UniProtKB - Q5SW19 (CLU_MOUSE)
Clustered mitochondria protein homolog
Cluh
Functioni
mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.
UniRule annotationGO - Molecular functioni
- mRNA binding Source: UniProtKB
GO - Biological processi
- intracellular distribution of mitochondria Source: UniProtKB
- mitochondrion organization Source: UniProtKB
Names & Taxonomyi
Protein namesi | Recommended name: Clustered mitochondria protein homologUniRule annotation |
Gene namesi | Name:Cluh Synonyms:Kiaa0664 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1921398, Cluh |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- Cytoplasmic granule UniRule annotation
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000366373 | 1 – 1315 | Clustered mitochondria protein homologAdd BLAST | 1315 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 279 | PhosphoserineBy similarity | 1 | |
Modified residuei | 281 | PhosphoserineBy similarity | 1 | |
Modified residuei | 655 | PhosphoserineBy similarity | 1 | |
Modified residuei | 725 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q5SW19 |
jPOSTi | Q5SW19 |
MaxQBi | Q5SW19 |
PaxDbi | Q5SW19 |
PeptideAtlasi | Q5SW19 |
PRIDEi | Q5SW19 |
ProteomicsDBi | 283530 [Q5SW19-1] 283531 [Q5SW19-2] 283532 [Q5SW19-3] |
PTM databases
iPTMneti | Q5SW19 |
PhosphoSitePlusi | Q5SW19 |
SwissPalmi | Q5SW19 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 216526, 5 interactors |
IntActi | Q5SW19, 3 interactors |
STRINGi | 10090.ENSMUSP00000090593 |
Miscellaneous databases
RNActi | Q5SW19, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 335 – 577 | CluPROSITE-ProRule annotationAdd BLAST | 243 | |
Repeati | 980 – 1013 | TPR 1Add BLAST | 34 | |
Repeati | 1022 – 1055 | TPR 2Add BLAST | 34 | |
Repeati | 1106 – 1139 | TPR 3Add BLAST | 34 | |
Repeati | 1148 – 1181 | TPR 4Add BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 35 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 638 – 672 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 1268 – 1315 | DisorderedSequence analysisAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 8 – 29 | Basic and acidic residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 638 – 656 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 1268 – 1295 | Basic and acidic residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1839, Eukaryota |
InParanoidi | Q5SW19 |
OrthoDBi | 60958at2759 |
PhylomeDBi | Q5SW19 |
TreeFami | TF300565 |
Family and domain databases
CDDi | cd15466, CLU-central, 1 hit |
Gene3Di | 1.25.40.10, 1 hit 3.30.2280.10, 1 hit |
HAMAPi | MF_03013, CLU, 1 hit |
InterProi | View protein in InterPro IPR033646, CLU-central IPR025697, CLU_dom IPR028275, CLU_N IPR027523, CLU_prot IPR023231, GSKIP_dom_sf IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR12601, PTHR12601, 1 hit |
Pfami | View protein in Pfam PF13236, CLU, 1 hit PF15044, CLU_N, 1 hit PF12807, eIF3_p135, 1 hit |
SUPFAMi | SSF103107, SSF103107, 1 hit SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS51823, CLU, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLNGDCSEN LKKEEGTSEP PRENGLDEGE PGDETTGQEV IVIQDTGFSV
60 70 80 90 100
KILAPGIEPF SLQVSPQEMV QEIHQVLMDR EDTCHRTCFS LHLDGNMLDH
110 120 130 140 150
FSELRSVEGL QEGSVLRVVE EPYTVREARI HVRHVRDLLK SLDPSDAFNG
160 170 180 190 200
VDCNSLSFLS VFTDGDLGDS GKRKKGLEMD PIDCTPPEYI LPGSRERPLC
210 220 230 240 250
PLQPQNRDWK PLQCLKVLTM SGWNPPPGNR KMHGDLMYLF VITAEDRQVS
260 270 280 290 300
ITASTRGFYL NQSTAYHFNP KPASPRFLSH SLVELLNQIS PTFKKNFAVL
310 320 330 340 350
QKKRVQRHPF ERIATPFQVY SWTAPQAEHA MDCVRAEDAY TSRLGYEEHI
360 370 380 390 400
PGQTRDWNEE LQTTRELPRK NLPERLLRER AIFKVHSDFT AAATRGAMAV
410 420 430 440 450
IDGNVMAINP SEETKMQMFI WNNIFFSLGF DVRDHYKDFG GDVAAYVAPT
460 470 480 490 500
NDLNGVRTYN AVDVEGLYTL GTVVVDYRGY RVTAQSIIPG ILERDQEQSV
510 520 530 540 550
IYGSIDFGKT VVSHPRYLEL LERTSRPLKI LRHRVLNDRD EEVELCSSVE
560 570 580 590 600
CKGIIGNDGR HYILDLLRTF PPDLNFLPVP GEELPEECSR AGFPRTHRHK
610 620 630 640 650
LCCLRQELVD AFVEHRYLLF MKLAALQLMQ QKASKVETTT SLENGGLPSS
660 670 680 690 700
AETKSEDSIG PEAGCEEEGS SVSGLAKVKE LAETIASDDG TVDPRSREVI
710 720 730 740 750
RNACKAVGSI SSTAFDIRFN PDIFSPGVRF PESCQDEVRD QKQLLKDAAA
760 770 780 790 800
FLLSCQIPGL VKDCTEYAVL PMDGATLAEV MRQRGINMRY LGKVLDLVLR
810 820 830 840 850
SPARDQLDHI YKIGIGELIT RSAKHIFKTY LQGVELSGLS AAISHFLNCF
860 870 880 890 900
LSSYPNPVAH LPADELLSKK RNKRRKNRPP GAADNTAWAV MTPQELWKNI
910 920 930 940 950
CHEAKNYFDF TLECDSVDQA VETYGLQKIT LLREISLKTG IQILLKEYSF
960 970 980 990 1000
DSRHKPAFTE EDVLNIFPVV KHVNPKASDA FHFFQSGQAK VQQGFLKEGC
1010 1020 1030 1040 1050
ELINEALNLF NNVYGAMHVE ICACLRLLAR LHYIMGDYAE ALSNQQKAVL
1060 1070 1080 1090 1100
MSERVMGIEH PNTIQEYMHL ALYCFASSQL STALSLLYRA RYLMLLVFGE
1110 1120 1130 1140 1150
DHPEMALLDN NIGLVLHGVM EYDLSLRFLE NALAVTTKYH GPKALKVALS
1160 1170 1180 1190 1200
HHLVARVYES KAEFRSALQH EKEGYTIYKT QLGEDHEKTK ESSEYLKCLT
1210 1220 1230 1240 1250
QQAVALQRTM NEIYRNGSSA NIPPLKFTAP SMTSVLEQLN VINGILFIPL
1260 1270 1280 1290 1300
SQKDLENLKA EVARRHQLQE ANRNRDKAEE QPMAPEPEPE PERAVEDMGS
1310
PQTAKEGPSS LNLQG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J140 | A0A0R4J140_MOUSE | Clustered mitochondria protein homo... | Cluh | 1,353 | Annotation score: | ||
Z4YLI8 | Z4YLI8_MOUSE | Clustered mitochondria protein homo... | Cluh | 1,302 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 412 | E → D in AAH72573 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 817 | E → D in BAE32406 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1284 | A → APE in BAE34042 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 1284 | A → APE in BAC41440 (PubMed:12465718).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036578 | 761 – 811 | Missing in isoform 3. CuratedAdd BLAST | 51 | |
Alternative sequenceiVSP_036579 | 762 – 856 | KDCTE…SSYPN → REGLKGWVGAAERGCCPLVP PVPWFLDHIENLLVTSALAS PSLAHWQCPISQRRRQI in isoform 2. 1 PublicationAdd BLAST | 95 | |
Alternative sequenceiVSP_036580 | 857 – 1315 | Missing in isoform 2. 1 PublicationAdd BLAST | 459 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK036540 mRNA Translation: BAE20503.1 Different initiation. AK154146 mRNA Translation: BAE32406.1 Different initiation. AK154925 mRNA Translation: BAE32929.1 Different initiation. AK157310 mRNA Translation: BAE34042.1 Different initiation. AL607024 Genomic DNA Translation: CAI24374.1 Sequence problems. AL607024 Genomic DNA Translation: CAP19360.1 Sequence problems. BC060069 mRNA Translation: AAH60069.1 BC072573 mRNA Translation: AAH72573.1 Different initiation. BC094446 mRNA Translation: AAH94446.1 AB093256 Transcribed RNA Translation: BAC41440.3 |
RefSeqi | NP_001074627.1, NM_001081158.2 XP_006534416.1, XM_006534353.3 [Q5SW19-1] XP_006534417.1, XM_006534354.3 |
Genome annotation databases
GeneIDi | 74148 |
KEGGi | mmu:74148 |
UCSCi | uc007kca.1, mouse [Q5SW19-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK036540 mRNA Translation: BAE20503.1 Different initiation. AK154146 mRNA Translation: BAE32406.1 Different initiation. AK154925 mRNA Translation: BAE32929.1 Different initiation. AK157310 mRNA Translation: BAE34042.1 Different initiation. AL607024 Genomic DNA Translation: CAI24374.1 Sequence problems. AL607024 Genomic DNA Translation: CAP19360.1 Sequence problems. BC060069 mRNA Translation: AAH60069.1 BC072573 mRNA Translation: AAH72573.1 Different initiation. BC094446 mRNA Translation: AAH94446.1 AB093256 Transcribed RNA Translation: BAC41440.3 |
RefSeqi | NP_001074627.1, NM_001081158.2 XP_006534416.1, XM_006534353.3 [Q5SW19-1] XP_006534417.1, XM_006534354.3 |
3D structure databases
SMRi | Q5SW19 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 216526, 5 interactors |
IntActi | Q5SW19, 3 interactors |
STRINGi | 10090.ENSMUSP00000090593 |
PTM databases
iPTMneti | Q5SW19 |
PhosphoSitePlusi | Q5SW19 |
SwissPalmi | Q5SW19 |
Proteomic databases
EPDi | Q5SW19 |
jPOSTi | Q5SW19 |
MaxQBi | Q5SW19 |
PaxDbi | Q5SW19 |
PeptideAtlasi | Q5SW19 |
PRIDEi | Q5SW19 |
ProteomicsDBi | 283530 [Q5SW19-1] 283531 [Q5SW19-2] 283532 [Q5SW19-3] |
Genome annotation databases
GeneIDi | 74148 |
KEGGi | mmu:74148 |
UCSCi | uc007kca.1, mouse [Q5SW19-1] |
Organism-specific databases
CTDi | 23277 |
MGIi | MGI:1921398, Cluh |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG1839, Eukaryota |
InParanoidi | Q5SW19 |
OrthoDBi | 60958at2759 |
PhylomeDBi | Q5SW19 |
TreeFami | TF300565 |
Miscellaneous databases
BioGRID-ORCSi | 74148, 8 hits in 65 CRISPR screens |
ChiTaRSi | Cluh, mouse |
PROi | PR:Q5SW19 |
RNActi | Q5SW19, protein |
SOURCEi | Search... |
Family and domain databases
CDDi | cd15466, CLU-central, 1 hit |
Gene3Di | 1.25.40.10, 1 hit 3.30.2280.10, 1 hit |
HAMAPi | MF_03013, CLU, 1 hit |
InterProi | View protein in InterPro IPR033646, CLU-central IPR025697, CLU_dom IPR028275, CLU_N IPR027523, CLU_prot IPR023231, GSKIP_dom_sf IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR12601, PTHR12601, 1 hit |
Pfami | View protein in Pfam PF13236, CLU, 1 hit PF15044, CLU_N, 1 hit PF12807, eIF3_p135, 1 hit |
SUPFAMi | SSF103107, SSF103107, 1 hit SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS51823, CLU, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CLU_MOUSE | |
Accessioni | Q5SW19Primary (citable) accession number: Q5SW19 Secondary accession number(s): A8Y5E2 Q8CHD9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 24, 2009 |
Last sequence update: | March 24, 2009 | |
Last modified: | February 23, 2022 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families