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Protein

Pleckstrin homology domain-containing family S member 1

Gene

PLEKHS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family S member 1
Short name:
PH domain-containing family S member 1
Alternative name(s):
Epididymis luminal protein 185
Short name:
hEL185
Gene namesi
Name:PLEKHS1
Synonyms:C10orf81
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000148735.14
HGNCiHGNC:26285 PLEKHS1
neXtProtiNX_Q5SXH7

Pathology & Biotechi

Organism-specific databases

DisGeNETi79949
PharmGKBiPA134886856

Polymorphism and mutation databases

BioMutaiPLEKHS1
DMDMi172045921

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206751 – 462Pleckstrin homology domain-containing family S member 1Add BLAST462

Proteomic databases

MaxQBiQ5SXH7
PaxDbiQ5SXH7
PeptideAtlasiQ5SXH7
PRIDEiQ5SXH7
ProteomicsDBi63989
63990 [Q5SXH7-2]
63991 [Q5SXH7-3]
63992 [Q5SXH7-4]
63993 [Q5SXH7-5]

PTM databases

iPTMnetiQ5SXH7
PhosphoSitePlusiQ5SXH7

Expressioni

Gene expression databases

BgeeiENSG00000148735
CleanExiHS_C10orf81
ExpressionAtlasiQ5SXH7 baseline and differential
GenevisibleiQ5SXH7 HS

Organism-specific databases

HPAiHPA037583

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi123020, 3 interactors
IntActiQ5SXH7, 4 interactors
STRINGi9606.ENSP00000358316

Structurei

3D structure databases

ProteinModelPortaliQ5SXH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 129PHPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiENOG410II4G Eukaryota
ENOG410YTCM LUCA
HOVERGENiHBG107692
InParanoidiQ5SXH7
OMAiGCLFCHG
OrthoDBiEOG091G0BNK
PhylomeDBiQ5SXH7
TreeFamiTF334193

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5SXH7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGGKQFTFS YENEVCKQDY FIKSPPSQLF SSVTSWKKRF FILSKAGEKS
60 70 80 90 100
FSLSYYKDHH HRGSIEIDQN SSVEVGISSQ EKMQSVQKMF KCHPDEVMSI
110 120 130 140 150
RTTNREYFLI GHDREKIKDW VSFMSSFRQD IKATQQNTEE ELSLGNKRTL
160 170 180 190 200
FYSSPLLGPS STSEAVGSSS PRNGLQDKHL MEQSSPGFRQ THLQDLSEAT
210 220 230 240 250
QDVKEENHYL TPRSVLLELD NIIASSDSGE SIETDGPDQV SGRIECHYEP
260 270 280 290 300
MESSFFKETS HESVDSSKEE PQTLPETQDG DLHLQEQGSG IDWCLSPADV
310 320 330 340 350
EAQTTNDQKG SASLTVVQLS ILINNIPDES QVEKLNVFLS PPDVINYLAL
360 370 380 390 400
TEATGRICVS QWEGPPRLGC IFCHGDHLLA VNDLKPQSLE EVSLFLTRSI
410 420 430 440 450
QKEKLKLTIG RIPNSETFHA ASCMCPSKCQ SAAPSQLDKP RLNRAPKRSP
460
AIKKSQQKGA RE
Length:462
Mass (Da):51,763
Last modified:March 28, 2018 - v3
Checksum:i9D5927D6DE0CEFB6
GO
Isoform 2 (identifier: Q5SXH7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     311-324: Missing.

Show »
Length:448
Mass (Da):50,323
Checksum:i492D03E092D78F83
GO
Isoform 3 (identifier: Q5SXH7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     311-324: Missing.

Show »
Length:366
Mass (Da):40,922
Checksum:i9AC7EE1B4369AF03
GO
Isoform 4 (identifier: Q5SXH7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MAG → MEPKPQKSP
     358-462: Missing.

Show »
Length:363
Mass (Da):40,906
Checksum:iAB23D4A8D2393524
GO
Isoform 5 (identifier: Q5SXH7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     311-324: Missing.
     404-462: KLKLTIGRIP...KKSQQKGARE → DSFRILSYQV...NDGAGCWIIK

Show »
Length:465
Mass (Da):52,459
Checksum:iA9A9C93E5F2B9262
GO

Sequence cautioni

The sequence AAH36365 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB15687 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366P → R in AAH36365 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_080192254S → Y3 Publications1
Natural variantiVAR_039275337V → I. Corresponds to variant dbSNP:rs34024791Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0317271 – 82Missing in isoform 3. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_0317281 – 3MAG → MEPKPQKSP in isoform 4. 1 Publication3
Alternative sequenceiVSP_031729311 – 324Missing in isoform 2, isoform 3 and isoform 5. 3 PublicationsAdd BLAST14
Alternative sequenceiVSP_031730358 – 462Missing in isoform 4. 1 PublicationAdd BLAST105
Alternative sequenceiVSP_031731404 – 462KLKLT…KGARE → DSFRILSYQVAFGEGTELRD RAPGFRTSDRHDVAKRACME SDWCRDSKTAPSTNLCLSFL FCKIMTNDGAGCWIIK in isoform 5. 2 PublicationsAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ236306 mRNA Translation: ACI45238.1
AK027190 mRNA Translation: BAB15687.1 Different initiation.
AK126354 mRNA Translation: BAG54312.1
AK128811 mRNA Translation: BAC87618.1
AK292867 mRNA Translation: BAF85556.1
AL592546 Genomic DNA No translation available.
BC036365 mRNA Translation: AAH36365.2 Different initiation.
BC037870 mRNA Translation: AAH37870.1
CCDSiCCDS53580.1 [Q5SXH7-5]
CCDS53581.1 [Q5SXH7-3]
CCDS7583.1 [Q5SXH7-4]
RefSeqiNP_001180363.1, NM_001193434.1
NP_001180364.1, NM_001193435.1
NP_079165.3, NM_024889.4
NP_872407.1, NM_182601.1
UniGeneiHs.228320

Genome annotation databases

EnsembliENST00000361048; ENSP00000354332; ENSG00000148735
ENST00000369310; ENSP00000358316; ENSG00000148735
ENST00000369312; ENSP00000358318; ENSG00000148735
ENST00000619563; ENSP00000483759; ENSG00000148735
GeneIDi79949
KEGGihsa:79949
UCSCiuc001lar.3 human [Q5SXH7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPKHS1_HUMAN
AccessioniPrimary (citable) accession number: Q5SXH7
Secondary accession number(s): A8KA02
, B3KX00, B6EDE1, Q5SXH8, Q5SXI0, Q6ZQR5, Q8NE42, Q9H5D9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 28, 2018
Last modified: July 18, 2018
This is version 119 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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