UniProtKB - Q5SX78 (Q5SX78_MOUSE)
Protein
Colony-stimulating factor
Gene
Csf2
Organism
Mus musculus (Mouse)
Status
Functioni
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.ARBA annotation
GO - Molecular functioni
- cytokine activity Source: Ensembl
- granulocyte macrophage colony-stimulating factor receptor binding Source: InterPro
- growth factor activity Source: InterPro
GO - Biological processi
- cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: Ensembl
- immune response Source: InterPro
- macrophage differentiation Source: Ensembl
- myeloid dendritic cell differentiation Source: Ensembl
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- negative regulation of transcription, DNA-templated Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of interleukin-23 production Source: Ensembl
- positive regulation of macrophage derived foam cell differentiation Source: Ensembl
- positive regulation of podosome assembly Source: Ensembl
- positive regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
Names & Taxonomyi
Protein namesi | Recommended name: Colony-stimulating factorARBA annotationAlternative name(s): Granulocyte-macrophage colony-stimulating factorARBA annotation |
Gene namesi | Name:Csf2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1339752, Csf2 |
Subcellular locationi
Extracellular region or secreted
- Secreted ARBA annotation
Extracellular region or secreted
- extracellular space Source: Ensembl
Other locations
- intracellular membrane-bounded organelle Source: Ensembl
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5010844583 | 18 – 141 | Colony-stimulating factorSequence analysisAdd BLAST | 124 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000018916, Expressed in left lung lobe and 37 other tissues |
ExpressionAtlasi | Q5SX78, baseline and differential |
Interactioni
GO - Molecular functioni
- cytokine activity Source: Ensembl
- granulocyte macrophage colony-stimulating factor receptor binding Source: InterPro
- growth factor activity Source: InterPro
Family & Domainsi
Sequence similaritiesi
Belongs to the GM-CSF family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
HOGENOMi | CLU_152286_0_0_1 |
OMAi | VTRPWKH |
Family and domain databases
CDDi | cd00040, CSF2, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000773, GM_colony-stim-fac |
PANTHERi | PTHR10059, PTHR10059, 1 hit |
Pfami | View protein in Pfam PF01109, GM_CSF, 1 hit |
PRINTSi | PR00693, GMCSFACTOR |
SMARTi | View protein in SMART SM00040, CSF2, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00702, GM_CSF, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5SX78-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWLQNLLFLG IVVYSLSAPT RSPITVTRPW KHVEAIKEAL NLLDDMPVTL
60 70 80 90 100
NEEVEVVSNE FSFKKLTCVQ TRLKIFEQGL RGNFTKLKGA LNMTASYYQT
110 120 130 140
YCPPTPETDC ETQVTTYADF IDSLKTFLTD IPFECKKPGQ K
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU366957 mRNA Translation: ABY66391.1 AK053196 mRNA Translation: BAE20692.1 |
RefSeqi | NP_034099.2, NM_009969.4 |
Genome annotation databases
GeneIDi | 12981 |
KEGGi | mmu:12981 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU366957 mRNA Translation: ABY66391.1 AK053196 mRNA Translation: BAE20692.1 |
RefSeqi | NP_034099.2, NM_009969.4 |
3D structure databases
SMRi | Q5SX78 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 14363, 1809 antibodies |
Genome annotation databases
GeneIDi | 12981 |
KEGGi | mmu:12981 |
Organism-specific databases
CTDi | 1437 |
MGIi | MGI:1339752, Csf2 |
Phylogenomic databases
HOGENOMi | CLU_152286_0_0_1 |
OMAi | VTRPWKH |
Miscellaneous databases
BioGRID-ORCSi | 12981, 0 hits in 19 CRISPR screens |
ChiTaRSi | Csf2, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018916, Expressed in left lung lobe and 37 other tissues |
ExpressionAtlasi | Q5SX78, baseline and differential |
Family and domain databases
CDDi | cd00040, CSF2, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000773, GM_colony-stim-fac |
PANTHERi | PTHR10059, PTHR10059, 1 hit |
Pfami | View protein in Pfam PF01109, GM_CSF, 1 hit |
PRINTSi | PR00693, GMCSFACTOR |
SMARTi | View protein in SMART SM00040, CSF2, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00702, GM_CSF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5SX78_MOUSE | |
Accessioni | Q5SX78Primary (citable) accession number: Q5SX78 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | February 10, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |