UniProtKB - Q5SXG9 (Q5SXG9_MOUSE)
Protein
Submitted name:
Acetylcholine receptor subunit epsilon
Gene
Chrne
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- acetylcholine-gated cation-selective channel activity Source: InterPro
- transmembrane signaling receptor activity Source: InterPro
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channelARBA annotation, ReceptorARBA annotation |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Acetylcholine receptor subunit epsilonImported |
Gene namesi | Name:ChrneImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:87894, Chrne |
Subcellular locationi
Plasma membrane
- postsynaptic cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 241 – 263 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 275 – 295 | HelicalUniRule annotationAdd BLAST | 21 | |
Transmembranei | 307 – 330 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 458 – 480 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Membrane, Postsynaptic cell membraneARBA annotation, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | UniRule annotationAdd BLAST | 20 | |
ChainiPRO_5022270154 | 21 – 494 | UniRule annotationAdd BLAST | 474 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationProteomic databases
PRIDEi | Q5SXG9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000014609, Expressed in spermatid and 68 other tissues |
ExpressionAtlasi | Q5SXG9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 240 | Neur_chan_LBDInterPro annotationAdd BLAST | 215 | |
Domaini | 247 – 475 | Neur_chan_membInterPro annotationAdd BLAST | 229 |
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000160933 |
OrthoDBi | 588360at2759 |
PhylomeDBi | Q5SXG9 |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5SXG9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGALLGALL LLTLFGRSQG KNEELSLYHH LFDNYDPECR PVRRPEDTVT
60 70 80 90 100
ITLKVTLTNL ISLNEKEETL TTSVWIGIDW HDYRLNYSKD DFAGVGILRV
110 120 130 140 150
PSEHVWLPEI VLENNIDGQF GVAYDSNVLV YEGGYVSWLP PAIYRSTCAV
160 170 180 190 200
EVTYFPFDWQ NCSLIFRSQT YNAEEVEFIF AVDDDGNTIN KIDIDTAAFT
210 220 230 240 250
ENGEWAIDYC PGMIRRYEGG STEGPGETDV IYTLIIRRKP LFYVINIIVP
260 270 280 290 300
CVLISGLVLL AYFLPAQAGG QKCTVSINVL LAQTVFLFLI AQKIPETSLS
310 320 330 340 350
VPLLGRYLIF VMVVATLIVM NCVIVLNVSL RTPTTHATSP RLRQILLELL
360 370 380 390 400
PRLLGSSPPP EDPRTASPAR RASSVGILLR AEELILKKPR SELVFEGQRH
410 420 430 440 450
RHGTWTAAAL CQNLGAAAPE IRCCVDAVNF VAESTRDQEA TGEELSDWVR
460 470 480 490
MGKALDNVCF WAALVLFSVG STLIFLGGYF NQVPDLPYPP CIQP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP20782 | ACHE_MOUSE | Acetylcholine receptor subunit epsi... | Chrne Acre | 493 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL592547 Genomic DNA No translation available. |
RefSeqi | XP_006532069.1, XM_006532006.3 |
Genome annotation databases
Ensembli | ENSMUST00000014753; ENSMUSP00000014753; ENSMUSG00000014609 |
GeneIDi | 11448 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL592547 Genomic DNA No translation available. |
RefSeqi | XP_006532069.1, XM_006532006.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | Q5SXG9 |
Protocols and materials databases
Antibodypediai | 11366, 175 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000014753; ENSMUSP00000014753; ENSMUSG00000014609 |
GeneIDi | 11448 |
Organism-specific databases
CTDi | 1145 |
MGIi | MGI:87894, Chrne |
Phylogenomic databases
GeneTreei | ENSGT00940000160933 |
OrthoDBi | 588360at2759 |
PhylomeDBi | Q5SXG9 |
Miscellaneous databases
BioGRID-ORCSi | 11448, 0 hits in 17 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000014609, Expressed in spermatid and 68 other tissues |
ExpressionAtlasi | Q5SXG9, baseline and differential |
Family and domain databases
Gene3Di | 2.70.170.10, 1 hit |
InterProi | View protein in InterPro IPR006202, Neur_chan_lig-bd IPR036734, Neur_chan_lig-bd_sf IPR006201, Neur_channel IPR036719, Neuro-gated_channel_TM_sf IPR006029, Neurotrans-gated_channel_TM IPR018000, Neurotransmitter_ion_chnl_CS IPR002394, Nicotinic_acetylcholine_rcpt |
PANTHERi | PTHR18945, PTHR18945, 1 hit |
Pfami | View protein in Pfam PF02931, Neur_chan_LBD, 1 hit PF02932, Neur_chan_memb, 1 hit |
PRINTSi | PR00254, NICOTINICR PR00252, NRIONCHANNEL |
SUPFAMi | SSF63712, SSF63712, 1 hit SSF90112, SSF90112, 1 hit |
PROSITEi | View protein in PROSITE PS00236, NEUROTR_ION_CHANNEL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5SXG9_MOUSE | |
Accessioni | Q5SXG9Primary (citable) accession number: Q5SXG9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 21, 2004 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |