UniProtKB - Q5SZD4 (GLYL3_HUMAN)
Protein
Glycine N-acyltransferase-like protein 3
Gene
GLYATL3
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway.By similarity
Catalytic activityi
- EC:2.3.1.13By similarity
: Lipid metabolism Pathwayi
This protein is involved in Lipid metabolism.By similarityView all proteins of this organism that are known to be involved in Lipid metabolism.
GO - Molecular functioni
- glycine N-acyltransferase activity Source: UniProtKB
- N-acyltransferase activity Source: GO_Central
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
PathwayCommonsi | Q5SZD4 |
Reactomei | R-HSA-177128, Conjugation of salicylate with glycine R-HSA-177135, Conjugation of benzoate with glycine |
Names & Taxonomyi
Protein namesi | Recommended name: Glycine N-acyltransferase-like protein 3By similarity (EC:2.3.1.13By similarity)Alternative name(s): Acyl-CoA:glycine-N-acyltransferase-like protein 3By similarity |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21349, GLYATL3 |
MIMi | 614763, gene |
neXtProti | NX_Q5SZD4 |
VEuPathDBi | HostDB:ENSG00000203972.9 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000203972 |
PharmGKBi | PA165617919 |
Miscellaneous databases
Pharosi | Q5SZD4, Tdark |
Genetic variation databases
BioMutai | GLYATL3 |
DMDMi | 269849680 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000336055 | 1 – 288 | Glycine N-acyltransferase-like protein 3Add BLAST | 288 |
Proteomic databases
EPDi | Q5SZD4 |
MassIVEi | Q5SZD4 |
PaxDbi | Q5SZD4 |
PeptideAtlasi | Q5SZD4 |
PRIDEi | Q5SZD4 |
ProteomicsDBi | 64055 |
PTM databases
iPTMneti | Q5SZD4 |
PhosphoSitePlusi | Q5SZD4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000203972, Expressed in liver and 12 other tissues |
ExpressionAtlasi | Q5SZD4, baseline and differential |
Organism-specific databases
HPAi | ENSG00000203972, Group enriched (intestine, liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 133128, 1 interactor |
IntActi | Q5SZD4, 1 interactor |
STRINGi | 9606.ENSP00000360240 |
Miscellaneous databases
RNActi | Q5SZD4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycine N-acyltransferase family.Curated
Phylogenomic databases
eggNOGi | ENOG502RFRQ, Eukaryota |
GeneTreei | ENSGT00950000183133 |
HOGENOMi | CLU_060336_0_0_1 |
InParanoidi | Q5SZD4 |
OMAi | AVHFSPV |
OrthoDBi | 1221333at2759 |
PhylomeDBi | Q5SZD4 |
TreeFami | TF353258 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR010313, Glycine_N-acyltransferase IPR013652, Glycine_N-acyltransferase_C IPR015938, Glycine_N-acyltransferase_N |
PANTHERi | PTHR15298, PTHR15298, 1 hit |
Pfami | View protein in Pfam PF08444, Gly_acyl_tr_C, 1 hit PF06021, Gly_acyl_tr_N, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5SZD4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLVLNCSTKL LILEKMLKSC FPESLKVYGA VMNINRGNPF QKEVVLDSWP
60 70 80 90 100
DFKAVITRRQ REAETDNLDH YTNAYAVFYK DVRAYRQLLE ECDVFNWDQV
110 120 130 140 150
FQIQGLQSEL YDVSKAVANS KQLNIKLTSF KAVHFSPVSS LPDTSFLKGP
160 170 180 190 200
SPRLTYLSVA NADLLNRTWS RGGNEQCLRY IANLISCFPS VCVRDEKGNP
210 220 230 240 250
VSWSITDQFA TMCHGYTLPE HRRKGYSRLV ALTLARKLQS RGFPSQGNVL
260 270 280
DDNTASISLL KSLHAEFLPC RFHRLILTPA TFSGLPHL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF5GXQ5 | F5GXQ5_HUMAN | Glycine N-acyltransferase-like prot... | GLYATL3 | 156 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 104 | Q → K in AK126371 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126371 mRNA No translation available. AL590244 Genomic DNA No translation available. |
CCDSi | CCDS47440.1 |
RefSeqi | NP_001010904.1, NM_001010904.1 |
Genome annotation databases
Ensembli | ENST00000371197; ENSP00000360240; ENSG00000203972 |
GeneIDi | 389396 |
KEGGi | hsa:389396 |
UCSCi | uc003ozi.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK126371 mRNA No translation available. AL590244 Genomic DNA No translation available. |
CCDSi | CCDS47440.1 |
RefSeqi | NP_001010904.1, NM_001010904.1 |
3D structure databases
SMRi | Q5SZD4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 133128, 1 interactor |
IntActi | Q5SZD4, 1 interactor |
STRINGi | 9606.ENSP00000360240 |
PTM databases
iPTMneti | Q5SZD4 |
PhosphoSitePlusi | Q5SZD4 |
Genetic variation databases
BioMutai | GLYATL3 |
DMDMi | 269849680 |
Proteomic databases
EPDi | Q5SZD4 |
MassIVEi | Q5SZD4 |
PaxDbi | Q5SZD4 |
PeptideAtlasi | Q5SZD4 |
PRIDEi | Q5SZD4 |
ProteomicsDBi | 64055 |
Protocols and materials databases
Antibodypediai | 30820, 51 antibodies |
Genome annotation databases
Ensembli | ENST00000371197; ENSP00000360240; ENSG00000203972 |
GeneIDi | 389396 |
KEGGi | hsa:389396 |
UCSCi | uc003ozi.4, human |
Organism-specific databases
CTDi | 389396 |
GeneCardsi | GLYATL3 |
HGNCi | HGNC:21349, GLYATL3 |
HPAi | ENSG00000203972, Group enriched (intestine, liver) |
MIMi | 614763, gene |
neXtProti | NX_Q5SZD4 |
OpenTargetsi | ENSG00000203972 |
PharmGKBi | PA165617919 |
VEuPathDBi | HostDB:ENSG00000203972.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RFRQ, Eukaryota |
GeneTreei | ENSGT00950000183133 |
HOGENOMi | CLU_060336_0_0_1 |
InParanoidi | Q5SZD4 |
OMAi | AVHFSPV |
OrthoDBi | 1221333at2759 |
PhylomeDBi | Q5SZD4 |
TreeFami | TF353258 |
Enzyme and pathway databases
PathwayCommonsi | Q5SZD4 |
Reactomei | R-HSA-177128, Conjugation of salicylate with glycine R-HSA-177135, Conjugation of benzoate with glycine |
Miscellaneous databases
BioGRID-ORCSi | 389396, 2 hits in 985 CRISPR screens |
ChiTaRSi | GLYATL3, human |
GenomeRNAii | 389396 |
Pharosi | Q5SZD4, Tdark |
PROi | PR:Q5SZD4 |
RNActi | Q5SZD4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000203972, Expressed in liver and 12 other tissues |
ExpressionAtlasi | Q5SZD4, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR010313, Glycine_N-acyltransferase IPR013652, Glycine_N-acyltransferase_C IPR015938, Glycine_N-acyltransferase_N |
PANTHERi | PTHR15298, PTHR15298, 1 hit |
Pfami | View protein in Pfam PF08444, Gly_acyl_tr_C, 1 hit PF06021, Gly_acyl_tr_N, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLYL3_HUMAN | |
Accessioni | Q5SZD4Primary (citable) accession number: Q5SZD4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | November 24, 2009 | |
Last modified: | April 7, 2021 | |
This is version 114 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families