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Entry version 145 (29 Sep 2021)
Sequence version 1 (21 Dec 2004)
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Protein

Zinc finger protein 678

Gene

ZNF678

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri97 – 119C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri125 – 147C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri181 – 203C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri209 – 231C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5SXM1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 678
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF678
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28652, ZNF678

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5SXM1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000181450

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000181450

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5SXM1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF678

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74756138

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002339981 – 525Zinc finger protein 678Add BLAST525

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5SXM1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5SXM1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5SXM1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SXM1

PeptideAtlas

More...
PeptideAtlasi
Q5SXM1

PRoteomics IDEntifications database

More...
PRIDEi
Q5SXM1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63995

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SXM1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SXM1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000181450, Expressed in endometrium and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5SXM1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SXM1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000181450, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q5SXM1, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344828

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5SXM1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5SXM1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri97 – 119C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri125 – 147C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri153 – 175C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri181 – 203C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri209 – 231C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri237 – 259C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 287C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri293 – 315C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri321 – 343C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri405 – 427C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri433 – 455C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri461 – 483C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri489 – 511C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154251

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_44_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SXM1

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHTEIRK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SXM1

TreeFam database of animal gene trees

More...
TreeFami
TF341817

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 14 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5SXM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTISLCIGV CAFEGANTST SFYKLVYTAI LSYSIQDLLP EQDMKDLCQK
60 70 80 90 100
VTLTRHRSWG LDNLHLVKDW RTVNEGKGQK EYCNRLTQCS STKSKIFQCI
110 120 130 140 150
ECGRNFSWRS ILTEHKRIHT GEKPYKCEEC GKVFNRCSNL TKHKRIHTGE
160 170 180 190 200
KPYKCDECGK VFNWWSQLTN HKKIHTGEKP YKCDECDKVF NWWSQLTSHK
210 220 230 240 250
KIHSGEKPYP CEECGKAFTQ FSNLTQHKRI HTGEKPYKCK ECCKAFNKFS
260 270 280 290 300
NLTQHKRIHT GEKPYKCEEC GNVFNECSHL TRHRRIHTGE KPYKCEECGK
310 320 330 340 350
AFTQFASLTR HKRIHTGEKP YQCEECGKTF NRCSHLSSHK RIHTGEKPYK
360 370 380 390 400
CEECGRTFTQ FSNLTQHKRI HTGEKPYKCK ECGKAFNKFS SLTQHRRIHT
410 420 430 440 450
GVKPYKCEEC GKVFKQCSHL TSHKRIHTGE KPYKCKECGK AFYQSSILSK
460 470 480 490 500
HKRIHTEEKP YKCEECGKAF NQFSSLTRHK RIHTGEKRYK CKECGKGFYQ
510 520
SSIHSKYKRI YTGEEPDKCK KCGSL
Length:525
Mass (Da):61,411
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i23FD2180FF0F0152
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1APK8B1APK8_HUMAN
Zinc finger protein 678
ZNF678
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYU6V9GYU6_HUMAN
Zinc finger protein 678
ZNF678
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026154144K → E1 PublicationCorresponds to variant dbSNP:rs17854209Ensembl.1
Natural variantiVAR_061962152P → T. Corresponds to variant dbSNP:rs61283390Ensembl.1
Natural variantiVAR_057441197T → I. Corresponds to variant dbSNP:rs12118505Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL592310 Genomic DNA No translation available.
BC042500 mRNA Translation: AAH42500.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343776; ENSP00000344828; ENSG00000181450
ENST00000397097; ENSP00000440403; ENSG00000181450

UCSC genome browser

More...
UCSCi
uc001hqw.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592310 Genomic DNA No translation available.
BC042500 mRNA Translation: AAH42500.1

3D structure databases

SMRiQ5SXM1
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ5SXM1, 2 interactors
STRINGi9606.ENSP00000344828

PTM databases

iPTMnetiQ5SXM1
PhosphoSitePlusiQ5SXM1

Genetic variation databases

BioMutaiZNF678
DMDMi74756138

Proteomic databases

EPDiQ5SXM1
jPOSTiQ5SXM1
MassIVEiQ5SXM1
PaxDbiQ5SXM1
PeptideAtlasiQ5SXM1
PRIDEiQ5SXM1
ProteomicsDBi63995

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34656, 76 antibodies

Genome annotation databases

EnsembliENST00000343776; ENSP00000344828; ENSG00000181450
ENST00000397097; ENSP00000440403; ENSG00000181450
UCSCiuc001hqw.3, human

Organism-specific databases

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF678
HGNCiHGNC:28652, ZNF678
HPAiENSG00000181450, Low tissue specificity
neXtProtiNX_Q5SXM1
OpenTargetsiENSG00000181450
VEuPathDBiHostDB:ENSG00000181450

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000154251
HOGENOMiCLU_002678_44_0_1
InParanoidiQ5SXM1
OMAiGHTEIRK
PhylomeDBiQ5SXM1
TreeFamiTF341817

Enzyme and pathway databases

PathwayCommonsiQ5SXM1
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF678, human
PharosiQ5SXM1, Tdark

Protein Ontology

More...
PROi
PR:Q5SXM1
RNActiQ5SXM1, protein

Gene expression databases

BgeeiENSG00000181450, Expressed in endometrium and 208 other tissues
ExpressionAtlasiQ5SXM1, baseline and differential
GenevisibleiQ5SXM1, HS

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 14 hits
SUPFAMiSSF57667, SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 14 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN678_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SXM1
Secondary accession number(s): Q8IVQ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 21, 2004
Last modified: September 29, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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