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Protein

Transmembrane protein 69

Gene

TMEM69

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 69
Gene namesi
Name:TMEM69
Synonyms:C1orf154
ORF Names:HSPC229
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159596.6
HGNCiHGNC:28035 TMEM69
neXtProtiNX_Q5SWH9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei122 – 142HelicalSequence analysisAdd BLAST21
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51249
OpenTargetsiENSG00000159596
PharmGKBiPA142670782

Polymorphism and mutation databases

BioMutaiTMEM69
DMDMi74743934

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002828501 – 247Transmembrane protein 69Add BLAST247

Proteomic databases

EPDiQ5SWH9
MaxQBiQ5SWH9
PaxDbiQ5SWH9
PeptideAtlasiQ5SWH9
PRIDEiQ5SWH9
ProteomicsDBi63975

PTM databases

iPTMnetiQ5SWH9
PhosphoSitePlusiQ5SWH9

Expressioni

Gene expression databases

BgeeiENSG00000159596 Expressed in 201 organ(s), highest expression level in oocyte
CleanExiHS_TMEM69
GenevisibleiQ5SWH9 HS

Organism-specific databases

HPAiHPA026993

Interactioni

Protein-protein interaction databases

IntActiQ5SWH9, 3 interactors
STRINGi9606.ENSP00000361095

Structurei

3D structure databases

ProteinModelPortaliQ5SWH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW9X Eukaryota
ENOG410XW1Y LUCA
GeneTreeiENSGT00390000015318
HOGENOMiHOG000054203
HOVERGENiHBG095693
InParanoidiQ5SWH9
OMAiWFKALRI
OrthoDBiEOG091G0G1R
PhylomeDBiQ5SWH9
TreeFamiTF336126

Family and domain databases

InterProiView protein in InterPro
IPR021836 DUF3429
PANTHERiPTHR15887 PTHR15887, 1 hit
PfamiView protein in Pfam
PF11911 DUF3429, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SWH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRFIQKFSQ ASSKILKYSF PVGLRTSRTD ILSLKMSLQQ NFSPCPRPWL
60 70 80 90 100
SSSFPAYMSK TQCYHTSPCS FKKQQKQALL ARPSSTITYL TDSPKPALCV
110 120 130 140 150
TLAGLIPFVA PPLVMLMTKT YIPILAFTQM AYGASFLSFL GGIRWGFALP
160 170 180 190 200
EGSPAKPDYL NLASSAAPLF FSWFAFLISE RLSEAIVTVI MGMGVAFHLE
210 220 230 240
LFLLPHYPNW FKALRIVVTL LATFSFIITL VVKSSFPEKG HKRPGQV
Length:247
Mass (Da):27,551
Last modified:December 21, 2004 - v1
Checksum:i02A2C30DC7352AD1
GO

Sequence cautioni

The sequence AAF36149 differs from that shown. Reason: Frameshift at position 53.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12S → M in AAF36149 (PubMed:11042152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151063 mRNA Translation: AAF36149.1 Frameshift.
AL604028 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06954.1
BC013608 mRNA Translation: AAH13608.2
BC034147 mRNA Translation: AAH34147.2
BC039718 mRNA Translation: AAH39718.2
BC046130 mRNA Translation: AAH46130.2
BC064539 mRNA Translation: AAH64539.2
BC073836 mRNA Translation: AAH73836.2
BC121117 mRNA Translation: AAI21118.2
BC133692 mRNA Translation: AAI33693.1
CCDSiCCDS41325.1
RefSeqiNP_057570.2, NM_016486.3
UniGeneiHs.699548

Genome annotation databases

EnsembliENST00000372025; ENSP00000361095; ENSG00000159596
GeneIDi51249
KEGGihsa:51249
UCSCiuc001cor.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151063 mRNA Translation: AAF36149.1 Frameshift.
AL604028 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06954.1
BC013608 mRNA Translation: AAH13608.2
BC034147 mRNA Translation: AAH34147.2
BC039718 mRNA Translation: AAH39718.2
BC046130 mRNA Translation: AAH46130.2
BC064539 mRNA Translation: AAH64539.2
BC073836 mRNA Translation: AAH73836.2
BC121117 mRNA Translation: AAI21118.2
BC133692 mRNA Translation: AAI33693.1
CCDSiCCDS41325.1
RefSeqiNP_057570.2, NM_016486.3
UniGeneiHs.699548

3D structure databases

ProteinModelPortaliQ5SWH9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5SWH9, 3 interactors
STRINGi9606.ENSP00000361095

PTM databases

iPTMnetiQ5SWH9
PhosphoSitePlusiQ5SWH9

Polymorphism and mutation databases

BioMutaiTMEM69
DMDMi74743934

Proteomic databases

EPDiQ5SWH9
MaxQBiQ5SWH9
PaxDbiQ5SWH9
PeptideAtlasiQ5SWH9
PRIDEiQ5SWH9
ProteomicsDBi63975

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372025; ENSP00000361095; ENSG00000159596
GeneIDi51249
KEGGihsa:51249
UCSCiuc001cor.2 human

Organism-specific databases

CTDi51249
DisGeNETi51249
EuPathDBiHostDB:ENSG00000159596.6
GeneCardsiTMEM69
H-InvDBiHIX0000539
HGNCiHGNC:28035 TMEM69
HPAiHPA026993
neXtProtiNX_Q5SWH9
OpenTargetsiENSG00000159596
PharmGKBiPA142670782
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW9X Eukaryota
ENOG410XW1Y LUCA
GeneTreeiENSGT00390000015318
HOGENOMiHOG000054203
HOVERGENiHBG095693
InParanoidiQ5SWH9
OMAiWFKALRI
OrthoDBiEOG091G0G1R
PhylomeDBiQ5SWH9
TreeFamiTF336126

Miscellaneous databases

GeneWikiiTMEM69
GenomeRNAii51249
PROiPR:Q5SWH9

Gene expression databases

BgeeiENSG00000159596 Expressed in 201 organ(s), highest expression level in oocyte
CleanExiHS_TMEM69
GenevisibleiQ5SWH9 HS

Family and domain databases

InterProiView protein in InterPro
IPR021836 DUF3429
PANTHERiPTHR15887 PTHR15887, 1 hit
PfamiView protein in Pfam
PF11911 DUF3429, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMM69_HUMAN
AccessioniPrimary (citable) accession number: Q5SWH9
Secondary accession number(s): Q3SWW5, Q7Z2G0, Q9P0P9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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