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Protein

DNL-type zinc finger protein

Gene

DNLZ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri64 – 161DNL-typePROSITE-ProRule annotationAdd BLAST98

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNL-type zinc finger protein
Alternative name(s):
Hsp70-escort protein 1
Short name:
HEP1
mtHsp70-escort protein
Gene namesi
Name:DNLZ
Synonyms:C9orf151
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000213221.4
HGNCiHGNC:33879 DNLZ
neXtProtiNX_Q5SXM8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi728489
OpenTargetsiENSG00000213221
PharmGKBiPA162384018

Polymorphism and mutation databases

DMDMi74743980

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49MitochondrionSequence analysisAdd BLAST49
ChainiPRO_000031716650 – 178DNL-type zinc finger proteinAdd BLAST129

Proteomic databases

EPDiQ5SXM8
MaxQBiQ5SXM8
PaxDbiQ5SXM8
PeptideAtlasiQ5SXM8
PRIDEiQ5SXM8
ProteomicsDBi63998

PTM databases

iPTMnetiQ5SXM8
PhosphoSitePlusiQ5SXM8

Expressioni

Gene expression databases

BgeeiENSG00000213221 Expressed in 91 organ(s), highest expression level in heart left ventricle
CleanExiHS_DNLZ
ExpressionAtlasiQ5SXM8 baseline and differential
GenevisibleiQ5SXM8 HS

Organism-specific databases

HPAiHPA062738

Interactioni

Subunit structurei

Oligomerizes in a concentration-dependent fashion. Interacts with HSPA9.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi608915, 23 interactors
STRINGi9606.ENSP00000360803

Structurei

3D structure databases

ProteinModelPortaliQ5SXM8
SMRiQ5SXM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri64 – 161DNL-typePROSITE-ProRule annotationAdd BLAST98

Keywords - Domaini

Transit peptide, Zinc-finger

Phylogenomic databases

eggNOGiKOG3277 Eukaryota
ENOG41121WI LUCA
GeneTreeiENSGT00390000008220
HOGENOMiHOG000060212
HOVERGENiHBG095506
InParanoidiQ5SXM8
KOiK17808
OMAiRRAWAWG
OrthoDBiEOG091G0T58
PhylomeDBiQ5SXM8
TreeFamiTF313165

Family and domain databases

InterProiView protein in InterPro
IPR024158 Mt_import_TIM15
IPR007853 Znf_DNL-typ
PANTHERiPTHR20922 PTHR20922, 1 hit
PfamiView protein in Pfam
PF05180 zf-DNL, 1 hit
PROSITEiView protein in PROSITE
PS51501 ZF_DNL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5SXM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRTALRGAP RLLSRVQPRA PCLRRLWGRG ARPEVAGRRR AWAWGWRRSS
60 70 80 90 100
SEQGPGPAAA LGRVEAAHYQ LVYTCKVCGT RSSKRISKLA YHQGVVIVTC
110 120 130 140 150
PGCQNHHIIA DNLGWFSDLN GKRNIEEILT ARGEQVHRVA GEGALELVLE
160 170
AAGAPTSTAA PEAGEDEGPP SPGKTEPS
Length:178
Mass (Da):19,204
Last modified:December 21, 2004 - v1
Checksum:i5BB1094917DDD85B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SXM7Q5SXM7_HUMAN
DNL-type zinc finger protein
DNLZ
117Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053993169P → H. Corresponds to variant dbSNP:rs3812553Ensembl.1
Natural variantiVAR_053994178S → T. Corresponds to variant dbSNP:rs3812552Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592301 Genomic DNA No translation available.
BC146915 mRNA Translation: AAI46916.1
BC146924 mRNA Translation: AAI46925.1
CCDSiCCDS35179.1
RefSeqiNP_001074318.1, NM_001080849.2
UniGeneiHs.528581

Genome annotation databases

EnsembliENST00000371738; ENSP00000360803; ENSG00000213221
GeneIDi728489
KEGGihsa:728489
UCSCiuc004chf.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592301 Genomic DNA No translation available.
BC146915 mRNA Translation: AAI46916.1
BC146924 mRNA Translation: AAI46925.1
CCDSiCCDS35179.1
RefSeqiNP_001074318.1, NM_001080849.2
UniGeneiHs.528581

3D structure databases

ProteinModelPortaliQ5SXM8
SMRiQ5SXM8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi608915, 23 interactors
STRINGi9606.ENSP00000360803

PTM databases

iPTMnetiQ5SXM8
PhosphoSitePlusiQ5SXM8

Polymorphism and mutation databases

DMDMi74743980

Proteomic databases

EPDiQ5SXM8
MaxQBiQ5SXM8
PaxDbiQ5SXM8
PeptideAtlasiQ5SXM8
PRIDEiQ5SXM8
ProteomicsDBi63998

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371738; ENSP00000360803; ENSG00000213221
GeneIDi728489
KEGGihsa:728489
UCSCiuc004chf.3 human

Organism-specific databases

CTDi728489
DisGeNETi728489
EuPathDBiHostDB:ENSG00000213221.4
GeneCardsiDNLZ
HGNCiHGNC:33879 DNLZ
HPAiHPA062738
neXtProtiNX_Q5SXM8
OpenTargetsiENSG00000213221
PharmGKBiPA162384018
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3277 Eukaryota
ENOG41121WI LUCA
GeneTreeiENSGT00390000008220
HOGENOMiHOG000060212
HOVERGENiHBG095506
InParanoidiQ5SXM8
KOiK17808
OMAiRRAWAWG
OrthoDBiEOG091G0T58
PhylomeDBiQ5SXM8
TreeFamiTF313165

Miscellaneous databases

GenomeRNAii728489
PROiPR:Q5SXM8

Gene expression databases

BgeeiENSG00000213221 Expressed in 91 organ(s), highest expression level in heart left ventricle
CleanExiHS_DNLZ
ExpressionAtlasiQ5SXM8 baseline and differential
GenevisibleiQ5SXM8 HS

Family and domain databases

InterProiView protein in InterPro
IPR024158 Mt_import_TIM15
IPR007853 Znf_DNL-typ
PANTHERiPTHR20922 PTHR20922, 1 hit
PfamiView protein in Pfam
PF05180 zf-DNL, 1 hit
PROSITEiView protein in PROSITE
PS51501 ZF_DNL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDNLZ_HUMAN
AccessioniPrimary (citable) accession number: Q5SXM8
Secondary accession number(s): B2RUX5, B9EJE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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