UniProtKB - Q5SX79 (SHRM1_MOUSE)
Protein
Protein Shroom1
Gene
Shroom1
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in the assembly of microtubule arrays during cell elongation.By similarity
GO - Molecular functioni
- actin filament binding Source: UniProtKB
- myosin II binding Source: UniProtKB
GO - Biological processi
- actin filament bundle assembly Source: UniProtKB
- actin filament organization Source: GO_Central
- cell morphogenesis Source: UniProtKB
Keywordsi
Molecular function | Actin-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Shroom1 |
Gene namesi | Name:Shroom1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919024, Shroom1 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Cytoskeleton
- cortical actin cytoskeleton Source: GO_Central
- microtubule Source: UniProtKB-KW
Plasma Membrane
- apical plasma membrane Source: GO_Central
Other locations
- adherens junction Source: GO_Central
- apical junction complex Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286062 | 1 – 823 | Protein Shroom1Add BLAST | 823 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 103 | PhosphoserineCombined sources | 1 | |
Modified residuei | 133 | PhosphoserineBy similarity | 1 | |
Modified residuei | 137 | PhosphoserineBy similarity | 1 | |
Modified residuei | 166 | PhosphoserineBy similarity | 1 | |
Modified residuei | 190 | PhosphoserineBy similarity | 1 | |
Modified residuei | 224 | PhosphoserineBy similarity | 1 | |
Modified residuei | 383 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 385 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q5SX79 |
PRIDEi | Q5SX79 |
ProteomicsDBi | 257160 [Q5SX79-1] 257161 [Q5SX79-2] |
PTM databases
iPTMneti | Q5SX79 |
PhosphoSitePlusi | Q5SX79 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000018387, Expressed in ectoplacental cone and 83 other tissues |
ExpressionAtlasi | Q5SX79, baseline and differential |
Genevisiblei | Q5SX79, MM |
Interactioni
Subunit structurei
Interacts with F-actin.
By similarityGO - Molecular functioni
- actin filament binding Source: UniProtKB
- myosin II binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 214917, 1 interactor |
STRINGi | 10090.ENSMUSP00000104641 |
Miscellaneous databases
RNActi | Q5SX79, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 145 – 233 | ASD1PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 517 – 796 | ASD2PROSITE-ProRule annotationAdd BLAST | 280 |
Domaini
The ASD1 domain mediates F-actin binding.By similarity
Sequence similaritiesi
Belongs to the shroom family.Curated
Phylogenomic databases
eggNOGi | ENOG502SM3B, Eukaryota |
GeneTreei | ENSGT00940000160656 |
HOGENOMi | CLU_016932_0_0_1 |
InParanoidi | Q5SX79 |
OMAi | VSRPTCC |
OrthoDBi | 729991at2759 |
PhylomeDBi | Q5SX79 |
TreeFami | TF335754 |
Family and domain databases
InterProi | View protein in InterPro IPR014800, ASD1_dom IPR014799, ASD2_dom IPR027685, Shroom_fam |
PANTHERi | PTHR15012, PTHR15012, 2 hits |
Pfami | View protein in Pfam PF08688, ASD1, 1 hit PF08687, ASD2, 1 hit |
PROSITEi | View protein in PROSITE PS51306, ASD1, 1 hit PS51307, ASD2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5SX79-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEALGTGRDR TSQASATESL DLRRLSTRAD SAYSSFSTAS GDPETRTPSP
60 70 80 90 100
GTERLPYLDW DYVRVVWGSQ SPTSKDAVLS TTQRPVQAVA GHSDPRSPEV
110 120 130 140 150
QGSPGPLNRQ DTPLLYALAA EAEATAHTAE PPSPPASRDA YRQRLQGAQR
160 170 180 190 200
RVLRETSFQR KEFRMSLPGR LRPAVPTRLP TAHVRSASSS QELGEEEPAR
210 220 230 240 250
TAVPALAAAG RGRLSSQQRQ CCFSEPGKLH RVGWSGGPTG EDLRKDYSTQ
260 270 280 290 300
ELQRGMHAKS KGLLETQSLS STELNSGPAD LGNAHRPAGR SQSVSGEVMG
310 320 330 340 350
PCKGSERTVA TVQAVPQRAD IRRPLLHTKL SRSLTQKEVT GVCPGEALQT
360 370 380 390 400
KPAGCGRRIS ETSVSTPGPS LPEDDVFLRE AKTPSPQDSQ GLPTSTSYRQ
410 420 430 440 450
YENDLSKKAG QIAVSAERPL HETPGITGTE DCGQAVNGSV DLSRPTSIPE
460 470 480 490 500
TTNDDIPTFD TNGTTDPSAA TEKKPLKPPP VDVLRPSDSE TPGSPHHTSL
510 520 530 540 550
TWGQFDSKTT WPSRHFEALV QELARLDPSL SRTLAAQPGP EPPQGLLDGL
560 570 580 590 600
FPVEEIRSAM RPALEEMGEK AAGASEEGSC GHHLTQDLQT SQEASRSENS
610 620 630 640 650
TPDPDQSSGQ EFPEGNSTQA KKVELARLLQ KMLQDLHAEQ ERLRGTAADW
660 670 680 690 700
TQRNGALEAA VSQACTPREL ERFRRFMTDL ERVLGLLLLL GSRLVRVNLA
710 720 730 740 750
LARAGSNSDP DERASLLQRL QLLQRQQEEA KELKEHVARR EQTLRQVLER
760 770 780 790 800
ELPAEHLRSY CVLLASKARI LSQQRSLDDR IRFLKDQLDT IWSDLSHHPL
810 820
SPRLTWAPAI RPLNKQPFLA TLI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z3D5 | D3Z3D5_MOUSE | Protein Shroom1 | Shroom1 | 715 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024963 | 332 – 394 | Missing in isoform 2. 1 PublicationAdd BLAST | 63 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596095 Genomic DNA No translation available. BC005761 mRNA Translation: AAH05761.1 BC031598 mRNA Translation: AAH31598.1 |
CCDSi | CCDS24680.2 [Q5SX79-1] CCDS70182.1 [Q5SX79-2] |
RefSeqi | NP_001277718.1, NM_001290789.1 [Q5SX79-2] NP_082193.2, NM_027917.3 [Q5SX79-1] |
Genome annotation databases
Ensembli | ENSMUST00000018531; ENSMUSP00000018531; ENSMUSG00000018387 [Q5SX79-2] ENSMUST00000109013; ENSMUSP00000104641; ENSMUSG00000018387 [Q5SX79-1] |
GeneIDi | 71774 |
KEGGi | mmu:71774 |
UCSCi | uc007iwc.2, mouse [Q5SX79-1] uc007iwd.2, mouse [Q5SX79-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596095 Genomic DNA No translation available. BC005761 mRNA Translation: AAH05761.1 BC031598 mRNA Translation: AAH31598.1 |
CCDSi | CCDS24680.2 [Q5SX79-1] CCDS70182.1 [Q5SX79-2] |
RefSeqi | NP_001277718.1, NM_001290789.1 [Q5SX79-2] NP_082193.2, NM_027917.3 [Q5SX79-1] |
3D structure databases
SMRi | Q5SX79 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 214917, 1 interactor |
STRINGi | 10090.ENSMUSP00000104641 |
PTM databases
iPTMneti | Q5SX79 |
PhosphoSitePlusi | Q5SX79 |
Proteomic databases
PaxDbi | Q5SX79 |
PRIDEi | Q5SX79 |
ProteomicsDBi | 257160 [Q5SX79-1] 257161 [Q5SX79-2] |
Protocols and materials databases
Antibodypediai | 64246, 50 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000018531; ENSMUSP00000018531; ENSMUSG00000018387 [Q5SX79-2] ENSMUST00000109013; ENSMUSP00000104641; ENSMUSG00000018387 [Q5SX79-1] |
GeneIDi | 71774 |
KEGGi | mmu:71774 |
UCSCi | uc007iwc.2, mouse [Q5SX79-1] uc007iwd.2, mouse [Q5SX79-2] |
Organism-specific databases
CTDi | 134549 |
MGIi | MGI:1919024, Shroom1 |
Phylogenomic databases
eggNOGi | ENOG502SM3B, Eukaryota |
GeneTreei | ENSGT00940000160656 |
HOGENOMi | CLU_016932_0_0_1 |
InParanoidi | Q5SX79 |
OMAi | VSRPTCC |
OrthoDBi | 729991at2759 |
PhylomeDBi | Q5SX79 |
TreeFami | TF335754 |
Miscellaneous databases
BioGRID-ORCSi | 71774, 2 hits in 52 CRISPR screens |
ChiTaRSi | Shroom1, mouse |
PROi | PR:Q5SX79 |
RNActi | Q5SX79, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018387, Expressed in ectoplacental cone and 83 other tissues |
ExpressionAtlasi | Q5SX79, baseline and differential |
Genevisiblei | Q5SX79, MM |
Family and domain databases
InterProi | View protein in InterPro IPR014800, ASD1_dom IPR014799, ASD2_dom IPR027685, Shroom_fam |
PANTHERi | PTHR15012, PTHR15012, 2 hits |
Pfami | View protein in Pfam PF08688, ASD1, 1 hit PF08687, ASD2, 1 hit |
PROSITEi | View protein in PROSITE PS51306, ASD1, 1 hit PS51307, ASD2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SHRM1_MOUSE | |
Accessioni | Q5SX79Primary (citable) accession number: Q5SX79 Secondary accession number(s): B1AQY5 Q99JP8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | May 1, 2007 | |
Last modified: | April 7, 2021 | |
This is version 94 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families