Trim38

Functionⁱ

GO - Molecular functionⁱ

zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of defense response to virus
Source: MGI
Inferred from mutant phenotypeⁱ
- 22539786
positive regulation of DNA-binding transcription factor activity Source: MGI
positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
positive regulation of NF-kappaB transcription factor activity Source: MGI
positive regulation of viral entry into host cell Source: MGI
positive regulation of viral genome replication
Source: MGI
Inferred from direct assayⁱ
- 22539786
proteasome-mediated ubiquitin-dependent protein catabolic process
Source: MGI
Inferred from direct assayⁱ
- 22539786
protein K48-linked ubiquitination
Source: MGI
Inferred from direct assayⁱ
- 22539786
regulation of interferon-beta production
Source: MGI
Inferred from direct assayⁱ
- 22539786

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Tripartite motif-containing 38Imported
Gene namesⁱ	Name:Trim38Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 13

Organism-specific databases

MGIⁱ	MGI:2684869 Trim38

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

PTM databases

iPTMnetⁱ	Q5SZ99
PhosphoSitePlusⁱ	Q5SZ99

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000064140 Expressed in 14 organ(s), highest expression level in colon

Bgeeⁱ

ENSMUSG00000064140 Expressed in 14 organ(s), highest expression level in colon

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000073709

STRINGⁱ

10090.ENSMUSP00000073709

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5SZ99
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	16 – 62	RING-typeInterPro annotationAdd BLAST	47
Domainⁱ	90 – 131	B box-typeInterPro annotationAdd BLAST	42
Domainⁱ	276 – 471	B30.2/SPRYInterPro annotationAdd BLAST	196

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	135 – 159	Sequence analysisAdd BLAST		25
Coiled coilⁱ	211 – 263	Sequence analysisAdd BLAST		53

Keywords - Domainⁱ

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG2177 Eukaryota ENOG4111G04 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118893
HOVERGENⁱ	HBG001357
InParanoidⁱ	Q5SZ99
KEGG Orthology (KO) More...KOⁱ	K12014
OMAⁱ	PDTAHHE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05W2
PhylomeDBⁱ	Q5SZ99
TreeFamⁱ	TF342569

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00021 BBOX, 1 hit cd15815 SPRY_PRY_TRIM38, 1 hit
Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR006574 PRY IPR035790 SPRY/PRY_TRIM38 IPR003877 SPRY_dom IPR000315 Znf_B-box IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13765 PRY, 1 hit PF00622 SPRY, 1 hit PF00643 zf-B_box, 1 hit
PRINTSⁱ	PR01407 BUTYPHLNCDUF
SMARTⁱ	View protein in SMART SM00336 BBOX, 1 hit SM00589 PRY, 1 hit SM00184 RING, 1 hit SM00449 SPRY, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50119 ZF_BBOX, 1 hit PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q5SZ99-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSDFSTVKI RKVTSCSICK AMMSHPVSIN CGHSYCKSCI QSYYCNVSPK 
        60         70         80         90        100
TGWKMLGCPL CSSPFSLENL RPNKELETII DMIKGMEEQD QDMVCEEHEE 
       110        120        130        140        150
KFNRFCEDDG QLLCWRCYWE DRHKGHTLAH VKDVYQNYKE KLQNTMTKLR 
       160        170        180        190        200
ELQENHEVQI HFITHQINAW KDAVEDRRQT IKSNFKNLQS FLQEEEKFYL 
       210        220        230        240        250
WRLENEEKEM LVQLEGSEAN LQQTFERAQC QIQELEAKCQ GSAQKLLQDV 
       260        270        280        290        300
KNTLSRCEAM KRNPLKADPL KVHTKCNVSE LYFDVKTILR RHQVSVILDP 
       310        320        330        340        350
STAHLDLALT KGGRLVTYKR CPRDLQARSS AKRFYGLPCV LGCEGFTSGR 
       360        370        380        390        400
YYFEVSVENA TSWDLGVCVE NVHRGFNMKK EPESGFWTIK MSEEDGLEAL 
       410        420        430        440        450
TSTPTPPLHL IEKPQILGVF LDYEAGAVSF YSVTTGSHIF TFPKASFQDT 
       460        470 
LRPFFQVYQY SPLFLPAINN Q

Length:471

Mass (Da):54,430

Last modified:December 21, 2004 - v1

Checksum:ⁱ9C4BE6BACFAD6540

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A286YDR5	A0A286YDR5_MOUSE		Tripartite motif-containing 38 Tripartite motif-containing 38	Trim38	249	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL590388 Genomic DNA No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001025106.1, NM_001029935.2 XP_006516700.1, XM_006516637.2 XP_011242605.1, XM_011244303.1
UniGeneⁱ	Mm.314151

Genome annotation databases

Ensemblⁱ	ENSMUST00000074067; ENSMUSP00000073709; ENSMUSG00000064140 ENSMUST00000226039; ENSMUSP00000153240; ENSMUSG00000064140
GeneIDⁱ	214158
KEGGⁱ	mmu:214158
UCSC genome browser More...UCSCⁱ	uc007pva.2 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q5SZ99	Tripartite motif-containing 38		MOUSE		471	UniRef90_Q5SZ99
UPI000A311EF1		MUSPA		474
UPI000A3158C7		MUSCR		474

Protein	Similar proteins		Species	Score	Length	Source
Q5SZ99	E3 ubiquitin-protein ligase TRIM38		HUMAN		465	UniRef50_O00635
E3 ubiquitin-protein ligase TRIM38		BOVIN		460
Uncharacterized protein		PAPAN		468
Tripartite motif-containing protein 38 (Fragment)		MACMU		272
Tripartite motif containing 38		GORGO		465
+147

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL590388 Genomic DNA No translation available.
RefSeqⁱ	NP_001025106.1, NM_001029935.2 XP_006516700.1, XM_006516637.2 XP_011242605.1, XM_011244303.1
UniGeneⁱ	Mm.314151

3D structure databases

ProteinModelPortalⁱ	Q5SZ99
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000073709

STRINGⁱ

10090.ENSMUSP00000073709

PTM databases

iPTMnetⁱ	Q5SZ99
PhosphoSitePlusⁱ	Q5SZ99

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000074067; ENSMUSP00000073709; ENSMUSG00000064140 ENSMUST00000226039; ENSMUSP00000153240; ENSMUSG00000064140
GeneIDⁱ	214158
KEGGⁱ	mmu:214158
UCSCⁱ	uc007pva.2 mouse

Organism-specific databases

CTDⁱ	10475
MGIⁱ	MGI:2684869 Trim38

Phylogenomic databases

eggNOGⁱ	KOG2177 Eukaryota ENOG4111G04 LUCA
GeneTreeⁱ	ENSGT00760000118893
HOVERGENⁱ	HBG001357
InParanoidⁱ	Q5SZ99
KOⁱ	K12014
OMAⁱ	PDTAHHE
OrthoDBⁱ	EOG091G05W2
PhylomeDBⁱ	Q5SZ99
TreeFamⁱ	TF342569

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000064140 Expressed in 14 organ(s), highest expression level in colon

Bgeeⁱ

ENSMUSG00000064140 Expressed in 14 organ(s), highest expression level in colon

Family and domain databases

CDDⁱ	cd00021 BBOX, 1 hit cd15815 SPRY_PRY_TRIM38, 1 hit
Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001870 B30.2/SPRY IPR003879 Butyrophylin_SPRY IPR013320 ConA-like_dom_sf IPR006574 PRY IPR035790 SPRY/PRY_TRIM38 IPR003877 SPRY_dom IPR000315 Znf_B-box IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD IPR017907 Znf_RING_CS
Pfamⁱ	View protein in Pfam PF13765 PRY, 1 hit PF00622 SPRY, 1 hit PF00643 zf-B_box, 1 hit
PRINTSⁱ	PR01407 BUTYPHLNCDUF
SMARTⁱ	View protein in SMART SM00336 BBOX, 1 hit SM00589 PRY, 1 hit SM00184 RING, 1 hit SM00449 SPRY, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS50188 B302_SPRY, 1 hit PS50119 ZF_BBOX, 1 hit PS00518 ZF_RING_1, 1 hit PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5SZ99_MOUSE
Accessionⁱ	Q5SZ99Primary (citable) accession number: Q5SZ99
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 21, 2004
	Last sequence update:	December 21, 2004
	Last modified:	October 10, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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UniParc

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Supporting data

UniProtKB - Q5SZ99 (Q5SZ99_MOUSE)

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Tripartite motif-containing 38

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ