UniProtKB - Q5SZ99 (Q5SZ99_MOUSE)
Protein
Submitted name:
Tripartite motif-containing 38
Gene
Trim38
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- protein homodimerization activity Source: GO_Central
- protein kinase binding Source: GO_Central
- ubiquitin protein ligase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- innate immune response Source: GO_Central
- negative regulation of defense response to virus Source: MGI
- positive regulation of autophagy Source: GO_Central
- positive regulation of DNA-binding transcription factor activity Source: MGI
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
- positive regulation of NF-kappaB transcription factor activity Source: MGI
- positive regulation of viral entry into host cell Source: MGI
- positive regulation of viral genome replication Source: MGI
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: MGI
- protein K48-linked ubiquitination Source: MGI
- protein polyubiquitination Source: GO_Central
- protein ubiquitination Source: GO_Central
- regulation of gene expression Source: GO_Central
- regulation of interferon-beta production Source: MGI
- regulation of protein localization Source: GO_Central
- regulation of viral entry into host cell Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Tripartite motif-containing 38Imported |
Gene namesi | Name:Trim38Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2684869, Trim38 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Nucleus
- nucleoplasm Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000064140, Expressed in jejunum and 40 other tissues |
Interactioni
GO - Molecular functioni
- protein homodimerization activity Source: GO_Central
- protein kinase binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000073709 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 62 | RING-typeInterPro annotationAdd BLAST | 47 | |
Domaini | 90 – 131 | B box-typeInterPro annotationAdd BLAST | 42 | |
Domaini | 276 – 471 | B30.2/SPRYInterPro annotationAdd BLAST | 196 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 135 – 159 | Sequence analysisAdd BLAST | 25 | |
Coiled coili | 211 – 263 | Sequence analysisAdd BLAST | 53 |
Keywords - Domaini
Coiled coilSequence analysisARBA annotation, Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000160468 |
HOGENOMi | CLU_013137_0_3_1 |
InParanoidi | Q5SZ99 |
OMAi | MLRRYQV |
OrthoDBi | 423686at2759 |
PhylomeDBi | Q5SZ99 |
TreeFami | TF342569 |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit cd15815, SPRY_PRY_TRIM38, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR035790, SPRY/PRY_TRIM38 IPR003877, SPRY_dom IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5SZ99-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSDFSTVKI RKVTSCSICK AMMSHPVSIN CGHSYCKSCI QSYYCNVSPK
60 70 80 90 100
TGWKMLGCPL CSSPFSLENL RPNKELETII DMIKGMEEQD QDMVCEEHEE
110 120 130 140 150
KFNRFCEDDG QLLCWRCYWE DRHKGHTLAH VKDVYQNYKE KLQNTMTKLR
160 170 180 190 200
ELQENHEVQI HFITHQINAW KDAVEDRRQT IKSNFKNLQS FLQEEEKFYL
210 220 230 240 250
WRLENEEKEM LVQLEGSEAN LQQTFERAQC QIQELEAKCQ GSAQKLLQDV
260 270 280 290 300
KNTLSRCEAM KRNPLKADPL KVHTKCNVSE LYFDVKTILR RHQVSVILDP
310 320 330 340 350
STAHLDLALT KGGRLVTYKR CPRDLQARSS AKRFYGLPCV LGCEGFTSGR
360 370 380 390 400
YYFEVSVENA TSWDLGVCVE NVHRGFNMKK EPESGFWTIK MSEEDGLEAL
410 420 430 440 450
TSTPTPPLHL IEKPQILGVF LDYEAGAVSF YSVTTGSHIF TFPKASFQDT
460 470
LRPFFQVYQY SPLFLPAINN Q
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A286YDR5 | A0A286YDR5_MOUSE | Tripartite motif-containing 38 | Trim38 | 249 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590388 Genomic DNA No translation available. |
RefSeqi | NP_001025106.1, NM_001029935.2 XP_006516700.1, XM_006516637.2 XP_011242605.1, XM_011244303.1 |
Genome annotation databases
Ensembli | ENSMUST00000074067; ENSMUSP00000073709; ENSMUSG00000064140 ENSMUST00000226039; ENSMUSP00000153240; ENSMUSG00000064140 |
GeneIDi | 214158 |
KEGGi | mmu:214158 |
UCSCi | uc007pva.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL590388 Genomic DNA No translation available. |
RefSeqi | NP_001025106.1, NM_001029935.2 XP_006516700.1, XM_006516637.2 XP_011242605.1, XM_011244303.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000073709 |
PTM databases
PhosphoSitePlusi | Q5SZ99 |
Protocols and materials databases
Antibodypediai | 10788, 475 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000074067; ENSMUSP00000073709; ENSMUSG00000064140 ENSMUST00000226039; ENSMUSP00000153240; ENSMUSG00000064140 |
GeneIDi | 214158 |
KEGGi | mmu:214158 |
UCSCi | uc007pva.2, mouse |
Organism-specific databases
CTDi | 10475 |
MGIi | MGI:2684869, Trim38 |
Phylogenomic databases
eggNOGi | KOG2177, Eukaryota |
GeneTreei | ENSGT00940000160468 |
HOGENOMi | CLU_013137_0_3_1 |
InParanoidi | Q5SZ99 |
OMAi | MLRRYQV |
OrthoDBi | 423686at2759 |
PhylomeDBi | Q5SZ99 |
TreeFami | TF342569 |
Miscellaneous databases
BioGRID-ORCSi | 214158, 2 hits in 17 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000064140, Expressed in jejunum and 40 other tissues |
Family and domain databases
CDDi | cd00021, BBOX, 1 hit cd15815, SPRY_PRY_TRIM38, 1 hit |
Gene3Di | 2.60.120.920, 1 hit 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR035790, SPRY/PRY_TRIM38 IPR003877, SPRY_dom IPR000315, Znf_B-box IPR001841, Znf_RING IPR013083, Znf_RING/FYVE/PHD IPR017907, Znf_RING_CS |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit PF00643, zf-B_box, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00336, BBOX, 1 hit SM00589, PRY, 1 hit SM00184, RING, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit PS50119, ZF_BBOX, 1 hit PS00518, ZF_RING_1, 1 hit PS50089, ZF_RING_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5SZ99_MOUSE | |
Accessioni | Q5SZ99Primary (citable) accession number: Q5SZ99 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 21, 2004 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |