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Protein

Zinc finger MYM-type protein 1

Gene

ZMYM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 148MYM-type 1Add BLAST39
Zinc fingeri160 – 203MYM-type 2Add BLAST44
Zinc fingeri210 – 245MYM-type 3Add BLAST36
Zinc fingeri300 – 331MYM-type 4Add BLAST32
Zinc fingeri452 – 538TTF-typeAdd BLAST87

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MYM-type protein 1
Gene namesi
Name:ZMYM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197056.9
HGNCiHGNC:26253 ZMYM1
neXtProtiNX_Q5SVZ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197056
PharmGKBiPA134948969

Polymorphism and mutation databases

BioMutaiZMYM1
DMDMi74743897

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913771 – 1142Zinc finger MYM-type protein 1Add BLAST1142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki25Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki284Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ5SVZ6
MaxQBiQ5SVZ6
PaxDbiQ5SVZ6
PeptideAtlasiQ5SVZ6
PRIDEiQ5SVZ6
ProteomicsDBi63955

PTM databases

iPTMnetiQ5SVZ6
PhosphoSitePlusiQ5SVZ6

Expressioni

Gene expression databases

BgeeiENSG00000197056 Expressed in 173 organ(s), highest expression level in intestine
CleanExiHS_ZMYM1
ExpressionAtlasiQ5SVZ6 baseline and differential
GenevisibleiQ5SVZ6 HS

Organism-specific databases

HPAiHPA064019

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122922, 39 interactors
IntActiQ5SVZ6, 26 interactors
STRINGi9606.ENSP00000352920

Structurei

3D structure databases

ProteinModelPortaliQ5SVZ6
SMRiQ5SVZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi384 – 420Ser-richAdd BLAST37

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 148MYM-type 1Add BLAST39
Zinc fingeri160 – 203MYM-type 2Add BLAST44
Zinc fingeri210 – 245MYM-type 3Add BLAST36
Zinc fingeri300 – 331MYM-type 4Add BLAST32
Zinc fingeri452 – 538TTF-typeAdd BLAST87

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IXK1 Eukaryota
ENOG410XQ1Y LUCA
GeneTreeiENSGT00920000149037
HOGENOMiHOG000132949
HOVERGENiHBG076163
InParanoidiQ5SVZ6
OMAiKTIWDGA
OrthoDBiEOG091G01OH
PhylomeDBiQ5SVZ6
TreeFamiTF330114

Family and domain databases

InterProiView protein in InterPro
IPR025398 DUF4371
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR026625 TFII-I-rel
IPR011017 TRASH_dom
IPR010507 Znf_MYM
PANTHERiPTHR11697 PTHR11697, 1 hit
PfamiView protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF14291 DUF4371, 1 hit
PF06467 zf-FCS, 2 hits
SMARTiView protein in SMART
SM00746 TRASH, 5 hits
SUPFAMiSSF53098 SSF53098, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5SVZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEPLLGGEC DKAVASQLGL LDEIKTEPDN AQEYCHRQQS RTQENELKIN
60 70 80 90 100
AVFSESASQL TAGIQLSLAS SGVNKMLPSV STTAIQVSCA GCKKILQKGQ
110 120 130 140 150
TAYQRKGSAQ LFCSIPCITE YISSASSPVP SKRTCSNCSK DILNPKDVIS
160 170 180 190 200
VQLEDTTSCK TFCSLSCLSS YEEKRKPFVT ICTNSILTKC SMCQKTAIIQ
210 220 230 240 250
YEVKYQNVKH NLCSNACLSK FHSANNFIMN CCENCGTYCY TSSSLSHILQ
260 270 280 290 300
MEGQSHYFNS SKSITAYKQK PAKPLISVPC KPLKPSDEMI ETTSDLGKTE
310 320 330 340 350
LFCSINCFSA YSKAKMESSS VSVVSVVHDT STELLSPKKD TTPVISNIVS
360 370 380 390 400
LADTDVALPI MNTDVLQDTV SSVTATADVI VDLSKSSPSE PSNAVASSST
410 420 430 440 450
EQPSVSPSSS VFSQHAIGSS TEVQKDNMKS MKISDELCHP KCTSKVQKVK
460 470 480 490 500
GKSRSIKKSC CADFECLENS KKDVAFCYSC QLFCQKYFSC GRESFATHGT
510 520 530 540 550
SNWKKTLEKF RKHEKSEMHL KSLEFWREYQ FCDGAVSDDL SIHSKQIEGN
560 570 580 590 600
KKYLKLIIEN ILFLGKQCLP LRGNDQSVSS VNKGNFLELL EMRAKDKGEE
610 620 630 640 650
TFRLMNSQVD FYNSTQIQSD IIEIIKTEML QDIVNEINDS SAFSIICDET
660 670 680 690 700
INSAMKEQLS ICVRYPQKSS KAILIKERFL GFVDTEEMTG THLHRTIKTY
710 720 730 740 750
LQQIGVDMDK IHGQAYDSTT NLKIKFNKIA AEFKKEEPRA LYIHCYAHFL
760 770 780 790 800
DLSIIRFCKE VKELRSALKT LSSLFNTICM SGEMLANFRN IYRLSQNKTC
810 820 830 840 850
KKHISQSCWT VHDRTLLSVI DSLPEIIETL EVIASHSSNT SFADELSHLL
860 870 880 890 900
TLVSKFEFVF CLKFLYRVLS VTGILSKELQ NKTIDIFSLS SKIEAILECL
910 920 930 940 950
SSERNDVYFK TIWDGTEEIC QKITCKGFKV EKPSLQKRRK IQKSVDLGNS
960 970 980 990 1000
DNMFFPTSTE EQYKINIYYQ GLDTILQNLK LCFSEFDYCK IKQISELLFK
1010 1020 1030 1040 1050
WNEPLNETTA KHVQEFYKLD EDIIPELRFY RHYAKLNFVI DDSCINFVSL
1060 1070 1080 1090 1100
GCLFIQHGLH SNIPCLSKLL YIALSWPITS ASTENSFSTL PRLKTYLCNT
1110 1120 1130 1140
MGQEKLTGPA LMAVEQELVN KLMEPERLNE IVEKFISQMK EI
Length:1,142
Mass (Da):128,717
Last modified:December 21, 2004 - v1
Checksum:iC8F1197AB842C3E4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SVZ7Q5SVZ7_HUMAN
Zinc finger MYM-type protein 1
ZMYM1
461Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03458973V → M2 PublicationsCorresponds to variant dbSNP:rs2971408Ensembl.1
Natural variantiVAR_053767454R → Q. Corresponds to variant dbSNP:rs7552714Ensembl.1
Natural variantiVAR_053768493E → G. Corresponds to variant dbSNP:rs16837197Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537537 mRNA Translation: CAD97777.1
AL607089 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07428.1
CH471059 Genomic DNA Translation: EAX07430.1
CCDSiCCDS41302.1
RefSeqiNP_001276017.1, NM_001289088.1
NP_001276018.1, NM_001289089.1
NP_001276019.1, NM_001289090.1
NP_001306884.1, NM_001319955.1
NP_079048.3, NM_024772.4
UniGeneiHs.471243

Genome annotation databases

EnsembliENST00000359858; ENSP00000352920; ENSG00000197056
ENST00000373330; ENSP00000362427; ENSG00000197056
ENST00000611874; ENSP00000482579; ENSG00000197056
GeneIDi79830
KEGGihsa:79830
UCSCiuc001bym.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX537537 mRNA Translation: CAD97777.1
AL607089 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07428.1
CH471059 Genomic DNA Translation: EAX07430.1
CCDSiCCDS41302.1
RefSeqiNP_001276017.1, NM_001289088.1
NP_001276018.1, NM_001289089.1
NP_001276019.1, NM_001289090.1
NP_001306884.1, NM_001319955.1
NP_079048.3, NM_024772.4
UniGeneiHs.471243

3D structure databases

ProteinModelPortaliQ5SVZ6
SMRiQ5SVZ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122922, 39 interactors
IntActiQ5SVZ6, 26 interactors
STRINGi9606.ENSP00000352920

PTM databases

iPTMnetiQ5SVZ6
PhosphoSitePlusiQ5SVZ6

Polymorphism and mutation databases

BioMutaiZMYM1
DMDMi74743897

Proteomic databases

EPDiQ5SVZ6
MaxQBiQ5SVZ6
PaxDbiQ5SVZ6
PeptideAtlasiQ5SVZ6
PRIDEiQ5SVZ6
ProteomicsDBi63955

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359858; ENSP00000352920; ENSG00000197056
ENST00000373330; ENSP00000362427; ENSG00000197056
ENST00000611874; ENSP00000482579; ENSG00000197056
GeneIDi79830
KEGGihsa:79830
UCSCiuc001bym.5 human

Organism-specific databases

CTDi79830
EuPathDBiHostDB:ENSG00000197056.9
GeneCardsiZMYM1
H-InvDBiHIX0000408
HGNCiHGNC:26253 ZMYM1
HPAiHPA064019
neXtProtiNX_Q5SVZ6
OpenTargetsiENSG00000197056
PharmGKBiPA134948969
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXK1 Eukaryota
ENOG410XQ1Y LUCA
GeneTreeiENSGT00920000149037
HOGENOMiHOG000132949
HOVERGENiHBG076163
InParanoidiQ5SVZ6
OMAiKTIWDGA
OrthoDBiEOG091G01OH
PhylomeDBiQ5SVZ6
TreeFamiTF330114

Miscellaneous databases

ChiTaRSiZMYM1 human
GenomeRNAii79830
PROiPR:Q5SVZ6

Gene expression databases

BgeeiENSG00000197056 Expressed in 173 organ(s), highest expression level in intestine
CleanExiHS_ZMYM1
ExpressionAtlasiQ5SVZ6 baseline and differential
GenevisibleiQ5SVZ6 HS

Family and domain databases

InterProiView protein in InterPro
IPR025398 DUF4371
IPR008906 HATC_C_dom
IPR012337 RNaseH-like_sf
IPR026625 TFII-I-rel
IPR011017 TRASH_dom
IPR010507 Znf_MYM
PANTHERiPTHR11697 PTHR11697, 1 hit
PfamiView protein in Pfam
PF05699 Dimer_Tnp_hAT, 1 hit
PF14291 DUF4371, 1 hit
PF06467 zf-FCS, 2 hits
SMARTiView protein in SMART
SM00746 TRASH, 5 hits
SUPFAMiSSF53098 SSF53098, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZMYM1_HUMAN
AccessioniPrimary (citable) accession number: Q5SVZ6
Secondary accession number(s): D3DPR7, Q7Z3Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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