Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytospin-B

Gene

Specc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • actin cytoskeleton organization Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Cytospin-B
Alternative name(s):
Sperm antigen with calponin homology and coiled-coil domains 1
Gene namesi
Name:Specc1
Synonyms:Cytsb, Kiaa4061
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2442356 Specc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002540341 – 1067Cytospin-BAdd BLAST1067
Isoform 4 (identifier: Q5SXY1-3)
Initiator methionineiRemovedBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1
Modified residuei55PhosphoserineBy similarity1
Modified residuei76PhosphoserineCombined sources1
Modified residuei77PhosphothreonineBy similarity1
Modified residuei111PhosphoserineBy similarity1
Modified residuei133PhosphoserineCombined sources1
Modified residuei136PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
Modified residuei141PhosphothreonineBy similarity1
Modified residuei357PhosphothreonineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1
Modified residuei424PhosphoserineBy similarity1
Modified residuei847PhosphoserineCombined sources1
Modified residuei863PhosphoserineBy similarity1
Modified residuei912PhosphoserineBy similarity1
Modified residuei914PhosphoserineBy similarity1
Isoform 4 (identifier: Q5SXY1-3)
Lipidationi2N-myristoyl glycineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ5SXY1
PeptideAtlasiQ5SXY1
PRIDEiQ5SXY1

PTM databases

iPTMnetiQ5SXY1
PhosphoSitePlusiQ5SXY1

Expressioni

Gene expression databases

BgeeiENSMUSG00000042331 Expressed in 274 organ(s), highest expression level in blood
ExpressionAtlasiQ5SXY1 baseline and differential
GenevisibleiQ5SXY1 MM

Interactioni

Protein-protein interaction databases

IntActiQ5SXY1, 2 interactors
MINTiQ5SXY1
STRINGi10090.ENSMUSP00000104349

Structurei

3D structure databases

ProteinModelPortaliQ5SXY1
SMRiQ5SXY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini961 – 1066Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili574 – 773Sequence analysisAdd BLAST200

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi259 – 371Ser-richAdd BLAST113

Sequence similaritiesi

Belongs to the cytospin-A family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4678 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118856
HOGENOMiHOG000015307
InParanoidiQ5SXY1
OMAiIYLEHSP
OrthoDBiEOG091G01BX
PhylomeDBiQ5SXY1
TreeFamiTF316716

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
PfamiView protein in Pfam
PF00307 CH, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SXY1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRSAAKPWSP VAKAGSHGPD RTRPLPGTPS GMKSSKSSTS LAFESRLSKL
60 70 80 90 100
KRASSEDTLN KPGSASSGVA RLKKTSTSGA ISELTESRLR SNTGTIPTTK
110 120 130 140 150
RTGIPAPREL SVTISRERSV PRGPSSSKKL GSSPTSSCNP TPTKHLRTTP
160 170 180 190 200
AKPKQEHEGA EKAVLESQVR ELLAEAKTKD SEINRLRSEL KKCKERWALS
210 220 230 240 250
TEDANASDPS AEGTASPESD AQPLIRTLEE KNKTFQKELA DLEEENRALK
260 270 280 290 300
EKLTYLEQSP NSEGAASHTG DSSCPTSITH ESSFGSPVGN ELSSETDEYR
310 320 330 340 350
RTTHGSALRT SGSSSSDVTK ASLSPDASDF EHITADTPSR PLSATSNPFK
360 370 380 390 400
SSKGSPTGSS PNNASELSLA SLTEKIQKME ENQHSTAEEL QATLQELSDQ
410 420 430 440 450
QQMVQELTAE NEKLVDEKTI LETSFHQHRE RAEQLSQENE KLINLLQERV
460 470 480 490 500
KNEEPSAQGG KVLELEQKCT DILEKSRFER EKLLNIQQQL TCSLRKVEEE
510 520 530 540 550
NQGAIDMIKH LKEENEKLNG FLEHERCNNS VMAKTLEECR VTLEGLKMEN
560 570 580 590 600
GSLKALLEAD KQKAIEASST VGQTAENFEV QEMLKVARAE KDQLQLSCTE
610 620 630 640 650
LRQELLKANG EIKHVSSLLA KMEKDYSYLK EVCDHQAEQL SRTSLKLQEK
660 670 680 690 700
ASESDAEIKD MKETIFELED QVEQHRAVKL HNNQLISELE GSVIKLEEQK
710 720 730 740 750
SDLERQLKTL TKQIKEETEE WRRFQADLQT AVVVANDIKC EAQQELRTVK
760 770 780 790 800
RRLLEEEEKN ARLQKELGDI QGHSRWVTGR ATLLPVNEEP EPSEADAAGR
810 820 830 840 850
WRGVYVNRTS PAPSDSATTV KSLIKSFDLG HSGGTGQSIS VHKTPRSPLS
860 870 880 890 900
GIPVRTAPAA AVSPMQRHST YSSMKPASKG TSQRLDLPDL PLSDLLKGRA
910 920 930 940 950
EDRKSDPYLR KSPSLESLSR PPSLGFGNTR LLSASTGGLK PSKLSVERRD
960 970 980 990 1000
PLAALAREYG GSKRNALLKW CQKKTEGYAN IDITNFSSSW SDGLALCALL
1010 1020 1030 1040 1050
HTYLPAHIPY QELNSQEKKR NLLLAFEAAQ SVGINPSLEL SEMLYTDRPD
1060
WQSVMQYVAQ IYKYFET
Length:1,067
Mass (Da):118,101
Last modified:October 31, 2006 - v2
Checksum:iB199047FB7DF1957
GO
Isoform 2 (identifier: Q5SXY1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     785-790: PVNEEP → SMVSVS
     791-1067: Missing.

Show »
Length:790
Mass (Da):87,746
Checksum:iD7D7596CA36B3AA1
GO
Isoform 4 (identifier: Q5SXY1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: MRSAAKPWSP...ELTESRLRSN → MGNHSAKLEEPE

Show »
Length:987
Mass (Da):109,842
Checksum:iE44D5DFB02E5B68E
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YUR2A0A0J9YUR2_MOUSE
Cytospin-B
Specc1
978Annotation score:
A0A0J9YTU3A0A0J9YTU3_MOUSE
Cytospin-B
Specc1
1,058Annotation score:
A0A0J9YUG8A0A0J9YUG8_MOUSE
Cytospin-B
Specc1
407Annotation score:
A0A0J9YUF8A0A0J9YUF8_MOUSE
Cytospin-B
Specc1
781Annotation score:
A0A0J9YV86A0A0J9YV86_MOUSE
Cytospin-B
Specc1
710Annotation score:
A0A0J9YV47A0A0J9YV47_MOUSE
Cytospin-B
Specc1
121Annotation score:

Sequence cautioni

The sequence BAD90492 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti776 – 784Missing in BAD90492 (Ref. 1) Curated9

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0211661 – 92MRSAA…RLRSN → MGNHSAKLEEPE in isoform 4. 2 PublicationsAdd BLAST92
Alternative sequenceiVSP_021167785 – 790PVNEEP → SMVSVS in isoform 2. Curated6
Alternative sequenceiVSP_021168791 – 1067Missing in isoform 2. CuratedAdd BLAST277

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220465 mRNA Translation: BAD90492.1 Different initiation.
AL592080 Genomic DNA Translation: CAI23916.1
AL592080, AL596110 Genomic DNA Translation: CAI23917.1
AL596110, AL592080 Genomic DNA Translation: CAI35329.1
AK046469 mRNA Translation: BAC32744.2
AK050982 mRNA Translation: BAC34484.2
UniGeneiMm.438022
Mm.458025
Mm.459461

Genome annotation databases

EnsembliENSMUST00000049836; ENSMUSP00000063102; ENSMUSG00000042331 [Q5SXY1-2]
ENSMUST00000092415; ENSMUSP00000090071; ENSMUSG00000042331 [Q5SXY1-3]
ENSMUST00000108709; ENSMUSP00000104349; ENSMUSG00000042331 [Q5SXY1-1]
ENSMUST00000201624; ENSMUSP00000144659; ENSMUSG00000042331 [Q5SXY1-2]
ENSMUST00000201671; ENSMUSP00000144030; ENSMUSG00000042331 [Q5SXY1-2]
ENSMUST00000202389; ENSMUSP00000144055; ENSMUSG00000042331 [Q5SXY1-1]
ENSMUST00000202905; ENSMUSP00000144311; ENSMUSG00000042331 [Q5SXY1-1]
UCSCiuc007jin.2 mouse [Q5SXY1-3]
uc033fwe.1 mouse [Q5SXY1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220465 mRNA Translation: BAD90492.1 Different initiation.
AL592080 Genomic DNA Translation: CAI23916.1
AL592080, AL596110 Genomic DNA Translation: CAI23917.1
AL596110, AL592080 Genomic DNA Translation: CAI35329.1
AK046469 mRNA Translation: BAC32744.2
AK050982 mRNA Translation: BAC34484.2
UniGeneiMm.438022
Mm.458025
Mm.459461

3D structure databases

ProteinModelPortaliQ5SXY1
SMRiQ5SXY1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5SXY1, 2 interactors
MINTiQ5SXY1
STRINGi10090.ENSMUSP00000104349

PTM databases

iPTMnetiQ5SXY1
PhosphoSitePlusiQ5SXY1

Proteomic databases

PaxDbiQ5SXY1
PeptideAtlasiQ5SXY1
PRIDEiQ5SXY1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049836; ENSMUSP00000063102; ENSMUSG00000042331 [Q5SXY1-2]
ENSMUST00000092415; ENSMUSP00000090071; ENSMUSG00000042331 [Q5SXY1-3]
ENSMUST00000108709; ENSMUSP00000104349; ENSMUSG00000042331 [Q5SXY1-1]
ENSMUST00000201624; ENSMUSP00000144659; ENSMUSG00000042331 [Q5SXY1-2]
ENSMUST00000201671; ENSMUSP00000144030; ENSMUSG00000042331 [Q5SXY1-2]
ENSMUST00000202389; ENSMUSP00000144055; ENSMUSG00000042331 [Q5SXY1-1]
ENSMUST00000202905; ENSMUSP00000144311; ENSMUSG00000042331 [Q5SXY1-1]
UCSCiuc007jin.2 mouse [Q5SXY1-3]
uc033fwe.1 mouse [Q5SXY1-1]

Organism-specific databases

MGIiMGI:2442356 Specc1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4678 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118856
HOGENOMiHOG000015307
InParanoidiQ5SXY1
OMAiIYLEHSP
OrthoDBiEOG091G01BX
PhylomeDBiQ5SXY1
TreeFamiTF316716

Miscellaneous databases

ChiTaRSiSpecc1 mouse
PROiPR:Q5SXY1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042331 Expressed in 274 organ(s), highest expression level in blood
ExpressionAtlasiQ5SXY1 baseline and differential
GenevisibleiQ5SXY1 MM

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
PfamiView protein in Pfam
PF00307 CH, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYTSB_MOUSE
AccessioniPrimary (citable) accession number: Q5SXY1
Secondary accession number(s): Q5DTQ5
, Q5SXY0, Q8BKR3, Q8BL39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: November 7, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again