UniProtKB - Q5SY80 (CTSRE_HUMAN)

BLAST

>sp|Q5SY80|CTSRE_HUMAN Cation channel sperm-associated protein subunit epsilon OS=Homo sapiens OX=9606 GN=CATSPERE PE=2 SV=1
MSAREVAVLLLWLSCYGSALWRYSTNSPNYRIFSTRSTIKLEYEGTLFTEWSVPETCFVL
NKSSPTTELRCSSPGVHAIKPIVTGPDEEERYLFVESSHTCFLWYYRVRHFFNNFTQLIT
VWAYDPESADPDELLGNAEEPSINSIVLSTQMATLGQKPVIHTVLKRKVYSSNEKMRRGT
WRIVVPMTKDDALKEIRGNQVTFQDCFIADFLILLTFPLLTIPEIPGYLPISSPRGSQLM
ASWDACVVASAVLVTDMETFHTTDSFKSWTRIRVPPDILSDDERRSVAHVILSRDGIVFL
INGVLYIKSFRGFIRLGGIVNLPDGGITGISSRKWCWVNYLLKAKGRRSTFAVWTENEIY
LGSILLKFARLVTTTELKNILSLSVTATLTIDRVEYTGHPLEIAVFLNYCTVCNVTKKIF
LVIYNEDTKQWVSQDFTLDAPIDSVTMPHFTFSALPGLLLWNKHSIYYCYHNFTFTGILQ
TPAGHGNLSMLSNDSIIHEVFIDYYGDILVKMENNVIFYSKINTRDAVKLHLWTNYTTRA
FIFLSTSGQTYFLYALDDGTIQIQDYPLHLEAQSIAFTTKDKCPYMAFHNNVAHVFYFLD
KGEALTVWTQIVYPENTGLYVIVESYGPKILQESHEISFEAAFGYCTKTLTLTFYQNVDY
ERISDYFETQDKHTGLVLVQFRPSEYSKACPIAQKVFQIAVGCDDKKFIAIKGFSKKGCH
HHDFSYVIEKSYLRHQPSKNLRVRYIWGEYGCPLRLDFTEKFQPVVQLFDDNGYVKDVEA
NFIVWEIHGRDDYSFNNTMAQSGCLHEAQTWKSMIELNKHLPLEEVWGPENYKHCFSYAI
GKPGDLNQPYEIINSSNGNHIFWPMGHSGMYVFRVKILDPNYSFCNLTAMFAIETFGLIP
SPSVYLVASFLFVLMLLFFTILVLSYFRYMRIYRRYIYEPLHKPQRKRKKN

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History
Entry version 108 (07 Nov 2018)
Sequence version 1 (21 Dec 2004)
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Protein

Cation channel sperm-associated protein subunit epsilon

Gene

CATSPERE

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.By similarity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cation channel sperm-associated protein subunit epsilonBy similarity Short name: CatSper-epsilonBy similarity Short name: CatSperepsilonBy similarity
Gene namesⁱ	Name:CATSPEREImported Synonyms:C1orf101Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179397.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:28491 CATSPERE
MIMⁱ	617510 gene
neXtProtⁱ	NX_Q5SY80

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 903	ExtracellularSequence analysisAdd BLAST	884
Transmembraneⁱ	904 – 924	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	925 – 951	CytoplasmicSequence analysisAdd BLAST	27

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	257044
Open Targets More...OpenTargetsⁱ	ENSG00000179397
PharmGKBⁱ	PA142672485

Polymorphism and mutation databases

BioMutaⁱ	C1orf101
DMDMⁱ	74744048

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000251216	20 – 951	Cation channel sperm-associated protein subunit epsilonAdd BLAST		932

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	61	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	114	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	472	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	535	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q5SY80
PeptideAtlas More...PeptideAtlasⁱ	Q5SY80
PRIDEⁱ	Q5SY80
ProteomicsDBⁱ	64019 64020 [Q5SY80-2]

PTM databases

iPTMnetⁱ	Q5SY80
PhosphoSitePlusⁱ	Q5SY80

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000179397 Expressed in 103 organ(s), highest expression level in testis
CleanExⁱ	HS_C1orf101
ExpressionAtlasⁱ	Q5SY80 baseline and differential
Genevisibleⁱ	Q5SY80 HS

Interactionⁱ

Subunit structureⁱ

Component of the CatSper complex.By similarity

Protein-protein interaction databases

IntActⁱ	Q5SY80, 1 interactor
STRINGⁱ	9606.ENSP00000355492

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5SY80
SMRⁱ	Q5SY80
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the CATSPERD family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IKC9 Eukaryota ENOG4112B54 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00560000077286
HOGENOMⁱ	HOG000082422
HOVERGENⁱ	HBG080959
InParanoidⁱ	Q5SY80
OMAⁱ	METFQTN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01WR
PhylomeDBⁱ	Q5SY80
TreeFamⁱ	TF336183

Family and domain databases

InterProⁱ	View protein in InterPro IPR028751 CATSPERD/E
PANTHERⁱ	PTHR33722 PTHR33722, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15020 CATSPERD, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q5SY80-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAREVAVLL LWLSCYGSAL WRYSTNSPNY RIFSTRSTIK LEYEGTLFTE 
        60         70         80         90        100
WSVPETCFVL NKSSPTTELR CSSPGVHAIK PIVTGPDEEE RYLFVESSHT 
       110        120        130        140        150
CFLWYYRVRH FFNNFTQLIT VWAYDPESAD PDELLGNAEE PSINSIVLST 
       160        170        180        190        200
QMATLGQKPV IHTVLKRKVY SSNEKMRRGT WRIVVPMTKD DALKEIRGNQ 
       210        220        230        240        250
VTFQDCFIAD FLILLTFPLL TIPEIPGYLP ISSPRGSQLM ASWDACVVAS 
       260        270        280        290        300
AVLVTDMETF HTTDSFKSWT RIRVPPDILS DDERRSVAHV ILSRDGIVFL 
       310        320        330        340        350
INGVLYIKSF RGFIRLGGIV NLPDGGITGI SSRKWCWVNY LLKAKGRRST 
       360        370        380        390        400
FAVWTENEIY LGSILLKFAR LVTTTELKNI LSLSVTATLT IDRVEYTGHP 
       410        420        430        440        450
LEIAVFLNYC TVCNVTKKIF LVIYNEDTKQ WVSQDFTLDA PIDSVTMPHF 
       460        470        480        490        500
TFSALPGLLL WNKHSIYYCY HNFTFTGILQ TPAGHGNLSM LSNDSIIHEV 
       510        520        530        540        550
FIDYYGDILV KMENNVIFYS KINTRDAVKL HLWTNYTTRA FIFLSTSGQT 
       560        570        580        590        600
YFLYALDDGT IQIQDYPLHL EAQSIAFTTK DKCPYMAFHN NVAHVFYFLD 
       610        620        630        640        650
KGEALTVWTQ IVYPENTGLY VIVESYGPKI LQESHEISFE AAFGYCTKTL 
       660        670        680        690        700
TLTFYQNVDY ERISDYFETQ DKHTGLVLVQ FRPSEYSKAC PIAQKVFQIA 
       710        720        730        740        750
VGCDDKKFIA IKGFSKKGCH HHDFSYVIEK SYLRHQPSKN LRVRYIWGEY 
       760        770        780        790        800
GCPLRLDFTE KFQPVVQLFD DNGYVKDVEA NFIVWEIHGR DDYSFNNTMA 
       810        820        830        840        850
QSGCLHEAQT WKSMIELNKH LPLEEVWGPE NYKHCFSYAI GKPGDLNQPY 
       860        870        880        890        900
EIINSSNGNH IFWPMGHSGM YVFRVKILDP NYSFCNLTAM FAIETFGLIP 
       910        920        930        940        950
SPSVYLVASF LFVLMLLFFT ILVLSYFRYM RIYRRYIYEP LHKPQRKRKK 

N

Length:951

Mass (Da):109,662

Last modified:December 21, 2004 - v1

Checksum:ⁱD00AA5E03F6DBF47

Isoform 2 (identifier: Q5SY80-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
831-832: NY → FL
833-951: Missing.

« Hide

        10         20         30         40         50
MSAREVAVLL LWLSCYGSAL WRYSTNSPNY RIFSTRSTIK LEYEGTLFTE 
        60         70         80         90        100
WSVPETCFVL NKSSPTTELR CSSPGVHAIK PIVTGPDEEE RYLFVESSHT 
       110        120        130        140        150
CFLWYYRVRH FFNNFTQLIT VWAYDPESAD PDELLGNAEE PSINSIVLST 
       160        170        180        190        200
QMATLGQKPV IHTVLKRKVY SSNEKMRRGT WRIVVPMTKD DALKEIRGNQ 
       210        220        230        240        250
VTFQDCFIAD FLILLTFPLL TIPEIPGYLP ISSPRGSQLM ASWDACVVAS 
       260        270        280        290        300
AVLVTDMETF HTTDSFKSWT RIRVPPDILS DDERRSVAHV ILSRDGIVFL 
       310        320        330        340        350
INGVLYIKSF RGFIRLGGIV NLPDGGITGI SSRKWCWVNY LLKAKGRRST 
       360        370        380        390        400
FAVWTENEIY LGSILLKFAR LVTTTELKNI LSLSVTATLT IDRVEYTGHP 
       410        420        430        440        450
LEIAVFLNYC TVCNVTKKIF LVIYNEDTKQ WVSQDFTLDA PIDSVTMPHF 
       460        470        480        490        500
TFSALPGLLL WNKHSIYYCY HNFTFTGILQ TPAGHGNLSM LSNDSIIHEV 
       510        520        530        540        550
FIDYYGDILV KMENNVIFYS KINTRDAVKL HLWTNYTTRA FIFLSTSGQT 
       560        570        580        590        600
YFLYALDDGT IQIQDYPLHL EAQSIAFTTK DKCPYMAFHN NVAHVFYFLD 
       610        620        630        640        650
KGEALTVWTQ IVYPENTGLY VIVESYGPKI LQESHEISFE AAFGYCTKTL 
       660        670        680        690        700
TLTFYQNVDY ERISDYFETQ DKHTGLVLVQ FRPSEYSKAC PIAQKVFQIA 
       710        720        730        740        750
VGCDDKKFIA IKGFSKKGCH HHDFSYVIEK SYLRHQPSKN LRVRYIWGEY 
       760        770        780        790        800
GCPLRLDFTE KFQPVVQLFD DNGYVKDVEA NFIVWEIHGR DDYSFNNTMA 
       810        820        830 
QSGCLHEAQT WKSMIELNKH LPLEEVWGPE FL

Note: No experimental confirmation available.

Show »

Length:832

Mass (Da):95,559

Checksum:ⁱ54BDC52DCC4F0C03

Isoform 3 (identifier: Q5SY80-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-151: Missing.

« Hide

        10         20         30         40         50
MATLGQKPVI HTVLKRKVYS SNEKMRRGTW RIVVPMTKDD ALKEIRGNQV 
        60         70         80         90        100
TFQDCFIADF LILLTFPLLT IPEIPGYLPI SSPRGSQLMA SWDACVVASA 
       110        120        130        140        150
VLVTDMETFH TTDSFKSWTR IRVPPDILSD DERRSVAHVI LSRDGIVFLI 
       160        170        180        190        200
NGVLYIKSFR GFIRLGGIVN LPDGGITGIS SRKWCWVNYL LKAKGRRSTF 
       210        220        230        240        250
AVWTENEIYL GSILLKFARL VTTTELKNIL SLSVTATLTI DRVEYTGHPL 
       260        270        280        290        300
EIAVFLNYCT VCNVTKKIFL VIYNEDTKQW VSQDFTLDAP IDSVTMPHFT 
       310        320        330        340        350
FSALPGLLLW NKHSIYYCYH NFTFTGILQT PAGHGNLSML SNDSIIHEVF 
       360        370        380        390        400
IDYYGDILVK MENNVIFYSK INTRDAVKLH LWTNYTTRAF IFLSTSGQTY 
       410        420        430        440        450
FLYALDDGTI QIQDYPLHLE AQSIAFTTKD KCPYMAFHNN VAHVFYFLDK 
       460        470        480        490        500
GEALTVWTQI VYPENTGLYV IVESYGPKIL QESHEISFEA AFGYCTKTLT 
       510        520        530        540        550
LTFYQNVDYE RISDYFETQD KHTGLVLVQF RPSEYSKACP IAQKVFQIAV 
       560        570        580        590        600
GCDDKKFIAI KGFSKKGCHH HDFSYVIEKS YLRHQPSKNL RVRYIWGEYG 
       610        620        630        640        650
CPLRLDFTEK FQPVVQLFDD NGYVKDVEAN FIVWEIHGRD DYSFNNTMAQ 
       660        670        680        690        700
SGCLHEAQTW KSMIELNKHL PLEEVWGPEN YKHCFSYAIG KPGDLNQPYE 
       710        720        730        740        750
IINSSNGNHI FWPMGHSGMY VFRVKILDPN YSFCNLTAMF AIETFGLIPS 
       760        770        780        790        800
PSVYLVASFL FVLMLLFFTI LVLSYFRYMR IYRRYIYEPL HKPQRKRKKN

Show »

Length:800

Mass (Da):92,316

Checksum:ⁱ83993958154F297F

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	B1AQM6	B1AQM6_HUMAN		Cation channel sperm-associated pro... Cation channel sperm-associated protein subunit epsilon	CATSPERE	871	Annotation score:

Sequence cautionⁱ

The sequence BC028392 differs from that shown. Reason: Frameshift at position 418.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_061566	56	T → S. Corresponds to variant dbSNP:rs58602830Ensembl.	1
Natural variantⁱVAR_027661	66	T → K. Corresponds to variant dbSNP:rs11586356Ensembl.	1
Natural variantⁱVAR_035494	653	T → I in a breast cancer sample; somatic mutation. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_044251	1 – 151	Missing in isoform 3. 1 PublicationAdd BLAST	151
Alternative sequenceⁱVSP_020748	831 – 832	NY → FL in isoform 2. 1 Publication	2
Alternative sequenceⁱVSP_020749	833 – 951	Missing in isoform 2. 1 PublicationAdd BLAST	119

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK302609 mRNA Translation: BAH13761.1 AK303059 mRNA Translation: BAG64176.1 AC099757 Genomic DNA No translation available. AL591594 Genomic DNA No translation available. CH471148 Genomic DNA Translation: EAW77109.1 BC032859 mRNA Translation: AAH32859.1 BC028392 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1625.1 [Q5SY80-2] CCDS44340.1 [Q5SY80-1] CCDS55693.1 [Q5SY80-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001124429.1, NM_001130957.1 [Q5SY80-1] NP_001229269.1, NM_001242340.1 [Q5SY80-3] NP_776168.1, NM_173807.4 [Q5SY80-2] XP_011542441.1, XM_011544139.2 [Q5SY80-3] XP_011542444.1, XM_011544142.2 [Q5SY80-3] XP_011542451.1, XM_011544149.2 [Q5SY80-3] XP_016856435.1, XM_017000946.1 [Q5SY80-3] XP_016856438.1, XM_017000949.1 [Q5SY80-3] XP_016856439.1, XM_017000950.1 [Q5SY80-3]
UniGeneⁱ	Hs.459534

Genome annotation databases

Ensemblⁱ	ENST00000366531; ENSP00000355489; ENSG00000179397 [Q5SY80-3] ENST00000366533; ENSP00000355491; ENSG00000179397 [Q5SY80-2] ENST00000366534; ENSP00000355492; ENSG00000179397 [Q5SY80-1]
GeneIDⁱ	257044
KEGGⁱ	hsa:257044
UCSC genome browser More...UCSCⁱ	uc001ial.4 human [Q5SY80-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5SY80	Catsper channel auxiliary subunit epsilon		PANTR		959	UniRef90_Q5SY80
CATSPERE isoform 3		PONAB		951
Uncharacterized protein		PANPA		951
Catsper channel auxiliary subunit epsilon		GORGO		951
Uncharacterized protein		NOMLE		932
+24

Protein	Similar proteins		Species	Score	Length	Source
Q5SY80	Catsper channel auxiliary subunit epsilon		PANTR		959	UniRef50_Q5SY80
Catsper channel auxiliary subunit epsilon		GORGO		951
CATSPERE isoform 3		PONAB		951
Uncharacterized protein		PANPA		951
Uncharacterized protein		NOMLE		932
+72

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK302609 mRNA Translation: BAH13761.1 AK303059 mRNA Translation: BAG64176.1 AC099757 Genomic DNA No translation available. AL591594 Genomic DNA No translation available. CH471148 Genomic DNA Translation: EAW77109.1 BC032859 mRNA Translation: AAH32859.1 BC028392 mRNA No translation available.
CCDSⁱ	CCDS1625.1 [Q5SY80-2] CCDS44340.1 [Q5SY80-1] CCDS55693.1 [Q5SY80-3]
RefSeqⁱ	NP_001124429.1, NM_001130957.1 [Q5SY80-1] NP_001229269.1, NM_001242340.1 [Q5SY80-3] NP_776168.1, NM_173807.4 [Q5SY80-2] XP_011542441.1, XM_011544139.2 [Q5SY80-3] XP_011542444.1, XM_011544142.2 [Q5SY80-3] XP_011542451.1, XM_011544149.2 [Q5SY80-3] XP_016856435.1, XM_017000946.1 [Q5SY80-3] XP_016856438.1, XM_017000949.1 [Q5SY80-3] XP_016856439.1, XM_017000950.1 [Q5SY80-3]
UniGeneⁱ	Hs.459534

3D structure databases

ProteinModelPortalⁱ	Q5SY80
SMRⁱ	Q5SY80
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q5SY80, 1 interactor
STRINGⁱ	9606.ENSP00000355492

PTM databases

iPTMnetⁱ	Q5SY80
PhosphoSitePlusⁱ	Q5SY80

Polymorphism and mutation databases

BioMutaⁱ	C1orf101
DMDMⁱ	74744048

Proteomic databases

PaxDbⁱ	Q5SY80
PeptideAtlasⁱ	Q5SY80
PRIDEⁱ	Q5SY80
ProteomicsDBⁱ	64019 64020 [Q5SY80-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	257044
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000366531; ENSP00000355489; ENSG00000179397 [Q5SY80-3] ENST00000366533; ENSP00000355491; ENSG00000179397 [Q5SY80-2] ENST00000366534; ENSP00000355492; ENSG00000179397 [Q5SY80-1]
GeneIDⁱ	257044
KEGGⁱ	hsa:257044
UCSCⁱ	uc001ial.4 human [Q5SY80-1]

Organism-specific databases

CTDⁱ	257044
DisGeNETⁱ	257044
EuPathDBⁱ	HostDB:ENSG00000179397.17
GeneCardsⁱ	CATSPERE
H-InvDBⁱ	HIX0001749
HGNCⁱ	HGNC:28491 CATSPERE
MIMⁱ	617510 gene
neXtProtⁱ	NX_Q5SY80
OpenTargetsⁱ	ENSG00000179397
PharmGKBⁱ	PA142672485
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IKC9 Eukaryota ENOG4112B54 LUCA
GeneTreeⁱ	ENSGT00560000077286
HOGENOMⁱ	HOG000082422
HOVERGENⁱ	HBG080959
InParanoidⁱ	Q5SY80
OMAⁱ	METFQTN
OrthoDBⁱ	EOG091G01WR
PhylomeDBⁱ	Q5SY80
TreeFamⁱ	TF336183

Miscellaneous databases

ChiTaRSⁱ	C1orf101 human
GenomeRNAiⁱ	257044
Protein Ontology More...PROⁱ	PR:Q5SY80
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179397 Expressed in 103 organ(s), highest expression level in testis
CleanExⁱ	HS_C1orf101
ExpressionAtlasⁱ	Q5SY80 baseline and differential
Genevisibleⁱ	Q5SY80 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR028751 CATSPERD/E
PANTHERⁱ	PTHR33722 PTHR33722, 1 hit
Pfamⁱ	View protein in Pfam PF15020 CATSPERD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CTSRE_HUMAN
Accessionⁱ	Q5SY80Primary (citable) accession number: Q5SY80 Secondary accession number(s): B4DZR4 , B7Z7X5, E9PEA3, Q8IYZ6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	December 21, 2004
	Last modified:	November 7, 2018
	This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5SY80 (CTSRE_HUMAN)

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Cation channel sperm-associated protein subunit epsilon

CATSPERE

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ