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Entry version 150 (22 Apr 2020)
Sequence version 1 (21 Dec 2004)
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Protein

snRNA-activating protein complex subunit 4

Gene

SNAPC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi317 – 341H-T-H motifPROSITE-ProRule annotationAdd BLAST25
DNA bindingi424 – 447H-T-H motifPROSITE-ProRule annotationAdd BLAST24
DNA bindingi476 – 499H-T-H motifPROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
snRNA-activating protein complex subunit 4
Short name:
SNAPc subunit 4
Alternative name(s):
Proximal sequence element-binding transcription factor subunit alpha
Short name:
PSE-binding factor subunit alpha
Short name:
PTF subunit alpha
snRNA-activating protein complex 190 kDa subunit
Short name:
SNAPc 190 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNAPC4Imported
Synonyms:SNAP190Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11137 SNAPC4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602777 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5SXM2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi94Q → A: Abolishes SNAPC5 binding in the absence of SNAPC1. Minimal effect on SNAPC5 binding in the presence of SNAPC1. 1 Publication1
Mutagenesisi94Q → L: Abolishes SNAPC5 binding in the absence of SNAPC1. Minimal effect on SNAPC5 binding in the presence of SNAPC1. 1 Publication1
Mutagenesisi115Q → L: Abolishes SNAPC5 binding in the absence of SNAPC1. Minimal effect on SNAPC5 binding in the presence of SNAPC1. 1 Publication1
Mutagenesisi1314L → A: Abolishes SNAPC2-binding. 1 Publication1
Mutagenesisi1355L → A: Abolishes SNAPC2-binding. 1 Publication1
Mutagenesisi1362L → A: Abolishes SNAPC2-binding. 1 Publication1
Mutagenesisi1364L → A: Abolishes SNAPC2-binding. 1 Publication1
Mutagenesisi1369L → A: Decreased binding to SNAPC2. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6621

Open Targets

More...
OpenTargetsi
ENSG00000165684

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35985

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5SXM2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SNAPC4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762223

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001971201 – 1469snRNA-activating protein complex subunit 4Add BLAST1469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei68PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Modified residuei626PhosphoserineCombined sources1
Modified residuei1157PhosphothreonineCombined sources1
Modified residuei1224PhosphoserineCombined sources1
Modified residuei1398PhosphoserineCombined sources1
Modified residuei1400PhosphoserineCombined sources1
Modified residuei1440PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5SXM2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5SXM2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5SXM2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5SXM2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SXM2

PeptideAtlas

More...
PeptideAtlasi
Q5SXM2

PRoteomics IDEntifications database

More...
PRIDEi
Q5SXM2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63996

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SXM2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SXM2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165684 Expressed in epithelium of bronchus and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5SXM2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SXM2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165684 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC4 interacts with SNAPC1, SNAPC2, SNAPC5, BRF2 and TBP.

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112505, 17 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q5SXM2

Protein interaction database and analysis system

More...
IntActi
Q5SXM2, 22 interactors

Molecular INTeraction database

More...
MINTi
Q5SXM2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000298532

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5SXM2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5SXM2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini250 – 288Myb-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini289 – 343HTH myb-type 1PROSITE-ProRule annotationAdd BLAST55
Domaini344 – 395Myb-like 2PROSITE-ProRule annotationAdd BLAST52
Domaini396 – 451HTH myb-type 2PROSITE-ProRule annotationAdd BLAST56
Domaini452 – 503HTH myb-type 3PROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 133SNAPC5-binding1 PublicationAdd BLAST50
Regioni1281 – 1393SNAPC2-binding1 PublicationAdd BLAST113

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi931 – 1264Pro-richSequence analysisAdd BLAST334

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0048 Eukaryota
COG5147 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160404

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004641_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SXM2

KEGG Orthology (KO)

More...
KOi
K09453

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWHGTFQ

Database of Orthologous Groups

More...
OrthoDBi
219341at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SXM2

TreeFam database of animal gene trees

More...
TreeFami
TF313064

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00167 SANT, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR017877 Myb-like_dom
IPR017930 Myb_dom
IPR001005 SANT/Myb

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00249 Myb_DNA-binding, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00717 SANT, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51294 HTH_MYB, 3 hits
PS50090 MYB_LIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5SXM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVDAEREKI TQEIKELERI LDPGSSGSHV EISESSLESD SEADSLPSED
60 70 80 90 100
LDPADPPISE EERWGEASND EDDPKDKTLP EDPETCLQLN MVYQEVIQEK
110 120 130 140 150
LAEANLLLAQ NREQQEELMR DLAGSKGTKV KDGKSLPPST YMGHFMKPYF
160 170 180 190 200
KDKVTGVGPP ANEDTREKAA QGIKAFEELL VTKWKNWEKA LLRKSVVSDR
210 220 230 240 250
LQRLLQPKLL KLEYLHQKQS KVSSELERQA LEKQGREAEK EIQDINQLPE
260 270 280 290 300
EALLGNRLDS HDWEKISNIN FEGSRSAEEI RKFWQNSEHP SINKQEWSRE
310 320 330 340 350
EEERLQAIAA AHGHLEWQKI AEELGTSRSA FQCLQKFQQH NKALKRKEWT
360 370 380 390 400
EEEDRMLTQL VQEMRVGSHI PYRRIVYYME GRDSMQLIYR WTKSLDPGLK
410 420 430 440 450
KGYWAPEEDA KLLQAVAKYG EQDWFKIREE VPGRSDAQCR DRYLRRLHFS
460 470 480 490 500
LKKGRWNLKE EEQLIELIEK YGVGHWAKIA SELPHRSGSQ CLSKWKIMMG
510 520 530 540 550
KKQGLRRRRR RARHSVRWSS TSSSGSSSGS SGGSSSSSSS SSEEDEPEQA
560 570 580 590 600
QAGEGDRALL SPQYMVPDMD LWVPARQSTS QPWRGGAGAW LGGPAASLSP
610 620 630 640 650
PKGSSASQGG SKEASTTAAA PGEETSPVQV PARAHGPVPR SAQASHSADT
660 670 680 690 700
RPAGAEKQAL EGGRRLLTVP VETVLRVLRA NTAARSCTQK EQLRQPPLPT
710 720 730 740 750
SSPGVSSGDS VARSHVQWLR HRATQSGQRR WRHALHRRLL NRRLLLAVTP
760 770 780 790 800
WVGDVVVPCT QASQRPAVVQ TQADGLREQL QQARLASTPV FTLFTQLFHI
810 820 830 840 850
DTAGCLEVVR ERKALPPRLP QAGARDPPVH LLQASSSAQS TPGHLFPNVP
860 870 880 890 900
AQEASKSASH KGSRRLASSR VERTLPQASL LASTGPRPKP KTVSELLQEK
910 920 930 940 950
RLQEARAREA TRGPVVLPSQ LLVSSSVILQ PPLPHTPHGR PAPGPTVLNV
960 970 980 990 1000
PLSGPGAPAA AKPGTSGSWQ EAGTSAKDKR LSTMQALPLA PVFSEAEGTA
1010 1020 1030 1040 1050
PAASQAPALG PGQISVSCPE SGLGQSQAPA ASRKQGLPEA PPFLPAAPSP
1060 1070 1080 1090 1100
TPLPVQPLSL THIGGPHVAT SVPLPVTWVL TAQGLLPVPV PAVVSLPRPA
1110 1120 1130 1140 1150
GTPGPAGLLA TLLPPLTETR AAQGPRAPAL SSSWQPPANM NREPEPSCRT
1160 1170 1180 1190 1200
DTPAPPTHAL SQSPAEADGS VAFVPGEAQV AREIPEPRTS SHADPPEAEP
1210 1220 1230 1240 1250
PWSGRLPAFG GVIPATEPRG TPGSPSGTQE PRGPLGLEKL PLRQPGPEKG
1260 1270 1280 1290 1300
ALDLEKPPLP QPGPEKGALD LGLLSQEGEA ATQQWLGGQR GVRVPLLGSR
1310 1320 1330 1340 1350
LPYQPPALCS LRALSGLLLH KKALEHKATS LVVGGEAERP AGALQASLGL
1360 1370 1380 1390 1400
VRGQLQDNPA YLLLRARFLA AFTLPALLAT LAPQGVRTTL SVPSRVGSES
1410 1420 1430 1440 1450
EDEDLLSELE LADRDGQPGC TTATCPIQGA PDSGKCSASS CLDTSNDPDD
1460
LDVLRTRHAR HTRKRRRLV
Length:1,469
Mass (Da):159,433
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i78CBCFB1887E106C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GUB4A0A1B0GUB4_HUMAN
snRNA-activating protein complex su...
SNAPC4
451Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1046A → G in AAC02972 (PubMed:9418884).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05945544D → N. Corresponds to variant dbSNP:rs7031489Ensembl.1
Natural variantiVAR_050193799H → Q. Corresponds to variant dbSNP:rs3812571Ensembl.1
Natural variantiVAR_0501941448P → S. Corresponds to variant dbSNP:rs3812561Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF032387 mRNA Translation: AAC02972.1
AL592301 Genomic DNA Translation: CAI13935.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6998.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T09219

NCBI Reference Sequences

More...
RefSeqi
NP_003077.2, NM_003086.3
XP_005266153.1, XM_005266096.2
XP_006717304.1, XM_006717241.2
XP_006717305.1, XM_006717242.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298532; ENSP00000298532; ENSG00000165684

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6621

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6621

UCSC genome browser

More...
UCSCi
uc004chh.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032387 mRNA Translation: AAC02972.1
AL592301 Genomic DNA Translation: CAI13935.1
CCDSiCCDS6998.1
PIRiT09219
RefSeqiNP_003077.2, NM_003086.3
XP_005266153.1, XM_005266096.2
XP_006717304.1, XM_006717241.2
XP_006717305.1, XM_006717242.3

3D structure databases

SMRiQ5SXM2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112505, 17 interactors
CORUMiQ5SXM2
IntActiQ5SXM2, 22 interactors
MINTiQ5SXM2
STRINGi9606.ENSP00000298532

PTM databases

iPTMnetiQ5SXM2
PhosphoSitePlusiQ5SXM2

Polymorphism and mutation databases

BioMutaiSNAPC4
DMDMi74762223

Proteomic databases

EPDiQ5SXM2
jPOSTiQ5SXM2
MassIVEiQ5SXM2
MaxQBiQ5SXM2
PaxDbiQ5SXM2
PeptideAtlasiQ5SXM2
PRIDEiQ5SXM2
ProteomicsDBi63996

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
18701 191 antibodies

The DNASU plasmid repository

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DNASUi
6621

Genome annotation databases

EnsembliENST00000298532; ENSP00000298532; ENSG00000165684
GeneIDi6621
KEGGihsa:6621
UCSCiuc004chh.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6621
DisGeNETi6621

GeneCards: human genes, protein and diseases

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GeneCardsi
SNAPC4
HGNCiHGNC:11137 SNAPC4
HPAiENSG00000165684 Low tissue specificity
MIMi602777 gene
neXtProtiNX_Q5SXM2
OpenTargetsiENSG00000165684
PharmGKBiPA35985

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0048 Eukaryota
COG5147 LUCA
GeneTreeiENSGT00940000160404
HOGENOMiCLU_004641_0_0_1
InParanoidiQ5SXM2
KOiK09453
OMAiLWHGTFQ
OrthoDBi219341at2759
PhylomeDBiQ5SXM2
TreeFamiTF313064

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SNAPC4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SNAPC4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6621
PharosiQ5SXM2 Tbio

Protein Ontology

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PROi
PR:Q5SXM2
RNActiQ5SXM2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000165684 Expressed in epithelium of bronchus and 199 other tissues
ExpressionAtlasiQ5SXM2 baseline and differential
GenevisibleiQ5SXM2 HS

Family and domain databases

CDDicd00167 SANT, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017877 Myb-like_dom
IPR017930 Myb_dom
IPR001005 SANT/Myb
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 2 hits
SMARTiView protein in SMART
SM00717 SANT, 5 hits
SUPFAMiSSF46689 SSF46689, 3 hits
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 3 hits
PS50090 MYB_LIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNPC4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SXM2
Secondary accession number(s): Q9Y6P7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: December 21, 2004
Last modified: April 22, 2020
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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