UniProtKB - Q5SXY3 (Q5SXY3_HUMAN)
Protein
Submitted name:
Cholinergic receptor, nicotinic, beta 2 (Neuronal)
Gene
CHRNB2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- acetylcholine binding Source: Ensembl
- acetylcholine-gated cation-selective channel activity Source: Ensembl
- drug binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- transmembrane signaling receptor activity Source: InterPro
GO - Biological processi
- acetylcholine receptor signaling pathway Source: Ensembl
- action potential Source: Ensembl
- B cell activation Source: Ensembl
- behavioral response to nicotine Source: Ensembl
- calcium ion transport Source: Ensembl
- central nervous system projection neuron axonogenesis Source: Ensembl
- conditioned taste aversion Source: Ensembl
- lateral geniculate nucleus development Source: Ensembl
- locomotory behavior Source: Ensembl
- membrane depolarization Source: Ensembl
- memory Source: Ensembl
- negative regulation of action potential Source: Ensembl
- optic nerve morphogenesis Source: Ensembl
- positive regulation of B cell proliferation Source: Ensembl
- positive regulation of dopamine secretion Source: Ensembl
- positive regulation of synaptic transmission, dopaminergic Source: Ensembl
- regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
- regulation of circadian sleep/wake cycle, REM sleep Source: Ensembl
- regulation of dendrite morphogenesis Source: Ensembl
- regulation of dopamine metabolic process Source: Ensembl
- regulation of synapse assembly Source: Ensembl
- regulation of synaptic vesicle exocytosis Source: Ensembl
- response to cocaine Source: Ensembl
- response to ethanol Source: Ensembl
- response to hypoxia Source: Ensembl
- sensory perception of pain Source: Ensembl
- sensory perception of sound Source: Ensembl
- smooth muscle contraction Source: Ensembl
- social behavior Source: Ensembl
- synaptic transmission, cholinergic Source: Ensembl
- synaptic transmission involved in micturition Source: Ensembl
- vestibulocochlear nerve development Source: Ensembl
- visual learning Source: Ensembl
- visual perception Source: Ensembl
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channelARBA annotation, ReceptorImportedARBA annotation |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Cholinergic receptor, nicotinic, beta 2 (Neuronal)ImportedSubmitted name: cDNA, FLJ94017, Homo sapiens cholinergic receptor, nicotinic, beta polypeptide 2(neuronal) (CHRNB2), mRNAImported |
Gene namesi | Name:CHRNB2Imported ORF Names:hCG_18732Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000160716.4 |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- acetylcholine-gated channel complex Source: Ensembl
- external side of plasma membrane Source: Ensembl
- integral component of postsynaptic specialization membrane Source: Ensembl
- plasma membrane raft Source: Ensembl
Other locations
- cholinergic synapse Source: Ensembl
- dopaminergic synapse Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 235 – 256 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 268 – 288 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 300 – 321 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 461 – 483 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Membrane, Postsynaptic cell membraneARBA annotation, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | UniRule annotationAdd BLAST | 25 | |
ChainiPRO_5014309962 | 26 – 502 | UniRule annotationAdd BLAST | 477 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000160716, Expressed in epithelium of bronchus and 196 other tissues |
ExpressionAtlasi | Q5SXY3, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 29 – 234 | Neur_chan_LBDInterPro annotationAdd BLAST | 206 | |
Domaini | 241 – 478 | Neur_chan_membInterPro annotationAdd BLAST | 238 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_018074_1_3_1 |
OrthoDBi | 381858at2759 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR032932, CHRNB2 IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit PTHR18945:SF80, PTHR18945:SF80, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5SXY3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARRCGPVAL LLGFGLLRLC SGVWGTDTEE RLVEHLLDPS RYNKLIRPAT
60 70 80 90 100
NGSELVTVQL MVSLAQLISV HEREQIMTTN VWLTQEWEDY RLTWKPEEFD
110 120 130 140 150
NMKKVRLPSK HIWLPDVVLY NNADGMYEVS FYSNAVVSYD GSIFWLPPAI
160 170 180 190 200
YKSACKIEVK HFPFDQQNCT MKFRSWTYDR TEIDLVLKSE VASLDDFTPS
210 220 230 240 250
GEWDIVALPG RRNENPDDST YVDITYDFII RRKPLFYTIN LIIPCVLITS
260 270 280 290 300
LAILVFYLPS DCGEKMTLCI SVLLALTVFL LLISKIVPPT SLDVPLVGKY
310 320 330 340 350
LMFTMVLVTF SIVTSVCVLN VHHRSPTTHT MAPWVKVVFL EKLPALLFMQ
360 370 380 390 400
QPRHHCARQR LRLRRRQRER EGAGALFFRE APGADSCTCF VNRASVQGLA
410 420 430 440 450
GAFGAEPAPV AGPGRSGEPC GCGLREAVDG VRFIADHMRS EDDDQSVSED
460 470 480 490 500
WKYVAMVIDR LFLWIFVFVC VFGTIGMFLQ PLFQNYTTTT FLHSDHSAPS
SK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK313470 mRNA Translation: BAG36255.1 CH471121 Genomic DNA Translation: EAW53192.1 |
RefSeqi | NP_000739.1, NM_000748.2 |
Genome annotation databases
GeneIDi | 1141 |
KEGGi | hsa:1141 |
UCSCi | uc001ffg.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK313470 mRNA Translation: BAG36255.1 CH471121 Genomic DNA Translation: EAW53192.1 |
RefSeqi | NP_000739.1, NM_000748.2 |
3D structure databases
SMRi | Q5SXY3 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q5SXY3 |
Protocols and materials databases
Antibodypediai | 20401, 257 antibodies |
Genome annotation databases
GeneIDi | 1141 |
KEGGi | hsa:1141 |
UCSCi | uc001ffg.4, human |
Organism-specific databases
CTDi | 1141 |
EuPathDBi | HostDB:ENSG00000160716.4 |
PharmGKBi | PA115 |
Phylogenomic databases
HOGENOMi | CLU_018074_1_3_1 |
OrthoDBi | 381858at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1141, 4 hits in 845 CRISPR screens |
ChiTaRSi | CHRNB2, human |
GenomeRNAii | 1141 |
Gene expression databases
Bgeei | ENSG00000160716, Expressed in epithelium of bronchus and 196 other tissues |
ExpressionAtlasi | Q5SXY3, baseline and differential |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR032932, CHRNB2 IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit PTHR18945:SF80, PTHR18945:SF80, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
TIGRFAMsi | TIGR00860, LIC, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5SXY3_HUMAN | |
Accessioni | Q5SXY3Primary (citable) accession number: Q5SXY3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |