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Protein

Protein KIBRA

Gene

Wwc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ and may be associated with memory performance (By similarity). Regulates collagen-stimulated activation of the ERK/MAPK cascade.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2028269 Signaling by Hippo

Names & Taxonomyi

Protein namesi
Recommended name:
Protein KIBRA
Alternative name(s):
Kidney and brain protein
Short name:
KIBRA
WW domain-containing protein 1
Gene namesi
Name:Wwc1
Synonyms:Kiaa0869
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2388637 Wwc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002421541 – 1104Protein KIBRAAdd BLAST1104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei141PhosphoserineCombined sources1
Modified residuei535PhosphoserineBy similarity1
Modified residuei542Phosphoserine; by CDK1By similarity1
Modified residuei887PhosphoserineCombined sources1
Modified residuei891PhosphoserineCombined sources1
Modified residuei919PhosphoserineCombined sources1
Modified residuei921PhosphothreonineBy similarity1
Modified residuei923Phosphoserine; by CDK1By similarity1
Modified residuei939PhosphoserineCombined sources1
Modified residuei967Phosphoserine; by PKC/PRKCZBy similarity1
Modified residuei970Phosphoserine; by PKC/PRKCZBy similarity1

Post-translational modificationi

Phosphorylation at Ser-542 and Ser-923 by CDK1 in response to spindle damage stress regulates mitotic exit, these two sites are dephosphorylated by CDC14B.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5SXA9
PaxDbiQ5SXA9
PRIDEiQ5SXA9

PTM databases

iPTMnetiQ5SXA9
PhosphoSitePlusiQ5SXA9

Expressioni

Tissue specificityi

Mammary epithelium.1 Publication

Developmental stagei

Expressed in mammary tissue throughout development (at protein level). Strongly up-regulated during pregnancy, falls during lactation and is again up-regulated during involution of the gland at weaning.1 Publication

Gene expression databases

BgeeiENSMUSG00000018849 Expressed in 263 organ(s), highest expression level in cortex of kidney
CleanExiMM_WWC1
GenevisibleiQ5SXA9 MM

Interactioni

Subunit structurei

Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with PATJ (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018993

Structurei

3D structure databases

ProteinModelPortaliQ5SXA9
SMRiQ5SXA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 39WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini53 – 86WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini656 – 784C2Add BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni836 – 1104Interaction with histone H3By similarityAdd BLAST269
Regioni945 – 988Interaction with PRKCZBy similarityAdd BLAST44

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili107 – 193Sequence analysisAdd BLAST87
Coiled coili994 – 1024Sequence analysisAdd BLAST31

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1102 – 1104ADDV motif3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi255 – 294Ser-richAdd BLAST40
Compositional biasi421 – 461Ser-richAdd BLAST41
Compositional biasi816 – 873Glu-richAdd BLAST58

Domaini

The C2-domain mediates homodimerization.By similarity

Sequence similaritiesi

Belongs to the WWC family. KIBRA subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG3209 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00410000025556
HOGENOMiHOG000013211
HOVERGENiHBG058082
InParanoidiQ5SXA9
KOiK16685
OMAiHHTHIPR
OrthoDBiEOG091G0UU4
PhylomeDBiQ5SXA9
TreeFamiTF324040

Family and domain databases

CDDicd08680 C2_Kibra, 1 hit
cd00201 WW, 2 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037771 C2_WWC
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00397 WW, 2 hits
SMARTiView protein in SMART
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q5SXA9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRPELPLPE GWEEARDFDG KVYYIDHRNR TTSWIDPRDR YTKPLTFADC
60 70 80 90 100
ISDELPLGWE EAYDPQVGDY FIDHNTKTTQ IEDPRVQWRR EQEHMLKDYL
110 120 130 140 150
VVAQEALSAQ KEIYQVKQQR LELAQQEYQQ LHAVWEHKLG SQVSLVSGSS
160 170 180 190 200
SSSKYDPEIL KAEIATAKSR VNKLKREMVH LQHELQFKER GFQTLKKIDE
210 220 230 240 250
RMSDAQGGYK LDEAQAVLRE TKAIKKAITC GEKEKQDLIK SLAMLKDGFR
260 270 280 290 300
TDRGSHSDLW SSSSSLESSS FPMPKQFLDV SSQTDISGSF STSSNNQLAE
310 320 330 340 350
KVRLRLRYEE AKRRIANLKI QLAKLDSEAW PGVLDSERDR LILINEKEEL
360 370 380 390 400
LKEMRFISPR KWTQGEVEQL EMARRRLEKD LQAARDTQSK ALTERLKLNS
410 420 430 440 450
KRNQLVRELE EATRQVATLH SQLKSLSSSM QSLSSGSSPG SLTSSRGSLA
460 470 480 490 500
ASSLDSSTSA SFTDLYYDPF EQLDSELQSK VELLFLEGAT GFRPSGCITT
510 520 530 540 550
IHEDEVAKTQ KAEGGSRLQA LRSLSGTPRS MTSLSPRSSL SSPSPPCSPL
560 570 580 590 600
ITDPLLTGDA FLAPLEFEDT ELSTTLCELN LGGSGTQERY RLEEPGPEGK
610 620 630 640 650
PLGQAASVAP GCGLKVACVS AAVSDESVAG DSGVYEASAQ RPGTSEAAAF
660 670 680 690 700
DSDESEAVGA TRVQIALKYD EKNKQFAILI IQLSHLSALS LQQDQKVNIR
710 720 730 740 750
VAILPCSESS TCLFRTRPLD SANTLVFNEA FWVSISYPAL HQKTLRVDVC
760 770 780 790 800
TTDRSHTEEC LGGAQISLAE VCRSGERSTR WYNLLSYKYL KKQCREPQPT
810 820 830 840 850
EAPGPDHVDA VSALLEQTAV ELEKRQEGRS SSQTLEGSWT YEEEASENEA
860 870 880 890 900
VAEEEEEGEE DVFTEKVSPE AEECPALKVD RETNTDSVAP SPTVVRPKDR
910 920 930 940 950
RVGAPSTGPF LRGNTIIRSK TFSPGPQSQY VCRLNRSDSD SSTLSKKPPF
960 970 980 990 1000
VRNSLERRSV RMKRPSSVKS LRTERLIRTS LDLELDLQAT RTWHSQLTQE
1010 1020 1030 1040 1050
ISVLKELKEH LEQAKNHGEK ELPQWLREDE RFRLLLRMLE KKVDRGEHKS
1060 1070 1080 1090 1100
ELQADKMMRA AAKDVHRLRG QSCKEPPEVQ SFREKMAFFT RPRMNIPALS

ADDV
Length:1,104
Mass (Da):124,110
Last modified:December 21, 2004 - v1
Checksum:iD827EFD9AAB19FBA
GO

Sequence cautioni

The sequence AAH06733 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH37006 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141 – 145SQVSL → AGLPV in BAD90184 (Ref. 3) Curated5
Sequence conflicti348E → K in AAH06733 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ256090 mRNA Translation: ABB51169.1
AL596084, AL645912 Genomic DNA Translation: CAI24387.1
AL645912, AL596084 Genomic DNA Translation: CAI35081.1
AK220259 mRNA Translation: BAD90184.1
BC006733 mRNA Translation: AAH06733.1 Different initiation.
BC017638 mRNA Translation: AAH17638.1
BC037006 mRNA Translation: AAH37006.1 Different initiation.
CCDSiCCDS24545.1
RefSeqiNP_740749.1, NM_170779.1
UniGeneiMm.31267

Genome annotation databases

EnsembliENSMUST00000018993; ENSMUSP00000018993; ENSMUSG00000018849
GeneIDi211652
KEGGimmu:211652
UCSCiuc007ili.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ256090 mRNA Translation: ABB51169.1
AL596084, AL645912 Genomic DNA Translation: CAI24387.1
AL645912, AL596084 Genomic DNA Translation: CAI35081.1
AK220259 mRNA Translation: BAD90184.1
BC006733 mRNA Translation: AAH06733.1 Different initiation.
BC017638 mRNA Translation: AAH17638.1
BC037006 mRNA Translation: AAH37006.1 Different initiation.
CCDSiCCDS24545.1
RefSeqiNP_740749.1, NM_170779.1
UniGeneiMm.31267

3D structure databases

ProteinModelPortaliQ5SXA9
SMRiQ5SXA9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018993

PTM databases

iPTMnetiQ5SXA9
PhosphoSitePlusiQ5SXA9

Proteomic databases

MaxQBiQ5SXA9
PaxDbiQ5SXA9
PRIDEiQ5SXA9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018993; ENSMUSP00000018993; ENSMUSG00000018849
GeneIDi211652
KEGGimmu:211652
UCSCiuc007ili.1 mouse

Organism-specific databases

CTDi23286
MGIiMGI:2388637 Wwc1
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3209 Eukaryota
COG5021 LUCA
GeneTreeiENSGT00410000025556
HOGENOMiHOG000013211
HOVERGENiHBG058082
InParanoidiQ5SXA9
KOiK16685
OMAiHHTHIPR
OrthoDBiEOG091G0UU4
PhylomeDBiQ5SXA9
TreeFamiTF324040

Enzyme and pathway databases

ReactomeiR-MMU-2028269 Signaling by Hippo

Miscellaneous databases

PROiPR:Q5SXA9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018849 Expressed in 263 organ(s), highest expression level in cortex of kidney
CleanExiMM_WWC1
GenevisibleiQ5SXA9 MM

Family and domain databases

CDDicd08680 C2_Kibra, 1 hit
cd00201 WW, 2 hits
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037771 C2_WWC
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00397 WW, 2 hits
SMARTiView protein in SMART
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
PROSITEiView protein in PROSITE
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKIBRA_MOUSE
AccessioniPrimary (citable) accession number: Q5SXA9
Secondary accession number(s): Q571D0
, Q8K1Y3, Q8VD17, Q922W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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