.1
BX640686 mRNA Translation: CAE45813.1
CR933724 mRNA Translation: CAI46253.1
BN000687 mRNA Translation: CAH56764.1
CCDSiCCDS31960.1 [Q5SZK8-1]
RefSeqiNP_997244.4, NM_207361.5
UniGeneiHs.253994

Genome annotation databases

EnsembliENST00000280481; ENSP00000280481; ENSG00000150893
GeneIDi341640
KEGGihsa:341640
UCSCiuc001uwv.4 human [Q5SZK8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC017111 Genomic DNA No translation available.
AL354819 Genomic DNA No translation available.
AL590007 Genomic DNA No translation available.
AK127571 mRNA Translation: BAC87040.1 Different initiation.
BX538150 mRNA Translation: CAD98036.1
BX538304 mRNA Translation: CAD98088.1
BX640686 mRNA Translation: CAE45813.1
CR933724 mRNA Translation: CAI46253.1
BN000687 mRNA Translation: CAH56764.1
CCDSiCCDS31960.1 [Q5SZK8-1]
RefSeqiNP_997244.4, NM_207361.5
UniGeneiHs.253994

3D structure databases

ProteinModelPortaliQ5SZK8
SMRiQ5SZK8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131147, 45 interactors
CORUMiQ5SZK8
STRINGi9606.ENSP00000280481

PTM databases

iPTMnetiQ5SZK8
PhosphoSitePlusiQ5SZK8

Polymorphism and mutation databases

BioMutaiFREM2
DMDMi73620903

Proteomic databases

EPDiQ5SZK8
MaxQBiQ5SZK8
PaxDbiQ5SZK8
PeptideAtlasiQ5SZK8
PRIDEiQ5SZK8
ProteomicsDBi64078
64079 [Q5SZK8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280481; ENSP00000280481; ENSG00000150893
GeneIDi341640
KEGGihsa:341640
UCSCiuc001uwv.4 human [Q5SZK8-1]

Organism-specific databases

CTDi341640
DisGeNETi341640
EuPathDBiHostDB:ENSG00000150893.10
GeneCardsiFREM2
H-InvDBiHIX0026558
HGNCiHGNC:25396 FREM2
HPAiHPA028831
MalaCardsiFREM2
MIMi608945 gene
617666 phenotype
neXtProtiNX_Q5SZK8
Orphaneti2052 Fraser syndrome
93100 Renal agenesis, unilateral
PharmGKBiPA134930862
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1306 Eukaryota
KOG2090 Eukaryota
KOG3597 Eukaryota
ENOG410YBR4 LUCA
HOVERGENiHBG081537
InParanoidiQ5SZK8
OrthoDBiEOG091G02YT
PhylomeDBiQ5SZK8
TreeFamiTF316876

Miscellaneous databases

ChiTaRSiFREM2 human
GeneWikiiFREM2
GenomeRNAii341640
PROiPR:Q5SZK8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150893 Expressed in 115 organ(s), highest expression level in adrenal tissue
CleanExiHS_FREM2
GenevisibleiQ5SZK8 HS

Family and domain databases

Gene3Di2.60.40.2030, 5 hits
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR039005 CSPG_rpt
PfamiView protein in Pfam
PF03160 Calx-beta, 5 hits
SMARTiView protein in SMART
SM00237 Calx_beta, 5 hits
SUPFAMiSSF141072 SSF141072, 5 hits
PROSITEiView protein in PROSITE
PS51854 CSPG, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFREM2_HUMAN
AccessioniPrimary (citable) accession number: Q5SZK8
Secondary accession number(s): Q4QQG1
, Q5H9N8, Q5T6Q1, Q6N057, Q6ZSB4, Q7Z305, Q7Z341
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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