LDLRAP1

Functionⁱ

Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

amyloid-beta binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12805363
AP-1 adaptor complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12451172
AP-2 adaptor complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12451172
clathrin adaptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15728179
clathrin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12451172
low-density lipoprotein particle receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12221107
- 14528014
phosphatidylinositol-4,5-bisphosphate binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 12451172
phosphotyrosine residue binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12451172
receptor signaling complex scaffold activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15166224
signaling adaptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 12221107

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

amyloid precursor protein metabolic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12805363
cellular response to cytokine stimulus
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 28257760
cholesterol homeostasis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15166224
cholesterol metabolic process
Source: UniProtKB
Non-traceable author statementⁱ
- 12451172
cholesterol transport
Source: UniProtKB
Non-traceable author statementⁱ
- 12451172
low-density lipoprotein particle clearance
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
membrane organization Source: Reactome
positive regulation of cholesterol metabolic process
Source: BHF-UCL
Inferred by curatorⁱ
- 15166224
positive regulation of low-density lipoprotein particle clearance
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 28257760
positive regulation of receptor-mediated endocytosis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15166224
positive regulation of receptor-mediated endocytosis involved in cholesterol transport
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
positive regulation of vascular smooth muscle cell proliferation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 28257760
receptor internalization
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15166224
receptor-mediated endocytosis
Source: BHF-UCL
Inferred from direct assayⁱ
- 14528014
receptor-mediated endocytosis involved in cholesterol transport
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
regulation of protein binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15166224
regulation of protein localization to plasma membrane
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12805363

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cholesterol metabolism, Endocytosis, Lipid metabolism, Steroid metabolism, Sterol metabolism

Biological process

Cholesterol metabolism, Endocytosis, Lipid metabolism, Steroid metabolism, Sterol metabolism

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-8964026 Chylomicron clearance R-HSA-8964038 LDL clearance

Reactomeⁱ

R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8964026 Chylomicron clearance
R-HSA-8964038 LDL clearance

Protein family/group databases

MoonDBⁱ	Q5SW96 Curated

MoonDBⁱ

Q5SW96 Curated

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Low density lipoprotein receptor adapter protein 1Curated Alternative name(s): Autosomal recessive hypercholesterolemia protein1 Publication
Gene namesⁱ	Name:LDLRAP1Imported Synonyms:ARH1 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000157978.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18640 LDLRAP1
MIMⁱ	605747 gene
neXtProtⁱ	NX_Q5SW96

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Hypercholesterolemia, autosomal recessive (ARH)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA familial condition characterized by elevated circulating cholesterol contained in either low-density lipoproteins alone or also in very-low-density lipoproteins.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_023320	202	S → H in ARH; Lebanon; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs386629678EnsemblClinVar.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	165	F → A: Abolishes LDLR cytoplasmic tail binding. 1 Publication	1
Mutagenesisⁱ	165	F → V: Abolishes LDLR cytoplasmic tail binding. 1 Publication	1
Mutagenesisⁱ	212 – 213	LL → AA: Abolishes clathrin binding. 1 Publication	2
Mutagenesisⁱ	214	D → A: Abolishes clathrin binding. 1 Publication	1
Mutagenesisⁱ	216	E → A: Abolishes clathrin binding. 1 Publication	1
Mutagenesisⁱ	256	D → R: Abolishes interaction with AP2B1. 1 Publication	1
Mutagenesisⁱ	266	R → A: Abolishes AP-2 complex binding. 1 Publication	1

Keywords - Diseaseⁱ

Atherosclerosis, Disease mutation, Hyperlipidemia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26119
MalaCards human disease database More...MalaCardsⁱ	LDLRAP1
MIMⁱ	603813 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000157978
Orphanetⁱ	391665 Homozygous familial hypercholesterolemia
PharmGKBⁱ	PA128394641

Polymorphism and mutation databases

BioMutaⁱ	LDLRAP1
DMDMⁱ	116241254

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064675	1 – 308	Low density lipoprotein receptor adapter protein 1Add BLAST		308

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	14	PhosphoserineCombined sources	1
Modified residueⁱ	186	PhosphoserineCombined sources	1
Modified residueⁱ	202	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q5SW96
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5SW96
PaxDbⁱ	Q5SW96
PeptideAtlas More...PeptideAtlasⁱ	Q5SW96
PRIDEⁱ	Q5SW96
ProteomicsDBⁱ	63967

PTM databases

iPTMnetⁱ	Q5SW96
PhosphoSitePlusⁱ	Q5SW96

Expressionⁱ

Tissue specificityⁱ

Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes.

Gene expression databases

Bgeeⁱ	ENSG00000157978 Expressed in 218 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_LDLRAP1
Genevisibleⁱ	Q5SW96 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB003705 HPA050358

HPAⁱ

CAB003705
HPA050358

Interactionⁱ

Subunit structureⁱ

Interacts (via PID domain) with LDLR (via NPXY motif) (PubMed:12221107). Binds to soluble clathrin trimers (PubMed:12221107). Interacts with AP2B1; the interaction mediates the association with the AP-2 complex (PubMed:12221107). Interacts with VLDLR (By similarity). Interacts with LRP2 (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AP2B1	P63010	4	EBI-747813,EBI-432924
AP2B1	P63010-2	4	EBI-747813,EBI-11529439
HOXC8	P31273	4	EBI-747813,EBI-1752118
MAPK8IP3	Q9UPT6	4	EBI-747813,EBI-717887
PSD4	Q8NDX1-2	5	EBI-747813,EBI-12215623
STN1	Q9H668	8	EBI-747813,EBI-746930

GO - Molecular functionⁱ

clathrin adaptor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 15728179
clathrin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12451172
low-density lipoprotein particle receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12221107
- 14528014
phosphotyrosine residue binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12451172
receptor signaling complex scaffold activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15166224

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	117561, 13 interactors
ELMⁱ	Q5SW96
IntActⁱ	Q5SW96, 18 interactors
Molecular INTeraction database More...MINTⁱ	Q5SW96
STRINGⁱ	9606.ENSP00000363458

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	256 – 266	Combined sources		11

Show more details

3D structure databases

ProteinModelPortalⁱ	Q5SW96
SMRⁱ	Q5SW96
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q5SW96

EvolutionaryTraceⁱ

Q5SW96

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	42 – 196	PIDPROSITE-ProRule annotationAdd BLAST		155

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	249 – 276	AP-2 complex binding1 PublicationAdd BLAST		28

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	212 – 216	Clathrin box1 Publication		5
Motifⁱ	257 – 266	[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif1 Publication		10

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	23 – 26	Poly-Gly		4

Domainⁱ

The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1.1 Publication

The PID domain mediates interaction with the NPXY internalization motif of LDLR.By similarity

Phylogenomic databases

eggNOGⁱ	KOG3536 Eukaryota ENOG410ZHJT LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062937
HOGENOMⁱ	HOG000030906
HOVERGENⁱ	HBG058060
InParanoidⁱ	Q5SW96
KEGG Orthology (KO) More...KOⁱ	K12474
OMAⁱ	DIHYAQC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TOH
PhylomeDBⁱ	Q5SW96
TreeFamⁱ	TF314159

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00640 PID, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5SW96-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDALKSAGRA LIRSPSLAKQ SWGGGGRHRK LPENWTDTRE TLLEGMLFSL 
        60         70         80         90        100
KYLGMTLVEQ PKGEELSAAA IKRIVATAKA SGKKLQKVTL KVSPRGIILT 
       110        120        130        140        150
DNLTNQLIEN VSIYRISYCT ADKMHDKVFA YIAQSQHNQS LECHAFLCTK 
       160        170        180        190        200
RKMAQAVTLT VAQAFKVAFE FWQVSKEEKE KRDKASQEGG DVLGARQDCT 
       210        220        230        240        250
PSLKSLVATG NLLDLEETAK APLSTVSANT TNMDEVPRPQ ALSGSSVVWE 
       260        270        280        290        300
LDDGLDEAFS RLAQSRTNPQ VLDTGLTAQD MHYAQCLSPV DWDKPDSSGT 

EQDDLFSF

Length:308

Mass (Da):33,885

Last modified:October 17, 2006 - v3

Checksum:ⁱDE83168CB328D2A7

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_076925	56	T → M Probable disease-associated mutation found in patients with hypercholesterolemia. 1 PublicationCorresponds to variant dbSNP:rs752849346Ensembl.	1
Natural variantⁱVAR_023320	202	S → H in ARH; Lebanon; requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs386629678EnsemblClinVar.	1
Natural variantⁱVAR_028403	202	S → P5 PublicationsCorresponds to variant dbSNP:rs6687605EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY389348 Genomic DNA Translation: AAQ90407.1 AL117654 mRNA Translation: CAB56030.2 AL606491 Genomic DNA No translation available. BX572623 Genomic DNA No translation available. BC029770 mRNA Translation: AAH29770.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30639.1
PIRⁱ	T17340
NCBI Reference Sequences More...RefSeqⁱ	NP_056442.2, NM_015627.2
UniGeneⁱ	Hs.590911

Genome annotation databases

Ensemblⁱ	ENST00000374338; ENSP00000363458; ENSG00000157978
GeneIDⁱ	26119
KEGGⁱ	hsa:26119
UCSC genome browser More...UCSCⁱ	uc001bkl.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5SW96	LDLRAP1 isoform 1		PONAB		308	UniRef90_Q5SW96
Uncharacterized protein		AOTNA		308
LDLRAP1 isoform 1		PANTR		308
cDNA FLJ33900 fis, clone CTONG2008262, highly similar to Low density lipoprotein receptor adapter protein 1		HUMAN		308
Low density lipoprotein receptor adaptor protein 1		GORGO		308
+15

Protein	Similar proteins		Species	Score	Length	Source
Q5SW96	Low density lipoprotein receptor adapter protein 1		MOUSE		308	UniRef50_Q5SW96
Low density lipoprotein receptor adapter protein 1	)	RAT		306
Low density lipoprotein receptor adapter protein 1-B		XENLA		309
LDLRAP1 isoform 1		PANTR		308
Low density lipoprotein receptor adaptor protein 1		GORGO		308
+675

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY389348 Genomic DNA Translation: AAQ90407.1 AL117654 mRNA Translation: CAB56030.2 AL606491 Genomic DNA No translation available. BX572623 Genomic DNA No translation available. BC029770 mRNA Translation: AAH29770.2
CCDSⁱ	CCDS30639.1
PIRⁱ	T17340
RefSeqⁱ	NP_056442.2, NM_015627.2
UniGeneⁱ	Hs.590911

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2G30	X-ray	1.60	P	252-267	[»]
ProteinModelPortalⁱ	Q5SW96
SMRⁱ	Q5SW96
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117561, 13 interactors
ELMⁱ	Q5SW96
IntActⁱ	Q5SW96, 18 interactors
MINTⁱ	Q5SW96
STRINGⁱ	9606.ENSP00000363458

Protein family/group databases

MoonDBⁱ	Q5SW96 Curated

MoonDBⁱ

Q5SW96 Curated

PTM databases

iPTMnetⁱ	Q5SW96
PhosphoSitePlusⁱ	Q5SW96

Polymorphism and mutation databases

BioMutaⁱ	LDLRAP1
DMDMⁱ	116241254

Proteomic databases

EPDⁱ	Q5SW96
MaxQBⁱ	Q5SW96
PaxDbⁱ	Q5SW96
PeptideAtlasⁱ	Q5SW96
PRIDEⁱ	Q5SW96
ProteomicsDBⁱ	63967

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26119
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000374338; ENSP00000363458; ENSG00000157978
GeneIDⁱ	26119
KEGGⁱ	hsa:26119
UCSCⁱ	uc001bkl.5 human

Organism-specific databases

CTDⁱ	26119
DisGeNETⁱ	26119
EuPathDBⁱ	HostDB:ENSG00000157978.11
GeneCardsⁱ	LDLRAP1
H-InvDBⁱ	HIX0023695
HGNCⁱ	HGNC:18640 LDLRAP1
HPAⁱ	CAB003705 HPA050358
MalaCardsⁱ	LDLRAP1
MIMⁱ	603813 phenotype 605747 gene
neXtProtⁱ	NX_Q5SW96
OpenTargetsⁱ	ENSG00000157978
Orphanetⁱ	391665 Homozygous familial hypercholesterolemia
PharmGKBⁱ	PA128394641
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3536 Eukaryota ENOG410ZHJT LUCA
GeneTreeⁱ	ENSGT00530000062937
HOGENOMⁱ	HOG000030906
HOVERGENⁱ	HBG058060
InParanoidⁱ	Q5SW96
KOⁱ	K12474
OMAⁱ	DIHYAQC
OrthoDBⁱ	EOG091G0TOH
PhylomeDBⁱ	Q5SW96
TreeFamⁱ	TF314159

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828 Clathrin-mediated endocytosis R-HSA-8964026 Chylomicron clearance R-HSA-8964038 LDL clearance

Reactomeⁱ

R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-8964026 Chylomicron clearance
R-HSA-8964038 LDL clearance

Miscellaneous databases

ChiTaRSⁱ	LDLRAP1 human
EvolutionaryTraceⁱ	Q5SW96
GeneWikiⁱ	Low_density_lipoprotein_receptor_adapter_protein_1
GenomeRNAiⁱ	26119
Protein Ontology More...PROⁱ	PR:Q5SW96
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000157978 Expressed in 218 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_LDLRAP1
Genevisibleⁱ	Q5SW96 HS

Family and domain databases

Gene3Dⁱ	2.30.29.30, 1 hit
InterProⁱ	View protein in InterPro IPR011993 PH-like_dom_sf IPR006020 PTB/PI_dom
Pfamⁱ	View protein in Pfam PF00640 PID, 1 hit
SMARTⁱ	View protein in SMART SM00462 PTB, 1 hit
PROSITEⁱ	View protein in PROSITE PS01179 PID, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARH_HUMAN
Accessionⁱ	Q5SW96Primary (citable) accession number: Q5SW96 Secondary accession number(s): A2BHI5 , Q6TQS9, Q8N2Y0, Q9UFI9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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UniProtKB - Q5SW96 (ARH_HUMAN)

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Low density lipoprotein receptor adapter protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytoskeleton

Cytosol

Endosome

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ