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Entry version 132 (16 Oct 2019)
Sequence version 2 (15 Mar 2005)
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Protein

Protein phosphatase Slingshot homolog 2

Gene

Ssh2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.1 Publication

Miscellaneous

Tyrosine phosphatase activity has not been demonstrated for this protein to date.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei392Phosphocysteine intermediateCurated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Hydrolase, Protein phosphatase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein phosphatase Slingshot homolog 2 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
SSH-like protein 2
Short name:
SSH-2L
Short name:
mSSH-2L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ssh2
Synonyms:Kiaa1725, Ssh2l
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2679255 Ssh2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi392C → S: Abrogates phosphatase activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000948441 – 1423Protein phosphatase Slingshot homolog 2Add BLAST1423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei17PhosphoserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei36PhosphoserineBy similarity1
Modified residuei461PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei1217PhosphoserineBy similarity1
Modified residuei1422PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5SW75

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5SW75

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5SW75

PeptideAtlas

More...
PeptideAtlasi
Q5SW75

PRoteomics IDEntifications database

More...
PRIDEi
Q5SW75

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SW75

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SW75

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, heart, liver, skeletal muscle, testis and thymus. Also expressed at lower levels in kidney, small intestine and spleen.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the nervous system at 14.5 dpc.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000037926 Expressed in 244 organ(s), highest expression level in mesenteric lymph node

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5SW75 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SW75 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with filamentous actin.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
231916, 1 interactor

Protein interaction database and analysis system

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IntActi
Q5SW75, 1 interactor

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000042625

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5SW75

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini307 – 447Tyrosine-protein phosphataseAdd BLAST141

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1716 Eukaryota
COG2453 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157430

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SW75

KEGG Orthology (KO)

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KOi
K05766

Identification of Orthologs from Complete Genome Data

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OMAi
KWDPEGC

Database of Orthologous Groups

More...
OrthoDBi
1576308at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SW75

TreeFam database of animal gene trees

More...
TreeFami
TF319444

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014876 DEK_C
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08766 DEK_C, 1 hit
PF00782 DSPc, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00195 DSPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SW75-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALVTVQRSP TPSTTSSPCA SEADSGEEEC RSQPRSISES FLTVKGAALF
60 70 80 90 100
LPRGNGSSTP RVSHRRNKHA GDLQQHLQAM FILLRPEDNI RLAVRLESTY
110 120 130 140 150
QNRTRYMVVV STNGRQDTEE SIVLGMDFSS NDSSTCTMGL VLPLWSDTLI
160 170 180 190 200
HLDGDGGFSV STDNRVHIFK PVSVQAMWSA LQSLHKACEV ARMHNYYPGS
210 220 230 240 250
LFLTWVSYYE SHINSDQSSV NEWNAMQDVQ SHRPDSPALF TDIPTERERT
260 270 280 290 300
ERLIKTKLRE IMMQKDLENI TSKEIRTELE MQMVCNLREF KEFIDNEMIV
310 320 330 340 350
ILGQMDSPTQ IFEHVFLGSE WNASNLEDLQ NRGVRYILNV TREIDNFFPG
360 370 380 390 400
VFEYHNIRVY DEEATDLLAY WNDTYKFISK AKKHGSKCLV HCKMGVSRSA
410 420 430 440 450
STVIAYAMKE YGWNLDRAYD YVKERRTVTK PNPSFMRQLE EYQGILLASK
460 470 480 490 500
QRHNKLWRSH SDSDLSDHHE PICKPGLELN KKEMTTSADQ IAEVKTVENL
510 520 530 540 550
AAMPTVFMEH VVPQDANQKG LHTKERVICL EFSSQEFRAG QIEDELNLND
560 570 580 590 600
INGCSSGCCL SESKLPLDNC HASKALLQPG QAPDIANKFP DLAVEDLETD
610 620 630 640 650
ALKADMNVHL LPMEELTSRL KDLPMSPDLE SPSPQASCQA AISDFSTDRI
660 670 680 690 700
DFFSALEKFV ELSQETRSRS FSHSRIEELG GGRSEGCRLS VIEVAASEMA
710 720 730 740 750
ADDQRSSSLS NTPHASEESS VDEDQSKAIT ELVSPDIIMQ SHSENAISVK
760 770 780 790 800
EIVTEIESIS QGVGQVQLKG DILSNPCHTP KKSTIHELPL ERVPAPESKP
810 820 830 840 850
GHWEQDESFC SVQPELARDS GKCAPEEGCL TTHSSTADLE EEEPVEGEHD
860 870 880 890 900
WGPGMHSGAK WCPGSVRRAT LEFEERLRQE QENHGTASAG PTLSNRKNSK
910 920 930 940 950
NDSSVADLMP KWKSDETTPE HSFFLKEAEP SKGKGKCSGS EAGSLSHCER
960 970 980 990 1000
NPTMPDCELL EHHSLPAPQD CLGSDSRSKK QEGDLKKQRA VVPNQECDTQ
1010 1020 1030 1040 1050
AILLPLPKKI EIIEYTPTVT SLGHTEPGGE ATPSKEGEKQ GLRKVKMEQS
1060 1070 1080 1090 1100
ITMFCALDEN LNRTLEPSQV SLHPQVLPLP HSSSECDRPA DPNPMLSSPQ
1110 1120 1130 1140 1150
DKGDCPSTPF KTAAPFVSCS TQGASFSLDY LLPHSVVHLE GCTEQSSATD
1160 1170 1180 1190 1200
NELSPEQASW EDSRGHFLSS GSGMAHTSSP LTNEDLSLIN KLGDSVGVLQ
1210 1220 1230 1240 1250
KKLDPSPEAC RIPHSSSSEN IRDLSHSRGV VKEHAKEIES RVIFQAGFSK
1260 1270 1280 1290 1300
TSQMKRSASL AKLGYLDLCK DYLPDRELVS SESPHLKLLQ PFLRTDSGMH
1310 1320 1330 1340 1350
ALMAHEPSES AGAQQNPQPT KYSVEQLKTS ECIVQSKPVE RPSVQYAKEF
1360 1370 1380 1390 1400
GYSQQCLLPK ARPELTSSEG GLPLLQTQGL QYTGPSPGLA VAPRQQHGRT
1410 1420
HPLRRLKRAN DKKRTTNPFY NTM
Length:1,423
Mass (Da):158,230
Last modified:March 15, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F2608E87A72BAFD
GO
Isoform 2 (identifier: Q5SW75-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MALVTVQRSP...EEECRSQPRS → MTLSTLAGER...VISQNAINQL

Show »
Length:1,430
Mass (Da):158,900
Checksum:iDC554069F95CD99D
GO
Isoform 3 (identifier: Q5SW75-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: MALVTVQRSP...EEECRSQPRS → MTLSTLAGER...VISQNAINQL
     133-133: S → R
     134-1423: Missing.

Note: No experimental confirmation available.
Show »
Length:140
Mass (Da):15,439
Checksum:i05F40C9021BA2B9D
GO
Isoform 4 (identifier: Q5SW75-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-21: S → SSSYLEDSESAALLCCEYGESEIFSDFN

Note: Gene prediction based on EST data. No experimental confirmation available.
Show »
Length:1,450
Mass (Da):161,221
Checksum:iA76802D4C70636BF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J2A0A0A0R4J2A0_MOUSE
Protein phosphatase Slingshot homol...
Ssh2
1,429Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQJ2A0A0A0MQJ2_MOUSE
Protein phosphatase Slingshot homol...
Ssh2
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAE41593 differs from that shown. Intron retention.Curated
The sequence CAI24907 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI35940 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI51882 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti133Missing in BAE33137 (PubMed:16141072).Curated1
Sequence conflicti325N → D in BAE41593 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0163261 – 36MALVT…SQPRS → MTLSTLAGERKALPASTCSL GGPDMIPYFSANAVISQNAI NQL in isoform 2 and isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_01632721S → SSSYLEDSESAALLCCEYGE SEIFSDFN in isoform 4. Curated1
Alternative sequenceiVSP_016328133S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_016329134 – 1423Missing in isoform 3. 1 PublicationAdd BLAST1290

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB099288 mRNA Translation: BAC97811.1
AK155232 mRNA Translation: BAE33137.1
AK158449 mRNA Translation: BAE34514.1
AK170142 mRNA Translation: BAE41593.1 Sequence problems.
AL606724, AL607072, AL663066 Genomic DNA Translation: CAI24906.2
AL606724, AL663066 Genomic DNA Translation: CAI24907.1 Sequence problems.
AL663066, AL606724, AL607072 Genomic DNA Translation: CAI35939.2
AL663066, AL606724 Genomic DNA Translation: CAI35940.1 Sequence problems.
AL606724 Genomic DNA Translation: CAI51882.1 Sequence problems.
AL607072, AL606724, AL663066 Genomic DNA Translation: CAI52040.1
BC141392 mRNA Translation: AAI41393.1
BC141393 mRNA Translation: AAI41394.1
AK173243 mRNA Translation: BAD32521.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25076.1 [Q5SW75-1]

NCBI Reference Sequences

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RefSeqi
NP_001278119.1, NM_001291190.1
NP_808378.2, NM_177710.4 [Q5SW75-1]
XP_006533290.1, XM_006533227.3 [Q5SW75-4]
XP_006533292.1, XM_006533229.3 [Q5SW75-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000037912; ENSMUSP00000042625; ENSMUSG00000037926 [Q5SW75-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
237860

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:237860

UCSC genome browser

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UCSCi
uc007kgl.2 mouse [Q5SW75-1]
uc007kgo.2 mouse [Q5SW75-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB099288 mRNA Translation: BAC97811.1
AK155232 mRNA Translation: BAE33137.1
AK158449 mRNA Translation: BAE34514.1
AK170142 mRNA Translation: BAE41593.1 Sequence problems.
AL606724, AL607072, AL663066 Genomic DNA Translation: CAI24906.2
AL606724, AL663066 Genomic DNA Translation: CAI24907.1 Sequence problems.
AL663066, AL606724, AL607072 Genomic DNA Translation: CAI35939.2
AL663066, AL606724 Genomic DNA Translation: CAI35940.1 Sequence problems.
AL606724 Genomic DNA Translation: CAI51882.1 Sequence problems.
AL607072, AL606724, AL663066 Genomic DNA Translation: CAI52040.1
BC141392 mRNA Translation: AAI41393.1
BC141393 mRNA Translation: AAI41394.1
AK173243 mRNA Translation: BAD32521.1
CCDSiCCDS25076.1 [Q5SW75-1]
RefSeqiNP_001278119.1, NM_001291190.1
NP_808378.2, NM_177710.4 [Q5SW75-1]
XP_006533290.1, XM_006533227.3 [Q5SW75-4]
XP_006533292.1, XM_006533229.3 [Q5SW75-2]

3D structure databases

SMRiQ5SW75
ModBaseiSearch...

Protein-protein interaction databases

BioGridi231916, 1 interactor
IntActiQ5SW75, 1 interactor
STRINGi10090.ENSMUSP00000042625

PTM databases

iPTMnetiQ5SW75
PhosphoSitePlusiQ5SW75

Proteomic databases

EPDiQ5SW75
jPOSTiQ5SW75
PaxDbiQ5SW75
PeptideAtlasiQ5SW75
PRIDEiQ5SW75

Genome annotation databases

EnsembliENSMUST00000037912; ENSMUSP00000042625; ENSMUSG00000037926 [Q5SW75-1]
GeneIDi237860
KEGGimmu:237860
UCSCiuc007kgl.2 mouse [Q5SW75-1]
uc007kgo.2 mouse [Q5SW75-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
85464
MGIiMGI:2679255 Ssh2

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00940000157430
InParanoidiQ5SW75
KOiK05766
OMAiKWDPEGC
OrthoDBi1576308at2759
PhylomeDBiQ5SW75
TreeFamiTF319444

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Ssh2 mouse

Protein Ontology

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PROi
PR:Q5SW75

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000037926 Expressed in 244 organ(s), highest expression level in mesenteric lymph node
ExpressionAtlasiQ5SW75 baseline and differential
GenevisibleiQ5SW75 MM

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR014876 DEK_C
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PfamiView protein in Pfam
PF08766 DEK_C, 1 hit
PF00782 DSPc, 1 hit
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSSH2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SW75
Secondary accession number(s): B9EJ94
, Q3TDK8, Q3TYP8, Q3U2K3, Q5F268, Q5SW74, Q69ZC3, Q76I78
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: March 15, 2005
Last modified: October 16, 2019
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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