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Protein

Rab GDP dissociation inhibitor

Gene

GDI2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Rab GDP dissociation inhibitorUniRule annotation
Gene namesi
Name:GDI2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000057608.16
HGNCiHGNC:4227 GDI2

Subcellular locationi

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000057608

PTM / Processingi

Proteomic databases

MaxQBiQ5SX91
PeptideAtlasiQ5SX91
PRIDEiQ5SX91

Expressioni

Gene expression databases

BgeeiENSG00000057608 Expressed in 234 organ(s), highest expression level in female gonad
ExpressionAtlasiQ5SX91 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5SX91
SMRiQ5SX91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Rab GDI family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00530000063044
HOGENOMiHOG000171762
HOVERGENiHBG000839

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q5SX91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
KKFDLGQDVI DFTGHALALY RTDDYLDQPC YETINRIKLY SESLARYGKS
60 70 80 90 100
PYLYPLYGLG ELPQGFARLS AIYGGTYMLN KPIEEIIVQN GKVIGVKSEG
110 120 130 140 150
EIARCKQLIC DPSYVKDRVE KVGQVIRVIC ILSHPIKNTN DANSCQIIIP
160 170 180 190 200
QNQVNRKSDL LASVTSWYQK TWEQKARSLF PAHMMPPLIL RQRVMTLKTS

IRG
Length:203
Mass (Da):23,115
Last modified:December 21, 2004 - v1
Checksum:iC454C5614E2FCCF3
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P50395GDIB_HUMAN
Rab GDP dissociation inhibitor beta
GDI2 RABGDIB
445Annotation score:
Q5SX90Q5SX90_HUMAN
Rab GDP dissociation inhibitor
GDI2
148Annotation score:
Q5SX87Q5SX87_HUMAN
Rab GDP dissociation inhibitor
GDI2
263Annotation score:
Q5SX86Q5SX86_HUMAN
Rab GDP dissociation inhibitor
GDI2
155Annotation score:
V9GYF8V9GYF8_HUMAN
Rab GDP dissociation inhibitor
GDI2
130Annotation score:
V9GYJ7V9GYJ7_HUMAN
Rab GDP dissociation inhibitor
GDI2
125Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596094 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000447751; ENSP00000387565; ENSG00000057608
UCSCiuc057rkm.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596094 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliQ5SX91
SMRiQ5SX91
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ5SX91
PeptideAtlasiQ5SX91
PRIDEiQ5SX91

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000447751; ENSP00000387565; ENSG00000057608
UCSCiuc057rkm.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000057608.16
HGNCiHGNC:4227 GDI2
OpenTargetsiENSG00000057608
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063044
HOGENOMiHOG000171762
HOVERGENiHBG000839

Miscellaneous databases

ChiTaRSiGDI2 human

Gene expression databases

BgeeiENSG00000057608 Expressed in 234 organ(s), highest expression level in female gonad
ExpressionAtlasiQ5SX91 baseline and differential

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR018203 GDP_dissociation_inhibitor
IPR000806 RabGDI
PANTHERiPTHR11787 PTHR11787, 1 hit
PfamiView protein in Pfam
PF00996 GDI, 1 hit
PRINTSiPR00892 RABGDI
PR00891 RABGDIREP
SUPFAMiSSF51905 SSF51905, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SX91_HUMAN
AccessioniPrimary (citable) accession number: Q5SX91
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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