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UniProtKB - Q5SX40 (MYH1_MOUSE)
Protein
Myosin-1
Gene
Myh1
Organism
Mus musculus (Mouse)
Status
Functioni
Muscle contraction.
Caution
Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 179 – 186 | ATPSequence analysis | 8 |
GO - Molecular functioni
- actin filament binding Source: InterPro
- ATP binding Source: UniProtKB-KW
- calmodulin binding Source: UniProtKB-KW
- cytoskeletal motor activity Source: InterPro
GO - Biological processi
- muscle contraction Source: Ensembl
Keywordsi
Molecular function | Actin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Myosin-1Alternative name(s): Myosin heavy chain 1 Myosin heavy chain 2x Short name: MyHC-2x Myosin heavy chain, skeletal muscle, adult 1 |
Gene namesi | Name:Myh1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1339711, Myh1 |
VEuPathDBi | HostDB:ENSMUSG00000056328 |
Subcellular locationi
Other locations
Note: Thick filaments of the myofibrils.
Cytoskeleton
- muscle myosin complex Source: MGI
Other locations
- A band Source: MGI
- cytoplasmic ribonucleoprotein granule Source: MGI
- intercalated disc Source: MGI
- myosin filament Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Thick filamentPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123392 | 1 – 1942 | Myosin-1Add BLAST | 1942 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 36 | PhosphoserineBy similarity | 1 | |
Modified residuei | 64 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 69 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 130 | N6,N6,N6-trimethyllysineSequence analysis | 1 | |
Modified residuei | 389 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 419 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 424 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 625 | PhosphoserineBy similarity | 1 | |
Modified residuei | 760 | Pros-methylhistidineBy similarity | 1 | |
Modified residuei | 1095 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1099 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1165 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1240 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1246 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1258 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1264 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1268 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1289 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1291 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1295 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1306 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1309 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1467 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1470 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1477 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1495 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 1498 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1504 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1517 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1520 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1545 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1557 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1577 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1603 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1606 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1717 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1729 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1733 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1739 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1742 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q5SX40 |
MaxQBi | Q5SX40 |
PaxDbi | Q5SX40 |
PRIDEi | Q5SX40 |
ProteomicsDBi | 287527 |
PTM databases
iPTMneti | Q5SX40 |
PhosphoSitePlusi | Q5SX40 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000056328, Expressed in diaphragm and 154 other tissues |
ExpressionAtlasi | Q5SX40, baseline and differential |
Genevisiblei | Q5SX40, MM |
Interactioni
Subunit structurei
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
GO - Molecular functioni
- actin filament binding Source: InterPro
- calmodulin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 201643, 13 interactors |
IntActi | Q5SX40, 2 interactors |
STRINGi | 10090.ENSMUSP00000117569 |
Miscellaneous databases
RNActi | Q5SX40, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 82 | Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST | 50 | |
Domaini | 86 – 785 | Myosin motorPROSITE-ProRule annotationAdd BLAST | 700 | |
Domaini | 788 – 817 | IQPROSITE-ProRule annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 662 – 684 | Actin-bindingBy similarityAdd BLAST | 23 | |
Regioni | 764 – 778 | Actin-bindingBy similarityAdd BLAST | 15 | |
Regioni | 1156 – 1175 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 846 – 1942 | Sequence analysisAdd BLAST | 1097 |
Domaini
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0161, Eukaryota |
GeneTreei | ENSGT00940000154760 |
HOGENOMi | CLU_000192_8_1_1 |
InParanoidi | Q5SX40 |
OMAi | HKYEETH |
OrthoDBi | 47111at2759 |
PhylomeDBi | Q5SX40 |
TreeFami | TF314375 |
Family and domain databases
Gene3Di | 1.20.5.370, 4 hits 2.30.30.360, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase IPR014751, XRCC4-like_C |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5SX40-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSDAEMAVF GEAAPYLRKS EKERIEAQNK PFDAKSSVFV VDAKESFVKA
60 70 80 90 100
TVQSREGGKV TAKTEGGTTV TVKDDQVYPM NPPKYDKIED MAMMTHLHEP
110 120 130 140 150
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNAEVV AAYRGKKRQE
160 170 180 190 200
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA
210 220 230 240 250
VTGEKKKEEA TSGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF
260 270 280 290 300
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPDL
310 320 330 340 350
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAID ILGFTSDERV
360 370 380 390 400
SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QNLNSADLLK
410 420 430 440 450
ALCYPRVKVG NEYVTKGQTV QQVYNSVGAL AKAVYEKMFL WMVTRINQQL
460 470 480 490 500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE
510 520 530 540 550
QEEYKKEGIE WEFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS
560 570 580 590 600
FKNKLYEQHL GKSNNFQKPK PAKGKVEAHF SLVHYAGTVD YNIAGWLDKN
610 620 630 640 650
KDPLNETVVG LYQKSSMKTL AYLFSGAAAA AEAESGGGGG KKGAKKKGSS
660 670 680 690 700
FQTVSALFRE NLNKLMTNLR STHPHFVRCI IPNETKTPGA MEHELVLHQL
710 720 730 740 750
RCNGVLEGIR ICRKGFPSRI LYADFKQRYK VLNASAIPEG QFIDSKKASE
760 770 780 790 800
KLLGSIDIDH TQYKFGHTKV FFKAGLLGLL EEMRDDKLAQ LITRTQAMCR
810 820 830 840 850
GYLARVEYQK MVERRESIFC IQYNVRAFMN VKHWPWMKLY FKIKPLLKSA
860 870 880 890 900
ETEKEMANMK EEFEKAKENL AKAEAKRKEL EEKMVALMQE KNDLQLQVQS
910 920 930 940 950
EADSLADAEE RCDQLIKTKI QLEAKIKEVT ERAEDEEEIN AELTAKKRKL
960 970 980 990 1000
EDECSELKKD IDDLELTLAK VEKEKHATEN KVKNLTEEMA GLDETIAKLT
1010 1020 1030 1040 1050
KEKKALQEAH QQTLDDLQAE EDKVNTLTKA KIKLEQQVDD LEGSLEQEKK
1060 1070 1080 1090 1100
IRMDLERAKR KLEGDLKLAQ ESTMDVENDK QQLDEKLKKK EFEMSNLQSK
1110 1120 1130 1140 1150
IEDEQALGMQ LQKKIKELQA RIEELEEEIE AERASRAKAE KQRSDLSREL
1160 1170 1180 1190 1200
EEISERLEEA GGATSAQIEM NKKREAEFQK MRRDLEEATL QHEATAATLR
1210 1220 1230 1240 1250
KKHADSVAEL GEQIDNLQRV KQKLEKEKSE MKMEIDDLAS NMEVISKSKG
1260 1270 1280 1290 1300
NLEKMCRTLE DQVSELKTKE EEQQRLINEL TAQRGRLQTE SGEYSRQLDE
1310 1320 1330 1340 1350
KDSLVSQLSR GKQAFTQQIE ELKRQLEEEI KAKSALAHAL QSSRHDCDLL
1360 1370 1380 1390 1400
REQYEEEQEA KAELQRAMSK ANSEVAQWRT KYETDAIQRT EELEEAKKKL
1410 1420 1430 1440 1450
AQRLQDAEEH VEAVNAKCAS LEKTKQRLQN EVEDLMIDVE RTNAACAALD
1460 1470 1480 1490 1500
KKQRNFDKIL AEWKQKYEET HAELEASQKE SRSLSTELFK IKNAYEESLD
1510 1520 1530 1540 1550
HLETLKRENK NLQQEISDLT EQIAEGGKRI HELEKIKKQI EQEKSELQAA
1560 1570 1580 1590 1600
LEEAEASLEH EEGKILRIQL ELNQVKSEID RKIAEKDEEI DQLKRNHIRV
1610 1620 1630 1640 1650
VESMQSTLDA EIRSRNDAIR LKKKMEGDLN EMEIQLNHSN RMAAEALRNY
1660 1670 1680 1690 1700
RNTQGILKDT QLHLDDALRG QEDLKEQLAM VERRANLLQA EIEELRATLE
1710 1720 1730 1740 1750
QTERSRKIAE QELLDASERV QLLHTQNTSL INTKKKLETD ISQIQGEMED
1760 1770 1780 1790 1800
IVQEARNAEE KAKKAITDAA MMAEELKKEQ DTSAHLERMK KNLEQTVKDL
1810 1820 1830 1840 1850
QHRLDEAEQL ALKGGKKQIQ KLEARVRELE GEVENEQKRN VEAIKGLRKH
1860 1870 1880 1890 1900
ERRVKELTYQ TEEDRKNVLR LQDLVDKLQS KVKAYKRQAE EAEEQSNVNL
1910 1920 1930 1940
AKFRKIQHEL EEAEERADIA ESQVNKLRVK SREVHTKIIS EE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ1WNQ6 | Q1WNQ6_MOUSE | Myosin-1 | Myh1 | 95 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596129 Genomic DNA No translation available. BC108329 mRNA Translation: AAI08330.1 |
CCDSi | CCDS24855.1 |
RefSeqi | NP_109604.1, NM_030679.1 XP_017169807.1, XM_017314318.1 |
Genome annotation databases
Ensembli | ENSMUST00000018637; ENSMUSP00000018637; ENSMUSG00000056328 ENSMUST00000075734; ENSMUSP00000075147; ENSMUSG00000056328 ENSMUST00000124516; ENSMUSP00000117569; ENSMUSG00000056328 |
GeneIDi | 17879 |
KEGGi | mmu:17879 |
UCSCi | uc007jmg.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL596129 Genomic DNA No translation available. BC108329 mRNA Translation: AAI08330.1 |
CCDSi | CCDS24855.1 |
RefSeqi | NP_109604.1, NM_030679.1 XP_017169807.1, XM_017314318.1 |
3D structure databases
SMRi | Q5SX40 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 201643, 13 interactors |
IntActi | Q5SX40, 2 interactors |
STRINGi | 10090.ENSMUSP00000117569 |
PTM databases
iPTMneti | Q5SX40 |
PhosphoSitePlusi | Q5SX40 |
Proteomic databases
EPDi | Q5SX40 |
MaxQBi | Q5SX40 |
PaxDbi | Q5SX40 |
PRIDEi | Q5SX40 |
ProteomicsDBi | 287527 |
Protocols and materials databases
ABCDi | Q5SX40, 1 sequenced antibody |
Antibodypediai | 4383, 194 antibodies from 27 providers |
DNASUi | 17879 |
Genome annotation databases
Ensembli | ENSMUST00000018637; ENSMUSP00000018637; ENSMUSG00000056328 ENSMUST00000075734; ENSMUSP00000075147; ENSMUSG00000056328 ENSMUST00000124516; ENSMUSP00000117569; ENSMUSG00000056328 |
GeneIDi | 17879 |
KEGGi | mmu:17879 |
UCSCi | uc007jmg.1, mouse |
Organism-specific databases
CTDi | 4619 |
MGIi | MGI:1339711, Myh1 |
VEuPathDBi | HostDB:ENSMUSG00000056328 |
Phylogenomic databases
eggNOGi | KOG0161, Eukaryota |
GeneTreei | ENSGT00940000154760 |
HOGENOMi | CLU_000192_8_1_1 |
InParanoidi | Q5SX40 |
OMAi | HKYEETH |
OrthoDBi | 47111at2759 |
PhylomeDBi | Q5SX40 |
TreeFami | TF314375 |
Miscellaneous databases
BioGRID-ORCSi | 17879, 0 hits in 63 CRISPR screens |
ChiTaRSi | Myh1, mouse |
PROi | PR:Q5SX40 |
RNActi | Q5SX40, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000056328, Expressed in diaphragm and 154 other tissues |
ExpressionAtlasi | Q5SX40, baseline and differential |
Genevisiblei | Q5SX40, MM |
Family and domain databases
Gene3Di | 1.20.5.370, 4 hits 2.30.30.360, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000048, IQ_motif_EF-hand-BS IPR036961, Kinesin_motor_dom_sf IPR001609, Myosin_head_motor_dom IPR004009, Myosin_N IPR008989, Myosin_S1_N IPR002928, Myosin_tail IPR027417, P-loop_NTPase IPR014751, XRCC4-like_C |
Pfami | View protein in Pfam PF00063, Myosin_head, 1 hit PF02736, Myosin_N, 1 hit PF01576, Myosin_tail_1, 1 hit |
PRINTSi | PR00193, MYOSINHEAVY |
SMARTi | View protein in SMART SM00015, IQ, 1 hit SM00242, MYSc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50096, IQ, 1 hit PS51456, MYOSIN_MOTOR, 1 hit PS51844, SH3_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MYH1_MOUSE | |
Accessioni | Q5SX40Primary (citable) accession number: Q5SX40 Secondary accession number(s): Q32P18 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 23, 2022 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families