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UniProtKB - Q5SZD4 (GLYL3_HUMAN)

Entry version 109 (22 Apr 2020)
Sequence version 3 (24 Nov 2009)
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Protein

Glycine N-acyltransferase-like protein 3

Gene

GLYATL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Lipid metabolism

This protein is involved in Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in Lipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-177128 Conjugation of salicylate with glycine
R-HSA-177135 Conjugation of benzoate with glycine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycine N-acyltransferase-like protein 3By similarity (EC:2.3.1.13By similarity)
Alternative name(s):
Acyl-CoA:glycine-N-acyltransferase-like protein 3By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLYATL3Imported
Synonyms:C6orf140
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:21349 GLYATL3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		614763 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5SZD4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000203972

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA165617919

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5SZD4 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GLYATL3

Domain mapping of disease mutations (DMDM)

More...DMDMi		269849680

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003360551 – 288Glycine N-acyltransferase-like protein 3Add BLAST288

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5SZD4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5SZD4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5SZD4

PeptideAtlas

More...PeptideAtlasi		Q5SZD4

PRoteomics IDEntifications database

More...PRIDEi		Q5SZD4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		64055

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5SZD4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5SZD4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000203972 Expressed in liver and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5SZD4 baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000203972 Group enriched (intestine, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		133128, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q5SZD4, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000360240

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5SZD4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycine N-acyltransferase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IYSJ Eukaryota
ENOG4111RDK LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183133

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_060336_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5SZD4

KEGG Orthology (KO)

More...KOi		K22750

Identification of Orthologs from Complete Genome Data

More...OMAi		AVHFSPV

Database of Orthologous Groups

More...OrthoDBi		1221333at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5SZD4

TreeFam database of animal gene trees

More...TreeFami		TF353258

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR010313 Glycine_N-acyltransferase
IPR013652 Glycine_N-acyltransferase_C
IPR015938 Glycine_N-acyltransferase_N

The PANTHER Classification System

More...PANTHERi		PTHR15298 PTHR15298, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08444 Gly_acyl_tr_C, 1 hit
PF06021 Gly_acyl_tr_N, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55729 SSF55729, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5SZD4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLVLNCSTKL LILEKMLKSC FPESLKVYGA VMNINRGNPF QKEVVLDSWP 
        60         70         80         90        100
DFKAVITRRQ REAETDNLDH YTNAYAVFYK DVRAYRQLLE ECDVFNWDQV 
       110        120        130        140        150
FQIQGLQSEL YDVSKAVANS KQLNIKLTSF KAVHFSPVSS LPDTSFLKGP 
       160        170        180        190        200
SPRLTYLSVA NADLLNRTWS RGGNEQCLRY IANLISCFPS VCVRDEKGNP 
       210        220        230        240        250
VSWSITDQFA TMCHGYTLPE HRRKGYSRLV ALTLARKLQS RGFPSQGNVL 
       260        270        280 
DDNTASISLL KSLHAEFLPC RFHRLILTPA TFSGLPHL
Length:288
Mass (Da):32,704
Last modified:November 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE83D9766EFB7F1B8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GXQ5F5GXQ5_HUMAN
Glycine N-acyltransferase-like prot...
GLYATL3
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104Q → K in AK126371 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK126371 mRNA No translation available.
AL590244 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47440.1

NCBI Reference Sequences

More...RefSeqi		NP_001010904.1, NM_001010904.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000371197; ENSP00000360240; ENSG00000203972

Database of genes from NCBI RefSeq genomes

More...GeneIDi		389396

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:389396

UCSC genome browser

More...UCSCi		uc003ozi.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK126371 mRNA No translation available.
AL590244 Genomic DNA No translation available.
CCDSiCCDS47440.1
RefSeqiNP_001010904.1, NM_001010904.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi133128, 1 interactor
IntActiQ5SZD4, 1 interactor
STRINGi9606.ENSP00000360240

PTM databases

iPTMnetiQ5SZD4
PhosphoSitePlusiQ5SZD4

Polymorphism and mutation databases

BioMutaiGLYATL3
DMDMi269849680

Proteomic databases

EPDiQ5SZD4
MassIVEiQ5SZD4
PaxDbiQ5SZD4
PeptideAtlasiQ5SZD4
PRIDEiQ5SZD4
ProteomicsDBi64055

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30820 50 antibodies

Genome annotation databases

EnsembliENST00000371197; ENSP00000360240; ENSG00000203972
GeneIDi389396
KEGGihsa:389396
UCSCiuc003ozi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		389396

GeneCards: human genes, protein and diseases

More...GeneCardsi		GLYATL3
HGNCiHGNC:21349 GLYATL3
HPAiENSG00000203972 Group enriched (intestine, liver)
MIMi614763 gene
neXtProtiNX_Q5SZD4
OpenTargetsiENSG00000203972
PharmGKBiPA165617919

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IYSJ Eukaryota
ENOG4111RDK LUCA
GeneTreeiENSGT00950000183133
HOGENOMiCLU_060336_0_0_1
InParanoidiQ5SZD4
KOiK22750
OMAiAVHFSPV
OrthoDBi1221333at2759
PhylomeDBiQ5SZD4
TreeFamiTF353258

Enzyme and pathway databases

ReactomeiR-HSA-177128 Conjugation of salicylate with glycine
R-HSA-177135 Conjugation of benzoate with glycine

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GLYATL3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		389396
PharosiQ5SZD4 Tdark

Protein Ontology

More...PROi		PR:Q5SZD4
RNActiQ5SZD4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000203972 Expressed in liver and 4 other tissues
ExpressionAtlasiQ5SZD4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR010313 Glycine_N-acyltransferase
IPR013652 Glycine_N-acyltransferase_C
IPR015938 Glycine_N-acyltransferase_N
PANTHERiPTHR15298 PTHR15298, 1 hit
PfamiView protein in Pfam
PF08444 Gly_acyl_tr_C, 1 hit
PF06021 Gly_acyl_tr_N, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLYL3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SZD4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: November 24, 2009
Last modified: April 22, 2020
This is version 109 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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