Myosin-4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• actin filament binding Source: InterPro
• ATP binding Source: UniProtKB-KW
• calmodulin binding Source: UniProtKB-KW
• double-stranded RNA binding Source: MGIInferred from sequence orthologyⁱ
  • 21266579
• motor activity Source: InterPro

GO - Biological processⁱ

• muscle contraction Source: MGI
• response to activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 18310078

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• actin filament binding Source: InterPro
• calmodulin binding Source: UniProtKB-KW

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSSDAEMAVF GEAAPYLRKS EKERIEAQNK PFDAKSSVFV VDAKESYVKA 
        60         70         80         90        100
TVQSREGGKV TAKTEGGATV TVKDDQVFSM NPPKYDKIED MAMMTHLHEP 
       110        120        130        140        150
AVLYNLKERY AAWMIYTYSG LFCVTVNPYK WLPVYNPEVV AAYRGKKRQE 
       160        170        180        190        200
APPHIFSISD NAYQFMLTDR ENQSILITGE SGAGKTVNTK RVIQYFATIA 
       210        220        230        240        250
VTGDKKKEEA TSGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF 
       260        270        280        290        300
IRIHFGATGK LASADIETYL LEKSRVTFQL KAERSYHIFY QIMSNKKPEL 
       310        320        330        340        350
IEMLLITTNP YDFAYVSQGE ITVPSIDDQE ELMATDTAVD ILGFSADEKV 
       360        370        380        390        400
AIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL TSLNSADLLK 
       410        420        430        440        450
ALCYPRVKVG NEYVTKGQTV QQVYNSVGAL AKSMYEKMFL WMVTRINQQL 
       460        470        480        490        500
DTKQPRQYFI GVLDIAGFEI FDFNTLEQLC INFTNEKLQQ FFNHHMFVLE 
       510        520        530        540        550
QEEYKKEGID WEFIDFGMDL AACIELIEKP MGIFSILEEE CMFPKATDTS 
       560        570        580        590        600
FKNKLYEQHL GKSNNFQKPK PAKGKAEAHF SLVHYAGTVD YNIIGWLDKN 
       610        620        630        640        650
KDPLNETVVG LYQKSGLKTL AFLFSGGQAA EAEGGGGKKG GKKKGSSFQT 
       660        670        680        690        700
VSALFRENLN KLMTNLKSTH PHFVRCLIPN ETKTPGAMEH ELVLHQLRCN 
       710        720        730        740        750
GVLEGIRICR KGFPSRILYA DFKQRYKVLN ASAIPEGQFI DSKKASEKLL 
       760        770        780        790        800
GSIDIDHTQY KFGHTKVFFK AGLLGTLEEM RDEKLAQLIT RTQAVCRGYL 
       810        820        830        840        850
MRVEFKKMME RRESIFCIQY NVRAFMNVKH WPWMKLYFKI KPLLKSAETE 
       860        870        880        890        900
KEMANMKEDF EKAKEDLAKS EAKRKELEEK MVALMQEKND LQLQVQAEAD 
       910        920        930        940        950
GLADAEERCD QLIKTKIQLE AKIKELTERA EDEEEINAEL TAKKRKLEDE 
       960        970        980        990       1000
CSELKKDIDD LELTLAKVEK EKHATENKVK NLTEEMAGLD ENIAKLTKEK 
      1010       1020       1030       1040       1050
KALQEAHQQT LDDLQAEEDK VNTLTKAKTK LEQQVDDLEG SLEQEKKLRM 
      1060       1070       1080       1090       1100
DLERAKRKLE GDLKLAQEST MDIENDKQQL DEKLKKKEFE MSNLQSKIED 
      1110       1120       1130       1140       1150
EQALGMQLQK KIKELQARIE ELEEEIEAER ASRAKAEKQR SDLSRELEEI 
      1160       1170       1180       1190       1200
SERLEEAGGA TSAQIEMNKK REAEFQKMRR DLEEATLQHE ATAAALRKKH 
      1210       1220       1230       1240       1250
ADSVAELGEQ IDNLQRVKQK LEKEKSELKM EIDDLASNME TVSKAKGNLE 
      1260       1270       1280       1290       1300
KMCRTLEDQL SEVKTKEEEQ QRLINELSTQ KARLHTESGE FSRQLDEKDA 
      1310       1320       1330       1340       1350
MVSQLSRGKQ AFTQQIEELK RQLEEESKAK NALAHALQSA RHDCDLLREQ 
      1360       1370       1380       1390       1400
YEEEQEAKAE LQRAMSKANS EVAQWRTKYE TDAIQRTEEL EEAKKKLAQR 
      1410       1420       1430       1440       1450
LQDAEEHVEA VNSKCASLEK TKQRLQNEVE DLMIDVERSN AACAALDKKQ 
      1460       1470       1480       1490       1500
RNFDKVLAEW KQKYEETQAE LEASQKESRS LSTELFKVKN AYEESLDQLE 
      1510       1520       1530       1540       1550
TLKRENKNLQ QEISDLTEQI AEGGKHIHEL EKIKKQIDQE KSELQASLEE 
      1560       1570       1580       1590       1600
AEASLEHEEG KILRIQLELN QVKSEIDRKI AEKDEEIDQL KRNHLRVVES 
      1610       1620       1630       1640       1650
MQSTLDAEIR SRNDALRIKK KMEGDLNEME IQLNHANRQA AEAIRNLRNT 
      1660       1670       1680       1690       1700
QGMLKDTQLH LDDALRGQDD LKEQLAMVER RANLMQAEIE ELRASLEQTE 
      1710       1720       1730       1740       1750
RSRRVAEQEL LDASERVQLL HTQNTSLINT KKKLETDISQ IQGEMEDIVQ 
      1760       1770       1780       1790       1800
EARNAEEKAK KAITDAAMMA EELKKEQDTS AHLERMKKNM EQTVKDLQHR 
      1810       1820       1830       1840       1850
LDEAEQLALK GGKKQIQKLE ARVRELENEV ENEQKRNIEA VKGLRKHERR 
      1860       1870       1880       1890       1900
VKELTYQTEE DRKNVLRLQD LVDKLQTKVK AYKRQAEEAE EQSNVNLAKF 
      1910       1920       1930 
RKIQHELEEA EERADIAESQ VNKLRVKSRE VHTKVISEE             

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot