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Protein

Cation channel sperm-associated protein subunit epsilon

Gene

CATSPERE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cation channel sperm-associated protein subunit epsilonBy similarity
Short name:
CatSper-epsilonBy similarity
Short name:
CatSperepsilonBy similarity
Gene namesi
Name:CATSPEREImported
Synonyms:C1orf101Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000179397.17
HGNCiHGNC:28491 CATSPERE
MIMi617510 gene
neXtProtiNX_Q5SY80

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 903ExtracellularSequence analysisAdd BLAST884
Transmembranei904 – 924HelicalSequence analysisAdd BLAST21
Topological domaini925 – 951CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi257044
OpenTargetsiENSG00000179397
PharmGKBiPA142672485

Polymorphism and mutation databases

BioMutaiC1orf101
DMDMi74744048

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000025121620 – 951Cation channel sperm-associated protein subunit epsilonAdd BLAST932

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi472N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi535N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5SY80
PeptideAtlasiQ5SY80
PRIDEiQ5SY80
ProteomicsDBi64019
64020 [Q5SY80-2]

PTM databases

iPTMnetiQ5SY80
PhosphoSitePlusiQ5SY80

Expressioni

Gene expression databases

BgeeiENSG00000179397 Expressed in 103 organ(s), highest expression level in testis
CleanExiHS_C1orf101
ExpressionAtlasiQ5SY80 baseline and differential
GenevisibleiQ5SY80 HS

Interactioni

Subunit structurei

Component of the CatSper complex.By similarity

Protein-protein interaction databases

IntActiQ5SY80, 1 interactor
STRINGi9606.ENSP00000355492

Structurei

3D structure databases

ProteinModelPortaliQ5SY80
SMRiQ5SY80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CATSPERD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKC9 Eukaryota
ENOG4112B54 LUCA
GeneTreeiENSGT00560000077286
HOGENOMiHOG000082422
HOVERGENiHBG080959
InParanoidiQ5SY80
OMAiMETFQTN
OrthoDBiEOG091G01WR
PhylomeDBiQ5SY80
TreeFamiTF336183

Family and domain databases

InterProiView protein in InterPro
IPR028751 CATSPERD/E
PANTHERiPTHR33722 PTHR33722, 1 hit
PfamiView protein in Pfam
PF15020 CATSPERD, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SY80-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAREVAVLL LWLSCYGSAL WRYSTNSPNY RIFSTRSTIK LEYEGTLFTE
60 70 80 90 100
WSVPETCFVL NKSSPTTELR CSSPGVHAIK PIVTGPDEEE RYLFVESSHT
110 120 130 140 150
CFLWYYRVRH FFNNFTQLIT VWAYDPESAD PDELLGNAEE PSINSIVLST
160 170 180 190 200
QMATLGQKPV IHTVLKRKVY SSNEKMRRGT WRIVVPMTKD DALKEIRGNQ
210 220 230 240 250
VTFQDCFIAD FLILLTFPLL TIPEIPGYLP ISSPRGSQLM ASWDACVVAS
260 270 280 290 300
AVLVTDMETF HTTDSFKSWT RIRVPPDILS DDERRSVAHV ILSRDGIVFL
310 320 330 340 350
INGVLYIKSF RGFIRLGGIV NLPDGGITGI SSRKWCWVNY LLKAKGRRST
360 370 380 390 400
FAVWTENEIY LGSILLKFAR LVTTTELKNI LSLSVTATLT IDRVEYTGHP
410 420 430 440 450
LEIAVFLNYC TVCNVTKKIF LVIYNEDTKQ WVSQDFTLDA PIDSVTMPHF
460 470 480 490 500
TFSALPGLLL WNKHSIYYCY HNFTFTGILQ TPAGHGNLSM LSNDSIIHEV
510 520 530 540 550
FIDYYGDILV KMENNVIFYS KINTRDAVKL HLWTNYTTRA FIFLSTSGQT
560 570 580 590 600
YFLYALDDGT IQIQDYPLHL EAQSIAFTTK DKCPYMAFHN NVAHVFYFLD
610 620 630 640 650
KGEALTVWTQ IVYPENTGLY VIVESYGPKI LQESHEISFE AAFGYCTKTL
660 670 680 690 700
TLTFYQNVDY ERISDYFETQ DKHTGLVLVQ FRPSEYSKAC PIAQKVFQIA
710 720 730 740 750
VGCDDKKFIA IKGFSKKGCH HHDFSYVIEK SYLRHQPSKN LRVRYIWGEY
760 770 780 790 800
GCPLRLDFTE KFQPVVQLFD DNGYVKDVEA NFIVWEIHGR DDYSFNNTMA
810 820 830 840 850
QSGCLHEAQT WKSMIELNKH LPLEEVWGPE NYKHCFSYAI GKPGDLNQPY
860 870 880 890 900
EIINSSNGNH IFWPMGHSGM YVFRVKILDP NYSFCNLTAM FAIETFGLIP
910 920 930 940 950
SPSVYLVASF LFVLMLLFFT ILVLSYFRYM RIYRRYIYEP LHKPQRKRKK

N
Length:951
Mass (Da):109,662
Last modified:December 21, 2004 - v1
Checksum:iD00AA5E03F6DBF47
GO
Isoform 2 (identifier: Q5SY80-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     831-832: NY → FL
     833-951: Missing.

Note: No experimental confirmation available.
Show »
Length:832
Mass (Da):95,559
Checksum:i54BDC52DCC4F0C03
GO
Isoform 3 (identifier: Q5SY80-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Show »
Length:800
Mass (Da):92,316
Checksum:i83993958154F297F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AQM6B1AQM6_HUMAN
Cation channel sperm-associated pro...
CATSPERE
871Annotation score:

Sequence cautioni

The sequence BC028392 differs from that shown. Reason: Frameshift at position 418.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06156656T → S. Corresponds to variant dbSNP:rs58602830Ensembl.1
Natural variantiVAR_02766166T → K. Corresponds to variant dbSNP:rs11586356Ensembl.1
Natural variantiVAR_035494653T → I in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442511 – 151Missing in isoform 3. 1 PublicationAdd BLAST151
Alternative sequenceiVSP_020748831 – 832NY → FL in isoform 2. 1 Publication2
Alternative sequenceiVSP_020749833 – 951Missing in isoform 2. 1 PublicationAdd BLAST119

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302609 mRNA Translation: BAH13761.1
AK303059 mRNA Translation: BAG64176.1
AC099757 Genomic DNA No translation available.
AL591594 Genomic DNA No translation available.
CH471148 Genomic DNA Translation: EAW77109.1
BC032859 mRNA Translation: AAH32859.1
BC028392 mRNA No translation available.
CCDSiCCDS1625.1 [Q5SY80-2]
CCDS44340.1 [Q5SY80-1]
CCDS55693.1 [Q5SY80-3]
RefSeqiNP_001124429.1, NM_001130957.1 [Q5SY80-1]
NP_001229269.1, NM_001242340.1 [Q5SY80-3]
NP_776168.1, NM_173807.4 [Q5SY80-2]
XP_011542441.1, XM_011544139.2 [Q5SY80-3]
XP_011542444.1, XM_011544142.2 [Q5SY80-3]
XP_011542451.1, XM_011544149.2 [Q5SY80-3]
XP_016856435.1, XM_017000946.1 [Q5SY80-3]
XP_016856438.1, XM_017000949.1 [Q5SY80-3]
XP_016856439.1, XM_017000950.1 [Q5SY80-3]
UniGeneiHs.459534

Genome annotation databases

EnsembliENST00000366531; ENSP00000355489; ENSG00000179397 [Q5SY80-3]
ENST00000366533; ENSP00000355491; ENSG00000179397 [Q5SY80-2]
ENST00000366534; ENSP00000355492; ENSG00000179397 [Q5SY80-1]
GeneIDi257044
KEGGihsa:257044
UCSCiuc001ial.4 human [Q5SY80-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302609 mRNA Translation: BAH13761.1
AK303059 mRNA Translation: BAG64176.1
AC099757 Genomic DNA No translation available.
AL591594 Genomic DNA No translation available.
CH471148 Genomic DNA Translation: EAW77109.1
BC032859 mRNA Translation: AAH32859.1
BC028392 mRNA No translation available.
CCDSiCCDS1625.1 [Q5SY80-2]
CCDS44340.1 [Q5SY80-1]
CCDS55693.1 [Q5SY80-3]
RefSeqiNP_001124429.1, NM_001130957.1 [Q5SY80-1]
NP_001229269.1, NM_001242340.1 [Q5SY80-3]
NP_776168.1, NM_173807.4 [Q5SY80-2]
XP_011542441.1, XM_011544139.2 [Q5SY80-3]
XP_011542444.1, XM_011544142.2 [Q5SY80-3]
XP_011542451.1, XM_011544149.2 [Q5SY80-3]
XP_016856435.1, XM_017000946.1 [Q5SY80-3]
XP_016856438.1, XM_017000949.1 [Q5SY80-3]
XP_016856439.1, XM_017000950.1 [Q5SY80-3]
UniGeneiHs.459534

3D structure databases

ProteinModelPortaliQ5SY80
SMRiQ5SY80
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5SY80, 1 interactor
STRINGi9606.ENSP00000355492

PTM databases

iPTMnetiQ5SY80
PhosphoSitePlusiQ5SY80

Polymorphism and mutation databases

BioMutaiC1orf101
DMDMi74744048

Proteomic databases

PaxDbiQ5SY80
PeptideAtlasiQ5SY80
PRIDEiQ5SY80
ProteomicsDBi64019
64020 [Q5SY80-2]

Protocols and materials databases

DNASUi257044
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366531; ENSP00000355489; ENSG00000179397 [Q5SY80-3]
ENST00000366533; ENSP00000355491; ENSG00000179397 [Q5SY80-2]
ENST00000366534; ENSP00000355492; ENSG00000179397 [Q5SY80-1]
GeneIDi257044
KEGGihsa:257044
UCSCiuc001ial.4 human [Q5SY80-1]

Organism-specific databases

CTDi257044
DisGeNETi257044
EuPathDBiHostDB:ENSG00000179397.17
GeneCardsiCATSPERE
H-InvDBiHIX0001749
HGNCiHGNC:28491 CATSPERE
MIMi617510 gene
neXtProtiNX_Q5SY80
OpenTargetsiENSG00000179397
PharmGKBiPA142672485
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKC9 Eukaryota
ENOG4112B54 LUCA
GeneTreeiENSGT00560000077286
HOGENOMiHOG000082422
HOVERGENiHBG080959
InParanoidiQ5SY80
OMAiMETFQTN
OrthoDBiEOG091G01WR
PhylomeDBiQ5SY80
TreeFamiTF336183

Miscellaneous databases

ChiTaRSiC1orf101 human
GenomeRNAii257044
PROiPR:Q5SY80
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000179397 Expressed in 103 organ(s), highest expression level in testis
CleanExiHS_C1orf101
ExpressionAtlasiQ5SY80 baseline and differential
GenevisibleiQ5SY80 HS

Family and domain databases

InterProiView protein in InterPro
IPR028751 CATSPERD/E
PANTHERiPTHR33722 PTHR33722, 1 hit
PfamiView protein in Pfam
PF15020 CATSPERD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCTSRE_HUMAN
AccessioniPrimary (citable) accession number: Q5SY80
Secondary accession number(s): B4DZR4
, B7Z7X5, E9PEA3, Q8IYZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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