UniProtKB - Q5SX91 (Q5SX91_HUMAN)
Protein
Rab GDP dissociation inhibitor
Gene
GDI2
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.UniRule annotation
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB-KW
- Rab GDP-dissociation inhibitor activity Source: InterPro
GO - Biological processi
- protein transport Source: InterPro
- small GTPase mediated signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Rab GDP dissociation inhibitorUniRule annotation |
Gene namesi | Name:GDI2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000057608.16 |
HGNCi | HGNC:4227, GDI2 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotationPTM / Processingi
Proteomic databases
MaxQBi | Q5SX91 |
PeptideAtlasi | Q5SX91 |
PRIDEi | Q5SX91 |
ProteomicsDBi | 63988 |
Expressioni
Gene expression databases
Bgeei | ENSG00000057608, Expressed in female gonad and 247 other tissues |
ExpressionAtlasi | Q5SX91, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00950000182994 |
HOGENOMi | CLU_1351627_0_0_1 |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR018203, GDP_dissociation_inhibitor IPR000806, RabGDI |
PANTHERi | PTHR11787, PTHR11787, 1 hit |
Pfami | View protein in Pfam PF00996, GDI, 1 hit |
PRINTSi | PR00892, RABGDI PR00891, RABGDIREP |
SUPFAMi | SSF51905, SSF51905, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q5SX91-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
KKFDLGQDVI DFTGHALALY RTDDYLDQPC YETINRIKLY SESLARYGKS
60 70 80 90 100
PYLYPLYGLG ELPQGFARLS AIYGGTYMLN KPIEEIIVQN GKVIGVKSEG
110 120 130 140 150
EIARCKQLIC DPSYVKDRVE KVGQVIRVIC ILSHPIKNTN DANSCQIIIP
160 170 180 190 200
QNQVNRKSDL LASVTSWYQK TWEQKARSLF PAHMMPPLIL RQRVMTLKTS
IRG
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP50395 | GDIB_HUMAN | Rab GDP dissociation inhibitor beta | GDI2 RABGDIB | 445 | Annotation score: | ||
Q5SX87 | Q5SX87_HUMAN | Rab GDP dissociation inhibitor | GDI2 | 263 | Annotation score: | ||
Q5SX86 | Q5SX86_HUMAN | Rab GDP dissociation inhibitor | GDI2 | 155 | Annotation score: | ||
Q5SX90 | Q5SX90_HUMAN | Rab GDP dissociation inhibitor | GDI2 | 148 | Annotation score: | ||
V9GYF8 | V9GYF8_HUMAN | Rab GDP dissociation inhibitor | GDI2 | 130 | Annotation score: | ||
V9GYJ7 | V9GYJ7_HUMAN | Rab GDP dissociation inhibitor | GDI2 | 125 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596094 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000447751; ENSP00000387565; ENSG00000057608 |
UCSCi | uc057rkm.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596094 Genomic DNA No translation available. |
3D structure databases
SMRi | Q5SX91 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q5SX91 |
PeptideAtlasi | Q5SX91 |
PRIDEi | Q5SX91 |
ProteomicsDBi | 63988 |
Protocols and materials databases
Antibodypediai | 10649, 238 antibodies |
Genome annotation databases
Ensembli | ENST00000447751; ENSP00000387565; ENSG00000057608 |
UCSCi | uc057rkm.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000057608.16 |
HGNCi | HGNC:4227, GDI2 |
OpenTargetsi | ENSG00000057608 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182994 |
HOGENOMi | CLU_1351627_0_0_1 |
Miscellaneous databases
ChiTaRSi | GDI2, human |
Gene expression databases
Bgeei | ENSG00000057608, Expressed in female gonad and 247 other tissues |
ExpressionAtlasi | Q5SX91, baseline and differential |
Family and domain databases
Gene3Di | 3.50.50.60, 1 hit |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR018203, GDP_dissociation_inhibitor IPR000806, RabGDI |
PANTHERi | PTHR11787, PTHR11787, 1 hit |
Pfami | View protein in Pfam PF00996, GDI, 1 hit |
PRINTSi | PR00892, RABGDI PR00891, RABGDIREP |
SUPFAMi | SSF51905, SSF51905, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5SX91_HUMAN | |
Accessioni | Q5SX91Primary (citable) accession number: Q5SX91 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 21, 2004 |
Last sequence update: | December 21, 2004 | |
Last modified: | August 12, 2020 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |