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Protein

Protein phosphatase 1 regulatory subunit 15B

Gene

PPP1R15B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.2 Publications

Miscellaneous

The phosphatase activity of the PPP1R15B-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.

GO - Molecular functioni

  • protein phosphatase regulator activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTranslation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 15B
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158615.8
HGNCiHGNC:14951 PPP1R15B
MIMi613257 gene
neXtProtiNX_Q5SWA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Microcephaly, short stature, and impaired glucose metabolism 2 (MSSGM2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by microcephaly, mental retardation, short stature, and disturbed glucose metabolism.
See also OMIM:616817
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_074072658R → C in MSSGM2; no effect on localization; increased protein abundance; loss of interaction with protein phosphatase catalytic subunit PP1; decreased dephosphorylation of EIF2S1. 2 Publications1
Defects in PPP1R15B has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.1 Publication

Keywords - Diseasei

Diabetes mellitus, Disease mutation, Dwarfism, Mental retardation

Organism-specific databases

DisGeNETi84919
MalaCardsiPPP1R15B
MIMi616817 phenotype
Orphaneti391408 Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome
PharmGKBiPA33633

Polymorphism and mutation databases

BioMutaiPPP1R15B
DMDMi74743925

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003205201 – 713Protein phosphatase 1 regulatory subunit 15BAdd BLAST713

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei508PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5SWA1
MaxQBiQ5SWA1
PaxDbiQ5SWA1
PeptideAtlasiQ5SWA1
PRIDEiQ5SWA1
ProteomicsDBi63971

PTM databases

iPTMnetiQ5SWA1
PhosphoSitePlusiQ5SWA1

Expressioni

Gene expression databases

BgeeiENSG00000158615 Expressed in 203 organ(s), highest expression level in placenta
CleanExiHS_PPP1R15B
GenevisibleiQ5SWA1 HS

Organism-specific databases

HPAiHPA061088

Interactioni

Subunit structurei

Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PP1.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621365EBI-2815482,EBI-357253

Protein-protein interaction databases

IntActiQ5SWA1, 6 interactors
MINTiQ5SWA1
STRINGi9606.ENSP00000356156

Structurei

Secondary structure

1713
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5SWA1
SMRiQ5SWA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP1R15 family.Curated

Phylogenomic databases

eggNOGiENOG410IJ9C Eukaryota
ENOG4111TVA LUCA
HOGENOMiHOG000115677
HOVERGENiHBG103996
InParanoidiQ5SWA1
OrthoDBiEOG091G19MD
PhylomeDBiQ5SWA1
TreeFamiTF105548

Family and domain databases

InterProiView protein in InterPro
IPR019523 Prot_Pase1_reg-su15A/B_C
IPR019512 Prot_Pase1_reg-su15B_N
PfamiView protein in Pfam
PF10472 CReP_N, 1 hit
PF10488 PP1c_bdg, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SWA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGTGGSRK RLGPRAGFRF WPPFFPRRSQ AGSSKFPTPL GPENSGNPTL
60 70 80 90 100
LSSAQPETRV SYWTKLLSQL LAPLPGLLQK VLIWSQLFGG MFPTRWLDFA
110 120 130 140 150
GVYSALRALK GREKPAAPTA QKSLSSLQLD SSDPSVTSPL DWLEEGIHWQ
160 170 180 190 200
YSPPDLKLEL KAKGSALDPA AQAFLLEQQL WGVELLPSSL QSRLYSNREL
210 220 230 240 250
GSSPSGPLNI QRIDNFSVVS YLLNPSYLDC FPRLEVSYQN SDGNSEVVGF
260 270 280 290 300
QTLTPESSCL REDHCHPQPL SAELIPASWQ GCPPLSTEGL PEIHHLRMKR
310 320 330 340 350
LEFLQQANKG QDLPTPDQDN GYHSLEEEHS LLRMDPKHCR DNPTQFVPAA
360 370 380 390 400
GDIPGNTQES TEEKIELLTT EVPLALEEES PSEGCPSSEI PMEKEPGEGR
410 420 430 440 450
ISVVDYSYLE GDLPISARPA CSNKLIDYIL GGASSDLETS SDPEGEDWDE
460 470 480 490 500
EAEDDGFDSD SSLSDSDLEQ DPEGLHLWNS FCSVDPYNPQ NFTATIQTAA
510 520 530 540 550
RIVPEEPSDS EKDLSGKSDL ENSSQSGSLP ETPEHSSGEE DDWESSADEA
560 570 580 590 600
ESLKLWNSFC NSDDPYNPLN FKAPFQTSGE NEKGCRDSKT PSESIVAISE
610 620 630 640 650
CHTLLSCKVQ LLGSQESECP DSVQRDVLSG GRHTHVKRKK VTFLEEVTEY
660 670 680 690 700
YISGDEDRKG PWEEFARDGC RFQKRIQETE DAIGYCLTFE HRERMFNRLQ
710
GTCFKGLNVL KQC
Length:713
Mass (Da):79,152
Last modified:December 21, 2004 - v1
Checksum:i193679F622E34257
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28R → Q in BAD96597 (Ref. 2) Curated1
Sequence conflicti215N → D in BAB55266 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03919626P → S. Corresponds to variant dbSNP:rs12094135Ensembl.1
Natural variantiVAR_079851134P → S Found in a patient with isolated coloboma; unknown pathological significance. 1 Publication1
Natural variantiVAR_039197144E → K. Corresponds to variant dbSNP:rs4492688Ensembl.1
Natural variantiVAR_039198308N → S4 PublicationsCorresponds to variant dbSNP:rs3014626Ensembl.1
Natural variantiVAR_039199363E → G. Corresponds to variant dbSNP:rs2089891Ensembl.1
Natural variantiVAR_039200589K → E1 PublicationCorresponds to variant dbSNP:rs17855962Ensembl.1
Natural variantiVAR_074072658R → C in MSSGM2; no effect on localization; increased protein abundance; loss of interaction with protein phosphatase catalytic subunit PP1; decreased dephosphorylation of EIF2S1. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027650 mRNA Translation: BAB55266.1
AK222877 mRNA Translation: BAD96597.1
AL606489 Genomic DNA No translation available.
BC065280 mRNA Translation: AAH65280.1
AL833746 mRNA Translation: CAH56240.1
CCDSiCCDS1445.1
UniGeneiHs.304376

Genome annotation databases

EnsembliENST00000367188; ENSP00000356156; ENSG00000158615
UCSCiuc001hav.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027650 mRNA Translation: BAB55266.1
AK222877 mRNA Translation: BAD96597.1
AL606489 Genomic DNA No translation available.
BC065280 mRNA Translation: AAH65280.1
AL833746 mRNA Translation: CAH56240.1
CCDSiCCDS1445.1
UniGeneiHs.304376

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V0UX-ray7.88E/G/I/K/O631-701[»]
4V0VX-ray1.61B/D631-660[»]
4V0WX-ray1.55B/D631-669[»]
4V0XX-ray1.85B631-684[»]
ProteinModelPortaliQ5SWA1
SMRiQ5SWA1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5SWA1, 6 interactors
MINTiQ5SWA1
STRINGi9606.ENSP00000356156

PTM databases

iPTMnetiQ5SWA1
PhosphoSitePlusiQ5SWA1

Polymorphism and mutation databases

BioMutaiPPP1R15B
DMDMi74743925

Proteomic databases

EPDiQ5SWA1
MaxQBiQ5SWA1
PaxDbiQ5SWA1
PeptideAtlasiQ5SWA1
PRIDEiQ5SWA1
ProteomicsDBi63971

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367188; ENSP00000356156; ENSG00000158615
UCSCiuc001hav.5 human

Organism-specific databases

DisGeNETi84919
EuPathDBiHostDB:ENSG00000158615.8
GeneCardsiPPP1R15B
H-InvDBiHIX0021246
HGNCiHGNC:14951 PPP1R15B
HPAiHPA061088
MalaCardsiPPP1R15B
MIMi613257 gene
616817 phenotype
neXtProtiNX_Q5SWA1
Orphaneti391408 Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome
PharmGKBiPA33633
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ9C Eukaryota
ENOG4111TVA LUCA
HOGENOMiHOG000115677
HOVERGENiHBG103996
InParanoidiQ5SWA1
OrthoDBiEOG091G19MD
PhylomeDBiQ5SWA1
TreeFamiTF105548

Miscellaneous databases

ChiTaRSiPPP1R15B human
PROiPR:Q5SWA1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158615 Expressed in 203 organ(s), highest expression level in placenta
CleanExiHS_PPP1R15B
GenevisibleiQ5SWA1 HS

Family and domain databases

InterProiView protein in InterPro
IPR019523 Prot_Pase1_reg-su15A/B_C
IPR019512 Prot_Pase1_reg-su15B_N
PfamiView protein in Pfam
PF10472 CReP_N, 1 hit
PF10488 PP1c_bdg, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPR15B_HUMAN
AccessioniPrimary (citable) accession number: Q5SWA1
Secondary accession number(s): Q53GQ4
, Q658M2, Q6P156, Q96SN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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