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Entry version 108 (12 Aug 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Transmembrane protein 69

Gene

TMEM69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5SWH9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 69
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM69
Synonyms:C1orf154
ORF Names:HSPC229
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000159596.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28035, TMEM69

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5SWH9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51249

Open Targets

More...
OpenTargetsi
ENSG00000159596

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670782

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5SWH9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM69

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74743934

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002828501 – 247Transmembrane protein 69Add BLAST247

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5SWH9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5SWH9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5SWH9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5SWH9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SWH9

PeptideAtlas

More...
PeptideAtlasi
Q5SWH9

PRoteomics IDEntifications database

More...
PRIDEi
Q5SWH9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63975

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SWH9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SWH9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000159596, Expressed in oocyte and 213 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SWH9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000159596, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q5SWH9, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361095

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5SWH9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502RYSE, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015318

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_095371_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SWH9

Identification of Orthologs from Complete Genome Data

More...
OMAi
HYPSWFK

Database of Orthologous Groups

More...
OrthoDBi
1516042at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SWH9

TreeFam database of animal gene trees

More...
TreeFami
TF336126

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021836, DUF3429

The PANTHER Classification System

More...
PANTHERi
PTHR15887, PTHR15887, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11911, DUF3429, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5SWH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRFIQKFSQ ASSKILKYSF PVGLRTSRTD ILSLKMSLQQ NFSPCPRPWL
60 70 80 90 100
SSSFPAYMSK TQCYHTSPCS FKKQQKQALL ARPSSTITYL TDSPKPALCV
110 120 130 140 150
TLAGLIPFVA PPLVMLMTKT YIPILAFTQM AYGASFLSFL GGIRWGFALP
160 170 180 190 200
EGSPAKPDYL NLASSAAPLF FSWFAFLISE RLSEAIVTVI MGMGVAFHLE
210 220 230 240
LFLLPHYPNW FKALRIVVTL LATFSFIITL VVKSSFPEKG HKRPGQV
Length:247
Mass (Da):27,551
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i02A2C30DC7352AD1
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF36149 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12S → M in AAF36149 (PubMed:11042152).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF151063 mRNA Translation: AAF36149.1 Frameshift.
AL604028 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06954.1
BC013608 mRNA Translation: AAH13608.2
BC034147 mRNA Translation: AAH34147.2
BC039718 mRNA Translation: AAH39718.2
BC046130 mRNA Translation: AAH46130.2
BC064539 mRNA Translation: AAH64539.2
BC073836 mRNA Translation: AAH73836.2
BC121117 mRNA Translation: AAI21118.2
BC133692 mRNA Translation: AAI33693.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41325.1

NCBI Reference Sequences

More...
RefSeqi
NP_057570.2, NM_016486.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372025; ENSP00000361095; ENSG00000159596

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51249

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51249

UCSC genome browser

More...
UCSCi
uc001cor.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151063 mRNA Translation: AAF36149.1 Frameshift.
AL604028 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06954.1
BC013608 mRNA Translation: AAH13608.2
BC034147 mRNA Translation: AAH34147.2
BC039718 mRNA Translation: AAH39718.2
BC046130 mRNA Translation: AAH46130.2
BC064539 mRNA Translation: AAH64539.2
BC073836 mRNA Translation: AAH73836.2
BC121117 mRNA Translation: AAI21118.2
BC133692 mRNA Translation: AAI33693.1
CCDSiCCDS41325.1
RefSeqiNP_057570.2, NM_016486.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ5SWH9, 3 interactors
STRINGi9606.ENSP00000361095

PTM databases

iPTMnetiQ5SWH9
PhosphoSitePlusiQ5SWH9

Polymorphism and mutation databases

BioMutaiTMEM69
DMDMi74743934

Proteomic databases

EPDiQ5SWH9
jPOSTiQ5SWH9
MassIVEiQ5SWH9
MaxQBiQ5SWH9
PaxDbiQ5SWH9
PeptideAtlasiQ5SWH9
PRIDEiQ5SWH9
ProteomicsDBi63975

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32710, 28 antibodies

Genome annotation databases

EnsembliENST00000372025; ENSP00000361095; ENSG00000159596
GeneIDi51249
KEGGihsa:51249
UCSCiuc001cor.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51249
DisGeNETi51249
EuPathDBiHostDB:ENSG00000159596.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM69
HGNCiHGNC:28035, TMEM69
HPAiENSG00000159596, Low tissue specificity
neXtProtiNX_Q5SWH9
OpenTargetsiENSG00000159596
PharmGKBiPA142670782

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RYSE, Eukaryota
GeneTreeiENSGT00390000015318
HOGENOMiCLU_095371_0_0_1
InParanoidiQ5SWH9
OMAiHYPSWFK
OrthoDBi1516042at2759
PhylomeDBiQ5SWH9
TreeFamiTF336126

Enzyme and pathway databases

PathwayCommonsiQ5SWH9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
51249, 25 hits in 853 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TMEM69

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51249
PharosiQ5SWH9, Tdark

Protein Ontology

More...
PROi
PR:Q5SWH9
RNActiQ5SWH9, protein

Gene expression databases

BgeeiENSG00000159596, Expressed in oocyte and 213 other tissues
GenevisibleiQ5SWH9, HS

Family and domain databases

InterProiView protein in InterPro
IPR021836, DUF3429
PANTHERiPTHR15887, PTHR15887, 1 hit
PfamiView protein in Pfam
PF11911, DUF3429, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTMM69_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SWH9
Secondary accession number(s): Q3SWW5, Q7Z2G0, Q9P0P9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 21, 2004
Last modified: August 12, 2020
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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