Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 105 (13 Feb 2019)
Sequence version 1 (21 Dec 2004)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Protein phosphatase 1 regulatory subunit 15B

Gene

PPP1R15B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.2 Publications

Miscellaneous

The phosphatase activity of the PPP1R15B-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein phosphatase regulator activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranslation regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 15B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000158615.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14951 PPP1R15B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613257 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5SWA1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly, short stature, and impaired glucose metabolism 2 (MSSGM2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by microcephaly, mental retardation, short stature, and disturbed glucose metabolism.
See also OMIM:616817
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_074072658R → C in MSSGM2; no effect on localization; increased protein abundance; loss of interaction with protein phosphatase catalytic subunit PP1; decreased dephosphorylation of EIF2S1. 2 Publications1
Defects in PPP1R15B has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea.1 Publication

Keywords - Diseasei

Diabetes mellitus, Disease mutation, Dwarfism, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
84919

MalaCards human disease database

More...
MalaCardsi
PPP1R15B
MIMi616817 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
391408 Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33633

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP1R15B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74743925

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003205201 – 713Protein phosphatase 1 regulatory subunit 15BAdd BLAST713

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei203PhosphoserineCombined sources1
Modified residuei205PhosphoserineCombined sources1
Modified residuei508PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5SWA1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5SWA1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5SWA1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SWA1

PeptideAtlas

More...
PeptideAtlasi
Q5SWA1

PRoteomics IDEntifications database

More...
PRIDEi
Q5SWA1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
63971

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SWA1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SWA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158615 Expressed in 203 organ(s), highest expression level in placenta

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SWA1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA061088

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PP1.By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PPP1CAP621365EBI-2815482,EBI-357253

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q5SWA1, 6 interactors

Molecular INTeraction database

More...
MINTi
Q5SWA1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356156

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1713
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V0UX-ray7.88E/G/I/K/O631-701[»]
4V0VX-ray1.61B/D631-660[»]
4V0WX-ray1.55B/D631-669[»]
4V0XX-ray1.85B631-684[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5SWA1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5SWA1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PPP1R15 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ9C Eukaryota
ENOG4111TVA LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115677

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG103996

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SWA1

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SWA1

TreeFam database of animal gene trees

More...
TreeFami
TF105548

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019523 Prot_Pase1_reg-su15A/B_C
IPR019512 Prot_Pase1_reg-su15B_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10472 CReP_N, 1 hit
PF10488 PP1c_bdg, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5SWA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGTGGSRK RLGPRAGFRF WPPFFPRRSQ AGSSKFPTPL GPENSGNPTL
60 70 80 90 100
LSSAQPETRV SYWTKLLSQL LAPLPGLLQK VLIWSQLFGG MFPTRWLDFA
110 120 130 140 150
GVYSALRALK GREKPAAPTA QKSLSSLQLD SSDPSVTSPL DWLEEGIHWQ
160 170 180 190 200
YSPPDLKLEL KAKGSALDPA AQAFLLEQQL WGVELLPSSL QSRLYSNREL
210 220 230 240 250
GSSPSGPLNI QRIDNFSVVS YLLNPSYLDC FPRLEVSYQN SDGNSEVVGF
260 270 280 290 300
QTLTPESSCL REDHCHPQPL SAELIPASWQ GCPPLSTEGL PEIHHLRMKR
310 320 330 340 350
LEFLQQANKG QDLPTPDQDN GYHSLEEEHS LLRMDPKHCR DNPTQFVPAA
360 370 380 390 400
GDIPGNTQES TEEKIELLTT EVPLALEEES PSEGCPSSEI PMEKEPGEGR
410 420 430 440 450
ISVVDYSYLE GDLPISARPA CSNKLIDYIL GGASSDLETS SDPEGEDWDE
460 470 480 490 500
EAEDDGFDSD SSLSDSDLEQ DPEGLHLWNS FCSVDPYNPQ NFTATIQTAA
510 520 530 540 550
RIVPEEPSDS EKDLSGKSDL ENSSQSGSLP ETPEHSSGEE DDWESSADEA
560 570 580 590 600
ESLKLWNSFC NSDDPYNPLN FKAPFQTSGE NEKGCRDSKT PSESIVAISE
610 620 630 640 650
CHTLLSCKVQ LLGSQESECP DSVQRDVLSG GRHTHVKRKK VTFLEEVTEY
660 670 680 690 700
YISGDEDRKG PWEEFARDGC RFQKRIQETE DAIGYCLTFE HRERMFNRLQ
710
GTCFKGLNVL KQC
Length:713
Mass (Da):79,152
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i193679F622E34257
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti28R → Q in BAD96597 (Ref. 2) Curated1
Sequence conflicti215N → D in BAB55266 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03919626P → S. Corresponds to variant dbSNP:rs12094135Ensembl.1
Natural variantiVAR_079851134P → S Found in a patient with isolated coloboma; unknown pathological significance. 1 Publication1
Natural variantiVAR_039197144E → K. Corresponds to variant dbSNP:rs4492688Ensembl.1
Natural variantiVAR_039198308N → S4 PublicationsCorresponds to variant dbSNP:rs3014626Ensembl.1
Natural variantiVAR_039199363E → G. Corresponds to variant dbSNP:rs2089891Ensembl.1
Natural variantiVAR_039200589K → E1 PublicationCorresponds to variant dbSNP:rs17855962Ensembl.1
Natural variantiVAR_074072658R → C in MSSGM2; no effect on localization; increased protein abundance; loss of interaction with protein phosphatase catalytic subunit PP1; decreased dephosphorylation of EIF2S1. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027650 mRNA Translation: BAB55266.1
AK222877 mRNA Translation: BAD96597.1
AL606489 Genomic DNA No translation available.
BC065280 mRNA Translation: AAH65280.1
AL833746 mRNA Translation: CAH56240.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1445.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.304376

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000367188; ENSP00000356156; ENSG00000158615

UCSC genome browser

More...
UCSCi
uc001hav.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027650 mRNA Translation: BAB55266.1
AK222877 mRNA Translation: BAD96597.1
AL606489 Genomic DNA No translation available.
BC065280 mRNA Translation: AAH65280.1
AL833746 mRNA Translation: CAH56240.1
CCDSiCCDS1445.1
UniGeneiHs.304376

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V0UX-ray7.88E/G/I/K/O631-701[»]
4V0VX-ray1.61B/D631-660[»]
4V0WX-ray1.55B/D631-669[»]
4V0XX-ray1.85B631-684[»]
ProteinModelPortaliQ5SWA1
SMRiQ5SWA1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5SWA1, 6 interactors
MINTiQ5SWA1
STRINGi9606.ENSP00000356156

PTM databases

iPTMnetiQ5SWA1
PhosphoSitePlusiQ5SWA1

Polymorphism and mutation databases

BioMutaiPPP1R15B
DMDMi74743925

Proteomic databases

EPDiQ5SWA1
jPOSTiQ5SWA1
MaxQBiQ5SWA1
PaxDbiQ5SWA1
PeptideAtlasiQ5SWA1
PRIDEiQ5SWA1
ProteomicsDBi63971

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367188; ENSP00000356156; ENSG00000158615
UCSCiuc001hav.5 human

Organism-specific databases

DisGeNETi84919
EuPathDBiHostDB:ENSG00000158615.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPP1R15B

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0021246
HGNCiHGNC:14951 PPP1R15B
HPAiHPA061088
MalaCardsiPPP1R15B
MIMi613257 gene
616817 phenotype
neXtProtiNX_Q5SWA1
Orphaneti391408 Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome
PharmGKBiPA33633

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ9C Eukaryota
ENOG4111TVA LUCA
HOGENOMiHOG000115677
HOVERGENiHBG103996
InParanoidiQ5SWA1
PhylomeDBiQ5SWA1
TreeFamiTF105548

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPP1R15B human

Protein Ontology

More...
PROi
PR:Q5SWA1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158615 Expressed in 203 organ(s), highest expression level in placenta
GenevisibleiQ5SWA1 HS

Family and domain databases

InterProiView protein in InterPro
IPR019523 Prot_Pase1_reg-su15A/B_C
IPR019512 Prot_Pase1_reg-su15B_N
PfamiView protein in Pfam
PF10472 CReP_N, 1 hit
PF10488 PP1c_bdg, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPR15B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SWA1
Secondary accession number(s): Q53GQ4
, Q658M2, Q6P156, Q96SN1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: December 21, 2004
Last modified: February 13, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again