UniProtKB - Q5SVQ8 (ZBT41_HUMAN)
Protein
Zinc finger and BTB domain-containing protein 41
Gene
ZBTB41
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 207 – 230 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 361 – 383 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 389 – 411 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 422 – 445 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 463 – 485 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 491 – 514 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 518 – 541 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 547 – 569 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 575 – 597 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 603 – 625 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 631 – 654 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 668 – 690 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 696 – 718 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 724 – 747 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q5SVQ8 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger and BTB domain-containing protein 41 |
Gene namesi | Name:ZBTB41 Synonyms:FRBZ1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000177888.7 |
HGNCi | HGNC:24819, ZBTB41 |
neXtProti | NX_Q5SVQ8 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 360023 |
OpenTargetsi | ENSG00000177888 |
PharmGKBi | PA142670545 |
Miscellaneous databases
Pharosi | Q5SVQ8, Tdark |
Polymorphism and mutation databases
BioMutai | ZBTB41 |
DMDMi | 74756116 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000277814 | 1 – 909 | Zinc finger and BTB domain-containing protein 41Add BLAST | 909 |
Proteomic databases
EPDi | Q5SVQ8 |
jPOSTi | Q5SVQ8 |
MassIVEi | Q5SVQ8 |
MaxQBi | Q5SVQ8 |
PaxDbi | Q5SVQ8 |
PeptideAtlasi | Q5SVQ8 |
PRIDEi | Q5SVQ8 |
ProteomicsDBi | 63949 [Q5SVQ8-1] 63950 [Q5SVQ8-2] |
PTM databases
iPTMneti | Q5SVQ8 |
PhosphoSitePlusi | Q5SVQ8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177888, Expressed in forebrain and 214 other tissues |
Genevisiblei | Q5SVQ8, HS |
Organism-specific databases
HPAi | ENSG00000177888, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 131819, 4 interactors |
IntActi | Q5SVQ8, 1 interactor |
STRINGi | 9606.ENSP00000356375 |
Miscellaneous databases
RNActi | Q5SVQ8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 88 – 152 | BTBPROSITE-ProRule annotationAdd BLAST | 65 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 207 – 230 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 361 – 383 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 389 – 411 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 422 – 445 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 463 – 485 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 491 – 514 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 518 – 541 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 547 – 569 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 575 – 597 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 603 – 625 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 631 – 654 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 668 – 690 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 696 – 718 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 724 – 747 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00550000075080 |
HOGENOMi | CLU_014920_0_0_1 |
InParanoidi | Q5SVQ8 |
OMAi | EFFVYKN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q5SVQ8 |
TreeFami | TF350933 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q5SVQ8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKKRRKVTSN LEKIHLGYHK DSSEGNVAVE CDQVTYTHSA GRPTPEALHC
60 70 80 90 100
YQELPPSPDQ RKLLSSLQYN KNLLKYLNDD RQKQPSFCDL LIIVEGKEFS
110 120 130 140 150
AHKVVVAVGS SYFHACLSKN PSTDVVTLDH VTHSVFQHLL EFLYTSEFFV
160 170 180 190 200
YKYEIPLVLE AAKFLDIIDA VKLLNNENVA PFHSELTEKS SPEETLNELT
210 220 230 240 250
GRLSNNHQCK FCSRHFCYKK SLENHLAKTH RSLLLGKKHG LKMLERSFSA
260 270 280 290 300
RRSKRNRKCP VKFDDTSDDE QESGDGSDNL NQENFDKEKS DRNDSEDPGS
310 320 330 340 350
EYNAEEDELE EEMSDEYSDI EEQSEKDHND AEEEPEAGDS VGNVHEGLTP
360 370 380 390 400
VVIQNSNKKI LQCPKCDKTF DRIGKYESHT RVHTGEKPFE CDICHQRYST
410 420 430 440 450
KSNLTVHRKK HSNETEFHKK EHKCPYCNKL HASKKTLAKH VKRFHPENAQ
460 470 480 490 500
EFISIKKTKS ESWKCDICKK SFTRRPHLEE HMILHSQDKP FKCTYCEEHF
510 520 530 540 550
KSRFARLKHQ EKFHLGPFPC DICGRQFNDT GNLKRHIECT HGGKRKWTCF
560 570 580 590 600
ICGKSVRERT TLKEHLRIHS GEKPHLCSIC GQSFRHGSSY RLHLRVHHDD
610 620 630 640 650
KRYECDECGK TFIRHDHLTK HKKIHSGEKA HQCEECGKCF GRRDHLTVHY
660 670 680 690 700
KSVHLGEKVW QKYKATFHQC DVCKKIFKGK SSLEMHFRTH SGEKPYKCQI
710 720 730 740 750
CNQSFRIKKT LTKHLVIHSD ARPFNCQHCN ATFKRKDKLK YHIDHVHEIK
760 770 780 790 800
SPDDPLSTSE EKLVSLPVEY SSDDKIFQTE TKQYMDQPKV YQSEAKTMLQ
810 820 830 840 850
NVSAEVCVPV TLVPVQMPDT PSDLVRHTTT LPPSSHEILS PQPQSTDYPR
860 870 880 890 900
AADLAFLEKY TLTPQPANIV HPVRPEQMLD PREQSYLGTL LGLDSTTGVQ
NISTNEHHS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 182 | F → L in BAC87496 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_030601 | 327 | D → Y. Corresponds to variant dbSNP:rs10494751Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023092 | 627 | G → D in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_023093 | 628 – 909 | Missing in isoform 2. 1 PublicationAdd BLAST | 282 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY163816 mRNA Translation: AAN71742.2 AY336933 mRNA Translation: AAP97434.1 AK128549 mRNA Translation: BAC87496.1 AL356315 Genomic DNA No translation available. AL627208 Genomic DNA No translation available. BC132818 mRNA Translation: AAI32819.1 BC136600 mRNA Translation: AAI36601.1 BX640886 mRNA Translation: CAE45940.1 |
CCDSi | CCDS30960.1 [Q5SVQ8-1] |
RefSeqi | NP_919290.2, NM_194314.2 [Q5SVQ8-1] XP_016856694.1, XM_017001205.1 [Q5SVQ8-2] |
Genome annotation databases
Ensembli | ENST00000367405; ENSP00000356375; ENSG00000177888 [Q5SVQ8-1] |
GeneIDi | 360023 |
KEGGi | hsa:360023 |
UCSCi | uc001gtx.2, human [Q5SVQ8-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY163816 mRNA Translation: AAN71742.2 AY336933 mRNA Translation: AAP97434.1 AK128549 mRNA Translation: BAC87496.1 AL356315 Genomic DNA No translation available. AL627208 Genomic DNA No translation available. BC132818 mRNA Translation: AAI32819.1 BC136600 mRNA Translation: AAI36601.1 BX640886 mRNA Translation: CAE45940.1 |
CCDSi | CCDS30960.1 [Q5SVQ8-1] |
RefSeqi | NP_919290.2, NM_194314.2 [Q5SVQ8-1] XP_016856694.1, XM_017001205.1 [Q5SVQ8-2] |
3D structure databases
SMRi | Q5SVQ8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131819, 4 interactors |
IntActi | Q5SVQ8, 1 interactor |
STRINGi | 9606.ENSP00000356375 |
PTM databases
iPTMneti | Q5SVQ8 |
PhosphoSitePlusi | Q5SVQ8 |
Polymorphism and mutation databases
BioMutai | ZBTB41 |
DMDMi | 74756116 |
Proteomic databases
EPDi | Q5SVQ8 |
jPOSTi | Q5SVQ8 |
MassIVEi | Q5SVQ8 |
MaxQBi | Q5SVQ8 |
PaxDbi | Q5SVQ8 |
PeptideAtlasi | Q5SVQ8 |
PRIDEi | Q5SVQ8 |
ProteomicsDBi | 63949 [Q5SVQ8-1] 63950 [Q5SVQ8-2] |
Protocols and materials databases
ABCDi | Q5SVQ8, 2 sequenced antibodies |
Antibodypediai | 50783, 87 antibodies |
Genome annotation databases
Ensembli | ENST00000367405; ENSP00000356375; ENSG00000177888 [Q5SVQ8-1] |
GeneIDi | 360023 |
KEGGi | hsa:360023 |
UCSCi | uc001gtx.2, human [Q5SVQ8-1] |
Organism-specific databases
CTDi | 360023 |
DisGeNETi | 360023 |
EuPathDBi | HostDB:ENSG00000177888.7 |
GeneCardsi | ZBTB41 |
HGNCi | HGNC:24819, ZBTB41 |
HPAi | ENSG00000177888, Low tissue specificity |
neXtProti | NX_Q5SVQ8 |
OpenTargetsi | ENSG00000177888 |
PharmGKBi | PA142670545 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00550000075080 |
HOGENOMi | CLU_014920_0_0_1 |
InParanoidi | Q5SVQ8 |
OMAi | EFFVYKN |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q5SVQ8 |
TreeFami | TF350933 |
Enzyme and pathway databases
PathwayCommonsi | Q5SVQ8 |
Miscellaneous databases
BioGRID-ORCSi | 360023, 28 hits in 862 CRISPR screens |
ChiTaRSi | ZBTB41, human |
GenomeRNAii | 360023 |
Pharosi | Q5SVQ8, Tdark |
PROi | PR:Q5SVQ8 |
RNActi | Q5SVQ8, protein |
Gene expression databases
Bgeei | ENSG00000177888, Expressed in forebrain and 214 other tissues |
Genevisiblei | Q5SVQ8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 7 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 7 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 13 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZBT41_HUMAN | |
Accessioni | Q5SVQ8Primary (citable) accession number: Q5SVQ8 Secondary accession number(s): A2RUA8 Q8IZ99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations