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Entry version 95 (13 Feb 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Uncharacterized protein C6orf141

Gene

C6orf141

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C6orf141
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000197261.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21351 C6orf141

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5SZD1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000197261

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134885117

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C6orf141

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373454

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895371 – 244Uncharacterized protein C6orf141Add BLAST244

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5SZD1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5SZD1

PeptideAtlas

More...
PeptideAtlasi
Q5SZD1

PRoteomics IDEntifications database

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PRIDEi
Q5SZD1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64054

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SZD1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SZD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197261 Expressed in 132 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5SZD1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SZD1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036199

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126429, 85 interactors

Protein interaction database and analysis system

More...
IntActi
Q5SZD1, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5SZD1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5SZD1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IY9G Eukaryota
ENOG4111419 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007738

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058140

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SZD1

Identification of Orthologs from Complete Genome Data

More...
OMAi
KGRMTTR

Database of Orthologous Groups

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OrthoDBi
1359414at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SZD1

TreeFam database of animal gene trees

More...
TreeFami
TF336881

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037739 C6orf141

The PANTHER Classification System

More...
PANTHERi
PTHR36880 PTHR36880, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5SZD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNDPFARMET RGPQGAANPM DSSRSLGDLG PFPREVGRGA PLAPGARNPA
60 70 80 90 100
TAGASRSQGG GHEDRTADRA LGPRAGEELD RESWVREKVL FLLHPERWLG
110 120 130 140 150
TRGDPAREEV AGAEDLPHAG GEDHGEEPNY PSVFQRQKRI SGRRVAPPRD
160 170 180 190 200
AADPPKYVLV RVEDYQVTQE VLQTSWAKGR MTTRTEEHFV TALTFRSSRE
210 220 230 240
GQPGERWGPA ESRALQARTG ASRVHAAGRR VSPSPGTWLE EIKL
Length:244
Mass (Da):26,754
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB2EE557D7AE9FBF2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YDR2H0YDR2_HUMAN
Uncharacterized protein C6orf141
C6orf141
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH36917 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022939137Q → E3 PublicationsCorresponds to variant dbSNP:rs6919674Ensembl.1
Natural variantiVAR_030643235P → L. Corresponds to variant dbSNP:rs9473588Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK054918 mRNA Translation: BAB70828.1
AK289889 mRNA Translation: BAF82578.1
AL590244 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04335.1
BC036917 mRNA Translation: AAH36917.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS55018.1

NCBI Reference Sequences

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RefSeqi
NP_001139124.1, NM_001145652.1
XP_005248907.1, XM_005248850.3
XP_005248909.1, XM_005248852.2
XP_005248910.1, XM_005248853.2
XP_006715060.1, XM_006714997.2
XP_011512605.1, XM_011514303.2
XP_016865783.1, XM_017010294.1
XP_016865784.1, XM_017010295.1
XP_016865785.1, XM_017010296.1
XP_016865786.1, XM_017010297.1
XP_016865787.1, XM_017010298.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.722010

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371194; ENSP00000431184; ENSG00000197261
ENST00000414696; ENSP00000436754; ENSG00000197261
ENST00000529246; ENSP00000434602; ENSG00000197261

Database of genes from NCBI RefSeq genomes

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GeneIDi
135398

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:135398

UCSC genome browser

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UCSCi
uc011dwo.3 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK054918 mRNA Translation: BAB70828.1
AK289889 mRNA Translation: BAF82578.1
AL590244 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04335.1
BC036917 mRNA Translation: AAH36917.1 Different initiation.
CCDSiCCDS55018.1
RefSeqiNP_001139124.1, NM_001145652.1
XP_005248907.1, XM_005248850.3
XP_005248909.1, XM_005248852.2
XP_005248910.1, XM_005248853.2
XP_006715060.1, XM_006714997.2
XP_011512605.1, XM_011514303.2
XP_016865783.1, XM_017010294.1
XP_016865784.1, XM_017010295.1
XP_016865785.1, XM_017010296.1
XP_016865786.1, XM_017010297.1
XP_016865787.1, XM_017010298.1
UniGeneiHs.722010

3D structure databases

ProteinModelPortaliQ5SZD1
SMRiQ5SZD1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126429, 85 interactors
IntActiQ5SZD1, 3 interactors

PTM databases

iPTMnetiQ5SZD1
PhosphoSitePlusiQ5SZD1

Polymorphism and mutation databases

BioMutaiC6orf141
DMDMi317373454

Proteomic databases

jPOSTiQ5SZD1
PaxDbiQ5SZD1
PeptideAtlasiQ5SZD1
PRIDEiQ5SZD1
ProteomicsDBi64054

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
135398
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371194; ENSP00000431184; ENSG00000197261
ENST00000414696; ENSP00000436754; ENSG00000197261
ENST00000529246; ENSP00000434602; ENSG00000197261
GeneIDi135398
KEGGihsa:135398
UCSCiuc011dwo.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
135398
EuPathDBiHostDB:ENSG00000197261.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C6orf141
HGNCiHGNC:21351 C6orf141
HPAiHPA036199
neXtProtiNX_Q5SZD1
OpenTargetsiENSG00000197261
PharmGKBiPA134885117

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IY9G Eukaryota
ENOG4111419 LUCA
GeneTreeiENSGT00390000007738
HOVERGENiHBG058140
InParanoidiQ5SZD1
OMAiKGRMTTR
OrthoDBi1359414at2759
PhylomeDBiQ5SZD1
TreeFamiTF336881

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
135398

Protein Ontology

More...
PROi
PR:Q5SZD1

Gene expression databases

BgeeiENSG00000197261 Expressed in 132 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ5SZD1 baseline and differential
GenevisibleiQ5SZD1 HS

Family and domain databases

InterProiView protein in InterPro
IPR037739 C6orf141
PANTHERiPTHR36880 PTHR36880, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCF141_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SZD1
Secondary accession number(s): A8K1H4, Q8N400, Q96NQ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 11, 2011
Last modified: February 13, 2019
This is version 95 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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