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Protein

Clustered mitochondria protein homolog

Gene

Cluh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Clustered mitochondria protein homologUniRule annotation
Gene namesi
Name:Cluh
Synonyms:Kiaa0664
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1921398 Cluh

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003663731 – 1315Clustered mitochondria protein homologAdd BLAST1315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei279PhosphoserineBy similarity1
Modified residuei281PhosphoserineBy similarity1
Modified residuei655PhosphoserineBy similarity1
Modified residuei725PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5SW19
PaxDbiQ5SW19
PeptideAtlasiQ5SW19
PRIDEiQ5SW19

PTM databases

iPTMnetiQ5SW19
PhosphoSitePlusiQ5SW19
SwissPalmiQ5SW19

Interactioni

Protein-protein interaction databases

BioGridi216526, 1 interactor
IntActiQ5SW19, 5 interactors
MINTiQ5SW19
STRINGi10090.ENSMUSP00000090593

Structurei

3D structure databases

ProteinModelPortaliQ5SW19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini335 – 577CluPROSITE-ProRule annotationAdd BLAST243
Repeati980 – 1013TPR 1Add BLAST34
Repeati1022 – 1055TPR 2Add BLAST34
Repeati1106 – 1139TPR 3Add BLAST34
Repeati1148 – 1181TPR 4Add BLAST34

Sequence similaritiesi

Belongs to the CLU family.UniRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1839 Eukaryota
ENOG410XQUQ LUCA
HOVERGENiHBG108020
InParanoidiQ5SW19
KOiK03255
PhylomeDBiQ5SW19
TreeFamiTF300565

Family and domain databases

CDDicd15466 CLU-central, 1 hit
Gene3Di1.25.40.10, 1 hit
HAMAPiMF_03013 CLU, 1 hit
InterProiView protein in InterPro
IPR027523 CLU
IPR033646 CLU-central
IPR025697 CLU_dom
IPR028275 CLU_N
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13236 CLU, 1 hit
PF15044 CLU_N, 1 hit
PF12807 eIF3_p135, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS51823 CLU, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SW19-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLNGDCSEN LKKEEGTSEP PRENGLDEGE PGDETTGQEV IVIQDTGFSV
60 70 80 90 100
KILAPGIEPF SLQVSPQEMV QEIHQVLMDR EDTCHRTCFS LHLDGNMLDH
110 120 130 140 150
FSELRSVEGL QEGSVLRVVE EPYTVREARI HVRHVRDLLK SLDPSDAFNG
160 170 180 190 200
VDCNSLSFLS VFTDGDLGDS GKRKKGLEMD PIDCTPPEYI LPGSRERPLC
210 220 230 240 250
PLQPQNRDWK PLQCLKVLTM SGWNPPPGNR KMHGDLMYLF VITAEDRQVS
260 270 280 290 300
ITASTRGFYL NQSTAYHFNP KPASPRFLSH SLVELLNQIS PTFKKNFAVL
310 320 330 340 350
QKKRVQRHPF ERIATPFQVY SWTAPQAEHA MDCVRAEDAY TSRLGYEEHI
360 370 380 390 400
PGQTRDWNEE LQTTRELPRK NLPERLLRER AIFKVHSDFT AAATRGAMAV
410 420 430 440 450
IDGNVMAINP SEETKMQMFI WNNIFFSLGF DVRDHYKDFG GDVAAYVAPT
460 470 480 490 500
NDLNGVRTYN AVDVEGLYTL GTVVVDYRGY RVTAQSIIPG ILERDQEQSV
510 520 530 540 550
IYGSIDFGKT VVSHPRYLEL LERTSRPLKI LRHRVLNDRD EEVELCSSVE
560 570 580 590 600
CKGIIGNDGR HYILDLLRTF PPDLNFLPVP GEELPEECSR AGFPRTHRHK
610 620 630 640 650
LCCLRQELVD AFVEHRYLLF MKLAALQLMQ QKASKVETTT SLENGGLPSS
660 670 680 690 700
AETKSEDSIG PEAGCEEEGS SVSGLAKVKE LAETIASDDG TVDPRSREVI
710 720 730 740 750
RNACKAVGSI SSTAFDIRFN PDIFSPGVRF PESCQDEVRD QKQLLKDAAA
760 770 780 790 800
FLLSCQIPGL VKDCTEYAVL PMDGATLAEV MRQRGINMRY LGKVLDLVLR
810 820 830 840 850
SPARDQLDHI YKIGIGELIT RSAKHIFKTY LQGVELSGLS AAISHFLNCF
860 870 880 890 900
LSSYPNPVAH LPADELLSKK RNKRRKNRPP GAADNTAWAV MTPQELWKNI
910 920 930 940 950
CHEAKNYFDF TLECDSVDQA VETYGLQKIT LLREISLKTG IQILLKEYSF
960 970 980 990 1000
DSRHKPAFTE EDVLNIFPVV KHVNPKASDA FHFFQSGQAK VQQGFLKEGC
1010 1020 1030 1040 1050
ELINEALNLF NNVYGAMHVE ICACLRLLAR LHYIMGDYAE ALSNQQKAVL
1060 1070 1080 1090 1100
MSERVMGIEH PNTIQEYMHL ALYCFASSQL STALSLLYRA RYLMLLVFGE
1110 1120 1130 1140 1150
DHPEMALLDN NIGLVLHGVM EYDLSLRFLE NALAVTTKYH GPKALKVALS
1160 1170 1180 1190 1200
HHLVARVYES KAEFRSALQH EKEGYTIYKT QLGEDHEKTK ESSEYLKCLT
1210 1220 1230 1240 1250
QQAVALQRTM NEIYRNGSSA NIPPLKFTAP SMTSVLEQLN VINGILFIPL
1260 1270 1280 1290 1300
SQKDLENLKA EVARRHQLQE ANRNRDKAEE QPMAPEPEPE PERAVEDMGS
1310
PQTAKEGPSS LNLQG
Length:1,315
Mass (Da):148,068
Last modified:March 24, 2009 - v2
Checksum:i868CC53BDA8E3A65
GO
Isoform 2 (identifier: Q5SW19-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     762-856: KDCTEYAVLP...LNCFLSSYPN → REGLKGWVGA...CPISQRRRQI
     857-1315: Missing.

Note: No experimental confirmation available.
Show »
Length:818
Mass (Da):91,836
Checksum:iC4383C8232BD39B4
GO
Isoform 3 (identifier: Q5SW19-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     761-811: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:1,264
Mass (Da):142,251
Checksum:i5D3DD2D36406218C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J140A0A0R4J140_MOUSE
Clustered mitochondria protein homo...
Cluh
1,353Annotation score:
Z4YLI8Z4YLI8_MOUSE
Clustered mitochondria protein homo...
Cluh
1,302Annotation score:

Sequence cautioni

The sequence AAH72573 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE20503 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE32406 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE32929 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE34042 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI24374 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAP19360 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412E → D in AAH72573 (PubMed:15489334).Curated1
Sequence conflicti817E → D in BAE32406 (PubMed:16141072).Curated1
Sequence conflicti1284A → APE in BAE34042 (PubMed:16141072).Curated1
Sequence conflicti1284A → APE in BAC41440 (PubMed:12465718).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036578761 – 811Missing in isoform 3. CuratedAdd BLAST51
Alternative sequenceiVSP_036579762 – 856KDCTE…SSYPN → REGLKGWVGAAERGCCPLVP PVPWFLDHIENLLVTSALAS PSLAHWQCPISQRRRQI in isoform 2. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_036580857 – 1315Missing in isoform 2. 1 PublicationAdd BLAST459

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036540 mRNA Translation: BAE20503.1 Different initiation.
AK154146 mRNA Translation: BAE32406.1 Different initiation.
AK154925 mRNA Translation: BAE32929.1 Different initiation.
AK157310 mRNA Translation: BAE34042.1 Different initiation.
AL607024 Genomic DNA Translation: CAI24374.1 Sequence problems.
AL607024 Genomic DNA Translation: CAP19360.1 Sequence problems.
BC060069 mRNA Translation: AAH60069.1
BC072573 mRNA Translation: AAH72573.1 Different initiation.
BC094446 mRNA Translation: AAH94446.1
AB093256 Transcribed RNA Translation: BAC41440.3
RefSeqiNP_001074627.1, NM_001081158.2
XP_006534416.1, XM_006534353.3 [Q5SW19-1]
XP_006534417.1, XM_006534354.3 [Q5SW19-1]
UniGeneiMm.214574

Genome annotation databases

GeneIDi74148
KEGGimmu:74148
UCSCiuc007kca.1 mouse [Q5SW19-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK036540 mRNA Translation: BAE20503.1 Different initiation.
AK154146 mRNA Translation: BAE32406.1 Different initiation.
AK154925 mRNA Translation: BAE32929.1 Different initiation.
AK157310 mRNA Translation: BAE34042.1 Different initiation.
AL607024 Genomic DNA Translation: CAI24374.1 Sequence problems.
AL607024 Genomic DNA Translation: CAP19360.1 Sequence problems.
BC060069 mRNA Translation: AAH60069.1
BC072573 mRNA Translation: AAH72573.1 Different initiation.
BC094446 mRNA Translation: AAH94446.1
AB093256 Transcribed RNA Translation: BAC41440.3
RefSeqiNP_001074627.1, NM_001081158.2
XP_006534416.1, XM_006534353.3 [Q5SW19-1]
XP_006534417.1, XM_006534354.3 [Q5SW19-1]
UniGeneiMm.214574

3D structure databases

ProteinModelPortaliQ5SW19
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216526, 1 interactor
IntActiQ5SW19, 5 interactors
MINTiQ5SW19
STRINGi10090.ENSMUSP00000090593

PTM databases

iPTMnetiQ5SW19
PhosphoSitePlusiQ5SW19
SwissPalmiQ5SW19

Proteomic databases

EPDiQ5SW19
PaxDbiQ5SW19
PeptideAtlasiQ5SW19
PRIDEiQ5SW19

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi74148
KEGGimmu:74148
UCSCiuc007kca.1 mouse [Q5SW19-1]

Organism-specific databases

CTDi23277
MGIiMGI:1921398 Cluh
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1839 Eukaryota
ENOG410XQUQ LUCA
HOVERGENiHBG108020
InParanoidiQ5SW19
KOiK03255
PhylomeDBiQ5SW19
TreeFamiTF300565

Miscellaneous databases

ChiTaRSiCluh mouse
PROiPR:Q5SW19
SOURCEiSearch...

Family and domain databases

CDDicd15466 CLU-central, 1 hit
Gene3Di1.25.40.10, 1 hit
HAMAPiMF_03013 CLU, 1 hit
InterProiView protein in InterPro
IPR027523 CLU
IPR033646 CLU-central
IPR025697 CLU_dom
IPR028275 CLU_N
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13236 CLU, 1 hit
PF15044 CLU_N, 1 hit
PF12807 eIF3_p135, 1 hit
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS51823 CLU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLU_MOUSE
AccessioniPrimary (citable) accession number: Q5SW19
Secondary accession number(s): A8Y5E2
, Q3U014, Q3U4M5, Q3V3Q8, Q505Q6, Q6GQX1, Q6PAT1, Q8CHD9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: September 12, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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