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UniProtKB - Q5SVS4 (KMCP1_HUMAN)
Protein
Kidney mitochondrial carrier protein 1
Gene
SLC25A30
Organism
Homo sapiens (Human)
Status
Functioni
Probable transporter.
By similarityGO - Molecular functioni
- antiporter activity Source: GO_Central
- malate transmembrane transporter activity Source: GO_Central
- oxaloacetate transmembrane transporter activity Source: GO_Central
- succinate transmembrane transporter activity Source: GO_Central
- sulfate transmembrane transporter activity Source: GO_Central
- thiosulfate transmembrane transporter activity Source: GO_Central
GO - Biological processi
- malate transmembrane transport Source: GO_Central
- mitochondrial transport Source: InterPro
- oxaloacetate transport Source: GO_Central
- phosphate ion transmembrane transport Source: GO_Central
- succinate transmembrane transport Source: GO_Central
- sulfate transport Source: GO_Central
- thiosulfate transport Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q5SVS4 |
SignaLinki | Q5SVS4 |
Protein family/group databases
TCDBi | 2.A.29.24.4, the mitochondrial carrier (mc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Kidney mitochondrial carrier protein 1Alternative name(s): Solute carrier family 25 member 30 |
Gene namesi | Name:SLC25A30 Synonyms:KMCP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:27371, SLC25A30 |
MIMi | 610793, gene |
neXtProti | NX_Q5SVS4 |
VEuPathDBi | HostDB:ENSG00000174032 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
- mitochondrion Source: BHF-UCL
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 9 – 26 | Helical; Name=1Sequence analysisAdd BLAST | 18 | |
Transmembranei | 71 – 89 | Helical; Name=2Sequence analysisAdd BLAST | 19 | |
Transmembranei | 105 – 124 | Helical; Name=3Sequence analysisAdd BLAST | 20 | |
Transmembranei | 164 – 183 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Transmembranei | 204 – 224 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 264 – 283 | Helical; Name=6Sequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 253512 |
OpenTargetsi | ENSG00000174032 |
PharmGKBi | PA134931353 |
Miscellaneous databases
Pharosi | Q5SVS4, Tdark |
Genetic variation databases
BioMutai | SLC25A30 |
DMDMi | 74743890 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000288916 | 2 – 291 | Kidney mitochondrial carrier protein 1Add BLAST | 290 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q5SVS4 |
jPOSTi | Q5SVS4 |
MassIVEi | Q5SVS4 |
MaxQBi | Q5SVS4 |
PaxDbi | Q5SVS4 |
PeptideAtlasi | Q5SVS4 |
PRIDEi | Q5SVS4 |
ProteomicsDBi | 27787 63953 [Q5SVS4-1] |
PTM databases
GlyGeni | Q5SVS4, 1 site, 2 O-linked glycans (1 site) |
iPTMneti | Q5SVS4 |
PhosphoSitePlusi | Q5SVS4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000174032, Expressed in heart and 204 other tissues |
ExpressionAtlasi | Q5SVS4, baseline and differential |
Genevisiblei | Q5SVS4, HS |
Organism-specific databases
HPAi | ENSG00000174032, Tissue enhanced (heart muscle, skeletal muscle, tongue) |
Interactioni
Subunit structurei
Interacts with VDAC1.
1 PublicationProtein-protein interaction databases
BioGRIDi | 128971, 40 interactors |
IntActi | Q5SVS4, 10 interactors |
STRINGi | 9606.ENSP00000429168 |
Miscellaneous databases
RNActi | Q5SVS4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 7 – 96 | Solcar 1Add BLAST | 90 | |
Repeati | 104 – 189 | Solcar 2Add BLAST | 86 | |
Repeati | 198 – 289 | Solcar 3Add BLAST | 92 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0753, Eukaryota |
GeneTreei | ENSGT00940000158961 |
HOGENOMi | CLU_015166_14_2_1 |
InParanoidi | Q5SVS4 |
OMAi | KRMFVEH |
OrthoDBi | 1126848at2759 |
PhylomeDBi | Q5SVS4 |
TreeFami | TF323211 |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002030, Mit_uncoupling_UCP-like IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00784, MTUNCOUPLING |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5SVS4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSALNWKPFV YGGLASITAE CGTFPIDLTK TRLQIQGQTN DAKFKEIRYR
60 70 80 90 100
GMLHALVRIG REEGLKALYS GIAPAMLRQA SYGTIKIGTY QSLKRLFIER
110 120 130 140 150
PEDETLPINV ICGILSGVIS STIANPTDVL KIRMQAQSNT IQGGMIGNFM
160 170 180 190 200
NIYQQEGTRG LWKGVSLTAQ RAAIVVGVEL PVYDITKKHL ILSGLMGDTV
210 220 230 240 250
YTHFLSSFTC GLAGALASNP VDVVRTRMMN QRVLRDGRCS GYTGTLDCLL
260 270 280 290
QTWKNEGFFA LYKGFWPNWL RLGPWNIIFF VTYEQLKKLD L
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RIS9 | E5RIS9_HUMAN | Kidney mitochondrial carrier protei... | SLC25A30 | 94 | Annotation score: | ||
E5RIW6 | E5RIW6_HUMAN | Kidney mitochondrial carrier protei... | SLC25A30 | 137 | Annotation score: | ||
A0A087WWR9 | A0A087WWR9_HUMAN | Kidney mitochondrial carrier protei... | SLC25A30 | 119 | Annotation score: | ||
D6RJI0 | D6RJI0_HUMAN | Kidney mitochondrial carrier protei... | SLC25A30 | 37 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 204 | F → L in BAG64115 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053984 | 1 – 51 | Missing in isoform 2. 1 PublicationAdd BLAST | 51 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK302967 mRNA Translation: BAG64115.1 AL627107 Genomic DNA No translation available. BC132739 mRNA Translation: AAI32740.1 BC136760 mRNA Translation: AAI36761.1 |
CCDSi | CCDS31967.1 [Q5SVS4-1] CCDS66539.1 [Q5SVS4-2] |
RefSeqi | NP_001010875.1, NM_001010875.3 [Q5SVS4-1] NP_001273735.1, NM_001286806.1 [Q5SVS4-2] XP_016876013.1, XM_017020524.1 [Q5SVS4-1] |
Genome annotation databases
Ensembli | ENST00000519676.6; ENSP00000429168.1; ENSG00000174032.17 ENST00000539591.5; ENSP00000443542.1; ENSG00000174032.17 [Q5SVS4-2] |
GeneIDi | 253512 |
KEGGi | hsa:253512 |
MANE-Selecti | ENST00000519676.6; ENSP00000429168.1; NM_001010875.4; NP_001010875.1 |
UCSCi | uc001vag.5, human [Q5SVS4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK302967 mRNA Translation: BAG64115.1 AL627107 Genomic DNA No translation available. BC132739 mRNA Translation: AAI32740.1 BC136760 mRNA Translation: AAI36761.1 |
CCDSi | CCDS31967.1 [Q5SVS4-1] CCDS66539.1 [Q5SVS4-2] |
RefSeqi | NP_001010875.1, NM_001010875.3 [Q5SVS4-1] NP_001273735.1, NM_001286806.1 [Q5SVS4-2] XP_016876013.1, XM_017020524.1 [Q5SVS4-1] |
3D structure databases
AlphaFoldDBi | Q5SVS4 |
SMRi | Q5SVS4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128971, 40 interactors |
IntActi | Q5SVS4, 10 interactors |
STRINGi | 9606.ENSP00000429168 |
Protein family/group databases
TCDBi | 2.A.29.24.4, the mitochondrial carrier (mc) family |
PTM databases
GlyGeni | Q5SVS4, 1 site, 2 O-linked glycans (1 site) |
iPTMneti | Q5SVS4 |
PhosphoSitePlusi | Q5SVS4 |
Genetic variation databases
BioMutai | SLC25A30 |
DMDMi | 74743890 |
Proteomic databases
EPDi | Q5SVS4 |
jPOSTi | Q5SVS4 |
MassIVEi | Q5SVS4 |
MaxQBi | Q5SVS4 |
PaxDbi | Q5SVS4 |
PeptideAtlasi | Q5SVS4 |
PRIDEi | Q5SVS4 |
ProteomicsDBi | 27787 63953 [Q5SVS4-1] |
Protocols and materials databases
Antibodypediai | 49461, 15 antibodies from 6 providers |
DNASUi | 253512 |
Genome annotation databases
Ensembli | ENST00000519676.6; ENSP00000429168.1; ENSG00000174032.17 ENST00000539591.5; ENSP00000443542.1; ENSG00000174032.17 [Q5SVS4-2] |
GeneIDi | 253512 |
KEGGi | hsa:253512 |
MANE-Selecti | ENST00000519676.6; ENSP00000429168.1; NM_001010875.4; NP_001010875.1 |
UCSCi | uc001vag.5, human [Q5SVS4-1] |
Organism-specific databases
CTDi | 253512 |
DisGeNETi | 253512 |
GeneCardsi | SLC25A30 |
HGNCi | HGNC:27371, SLC25A30 |
HPAi | ENSG00000174032, Tissue enhanced (heart muscle, skeletal muscle, tongue) |
MIMi | 610793, gene |
neXtProti | NX_Q5SVS4 |
OpenTargetsi | ENSG00000174032 |
PharmGKBi | PA134931353 |
VEuPathDBi | HostDB:ENSG00000174032 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0753, Eukaryota |
GeneTreei | ENSGT00940000158961 |
HOGENOMi | CLU_015166_14_2_1 |
InParanoidi | Q5SVS4 |
OMAi | KRMFVEH |
OrthoDBi | 1126848at2759 |
PhylomeDBi | Q5SVS4 |
TreeFami | TF323211 |
Enzyme and pathway databases
PathwayCommonsi | Q5SVS4 |
SignaLinki | Q5SVS4 |
Miscellaneous databases
BioGRID-ORCSi | 253512, 9 hits in 1035 CRISPR screens |
ChiTaRSi | SLC25A30, human |
GenomeRNAii | 253512 |
Pharosi | Q5SVS4, Tdark |
PROi | PR:Q5SVS4 |
RNActi | Q5SVS4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174032, Expressed in heart and 204 other tissues |
ExpressionAtlasi | Q5SVS4, baseline and differential |
Genevisiblei | Q5SVS4, HS |
Family and domain databases
Gene3Di | 1.50.40.10, 1 hit |
InterProi | View protein in InterPro IPR002030, Mit_uncoupling_UCP-like IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
PRINTSi | PR00784, MTUNCOUPLING |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KMCP1_HUMAN | |
Accessioni | Q5SVS4Primary (citable) accession number: Q5SVS4 Secondary accession number(s): B2RN96, B4DZK3, F5H8H8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families