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Protein

Centrosomal protein of 170 kDa

Gene

CEP170

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092).2 Publications

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centrosomal protein of 170 kDa
Short name:
Cep170
Alternative name(s):
KARP-1-binding protein
Short name:
KARP1-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEP170
Synonyms:FAM68A, KAB, KIAA0470
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000143702.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28920 CEP170

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613023 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5SW79

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9859

Open Targets

More...
OpenTargetsi
ENSG00000143702

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128395757

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CEP170

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74743919

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002828871 – 1584Centrosomal protein of 170 kDaAdd BLAST1584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei138PhosphoserineCombined sources1
Modified residuei141PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei359PhosphoserineCombined sources1
Modified residuei364PhosphotyrosineCombined sources1
Modified residuei446PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei497PhosphoserineCombined sources1
Modified residuei501PhosphothreonineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei580PhosphoserineCombined sources1
Modified residuei630PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei644PhosphothreonineCombined sources1
Modified residuei667PhosphoserineCombined sources1
Modified residuei725PhosphoserineCombined sources1
Modified residuei760PhosphothreonineCombined sources1
Modified residuei838PhosphoserineCombined sources1
Modified residuei879PhosphoserineCombined sources1
Modified residuei881PhosphoserineCombined sources1
Modified residuei914PhosphothreonineCombined sources1
Modified residuei920PhosphothreonineCombined sources1
Modified residuei930PhosphoserineCombined sources1
Modified residuei933PhosphoserineCombined sources1
Modified residuei958PhosphoserineCombined sources1
Modified residuei1019PhosphoserineBy similarity1
Modified residuei1023PhosphothreonineBy similarity1
Modified residuei1058PhosphothreonineCombined sources1
Modified residuei1059PhosphoserineCombined sources1
Modified residuei1112PhosphoserineCombined sources1
Modified residuei1114PhosphoserineCombined sources1
Modified residuei1132PhosphoserineCombined sources1
Modified residuei1133PhosphoserineCombined sources1
Modified residuei1145PhosphoserineCombined sources1
Modified residuei1160PhosphoserineCombined sources1
Modified residuei1165PhosphoserineCombined sources1
Modified residuei1198PhosphoserineCombined sources1
Modified residuei1205PhosphoserineCombined sources1
Modified residuei1210PhosphoserineCombined sources1
Modified residuei1239PhosphoserineBy similarity1
Modified residuei1241PhosphoserineCombined sources1
Modified residuei1251PhosphoserineCombined sources1
Modified residuei1270PhosphoserineCombined sources1
Modified residuei1280PhosphoserineCombined sources1
Modified residuei1362PhosphoserineCombined sources1
Modified residuei1521PhosphoserineBy similarity1
Modified residuei1522PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated; probably by PLK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5SW79

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5SW79

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SW79

PeptideAtlas

More...
PeptideAtlasi
Q5SW79

PRoteomics IDEntifications database

More...
PRIDEi
Q5SW79

ProteomicsDB human proteome resource

More...
ProteomicsDBi
63964
63965 [Q5SW79-2]
63966 [Q5SW79-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SW79

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SW79

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q5SW79

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000143702 Expressed in 238 organ(s), highest expression level in corpus callosum

CleanEx database of gene expression profiles

More...
CleanExi
HS_CEP170

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5SW79 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SW79 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042151
HPA045597
HPA045787

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CCDC68 and CCDC120; leading to recruitment to centrosomes (PubMed:28422092). Interacts with PLK1 (PubMed:15616186). Interacts with NIN (By similarity). Interacts with FHDC1 (By similarity).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
vprP125204EBI-1104799,EBI-6164519From Human immunodeficiency virus type 1 group M subtype B (isolate NY5).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115193, 206 interactors

Database of interacting proteins

More...
DIPi
DIP-37594N

Protein interaction database and analysis system

More...
IntActi
Q5SW79, 172 interactors

Molecular INTeraction database

More...
MINTi
Q5SW79

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355500

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11584
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5SW79

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5SW79

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 73FHAPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni853 – 1584Targeting to microtubulesAdd BLAST732
Regioni1113 – 1584Targeting to centrosomesAdd BLAST472

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1467 – 1495Sequence analysisAdd BLAST29

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CEP170 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II6S Eukaryota
ENOG4110JY6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155103

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058059

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SW79

KEGG Orthology (KO)

More...
KOi
K16463

Identification of Orthologs from Complete Genome Data

More...
OMAi
SSGNKRW

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00LH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SW79

TreeFam database of animal gene trees

More...
TreeFami
TF328469

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060 FHA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026644 CEP170
IPR029300 CEP170_C
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15715:SF17 PTHR15715:SF17, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15308 CEP170_C, 1 hit
PF00498 FHA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00240 FHA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SW79-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLTSWFLVS SGGTRHRLPR EMIFVGRDDC ELMLQSRSVD KQHAVINYDA
60 70 80 90 100
STDEHLVKDL GSLNGTFVND VRIPEQTYIT LKLEDKLRFG YDTNLFTVVQ
110 120 130 140 150
GEMRVPEEAL KHEKFTIQLQ LSQKSSESEL SKSASAKSID SKVADAATEV
160 170 180 190 200
QHKTTEALKS EEKAMDISAM PRGTPLYGQP SWWGDDEVDE KRAFKTNGKP
210 220 230 240 250
EEKNHEAGTS GCGIDAKQVE EQSAAANEEV LFPFCREPSY FEIPTKEFQQ
260 270 280 290 300
PSQITESTIH EIPTKDTPSS HITGAGHASF TIEFDDSTPG KVTIRDHVTK
310 320 330 340 350
FTSDQRHKSK KSSPGTQDLL GIQTGMMAPE NKVADWLAQN NPPQMLWERT
360 370 380 390 400
EEDSKSIKSD VPVYLKRLKG NKHDDGTQSD SENAGAHRRC SKRATLEEHL
410 420 430 440 450
RRHHSEHKKL QKVQATEKHQ DQAVTSSAHH RGGHGVPHGK LLKQKSEEPS
460 470 480 490 500
VSIPFLQTAL LRSSGSLGHR PSQEMDKMLK NQATSATSEK DNDDDQSDKG
510 520 530 540 550
TYTIELENPN SEEVEARKMI DKVFGVDDNQ DYNRPVINEK HKDLIKDWAL
560 570 580 590 600
SSAAAVMEER KPLTTSGFHH SEEGTSSSGS KRWVSQWASL AANHTRHDQE
610 620 630 640 650
ERIMEFSAPL PLENETEISE SGMTVRSTGS ATSLASQGER RRRTLPQLPN
660 670 680 690 700
EEKSLESHRA KVVTQRSEIG EKQDTELQEK ETPTQVYQKD KQDADRPLSK
710 720 730 740 750
MNRAVNGETL KTGGDNKTLL HLGSSAPGKE KSETDKETSL VKQTLAKLQQ
760 770 780 790 800
QEQREEAQWT PTKLSSKNVS GQTDKCREET FKQESQPPEK NSGHSTSKGD
810 820 830 840 850
RVAQSESKRR KAEEILKSQT PKGGDKKESS KSLVRQGSFT IEKPSPNIPI
860 870 880 890 900
ELIPHINKQT SSTPSSLALT SASRIRERSE SLDPDSSMDT TLILKDTEAV
910 920 930 940 950
MAFLEAKLRE DNKTDEGPDT PSYNRDNSIS PESDVDTAST ISLVTGETER
960 970 980 990 1000
KSTQKRKSFT SLYKDRCSTG SPSKDVTKSS SSGAREKMEK KTKSRSTDVG
1010 1020 1030 1040 1050
SRADGRKFVQ SSGRIRQPSV DLTDDDQTSS VPHSAISDIM SSDQETYSCK
1060 1070 1080 1090 1100
PHGRTPLTSA DEHVHSKLEG SKVTKSKTSP VVSGSSSKST TLPRPRPTRT
1110 1120 1130 1140 1150
SLLRRARLGE ASDSELADAD KASVASEVST TSSTSKPPTG RRNISRIDLL
1160 1170 1180 1190 1200
AQPRRTRLGS LSARSDSEAT ISRSSASSRT AEAIIRSGAR LVPSDKFSPR
1210 1220 1230 1240 1250
IRANSISRLS DSKVKSMTSA HGSASVNSRW RRFPTDYAST SEDEFGSNRN
1260 1270 1280 1290 1300
SPKHTRLRTS PALKTTRLQS AGSAMPTSSS FKHRIKEQED YIRDWTAHRE
1310 1320 1330 1340 1350
EIARISQDLA LIAREINDVA GEIDSVTSSG TAPSTTVSTA ATTPGSAIDT
1360 1370 1380 1390 1400
REELVDRVFD ESLNFRKIPP LVHSKTPEGN NGRSGDPRPQ AAEPPDHLTI
1410 1420 1430 1440 1450
TRRRTWSRDE VMGDNLLLSS VFQFSKKIRQ SIDKTAGKIR ILFKDKDRNW
1460 1470 1480 1490 1500
DDIESKLRAE SEVPIVKTSS MEISSILQEL KRVEKQLQAI NAMIDPDGTL
1510 1520 1530 1540 1550
EALNNMGFPS AMLPSPPKQK SSPVNNHHSP GQTPTLGQPE ARALHPAAVS
1560 1570 1580
AAAEFENAES EADFSIHFNR FNPDGEEEDV TVQE
Length:1,584
Mass (Da):175,293
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50E981650D21B2E6
GO
Isoform 2 (identifier: Q5SW79-2) [UniParc]FASTAAdd to basket
Also known as: Gamma, 3

The sequence of this isoform differs from the canonical sequence as follows:
     425-522: Missing.
     1226-1261: Missing.
     1353-1353: E → EVGDLHGEMHK

Show »
Length:1,460
Mass (Da):161,408
Checksum:i4EEECA047C7B0EFA
GO
Isoform 3 (identifier: Q5SW79-3) [UniParc]FASTAAdd to basket
Also known as: Beta, KAB2

The sequence of this isoform differs from the canonical sequence as follows:
     425-522: Missing.

Show »
Length:1,486
Mass (Da):164,539
Checksum:i376DEE4949EC24D1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y2V6H0Y2V6_HUMAN
Centrosomal protein of 170 kDa
CEP170
1,558Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EMW0E7EMW0_HUMAN
Centrosomal protein of 170 kDa
CEP170
320Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWM2E7EWM2_HUMAN
Centrosomal protein of 170 kDa
CEP170
293Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4T4H0Y4T4_HUMAN
Centrosomal protein of 170 kDa
CEP170
263Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG47E5RG47_HUMAN
Centrosomal protein of 170 kDa
CEP170
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB92H0YB92_HUMAN
Centrosomal protein of 170 kDa
CEP170
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJT5E5RJT5_HUMAN
Centrosomal protein of 170 kDa
CEP170
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFU8E5RFU8_HUMAN
Centrosomal protein of 170 kDa
CEP170
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIH6E5RIH6_HUMAN
Centrosomal protein of 170 kDa
CEP170
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB66H0YB66_HUMAN
Centrosomal protein of 170 kDa
CEP170
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA32315 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031437213G → S3 PublicationsCorresponds to variant dbSNP:rs2631092Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_024240425 – 522Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST98
Alternative sequenceiVSP_0242411226 – 1261Missing in isoform 2. 3 PublicationsAdd BLAST36
Alternative sequenceiVSP_0242421353E → EVGDLHGEMHK in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB022657 mRNA Translation: BAA83378.1
AB022658 mRNA Translation: BAA83379.1
AB022659 mRNA Translation: BAA83380.1
AB007939 mRNA Translation: BAA32315.2 Different initiation.
AC092782 Genomic DNA No translation available.
AL606534 Genomic DNA No translation available.
BC050722 mRNA Translation: AAH50722.1 Different termination.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44337.1 [Q5SW79-3]
CCDS44338.1 [Q5SW79-2]
CCDS44339.1 [Q5SW79-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00095

NCBI Reference Sequences

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RefSeqi
NP_001035863.1, NM_001042404.1 [Q5SW79-3]
NP_001035864.1, NM_001042405.1 [Q5SW79-2]
NP_055627.2, NM_014812.2 [Q5SW79-1]
XP_016858425.1, XM_017002936.1 [Q5SW79-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.533635

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366542; ENSP00000355500; ENSG00000143702 [Q5SW79-1]
ENST00000366543; ENSP00000355501; ENSG00000143702 [Q5SW79-2]
ENST00000366544; ENSP00000355502; ENSG00000143702 [Q5SW79-3]
ENST00000450306; ENSP00000482707; ENSG00000276725 [Q5SW79-3]
ENST00000612450; ENSP00000483344; ENSG00000276725 [Q5SW79-1]
ENST00000621831; ENSP00000484359; ENSG00000276725 [Q5SW79-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9859

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9859

UCSC genome browser

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UCSCi
uc057qug.1 human [Q5SW79-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022657 mRNA Translation: BAA83378.1
AB022658 mRNA Translation: BAA83379.1
AB022659 mRNA Translation: BAA83380.1
AB007939 mRNA Translation: BAA32315.2 Different initiation.
AC092782 Genomic DNA No translation available.
AL606534 Genomic DNA No translation available.
BC050722 mRNA Translation: AAH50722.1 Different termination.
CCDSiCCDS44337.1 [Q5SW79-3]
CCDS44338.1 [Q5SW79-2]
CCDS44339.1 [Q5SW79-1]
PIRiT00095
RefSeqiNP_001035863.1, NM_001042404.1 [Q5SW79-3]
NP_001035864.1, NM_001042405.1 [Q5SW79-2]
NP_055627.2, NM_014812.2 [Q5SW79-1]
XP_016858425.1, XM_017002936.1 [Q5SW79-1]
UniGeneiHs.533635

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JONX-ray2.15A/B/C/D/E1-126[»]
ProteinModelPortaliQ5SW79
SMRiQ5SW79
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115193, 206 interactors
DIPiDIP-37594N
IntActiQ5SW79, 172 interactors
MINTiQ5SW79
STRINGi9606.ENSP00000355500

PTM databases

iPTMnetiQ5SW79
PhosphoSitePlusiQ5SW79

Polymorphism and mutation databases

BioMutaiCEP170
DMDMi74743919

Proteomic databases

EPDiQ5SW79
MaxQBiQ5SW79
PaxDbiQ5SW79
PeptideAtlasiQ5SW79
PRIDEiQ5SW79
ProteomicsDBi63964
63965 [Q5SW79-2]
63966 [Q5SW79-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366542; ENSP00000355500; ENSG00000143702 [Q5SW79-1]
ENST00000366543; ENSP00000355501; ENSG00000143702 [Q5SW79-2]
ENST00000366544; ENSP00000355502; ENSG00000143702 [Q5SW79-3]
ENST00000450306; ENSP00000482707; ENSG00000276725 [Q5SW79-3]
ENST00000612450; ENSP00000483344; ENSG00000276725 [Q5SW79-1]
ENST00000621831; ENSP00000484359; ENSG00000276725 [Q5SW79-2]
GeneIDi9859
KEGGihsa:9859
UCSCiuc057qug.1 human [Q5SW79-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9859
DisGeNETi9859
EuPathDBiHostDB:ENSG00000143702.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CEP170

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0004456
HGNCiHGNC:28920 CEP170
HPAiHPA042151
HPA045597
HPA045787
MIMi613023 gene
neXtProtiNX_Q5SW79
OpenTargetsiENSG00000143702
PharmGKBiPA128395757

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II6S Eukaryota
ENOG4110JY6 LUCA
GeneTreeiENSGT00940000155103
HOVERGENiHBG058059
InParanoidiQ5SW79
KOiK16463
OMAiSSGNKRW
OrthoDBiEOG091G00LH
PhylomeDBiQ5SW79
TreeFamiTF328469

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CEP170 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CEP170

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9859
PMAP-CutDBiQ5SW79

Protein Ontology

More...
PROi
PR:Q5SW79

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143702 Expressed in 238 organ(s), highest expression level in corpus callosum
CleanExiHS_CEP170
ExpressionAtlasiQ5SW79 baseline and differential
GenevisibleiQ5SW79 HS

Family and domain databases

CDDicd00060 FHA, 1 hit
InterProiView protein in InterPro
IPR026644 CEP170
IPR029300 CEP170_C
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR15715:SF17 PTHR15715:SF17, 1 hit
PfamiView protein in Pfam
PF15308 CEP170_C, 1 hit
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCE170_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SW79
Secondary accession number(s): O75058
, Q5SW77, Q5SW78, Q7LGA9, Q86W31, Q9UQ08, Q9UQ09
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 21, 2004
Last modified: December 5, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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