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Protein
Submitted name:

Eukaryotic translation initiation factor 2D

Gene

EIF2D

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic translation initiation factor 2DImported
Gene namesi
Name:EIF2DImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143486.15
HGNCiHGNC:6583 EIF2D

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143486

PTM / Processingi

Proteomic databases

PeptideAtlasiQ5SY38
PRIDEiQ5SY38

Expressioni

Gene expression databases

BgeeiENSG00000143486 Expressed in 219 organ(s), highest expression level in ectocervix
ExpressionAtlasiQ5SY38 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5SY38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 145PUAInterPro annotationAdd BLAST86

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili222 – 242Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00550000074865
HOGENOMiHOG000043078
HOVERGENiHBG006268

Family and domain databases

Gene3Di2.30.130.10, 1 hit
InterProiView protein in InterPro
IPR039757 EIF2D
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
PANTHERiPTHR12217 PTHR12217, 2 hits
SUPFAMiSSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q5SY38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFAKAFRVKS NTAIKGSDRR KLRADVTTAF PTLGTDQVSE LVPGKEELNI
60 70 80 90 100
VKLYAHKGDA VTVYVSGGNP ILFELEKNLY PTDLMLPGLV MPPAGLPQVQ
110 120 130 140 150
KGDLCAISLV GNRAPVAIGV AAMSTAEMLT SGLKGRGFSV LHTYQDHLWR
160 170 180 190 200
SGNKSSPPSI APLALDSADL SEEKGSVQMD STLQGDMRHM TLEGEEENGE
210 220 230 240 250
VHQAREDKSL SEAPEDTSTR GLNQDSTDSK TLQEQMDELL QQCFLHALKC
260 270
RVKKADLPLL TSTFLGSHMF
Length:270
Mass (Da):29,328
Last modified:October 5, 2016 - v8
Checksum:iD5D4741F4719DAAC
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P41214EIF2D_HUMAN
Eukaryotic translation initiation f...
EIF2D HCA56, LGTN
584Annotation score:
A0A087WVB6A0A087WVB6_HUMAN
Eukaryotic translation initiation f...
EIF2D
66Annotation score:
A0A087X1L6A0A087X1L6_HUMAN
Eukaryotic translation initiation f...
EIF2D
62Annotation score:
A0A087X202A0A087X202_HUMAN
Eukaryotic translation initiation f...
EIF2D
73Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei270Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244034 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000437518; ENSP00000394685; ENSG00000143486
UCSCiuc057oxi.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC244034 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliQ5SY38
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ5SY38
PRIDEiQ5SY38

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000437518; ENSP00000394685; ENSG00000143486
UCSCiuc057oxi.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000143486.15
HGNCiHGNC:6583 EIF2D
OpenTargetsiENSG00000143486
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00550000074865
HOGENOMiHOG000043078
HOVERGENiHBG006268

Miscellaneous databases

ChiTaRSiEIF2D human

Gene expression databases

BgeeiENSG00000143486 Expressed in 219 organ(s), highest expression level in ectocervix
ExpressionAtlasiQ5SY38 baseline and differential

Family and domain databases

Gene3Di2.30.130.10, 1 hit
InterProiView protein in InterPro
IPR039757 EIF2D
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
PANTHERiPTHR12217 PTHR12217, 2 hits
SUPFAMiSSF88697 SSF88697, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SY38_HUMAN
AccessioniPrimary (citable) accession number: Q5SY38
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: October 5, 2016
Last modified: November 7, 2018
This is version 97 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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