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Protein
Submitted name:

Splicing factor 3B subunit 4

Gene

SF3B4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Splicing factor 3B subunit 4Imported
Submitted name:
Splicing factor 3b, subunit 4, 49kDaImported
Gene namesi
Name:SF3B4Imported
ORF Names:RP11-196G18.20-002Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143368.9
HGNCiHGNC:10771 SF3B4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143368

PTM / Processingi

Proteomic databases

MaxQBiQ5SZ64
PRIDEiQ5SZ64

Expressioni

Gene expression databases

BgeeiENSG00000143368 Expressed in 203 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiQ5SZ64 baseline and differential

Interactioni

Protein-protein interaction databases

MINTiQ5SZ64

Structurei

3D structure databases

SMRiQ5SZ64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 48RRMInterPro annotationAdd BLAST48
Domaini57 – 136RRMInterPro annotationAdd BLAST80

Phylogenomic databases

eggNOGiKOG0131 Eukaryota
ENOG410XPT4 LUCA
GeneTreeiENSGT00870000136537
HOGENOMiHOG000200535
HOVERGENiHBG002295

Family and domain databases

CDDicd12335 RRM2_SF3B4, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034159 SF3B4_RRM2
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5SZ64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKDRVTGQH QGYGFVEFLS EEDADYAIKI MNMIKLYGKP IRVNKASAHN
60 70 80 90 100
KNLDVGANIF IGNLDPEIDE KLLYDTFSAF GVILQTPKIM RDPDTGNSKG
110 120 130 140 150
YAFINFASFD ASDAAIEAMN GQYLCNRPIT VSYAFKKDSK GERHGSAAER
160 170 180 190
LLAAQNPLSQ ADRPHQLFAD APPPPSAPNP VVSSLGSGLP
Length:190
Mass (Da):20,689
Last modified:December 21, 2004 - v1
Checksum:i23ACD344542A2942
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q15427SF3B4_HUMAN
Splicing factor 3B subunit 4
SF3B4 SAP49
424Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei190Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC239868 Genomic DNA No translation available.
AL591493, AL590487 Genomic DNA Translation: CAI12553.1
AL590487, AL591493 Genomic DNA Translation: CAI12647.1
UniGeneiHs.516160

Genome annotation databases

EnsembliENST00000457312; ENSP00000391114; ENSG00000143368
UCSCiuc057kma.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC239868 Genomic DNA No translation available.
AL591493, AL590487 Genomic DNA Translation: CAI12553.1
AL590487, AL591493 Genomic DNA Translation: CAI12647.1
UniGeneiHs.516160

3D structure databases

SMRiQ5SZ64
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiQ5SZ64

Proteomic databases

MaxQBiQ5SZ64
PRIDEiQ5SZ64

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457312; ENSP00000391114; ENSG00000143368
UCSCiuc057kma.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000143368.9
HGNCiHGNC:10771 SF3B4
OpenTargetsiENSG00000143368
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0131 Eukaryota
ENOG410XPT4 LUCA
GeneTreeiENSGT00870000136537
HOGENOMiHOG000200535
HOVERGENiHBG002295

Miscellaneous databases

ChiTaRSiSF3B4 human

Gene expression databases

BgeeiENSG00000143368 Expressed in 203 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiQ5SZ64 baseline and differential

Family and domain databases

CDDicd12335 RRM2_SF3B4, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034159 SF3B4_RRM2
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SZ64_HUMAN
AccessioniPrimary (citable) accession number: Q5SZ64
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 10, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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