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UniProtKB - Q5SX40 (MYH1_MOUSE)

Protein

Myosin-1

Gene

Myh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Muscle contraction.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi179 – 186ATPSequence analysis8

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Myosin heavy chain 1
Myosin heavy chain 2x
Short name:
MyHC-2x
Myosin heavy chain, skeletal muscle, adult 1
Gene namesi
Name:Myh1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1339711 Myh1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001233921 – 1942Myosin-1Add BLAST1942

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineBy similarity1
Modified residuei64PhosphothreonineBy similarity1
Modified residuei69PhosphothreonineBy similarity1
Modified residuei130N6,N6,N6-trimethyllysineSequence analysis1
Modified residuei389PhosphotyrosineBy similarity1
Modified residuei419PhosphothreonineBy similarity1
Modified residuei424PhosphotyrosineBy similarity1
Modified residuei625PhosphoserineBy similarity1
Modified residuei760Pros-methylhistidineBy similarity1
Modified residuei1095PhosphoserineBy similarity1
Modified residuei1099PhosphoserineBy similarity1
Modified residuei1165PhosphoserineBy similarity1
Modified residuei1240PhosphoserineBy similarity1
Modified residuei1246PhosphoserineBy similarity1
Modified residuei1258PhosphothreonineBy similarity1
Modified residuei1264PhosphoserineBy similarity1
Modified residuei1268PhosphothreonineBy similarity1
Modified residuei1289PhosphothreonineBy similarity1
Modified residuei1291PhosphoserineBy similarity1
Modified residuei1295PhosphoserineBy similarity1
Modified residuei1306PhosphoserineBy similarity1
Modified residuei1309PhosphoserineBy similarity1
Modified residuei1467PhosphotyrosineBy similarity1
Modified residuei1470PhosphothreonineBy similarity1
Modified residuei1477PhosphoserineBy similarity1
Modified residuei1495PhosphotyrosineBy similarity1
Modified residuei1498PhosphoserineBy similarity1
Modified residuei1504PhosphothreonineBy similarity1
Modified residuei1517PhosphoserineBy similarity1
Modified residuei1520PhosphothreonineBy similarity1
Modified residuei1545PhosphoserineBy similarity1
Modified residuei1557PhosphoserineBy similarity1
Modified residuei1577PhosphoserineBy similarity1
Modified residuei1603PhosphoserineBy similarity1
Modified residuei1606PhosphoserineBy similarity1
Modified residuei1717PhosphoserineBy similarity1
Modified residuei1729PhosphoserineBy similarity1
Modified residuei1733PhosphothreonineBy similarity1
Modified residuei1739PhosphothreonineBy similarity1
Modified residuei1742PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ5SX40
MaxQBiQ5SX40
PaxDbiQ5SX40
PRIDEiQ5SX40

PTM databases

iPTMnetiQ5SX40
PhosphoSitePlusiQ5SX40

Expressioni

Gene expression databases

BgeeiENSMUSG00000056328 Expressed in 127 organ(s), highest expression level in diaphragm
ExpressionAtlasiQ5SX40 baseline and differential
GenevisibleiQ5SX40 MM

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi201643, 4 interactors
IntActiQ5SX40, 3 interactors
MINTiQ5SX40
STRINGi10090.ENSMUSP00000018637

Structurei

3D structure databases

ProteinModelPortaliQ5SX40
SMRiQ5SX40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 82Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST50
Domaini86 – 785Myosin motorPROSITE-ProRule annotationAdd BLAST700
Domaini788 – 817IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni662 – 684Actin-bindingBy similarityAdd BLAST23
Regioni764 – 778Actin-bindingBy similarityAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili846 – 1942Sequence analysisAdd BLAST1097

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919
HOGENOMiHOG000173959
HOVERGENiHBG004704
InParanoidiQ5SX40
KOiK10352
OMAiIMDVEND
OrthoDBiEOG091G07UM
PhylomeDBiQ5SX40
TreeFamiTF314375

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5SX40-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSDAEMAVF GEAAPYLRKS EKERIEAQNK PFDAKSSVFV VDAKESFVKA 
        60         70         80         90        100
TVQSREGGKV TAKTEGGTTV TVKDDQVYPM NPPKYDKIED MAMMTHLHEP 
       110        120        130        140        150
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNAEVV AAYRGKKRQE 
       160        170        180        190        200
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA 
       210        220        230        240        250
VTGEKKKEEA TSGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF 
       260        270        280        290        300
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL 
       310        320        330        340        350
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAID ILGFTSDERV 
       360        370        380        390        400
SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QNLNSADLLK 
       410        420        430        440        450
ALCYPRVKVG NEYVTKGQTV QQVYNSVGAL AKAVYEKMFL WMVTRINQQL 
       460        470        480        490        500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE 
       510        520        530        540        550
QEEYKKEGIE WEFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS 
       560        570        580        590        600
FKNKLYEQHL GKSNNFQKPK PAKGKVEAHF SLVHYAGTVD YNIAGWLDKN 
       610        620        630        640        650
KDPLNETVVG LYQKSSMKTL AYLFSGAAAA AEAESGGGGG KKGAKKKGSS 
       660        670        680        690        700
FQTVSALFRE NLNKLMTNLR STHPHFVRCI IPNETKTPGA MEHELVLHQL 
       710        720        730        740        750
RCNGVLEGIR ICRKGFPSRI LYADFKQRYK VLNASAIPEG QFIDSKKASE 
       760        770        780        790        800
KLLGSIDIDH TQYKFGHTKV FFKAGLLGLL EEMRDDKLAQ LITRTQAMCR 
       810        820        830        840        850
GYLARVEYQK MVERRESIFC IQYNVRAFMN VKHWPWMKLY FKIKPLLKSA 
       860        870        880        890        900
ETEKEMANMK EEFEKAKENL AKAEAKRKEL EEKMVALMQE KNDLQLQVQS 
       910        920        930        940        950
EADSLADAEE RCDQLIKTKI QLEAKIKEVT ERAEDEEEIN AELTAKKRKL 
       960        970        980        990       1000
EDECSELKKD IDDLELTLAK VEKEKHATEN KVKNLTEEMA GLDETIAKLT 
      1010       1020       1030       1040       1050
KEKKALQEAH QQTLDDLQAE EDKVNTLTKA KIKLEQQVDD LEGSLEQEKK 
      1060       1070       1080       1090       1100
IRMDLERAKR KLEGDLKLAQ ESTMDVENDK QQLDEKLKKK EFEMSNLQSK 
      1110       1120       1130       1140       1150
IEDEQALGMQ LQKKIKELQA RIEELEEEIE AERASRAKAE KQRSDLSREL 
      1160       1170       1180       1190       1200
EEISERLEEA GGATSAQIEM NKKREAEFQK MRRDLEEATL QHEATAATLR 
      1210       1220       1230       1240       1250
KKHADSVAEL GEQIDNLQRV KQKLEKEKSE MKMEIDDLAS NMEVISKSKG 
      1260       1270       1280       1290       1300
NLEKMCRTLE DQVSELKTKE EEQQRLINEL TAQRGRLQTE SGEYSRQLDE 
      1310       1320       1330       1340       1350
KDSLVSQLSR GKQAFTQQIE ELKRQLEEEI KAKSALAHAL QSSRHDCDLL 
      1360       1370       1380       1390       1400
REQYEEEQEA KAELQRAMSK ANSEVAQWRT KYETDAIQRT EELEEAKKKL 
      1410       1420       1430       1440       1450
AQRLQDAEEH VEAVNAKCAS LEKTKQRLQN EVEDLMIDVE RTNAACAALD 
      1460       1470       1480       1490       1500
KKQRNFDKIL AEWKQKYEET HAELEASQKE SRSLSTELFK IKNAYEESLD 
      1510       1520       1530       1540       1550
HLETLKRENK NLQQEISDLT EQIAEGGKRI HELEKIKKQI EQEKSELQAA 
      1560       1570       1580       1590       1600
LEEAEASLEH EEGKILRIQL ELNQVKSEID RKIAEKDEEI DQLKRNHIRV 
      1610       1620       1630       1640       1650
VESMQSTLDA EIRSRNDAIR LKKKMEGDLN EMEIQLNHSN RMAAEALRNY 
      1660       1670       1680       1690       1700
RNTQGILKDT QLHLDDALRG QEDLKEQLAM VERRANLLQA EIEELRATLE 
      1710       1720       1730       1740       1750
QTERSRKIAE QELLDASERV QLLHTQNTSL INTKKKLETD ISQIQGEMED 
      1760       1770       1780       1790       1800
IVQEARNAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KNLEQTVKDL 
      1810       1820       1830       1840       1850
QHRLDEAEQL ALKGGKKQIQ KLEARVRELE GEVENEQKRN VEAIKGLRKH 
      1860       1870       1880       1890       1900
ERRVKELTYQ TEEDRKNVLR LQDLVDKLQS KVKAYKRQAE EAEEQSNVNL 
      1910       1920       1930       1940 
AKFRKIQHEL EEAEERADIA ESQVNKLRVK SREVHTKIIS EE
Length:1,942
Mass (Da):223,342
Last modified:December 21, 2004 - v1
Checksum:i946BBA18567A2FB0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q1WNQ6Q1WNQ6_MOUSE
Myosin-1
Myh1
95Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596129 Genomic DNA No translation available.
BC108329 mRNA Translation: AAI08330.1
CCDSiCCDS24855.1
RefSeqiNP_109604.1, NM_030679.1
XP_017169807.1, XM_017314318.1
UniGeneiMm.477065

Genome annotation databases

EnsembliENSMUST00000018637; ENSMUSP00000018637; ENSMUSG00000056328
ENSMUST00000075734; ENSMUSP00000075147; ENSMUSG00000056328
ENSMUST00000124516; ENSMUSP00000117569; ENSMUSG00000056328
GeneIDi17879
KEGGimmu:17879
UCSCiuc007jmg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596129 Genomic DNA No translation available.
BC108329 mRNA Translation: AAI08330.1
CCDSiCCDS24855.1
RefSeqiNP_109604.1, NM_030679.1
XP_017169807.1, XM_017314318.1
UniGeneiMm.477065

3D structure databases

ProteinModelPortaliQ5SX40
SMRiQ5SX40
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201643, 4 interactors
IntActiQ5SX40, 3 interactors
MINTiQ5SX40
STRINGi10090.ENSMUSP00000018637

PTM databases

iPTMnetiQ5SX40
PhosphoSitePlusiQ5SX40

Proteomic databases

EPDiQ5SX40
MaxQBiQ5SX40
PaxDbiQ5SX40
PRIDEiQ5SX40

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018637; ENSMUSP00000018637; ENSMUSG00000056328
ENSMUST00000075734; ENSMUSP00000075147; ENSMUSG00000056328
ENSMUST00000124516; ENSMUSP00000117569; ENSMUSG00000056328
GeneIDi17879
KEGGimmu:17879
UCSCiuc007jmg.1 mouse

Organism-specific databases

CTDi4619
MGIiMGI:1339711 Myh1

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919
HOGENOMiHOG000173959
HOVERGENiHBG004704
InParanoidiQ5SX40
KOiK10352
OMAiIMDVEND
OrthoDBiEOG091G07UM
PhylomeDBiQ5SX40
TreeFamiTF314375

Miscellaneous databases

PROiPR:Q5SX40
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056328 Expressed in 127 organ(s), highest expression level in diaphragm
ExpressionAtlasiQ5SX40 baseline and differential
GenevisibleiQ5SX40 MM

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYH1_MOUSE
AccessioniPrimary (citable) accession number: Q5SX40
Secondary accession number(s): Q32P18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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