UniProtKB - Q5SY80 (CTSRE_HUMAN)
Protein
Cation channel sperm-associated protein subunit epsilon
Gene
CATSPERE
Organism
Homo sapiens (Human)
Status
Functioni
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization.By similarity
Enzyme and pathway databases
PathwayCommonsi | Q5SY80 |
Names & Taxonomyi
Protein namesi | Recommended name: Cation channel sperm-associated protein subunit epsilonBy similarityShort name: CatSper-epsilonBy similarity Short name: CatSperepsilonBy similarity |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28491, CATSPERE |
MIMi | 617510, gene |
neXtProti | NX_Q5SY80 |
VEuPathDBi | HostDB:ENSG00000179397.17 |
Subcellular locationi
Plasma membrane
- flagellum membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Note: Specifically located in the principal piece of sperm tail.1 Publication
Plasma Membrane
- CatSper complex Source: UniProtKB
Other locations
- sperm principal piece Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 903 | ExtracellularSequence analysisAdd BLAST | 884 | |
Transmembranei | 904 – 924 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 925 – 951 | CytoplasmicSequence analysisAdd BLAST | 27 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Cilium, Flagellum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 257044 |
OpenTargetsi | ENSG00000179397 |
PharmGKBi | PA142672485 |
Miscellaneous databases
Pharosi | Q5SY80, Tdark |
Genetic variation databases
BioMutai | CATSPERE |
DMDMi | 74744048 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000251216 | 20 – 951 | Cation channel sperm-associated protein subunit epsilonAdd BLAST | 932 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 61 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 114 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 472 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 535 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | Q5SY80 |
MassIVEi | Q5SY80 |
PaxDbi | Q5SY80 |
PeptideAtlasi | Q5SY80 |
PRIDEi | Q5SY80 |
ProteomicsDBi | 5618 64019 [Q5SY80-1] 64020 [Q5SY80-2] |
PTM databases
GlyGeni | Q5SY80, 4 sites |
iPTMneti | Q5SY80 |
PhosphoSitePlusi | Q5SY80 |
Expressioni
Gene expression databases
Bgeei | ENSG00000179397, Expressed in testis and 122 other tissues |
ExpressionAtlasi | Q5SY80, baseline and differential |
Genevisiblei | Q5SY80, HS |
Organism-specific databases
HPAi | ENSG00000179397, Tissue enriched (testis) |
Interactioni
Subunit structurei
Component of the CatSper complex.
By similarityProtein-protein interaction databases
BioGRIDi | 129192, 1 interactor |
IntActi | Q5SY80, 1 interactor |
STRINGi | 9606.ENSP00000355492 |
Miscellaneous databases
RNActi | Q5SY80, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the CATSPERD family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R8SD, Eukaryota |
GeneTreei | ENSGT00940000162691 |
HOGENOMi | CLU_014273_0_0_1 |
InParanoidi | Q5SY80 |
OMAi | NYRHCFS |
OrthoDBi | 213907at2759 |
PhylomeDBi | Q5SY80 |
TreeFami | TF336183 |
Family and domain databases
InterProi | View protein in InterPro IPR028751, CATSPERD/E |
PANTHERi | PTHR33722, PTHR33722, 1 hit |
Pfami | View protein in Pfam PF15020, CATSPERD, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5SY80-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAREVAVLL LWLSCYGSAL WRYSTNSPNY RIFSTRSTIK LEYEGTLFTE
60 70 80 90 100
WSVPETCFVL NKSSPTTELR CSSPGVHAIK PIVTGPDEEE RYLFVESSHT
110 120 130 140 150
CFLWYYRVRH FFNNFTQLIT VWAYDPESAD PDELLGNAEE PSINSIVLST
160 170 180 190 200
QMATLGQKPV IHTVLKRKVY SSNEKMRRGT WRIVVPMTKD DALKEIRGNQ
210 220 230 240 250
VTFQDCFIAD FLILLTFPLL TIPEIPGYLP ISSPRGSQLM ASWDACVVAS
260 270 280 290 300
AVLVTDMETF HTTDSFKSWT RIRVPPDILS DDERRSVAHV ILSRDGIVFL
310 320 330 340 350
INGVLYIKSF RGFIRLGGIV NLPDGGITGI SSRKWCWVNY LLKAKGRRST
360 370 380 390 400
FAVWTENEIY LGSILLKFAR LVTTTELKNI LSLSVTATLT IDRVEYTGHP
410 420 430 440 450
LEIAVFLNYC TVCNVTKKIF LVIYNEDTKQ WVSQDFTLDA PIDSVTMPHF
460 470 480 490 500
TFSALPGLLL WNKHSIYYCY HNFTFTGILQ TPAGHGNLSM LSNDSIIHEV
510 520 530 540 550
FIDYYGDILV KMENNVIFYS KINTRDAVKL HLWTNYTTRA FIFLSTSGQT
560 570 580 590 600
YFLYALDDGT IQIQDYPLHL EAQSIAFTTK DKCPYMAFHN NVAHVFYFLD
610 620 630 640 650
KGEALTVWTQ IVYPENTGLY VIVESYGPKI LQESHEISFE AAFGYCTKTL
660 670 680 690 700
TLTFYQNVDY ERISDYFETQ DKHTGLVLVQ FRPSEYSKAC PIAQKVFQIA
710 720 730 740 750
VGCDDKKFIA IKGFSKKGCH HHDFSYVIEK SYLRHQPSKN LRVRYIWGEY
760 770 780 790 800
GCPLRLDFTE KFQPVVQLFD DNGYVKDVEA NFIVWEIHGR DDYSFNNTMA
810 820 830 840 850
QSGCLHEAQT WKSMIELNKH LPLEEVWGPE NYKHCFSYAI GKPGDLNQPY
860 870 880 890 900
EIINSSNGNH IFWPMGHSGM YVFRVKILDP NYSFCNLTAM FAIETFGLIP
910 920 930 940 950
SPSVYLVASF LFVLMLLFFT ILVLSYFRYM RIYRRYIYEP LHKPQRKRKK
N
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketB1AQM6 | B1AQM6_HUMAN | Cation channel sperm-associated pro... | CATSPERE | 871 | Annotation score: |
Sequence cautioni
The sequence BC028392 differs from that shown. Reason: Frameshift.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061566 | 56 | T → S. Corresponds to variant dbSNP:rs58602830Ensembl. | 1 | |
Natural variantiVAR_027661 | 66 | T → K. Corresponds to variant dbSNP:rs11586356Ensembl. | 1 | |
Natural variantiVAR_035494 | 653 | T → I in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044251 | 1 – 151 | Missing in isoform 3. 1 PublicationAdd BLAST | 151 | |
Alternative sequenceiVSP_020748 | 831 – 832 | NY → FL in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_020749 | 833 – 951 | Missing in isoform 2. 1 PublicationAdd BLAST | 119 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK302609 mRNA Translation: BAH13761.1 AK303059 mRNA Translation: BAG64176.1 AC099757 Genomic DNA No translation available. AL591594 Genomic DNA No translation available. CH471148 Genomic DNA Translation: EAW77109.1 BC032859 mRNA Translation: AAH32859.1 BC028392 mRNA No translation available. |
CCDSi | CCDS1625.1 [Q5SY80-2] CCDS44340.1 [Q5SY80-1] CCDS55693.1 [Q5SY80-3] |
RefSeqi | NP_001124429.1, NM_001130957.1 [Q5SY80-1] NP_001229269.1, NM_001242340.1 [Q5SY80-3] NP_776168.1, NM_173807.4 [Q5SY80-2] XP_011542441.1, XM_011544139.2 [Q5SY80-3] XP_011542444.1, XM_011544142.2 [Q5SY80-3] XP_011542451.1, XM_011544149.2 [Q5SY80-3] XP_016856435.1, XM_017000946.1 [Q5SY80-3] XP_016856438.1, XM_017000949.1 [Q5SY80-3] XP_016856439.1, XM_017000950.1 [Q5SY80-3] |
Genome annotation databases
Ensembli | ENST00000366531; ENSP00000355489; ENSG00000179397 [Q5SY80-3] ENST00000366533; ENSP00000355491; ENSG00000179397 [Q5SY80-2] ENST00000366534; ENSP00000355492; ENSG00000179397 [Q5SY80-1] |
GeneIDi | 257044 |
KEGGi | hsa:257044 |
UCSCi | uc001ial.4, human [Q5SY80-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK302609 mRNA Translation: BAH13761.1 AK303059 mRNA Translation: BAG64176.1 AC099757 Genomic DNA No translation available. AL591594 Genomic DNA No translation available. CH471148 Genomic DNA Translation: EAW77109.1 BC032859 mRNA Translation: AAH32859.1 BC028392 mRNA No translation available. |
CCDSi | CCDS1625.1 [Q5SY80-2] CCDS44340.1 [Q5SY80-1] CCDS55693.1 [Q5SY80-3] |
RefSeqi | NP_001124429.1, NM_001130957.1 [Q5SY80-1] NP_001229269.1, NM_001242340.1 [Q5SY80-3] NP_776168.1, NM_173807.4 [Q5SY80-2] XP_011542441.1, XM_011544139.2 [Q5SY80-3] XP_011542444.1, XM_011544142.2 [Q5SY80-3] XP_011542451.1, XM_011544149.2 [Q5SY80-3] XP_016856435.1, XM_017000946.1 [Q5SY80-3] XP_016856438.1, XM_017000949.1 [Q5SY80-3] XP_016856439.1, XM_017000950.1 [Q5SY80-3] |
3D structure databases
SMRi | Q5SY80 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129192, 1 interactor |
IntActi | Q5SY80, 1 interactor |
STRINGi | 9606.ENSP00000355492 |
PTM databases
GlyGeni | Q5SY80, 4 sites |
iPTMneti | Q5SY80 |
PhosphoSitePlusi | Q5SY80 |
Genetic variation databases
BioMutai | CATSPERE |
DMDMi | 74744048 |
Proteomic databases
jPOSTi | Q5SY80 |
MassIVEi | Q5SY80 |
PaxDbi | Q5SY80 |
PeptideAtlasi | Q5SY80 |
PRIDEi | Q5SY80 |
ProteomicsDBi | 5618 64019 [Q5SY80-1] 64020 [Q5SY80-2] |
Protocols and materials databases
Antibodypediai | 68517, 37 antibodies |
DNASUi | 257044 |
Genome annotation databases
Ensembli | ENST00000366531; ENSP00000355489; ENSG00000179397 [Q5SY80-3] ENST00000366533; ENSP00000355491; ENSG00000179397 [Q5SY80-2] ENST00000366534; ENSP00000355492; ENSG00000179397 [Q5SY80-1] |
GeneIDi | 257044 |
KEGGi | hsa:257044 |
UCSCi | uc001ial.4, human [Q5SY80-1] |
Organism-specific databases
CTDi | 257044 |
DisGeNETi | 257044 |
GeneCardsi | CATSPERE |
HGNCi | HGNC:28491, CATSPERE |
HPAi | ENSG00000179397, Tissue enriched (testis) |
MIMi | 617510, gene |
neXtProti | NX_Q5SY80 |
OpenTargetsi | ENSG00000179397 |
PharmGKBi | PA142672485 |
VEuPathDBi | HostDB:ENSG00000179397.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R8SD, Eukaryota |
GeneTreei | ENSGT00940000162691 |
HOGENOMi | CLU_014273_0_0_1 |
InParanoidi | Q5SY80 |
OMAi | NYRHCFS |
OrthoDBi | 213907at2759 |
PhylomeDBi | Q5SY80 |
TreeFami | TF336183 |
Enzyme and pathway databases
PathwayCommonsi | Q5SY80 |
Miscellaneous databases
BioGRID-ORCSi | 257044, 2 hits in 869 CRISPR screens |
ChiTaRSi | C1orf101, human |
GenomeRNAii | 257044 |
Pharosi | Q5SY80, Tdark |
PROi | PR:Q5SY80 |
RNActi | Q5SY80, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000179397, Expressed in testis and 122 other tissues |
ExpressionAtlasi | Q5SY80, baseline and differential |
Genevisiblei | Q5SY80, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028751, CATSPERD/E |
PANTHERi | PTHR33722, PTHR33722, 1 hit |
Pfami | View protein in Pfam PF15020, CATSPERD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CTSRE_HUMAN | |
Accessioni | Q5SY80Primary (citable) accession number: Q5SY80 Secondary accession number(s): B4DZR4 Q8IYZ6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 10, 2021 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families