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UniProtKB - Q5SWD9 (TSR1_MOUSE)
Protein
Pre-rRNA-processing protein TSR1 homolog
Gene
Tsr1
Organism
Mus musculus (Mouse)
Status
Functioni
Required during maturation of the 40S ribosomal subunit in the nucleolus.
By similarityGO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: GO_Central
- U3 snoRNA binding Source: GO_Central
GO - Biological processi
- endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
- maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
Keywordsi
Biological process | Ribosome biogenesis |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Names & Taxonomyi
Protein namesi | Recommended name: Pre-rRNA-processing protein TSR1 homolog |
Gene namesi | Name:Tsr1 Synonyms:Kiaa1401 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2144566, Tsr1 |
VEuPathDBi | HostDB:ENSMUSG00000038335 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Nucleus
- nucleolus Source: UniProtKB
Other locations
- preribosome, small subunit precursor Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311275 | 1 – 803 | Pre-rRNA-processing protein TSR1 homologAdd BLAST | 803 |
Proteomic databases
EPDi | Q5SWD9 |
MaxQBi | Q5SWD9 |
PaxDbi | Q5SWD9 |
PeptideAtlasi | Q5SWD9 |
PRIDEi | Q5SWD9 |
ProteomicsDBi | 300139 [Q5SWD9-1] 300140 [Q5SWD9-2] 300141 [Q5SWD9-3] |
PTM databases
iPTMneti | Q5SWD9 |
PhosphoSitePlusi | Q5SWD9 |
SwissPalmi | Q5SWD9 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000038335, Expressed in primitive streak and 308 other tissues |
ExpressionAtlasi | Q5SWD9, baseline and differential |
Genevisiblei | Q5SWD9, MM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 222666, 4 interactors |
IntActi | Q5SWD9, 1 interactor |
STRINGi | 10090.ENSMUSP00000039027 |
Miscellaneous databases
RNActi | Q5SWD9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 81 – 242 | Bms1-type GPROSITE-ProRule annotationAdd BLAST | 162 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 83 | DisorderedSequence analysisAdd BLAST | 83 | |
Regioni | 428 – 447 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 62 – 78 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 432 – 446 | Acidic residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1980, Eukaryota |
GeneTreei | ENSGT00940000153195 |
HOGENOMi | CLU_009858_1_0_1 |
InParanoidi | Q5SWD9 |
OMAi | KTPHQQV |
OrthoDBi | 186926at2759 |
PhylomeDBi | Q5SWD9 |
TreeFami | TF105717 |
Family and domain databases
InterProi | View protein in InterPro IPR012948, AARP2CN IPR039761, Bms1/Tsr1 IPR007034, BMS1_TSR1_C IPR030387, G_Bms1/Tsr1_dom |
PANTHERi | PTHR12858, PTHR12858, 1 hit |
Pfami | View protein in Pfam PF08142, AARP2CN, 1 hit PF04950, RIBIOP_C, 1 hit |
SMARTi | View protein in SMART SM00785, AARP2CN, 1 hit SM01362, DUF663, 1 hit |
PROSITEi | View protein in PROSITE PS51714, G_BMS1, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5SWD9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAHRSGPLK QQNKAHKGGR HHGGGSAQRD SKGRVGPKIL CKKLKRQLSR
60 70 80 90 100
IDQRHRASQL RKQKRESVLA EKRQLGSKDG PPHQVLVVPL HSRISLPEAF
110 120 130 140 150
KLLQNEDLGT VYLSERGSTQ SFMLLCPSLK HRWFFTYARP GDLHTLLDMA
160 170 180 190 200
KVADTILFLL DPLEGWDSTG DYCLSCLFAQ GLPTYTLAVQ GLSGFPPKKQ
210 220 230 240 250
IDARKKLSKM VEKRFPEDKL LLLDTQQESG MLLRQLANQK QRHLAFRDRR
260 270 280 290 300
AYLFAHVADF VPSEESDLVG TLKISGYVRG RTLNVNSLLH IVGHGDFQMN
310 320 330 340 350
QIDAPVDPFP LNPRVIKSQK KPNMAMEVCV TDAAPDMEED LKVLMKADPD
360 370 380 390 400
HQESLQTEAI PDPMEGEQTW PTEEELDEAD DLLKQRSRVV KKVPKGTSSY
410 420 430 440 450
QAEWILDEGD ESDGEGGEYD DIQHEGFMEE ESQDGSGEEE EEECETMTLG
460 470 480 490 500
ESVRDDLYDE KVDAEDEERM LEKYKQERLE EMFPDEMDTP RDVAARIRFQ
510 520 530 540 550
KYRGLKSFRT SPWDPKENLP RDYARIFQFQ NFVNTRKRIF KEIEEKEAEG
560 570 580 590 600
AEVGWYVTLH VSDVPVSVVE YFRQGAPLIA FSLLPYEQKM SVLNMVVSRN
610 620 630 640 650
PGNTEPVKAK EELIFHCGFR RFRASPLFSQ HTAADKHKFQ RFLTADAAFV
660 670 680 690 700
VTVFAPITFP PASVLLFKQR RNGMHSLIAT GHLFSVDPDR MVIKRVVLSG
710 720 730 740 750
HPFKIFTKMA VVRYMFFNRE DVMWFKPVEL RTKWGRRGHI KEPLGTHGHM
760 770 780 790 800
KCSFDGKLKS QDTVLMNLYK RVFPKWTYDP YVPEPVPWVK SDISSTVSEV
DME
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RCZ2 | D6RCZ2_MOUSE | Pre-rRNA-processing protein TSR1 ho... | Tsr1 | 90 | Annotation score: | ||
D6RI76 | D6RI76_MOUSE | Pre-rRNA-processing protein TSR1 ho... | Tsr1 | 65 | Annotation score: | ||
F6ZVN6 | F6ZVN6_MOUSE | Pre-rRNA-processing protein TSR1 ho... | Tsr1 | 40 | Annotation score: |
Sequence cautioni
The sequence AAH31531 differs from that shown. Reason: Frameshift.Curated
The sequence AAH31531 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 210 | M → T in AAH31531 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 335 | P → A in AAH31531 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 438 | E → K in BAE37023 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 464 | A → E in AAH31531 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 649 | F → L in AAH31531 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 707 | T → N in BAE32349 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029504 | 1 – 122 | Missing in isoform 2. 1 PublicationAdd BLAST | 122 | |
Alternative sequenceiVSP_029505 | 381 – 382 | DL → GQ in isoform 3. 1 Publication | 2 | |
Alternative sequenceiVSP_029506 | 383 – 803 | Missing in isoform 3. 1 PublicationAdd BLAST | 421 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK030545 mRNA Translation: BAE20453.1 AK134365 mRNA Translation: BAE22117.1 AK154063 mRNA Translation: BAE32349.1 AK162686 mRNA Translation: BAE37023.1 AK165662 mRNA Translation: BAE38324.1 AL604066 Genomic DNA No translation available. BC031531 mRNA Translation: AAH31531.1 Sequence problems. AK129350 mRNA Translation: BAC98160.1 |
CCDSi | CCDS36225.1 [Q5SWD9-1] |
RefSeqi | NP_796299.2, NM_177325.3 [Q5SWD9-1] |
Genome annotation databases
Ensembli | ENSMUST00000045807; ENSMUSP00000039027; ENSMUSG00000038335 [Q5SWD9-1] |
GeneIDi | 104662 |
KEGGi | mmu:104662 |
UCSCi | uc007kcm.1, mouse [Q5SWD9-3] uc007kcn.1, mouse [Q5SWD9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK030545 mRNA Translation: BAE20453.1 AK134365 mRNA Translation: BAE22117.1 AK154063 mRNA Translation: BAE32349.1 AK162686 mRNA Translation: BAE37023.1 AK165662 mRNA Translation: BAE38324.1 AL604066 Genomic DNA No translation available. BC031531 mRNA Translation: AAH31531.1 Sequence problems. AK129350 mRNA Translation: BAC98160.1 |
CCDSi | CCDS36225.1 [Q5SWD9-1] |
RefSeqi | NP_796299.2, NM_177325.3 [Q5SWD9-1] |
3D structure databases
AlphaFoldDBi | Q5SWD9 |
SMRi | Q5SWD9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 222666, 4 interactors |
IntActi | Q5SWD9, 1 interactor |
STRINGi | 10090.ENSMUSP00000039027 |
PTM databases
iPTMneti | Q5SWD9 |
PhosphoSitePlusi | Q5SWD9 |
SwissPalmi | Q5SWD9 |
Proteomic databases
EPDi | Q5SWD9 |
MaxQBi | Q5SWD9 |
PaxDbi | Q5SWD9 |
PeptideAtlasi | Q5SWD9 |
PRIDEi | Q5SWD9 |
ProteomicsDBi | 300139 [Q5SWD9-1] 300140 [Q5SWD9-2] 300141 [Q5SWD9-3] |
Protocols and materials databases
Antibodypediai | 10721, 108 antibodies from 23 providers |
Genome annotation databases
Ensembli | ENSMUST00000045807; ENSMUSP00000039027; ENSMUSG00000038335 [Q5SWD9-1] |
GeneIDi | 104662 |
KEGGi | mmu:104662 |
UCSCi | uc007kcm.1, mouse [Q5SWD9-3] uc007kcn.1, mouse [Q5SWD9-1] |
Organism-specific databases
CTDi | 55720 |
MGIi | MGI:2144566, Tsr1 |
VEuPathDBi | HostDB:ENSMUSG00000038335 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1980, Eukaryota |
GeneTreei | ENSGT00940000153195 |
HOGENOMi | CLU_009858_1_0_1 |
InParanoidi | Q5SWD9 |
OMAi | KTPHQQV |
OrthoDBi | 186926at2759 |
PhylomeDBi | Q5SWD9 |
TreeFami | TF105717 |
Enzyme and pathway databases
Reactomei | R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol |
Miscellaneous databases
BioGRID-ORCSi | 104662, 24 hits in 75 CRISPR screens |
ChiTaRSi | Tsr1, mouse |
PROi | PR:Q5SWD9 |
RNActi | Q5SWD9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038335, Expressed in primitive streak and 308 other tissues |
ExpressionAtlasi | Q5SWD9, baseline and differential |
Genevisiblei | Q5SWD9, MM |
Family and domain databases
InterProi | View protein in InterPro IPR012948, AARP2CN IPR039761, Bms1/Tsr1 IPR007034, BMS1_TSR1_C IPR030387, G_Bms1/Tsr1_dom |
PANTHERi | PTHR12858, PTHR12858, 1 hit |
Pfami | View protein in Pfam PF08142, AARP2CN, 1 hit PF04950, RIBIOP_C, 1 hit |
SMARTi | View protein in SMART SM00785, AARP2CN, 1 hit SM01362, DUF663, 1 hit |
PROSITEi | View protein in PROSITE PS51714, G_BMS1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TSR1_MOUSE | |
Accessioni | Q5SWD9Primary (citable) accession number: Q5SWD9 Secondary accession number(s): Q3TMW6 Q8K2F5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families