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Entry version 109 (16 Oct 2019)
Sequence version 1 (21 Dec 2004)
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Protein

Dapper homolog 2

Gene

DACT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q5SW24

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q5SW24

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dapper homolog 2
Alternative name(s):
Dapper antagonist of catenin 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DACT2
Synonyms:C6orf116
ORF Names:PP13671
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21231 DACT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608966 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5SW24

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
168002

Open Targets

More...
OpenTargetsi
ENSG00000164488

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134934623

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5SW24

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DACT2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74743909

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003261991 – 774Dapper homolog 2Add BLAST774

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5SW24

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SW24

PRoteomics IDEntifications database

More...
PRIDEi
Q5SW24

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
63960 [Q5SW24-1]
63961 [Q5SW24-2]
63962 [Q5SW24-3]
63963 [Q5SW24-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SW24

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SW24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164488 Expressed in 95 organ(s), highest expression level in placenta

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SW24 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA030251
HPA030252

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can form homodimers and heterodimers with DACT1 or DACT3.

Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, CSNK2B, DVL1, DVL2, DVL3, VANGL1, VANGL2, TGFBR1, CTNNB1, CTNND2, CTNND1, LEF1, TCF7, TCF7L1 and HDAC1 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127953, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q5SW24, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000355760

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili67 – 93Sequence analysisAdd BLAST27

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi771 – 774PDZ-bindingBy similarity4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dapper family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK2I Eukaryota
ENOG410ZHU0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183181

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112138

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SW24

KEGG Orthology (KO)

More...
KOi
K22154

Identification of Orthologs from Complete Genome Data

More...
OMAi
EFVHAQF

Database of Orthologous Groups

More...
OrthoDBi
242694at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SW24

TreeFam database of animal gene trees

More...
TreeFami
TF331300

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024853 Dact2
IPR024843 Dapper

The PANTHER Classification System

More...
PANTHERi
PTHR15919 PTHR15919, 1 hit
PTHR15919:SF13 PTHR15919:SF13, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15268 Dapper, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5SW24-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWTPGGPPGS AGWDRRRLGA RLRAAFAGLQ ELQGLRATQQ ERVRGALALQ
60 70 80 90 100
PPPAPAAPCG PHGLHGPEQQ LEAALAALQE QLSRLRQQDI GLKTHLDQLD
110 120 130 140 150
LQISKLQLDV GTASGEALDS DSRPSSGFYE MSDGGSCSLS TSCASVCSDH
160 170 180 190 200
ISPSLGSLLP VAQAHKARPS MGDWRPRSVD ETTVPAWRPQ ATEEGARPPG
210 220 230 240 250
SVEDAGQPWG TFWPRPVSTG DLDRALPADT GLQKASADAE LLGLLCQGVD
260 270 280 290 300
IPLHVPDPKY RQDLVSQGGR EVYPYPSPLH AVALQSPLFV LTKETPQRGG
310 320 330 340 350
PSFPRESPRG PAGLNTIQTG PVLEAGPARA RAYIDRLLHL WGRETPAKGS
360 370 380 390 400
EGEQGPLRHA ASPSPQRQGG WSTDGGGRLL VFAPGREDEG GPAQSRGAGR
410 420 430 440 450
GGPQQQGYMP LEGPQQSGSL PEEGSKPSNS CVLRETMVQA SPSSKAQQTP
460 470 480 490 500
SAQDYGRGNI ISPSRMLDKS PSPASGHFAH PSFAASLKMG PPKSKAEKIK
510 520 530 540 550
RSPMDKVLRF ARQPLLLLDR PEGAHAAPQP SLEWDPAHWP TGRGGLQRRP
560 570 580 590 600
ALAWEAPGRS CSESTLYPMP VLVPLAVAPQ ESHRTSAQAL FPFEASLLTS
610 620 630 640 650
VARRKHRRWQ STVEISARAR LASCPESNLG PPRPVARRAG GPLARGRPSL
660 670 680 690 700
VRQDAYTRSD SEPSKHSAEC DPRFPSVIPE TSEGESSDHT TNRFGDRESS
710 720 730 740 750
SSDEEGGAQS RDCDLALGYV AAGHAELAWT QEAPVSSGPL LSPVPKLCRI
760 770
KASKALKKKI RRFQPTALKV MTMV
Length:774
Mass (Da):82,700
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DA03DE7E12FE611
GO
Isoform 2 (identifier: Q5SW24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.

Note: No experimental confirmation available.
Show »
Length:604
Mass (Da):64,898
Checksum:i018FDB48B0545226
GO
Isoform 3 (identifier: Q5SW24-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-408: Missing.

Note: No experimental confirmation available.
Show »
Length:366
Mass (Da):39,578
Checksum:i010DEF81A7D34279
GO
Isoform 4 (identifier: Q5SW24-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-280: GDLDRALPAD...EVYPYPSPLH → ELCNAPGELD...TKSSGISRQQ
     281-774: Missing.

Note: No experimental confirmation available.
Show »
Length:280
Mass (Da):29,350
Checksum:i93407A7009A408E9
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI11791 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL55843 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti138S → F in AAH92498 (PubMed:15489334).Curated1
Sequence conflicti725A → E in AAL55843 (PubMed:15498874).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059969351E → G. Corresponds to variant dbSNP:rs6925614Ensembl.1
Natural variantiVAR_059970541T → P. Corresponds to variant dbSNP:rs10945501Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0325951 – 408Missing in isoform 3. 1 PublicationAdd BLAST408
Alternative sequenceiVSP_0325961 – 170Missing in isoform 2. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_032597220 – 280GDLDR…PSPLH → ELCNAPGELDMHAPPAGCTS SSLTGVGSGLRGKCGLCGCQ LPFCSVNTSSKTKSSGISRQ Q in isoform 4. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_032598281 – 774Missing in isoform 4. 1 PublicationAdd BLAST494

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF318336 mRNA Translation: AAL55843.1 Frameshift.
AL606970 Genomic DNA No translation available.
BC092498 mRNA Translation: AAH92498.1
BC111764 mRNA Translation: AAI11765.1
BC111790 mRNA Translation: AAI11791.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47519.1 [Q5SW24-1]
CCDS69241.1 [Q5SW24-4]
CCDS75554.1 [Q5SW24-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001273279.1, NM_001286350.1 [Q5SW24-2]
NP_001273280.1, NM_001286351.1 [Q5SW24-4]
NP_999627.2, NM_214462.4 [Q5SW24-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000366795; ENSP00000355760; ENSG00000164488 [Q5SW24-1]
ENST00000366796; ENSP00000355761; ENSG00000164488 [Q5SW24-4]
ENST00000607983; ENSP00000476434; ENSG00000164488 [Q5SW24-3]
ENST00000610183; ENSP00000476573; ENSG00000164488 [Q5SW24-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
168002

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:168002

UCSC genome browser

More...
UCSCi
uc003qwq.5 human [Q5SW24-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318336 mRNA Translation: AAL55843.1 Frameshift.
AL606970 Genomic DNA No translation available.
BC092498 mRNA Translation: AAH92498.1
BC111764 mRNA Translation: AAI11765.1
BC111790 mRNA Translation: AAI11791.1 Different initiation.
CCDSiCCDS47519.1 [Q5SW24-1]
CCDS69241.1 [Q5SW24-4]
CCDS75554.1 [Q5SW24-2]
RefSeqiNP_001273279.1, NM_001286350.1 [Q5SW24-2]
NP_001273280.1, NM_001286351.1 [Q5SW24-4]
NP_999627.2, NM_214462.4 [Q5SW24-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi127953, 6 interactors
IntActiQ5SW24, 2 interactors
STRINGi9606.ENSP00000355760

PTM databases

iPTMnetiQ5SW24
PhosphoSitePlusiQ5SW24

Polymorphism and mutation databases

BioMutaiDACT2
DMDMi74743909

Proteomic databases

MassIVEiQ5SW24
PaxDbiQ5SW24
PRIDEiQ5SW24
ProteomicsDBi63960 [Q5SW24-1]
63961 [Q5SW24-2]
63962 [Q5SW24-3]
63963 [Q5SW24-4]

Genome annotation databases

EnsembliENST00000366795; ENSP00000355760; ENSG00000164488 [Q5SW24-1]
ENST00000366796; ENSP00000355761; ENSG00000164488 [Q5SW24-4]
ENST00000607983; ENSP00000476434; ENSG00000164488 [Q5SW24-3]
ENST00000610183; ENSP00000476573; ENSG00000164488 [Q5SW24-2]
GeneIDi168002
KEGGihsa:168002
UCSCiuc003qwq.5 human [Q5SW24-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
168002
DisGeNETi168002

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DACT2
HGNCiHGNC:21231 DACT2
HPAiHPA030251
HPA030252
MIMi608966 gene
neXtProtiNX_Q5SW24
OpenTargetsiENSG00000164488
PharmGKBiPA134934623

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IK2I Eukaryota
ENOG410ZHU0 LUCA
GeneTreeiENSGT00950000183181
HOGENOMiHOG000112138
InParanoidiQ5SW24
KOiK22154
OMAiEFVHAQF
OrthoDBi242694at2759
PhylomeDBiQ5SW24
TreeFamiTF331300

Enzyme and pathway databases

SignaLinkiQ5SW24
SIGNORiQ5SW24

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
168002
PharosiQ5SW24

Protein Ontology

More...
PROi
PR:Q5SW24

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164488 Expressed in 95 organ(s), highest expression level in placenta
GenevisibleiQ5SW24 HS

Family and domain databases

InterProiView protein in InterPro
IPR024853 Dact2
IPR024843 Dapper
PANTHERiPTHR15919 PTHR15919, 1 hit
PTHR15919:SF13 PTHR15919:SF13, 1 hit
PfamiView protein in Pfam
PF15268 Dapper, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDACT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SW24
Secondary accession number(s): Q2NKJ2, Q569G0, Q8WYW2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: December 21, 2004
Last modified: October 16, 2019
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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