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UniProtKB - Q5SVQ8 (ZBT41_HUMAN)

Entry version 150 (02 Jun 2021)
Sequence version 1 (21 Dec 2004)
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Protein

Zinc finger and BTB domain-containing protein 41

Gene

ZBTB41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri207 – 230C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri361 – 383C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 445C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri463 – 485C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 514C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri518 – 541C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri547 – 569C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 654C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri668 – 690C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri696 – 718C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri724 – 747C2H2-type 14PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5SVQ8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 41
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBTB41
Synonyms:FRBZ1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:24819, ZBTB41

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5SVQ8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000177888.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		360023

Open Targets

More...OpenTargetsi		ENSG00000177888

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670545

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5SVQ8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZBTB41

Domain mapping of disease mutations (DMDM)

More...DMDMi		74756116

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002778141 – 909Zinc finger and BTB domain-containing protein 41Add BLAST909

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5SVQ8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5SVQ8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5SVQ8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5SVQ8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5SVQ8

PeptideAtlas

More...PeptideAtlasi		Q5SVQ8

PRoteomics IDEntifications database

More...PRIDEi		Q5SVQ8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		63949 [Q5SVQ8-1]
63950 [Q5SVQ8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5SVQ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5SVQ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000177888, Expressed in forebrain and 215 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5SVQ8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000177888, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131819, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q5SVQ8, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356375

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5SVQ8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5SVQ8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini88 – 152BTBPROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni252 – 344DisorderedSequence analysisAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi281 – 299Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi300 – 320Acidic residuesSequence analysisAdd BLAST21
Compositional biasi321 – 340Basic and acidic residuesSequence analysisAdd BLAST20

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri207 – 230C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri361 – 383C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 445C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri463 – 485C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 514C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri518 – 541C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri547 – 569C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 654C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri668 – 690C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri696 – 718C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri724 – 747C2H2-type 14PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000075080

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014920_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5SVQ8

Identification of Orthologs from Complete Genome Data

More...OMAi		EFFVYKN

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5SVQ8

TreeFam database of animal gene trees

More...TreeFami		TF350933

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.710.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00651, BTB, 1 hit
PF00096, zf-C2H2, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00225, BTB, 1 hit
SM00355, ZnF_C2H2, 14 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54695, SSF54695, 1 hit
SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50097, BTB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5SVQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKRRKVTSN LEKIHLGYHK DSSEGNVAVE CDQVTYTHSA GRPTPEALHC 
        60         70         80         90        100
YQELPPSPDQ RKLLSSLQYN KNLLKYLNDD RQKQPSFCDL LIIVEGKEFS 
       110        120        130        140        150
AHKVVVAVGS SYFHACLSKN PSTDVVTLDH VTHSVFQHLL EFLYTSEFFV 
       160        170        180        190        200
YKYEIPLVLE AAKFLDIIDA VKLLNNENVA PFHSELTEKS SPEETLNELT 
       210        220        230        240        250
GRLSNNHQCK FCSRHFCYKK SLENHLAKTH RSLLLGKKHG LKMLERSFSA 
       260        270        280        290        300
RRSKRNRKCP VKFDDTSDDE QESGDGSDNL NQENFDKEKS DRNDSEDPGS 
       310        320        330        340        350
EYNAEEDELE EEMSDEYSDI EEQSEKDHND AEEEPEAGDS VGNVHEGLTP 
       360        370        380        390        400
VVIQNSNKKI LQCPKCDKTF DRIGKYESHT RVHTGEKPFE CDICHQRYST 
       410        420        430        440        450
KSNLTVHRKK HSNETEFHKK EHKCPYCNKL HASKKTLAKH VKRFHPENAQ 
       460        470        480        490        500
EFISIKKTKS ESWKCDICKK SFTRRPHLEE HMILHSQDKP FKCTYCEEHF 
       510        520        530        540        550
KSRFARLKHQ EKFHLGPFPC DICGRQFNDT GNLKRHIECT HGGKRKWTCF 
       560        570        580        590        600
ICGKSVRERT TLKEHLRIHS GEKPHLCSIC GQSFRHGSSY RLHLRVHHDD 
       610        620        630        640        650
KRYECDECGK TFIRHDHLTK HKKIHSGEKA HQCEECGKCF GRRDHLTVHY 
       660        670        680        690        700
KSVHLGEKVW QKYKATFHQC DVCKKIFKGK SSLEMHFRTH SGEKPYKCQI 
       710        720        730        740        750
CNQSFRIKKT LTKHLVIHSD ARPFNCQHCN ATFKRKDKLK YHIDHVHEIK 
       760        770        780        790        800
SPDDPLSTSE EKLVSLPVEY SSDDKIFQTE TKQYMDQPKV YQSEAKTMLQ 
       810        820        830        840        850
NVSAEVCVPV TLVPVQMPDT PSDLVRHTTT LPPSSHEILS PQPQSTDYPR 
       860        870        880        890        900
AADLAFLEKY TLTPQPANIV HPVRPEQMLD PREQSYLGTL LGLDSTTGVQ 

NISTNEHHS
Length:909
Mass (Da):105,192
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBAB9F19F2F40772F
GO
Isoform 2 (identifier: Q5SVQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     627-627: G → D
     628-909: Missing.

Show »
Length:627
Mass (Da):72,945
Checksum:i350F812D7C761F03
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti182F → L in BAC87496 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030601327D → Y. Corresponds to variant dbSNP:rs10494751Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023092627G → D in isoform 2. 1 Publication1
Alternative sequenceiVSP_023093628 – 909Missing in isoform 2. 1 PublicationAdd BLAST282

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY163816 mRNA Translation: AAN71742.2
AY336933 mRNA Translation: AAP97434.1
AK128549 mRNA Translation: BAC87496.1
AL356315 Genomic DNA No translation available.
AL627208 Genomic DNA No translation available.
BC132818 mRNA Translation: AAI32819.1
BC136600 mRNA Translation: AAI36601.1
BX640886 mRNA Translation: CAE45940.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30960.1 [Q5SVQ8-1]

NCBI Reference Sequences

More...RefSeqi		NP_919290.2, NM_194314.2 [Q5SVQ8-1]
XP_016856694.1, XM_017001205.1 [Q5SVQ8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367405; ENSP00000356375; ENSG00000177888 [Q5SVQ8-1]
ENST00000467322; ENSP00000502173; ENSG00000177888 [Q5SVQ8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		360023

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:360023

UCSC genome browser

More...UCSCi		uc001gtx.2, human [Q5SVQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY163816 mRNA Translation: AAN71742.2
AY336933 mRNA Translation: AAP97434.1
AK128549 mRNA Translation: BAC87496.1
AL356315 Genomic DNA No translation available.
AL627208 Genomic DNA No translation available.
BC132818 mRNA Translation: AAI32819.1
BC136600 mRNA Translation: AAI36601.1
BX640886 mRNA Translation: CAE45940.1
CCDSiCCDS30960.1 [Q5SVQ8-1]
RefSeqiNP_919290.2, NM_194314.2 [Q5SVQ8-1]
XP_016856694.1, XM_017001205.1 [Q5SVQ8-2]

3D structure databases

SMRiQ5SVQ8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131819, 4 interactors
IntActiQ5SVQ8, 1 interactor
STRINGi9606.ENSP00000356375

PTM databases

iPTMnetiQ5SVQ8
PhosphoSitePlusiQ5SVQ8

Genetic variation databases

BioMutaiZBTB41
DMDMi74756116

Proteomic databases

EPDiQ5SVQ8
jPOSTiQ5SVQ8
MassIVEiQ5SVQ8
MaxQBiQ5SVQ8
PaxDbiQ5SVQ8
PeptideAtlasiQ5SVQ8
PRIDEiQ5SVQ8
ProteomicsDBi63949 [Q5SVQ8-1]
63950 [Q5SVQ8-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q5SVQ8, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		50783, 88 antibodies

The DNASU plasmid repository

More...DNASUi		360023

Genome annotation databases

EnsembliENST00000367405; ENSP00000356375; ENSG00000177888 [Q5SVQ8-1]
ENST00000467322; ENSP00000502173; ENSG00000177888 [Q5SVQ8-2]
GeneIDi360023
KEGGihsa:360023
UCSCiuc001gtx.2, human [Q5SVQ8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		360023
DisGeNETi360023

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZBTB41
HGNCiHGNC:24819, ZBTB41
HPAiENSG00000177888, Low tissue specificity
neXtProtiNX_Q5SVQ8
OpenTargetsiENSG00000177888
PharmGKBiPA142670545
VEuPathDBiHostDB:ENSG00000177888.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00550000075080
HOGENOMiCLU_014920_0_0_1
InParanoidiQ5SVQ8
OMAiEFFVYKN
OrthoDBi1318335at2759
PhylomeDBiQ5SVQ8
TreeFamiTF350933

Enzyme and pathway databases

PathwayCommonsiQ5SVQ8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		360023, 28 hits in 1013 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZBTB41, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		360023
PharosiQ5SVQ8, Tdark

Protein Ontology

More...PROi		PR:Q5SVQ8
RNActiQ5SVQ8, protein

Gene expression databases

BgeeiENSG00000177888, Expressed in forebrain and 215 other tissues
GenevisibleiQ5SVQ8, HS

Family and domain databases

Gene3Di3.30.710.10, 1 hit
InterProiView protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00651, BTB, 1 hit
PF00096, zf-C2H2, 7 hits
SMARTiView protein in SMART
SM00225, BTB, 1 hit
SM00355, ZnF_C2H2, 14 hits
SUPFAMiSSF54695, SSF54695, 1 hit
SSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 13 hits
PS50157, ZINC_FINGER_C2H2_2, 14 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZBT41_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SVQ8
Secondary accession number(s): A2RUA8
, Q6MZT8, Q6ZR25, Q7Z4T1, Q8IZ99
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 21, 2004
Last modified: June 2, 2021
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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