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UniProtKB - Q5SVQ8 (ZBT41_HUMAN)

Protein

Zinc finger and BTB domain-containing protein 41

Gene

ZBTB41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri207 – 230C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri361 – 383C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 445C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri463 – 485C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 514C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri518 – 541C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri547 – 569C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 654C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri668 – 690C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri696 – 718C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri724 – 747C2H2-type 14PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 41
Gene namesi
Name:ZBTB41
Synonyms:FRBZ1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000177888.7
HGNCiHGNC:24819 ZBTB41
neXtProtiNX_Q5SVQ8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177888
PharmGKBiPA142670545

Polymorphism and mutation databases

BioMutaiZBTB41
DMDMi74756116

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002778141 – 909Zinc finger and BTB domain-containing protein 41Add BLAST909

Proteomic databases

EPDiQ5SVQ8
MaxQBiQ5SVQ8
PaxDbiQ5SVQ8
PeptideAtlasiQ5SVQ8
PRIDEiQ5SVQ8
ProteomicsDBi63949
63950 [Q5SVQ8-2]

PTM databases

iPTMnetiQ5SVQ8
PhosphoSitePlusiQ5SVQ8

Expressioni

Gene expression databases

BgeeiENSG00000177888 Expressed in 198 organ(s), highest expression level in forebrain
CleanExiHS_ZBTB41
GenevisibleiQ5SVQ8 HS

Organism-specific databases

HPAiHPA034841
HPA034842

Interactioni

Protein-protein interaction databases

BioGridi131819, 2 interactors
IntActiQ5SVQ8, 1 interactor
STRINGi9606.ENSP00000356375

Structurei

3D structure databases

ProteinModelPortaliQ5SVQ8
SMRiQ5SVQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 152BTBPROSITE-ProRule annotationAdd BLAST65

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri207 – 230C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri361 – 383C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 445C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri463 – 485C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 514C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri518 – 541C2H2-type 7PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri547 – 569C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri603 – 625C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri631 – 654C2H2-type 11PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri668 – 690C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri696 – 718C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri724 – 747C2H2-type 14PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000075080
HOGENOMiHOG000054186
HOVERGENiHBG080093
InParanoidiQ5SVQ8
KOiK10513
OMAiGSDNLNQ
OrthoDBiEOG091G02KC
PhylomeDBiQ5SVQ8
TreeFamiTF350933

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5SVQ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKKRRKVTSN LEKIHLGYHK DSSEGNVAVE CDQVTYTHSA GRPTPEALHC 
        60         70         80         90        100
YQELPPSPDQ RKLLSSLQYN KNLLKYLNDD RQKQPSFCDL LIIVEGKEFS 
       110        120        130        140        150
AHKVVVAVGS SYFHACLSKN PSTDVVTLDH VTHSVFQHLL EFLYTSEFFV 
       160        170        180        190        200
YKYEIPLVLE AAKFLDIIDA VKLLNNENVA PFHSELTEKS SPEETLNELT 
       210        220        230        240        250
GRLSNNHQCK FCSRHFCYKK SLENHLAKTH RSLLLGKKHG LKMLERSFSA 
       260        270        280        290        300
RRSKRNRKCP VKFDDTSDDE QESGDGSDNL NQENFDKEKS DRNDSEDPGS 
       310        320        330        340        350
EYNAEEDELE EEMSDEYSDI EEQSEKDHND AEEEPEAGDS VGNVHEGLTP 
       360        370        380        390        400
VVIQNSNKKI LQCPKCDKTF DRIGKYESHT RVHTGEKPFE CDICHQRYST 
       410        420        430        440        450
KSNLTVHRKK HSNETEFHKK EHKCPYCNKL HASKKTLAKH VKRFHPENAQ 
       460        470        480        490        500
EFISIKKTKS ESWKCDICKK SFTRRPHLEE HMILHSQDKP FKCTYCEEHF 
       510        520        530        540        550
KSRFARLKHQ EKFHLGPFPC DICGRQFNDT GNLKRHIECT HGGKRKWTCF 
       560        570        580        590        600
ICGKSVRERT TLKEHLRIHS GEKPHLCSIC GQSFRHGSSY RLHLRVHHDD 
       610        620        630        640        650
KRYECDECGK TFIRHDHLTK HKKIHSGEKA HQCEECGKCF GRRDHLTVHY 
       660        670        680        690        700
KSVHLGEKVW QKYKATFHQC DVCKKIFKGK SSLEMHFRTH SGEKPYKCQI 
       710        720        730        740        750
CNQSFRIKKT LTKHLVIHSD ARPFNCQHCN ATFKRKDKLK YHIDHVHEIK 
       760        770        780        790        800
SPDDPLSTSE EKLVSLPVEY SSDDKIFQTE TKQYMDQPKV YQSEAKTMLQ 
       810        820        830        840        850
NVSAEVCVPV TLVPVQMPDT PSDLVRHTTT LPPSSHEILS PQPQSTDYPR 
       860        870        880        890        900
AADLAFLEKY TLTPQPANIV HPVRPEQMLD PREQSYLGTL LGLDSTTGVQ 

NISTNEHHS
Length:909
Mass (Da):105,192
Last modified:December 21, 2004 - v1
Checksum:iBAB9F19F2F40772F
GO
Isoform 2 (identifier: Q5SVQ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     627-627: G → D
     628-909: Missing.

Note: No experimental confirmation available.
Show »
Length:627
Mass (Da):72,945
Checksum:i350F812D7C761F03
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182F → L in BAC87496 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030601327D → Y. Corresponds to variant dbSNP:rs10494751Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023092627G → D in isoform 2. 1 Publication1
Alternative sequenceiVSP_023093628 – 909Missing in isoform 2. 1 PublicationAdd BLAST282

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY163816 mRNA Translation: AAN71742.2
AY336933 mRNA Translation: AAP97434.1
AK128549 mRNA Translation: BAC87496.1
AL356315 Genomic DNA No translation available.
AL627208 Genomic DNA No translation available.
BC132818 mRNA Translation: AAI32819.1
BC136600 mRNA Translation: AAI36601.1
BX640886 mRNA Translation: CAE45940.1
CCDSiCCDS30960.1 [Q5SVQ8-1]
RefSeqiNP_919290.2, NM_194314.2 [Q5SVQ8-1]
XP_016856694.1, XM_017001205.1 [Q5SVQ8-2]
UniGeneiHs.529439

Genome annotation databases

EnsembliENST00000367405; ENSP00000356375; ENSG00000177888 [Q5SVQ8-1]
GeneIDi360023
KEGGihsa:360023
UCSCiuc001gtx.2 human [Q5SVQ8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY163816 mRNA Translation: AAN71742.2
AY336933 mRNA Translation: AAP97434.1
AK128549 mRNA Translation: BAC87496.1
AL356315 Genomic DNA No translation available.
AL627208 Genomic DNA No translation available.
BC132818 mRNA Translation: AAI32819.1
BC136600 mRNA Translation: AAI36601.1
BX640886 mRNA Translation: CAE45940.1
CCDSiCCDS30960.1 [Q5SVQ8-1]
RefSeqiNP_919290.2, NM_194314.2 [Q5SVQ8-1]
XP_016856694.1, XM_017001205.1 [Q5SVQ8-2]
UniGeneiHs.529439

3D structure databases

ProteinModelPortaliQ5SVQ8
SMRiQ5SVQ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131819, 2 interactors
IntActiQ5SVQ8, 1 interactor
STRINGi9606.ENSP00000356375

PTM databases

iPTMnetiQ5SVQ8
PhosphoSitePlusiQ5SVQ8

Polymorphism and mutation databases

BioMutaiZBTB41
DMDMi74756116

Proteomic databases

EPDiQ5SVQ8
MaxQBiQ5SVQ8
PaxDbiQ5SVQ8
PeptideAtlasiQ5SVQ8
PRIDEiQ5SVQ8
ProteomicsDBi63949
63950 [Q5SVQ8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367405; ENSP00000356375; ENSG00000177888 [Q5SVQ8-1]
GeneIDi360023
KEGGihsa:360023
UCSCiuc001gtx.2 human [Q5SVQ8-1]

Organism-specific databases

CTDi360023
EuPathDBiHostDB:ENSG00000177888.7
GeneCardsiZBTB41
H-InvDBiHIX0200000
HGNCiHGNC:24819 ZBTB41
HPAiHPA034841
HPA034842
neXtProtiNX_Q5SVQ8
OpenTargetsiENSG00000177888
PharmGKBiPA142670545
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000075080
HOGENOMiHOG000054186
HOVERGENiHBG080093
InParanoidiQ5SVQ8
KOiK10513
OMAiGSDNLNQ
OrthoDBiEOG091G02KC
PhylomeDBiQ5SVQ8
TreeFamiTF350933

Miscellaneous databases

ChiTaRSiZBTB41 human
GenomeRNAii360023
PROiPR:Q5SVQ8

Gene expression databases

BgeeiENSG00000177888 Expressed in 198 organ(s), highest expression level in forebrain
CleanExiHS_ZBTB41
GenevisibleiQ5SVQ8 HS

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 13 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT41_HUMAN
AccessioniPrimary (citable) accession number: Q5SVQ8
Secondary accession number(s): A2RUA8
, Q6MZT8, Q6ZR25, Q7Z4T1, Q8IZ99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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