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Entry version 147 (02 Dec 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Histone acetyltransferase KAT7

Gene

Kat7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development (PubMed:21753189, PubMed:21149574, PubMed:23319590, PubMed:27733580, PubMed:31827282). Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation (By similarity). Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4 (By similarity). H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II (PubMed:31827282). Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (By similarity). H3K14ac is also required for T-cell development (PubMed:27733580). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing (By similarity). Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange (By similarity). Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites (By similarity). Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (By similarity).By similarity5 Publications
Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML) (PubMed:31827282). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells (PubMed:31827282).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Histone acetyltransferase activity is inhibited by GMNN in the context of a complex with CDT1, inhibiting histone H4 acetylation and DNA replication licensing.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi370ZincBy similarity1
Metal bindingi373ZincBy similarity1
Metal bindingi386ZincBy similarity1
Metal bindingi390ZincBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei510Proton donor/acceptorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei514acetyl-CoABy similarity1
Binding sitei523acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri178 – 221CCHHC-typePROSITE-ProRule annotationAdd BLAST44
Zinc fingeri367 – 392C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Chromatin regulator, Transferase
Biological processDNA damage, DNA repair, DNA replication, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3214847, HATs acetylate histones

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone acetyltransferase KAT7Curated (EC:2.3.1.481 Publication)
Alternative name(s):
Histone acetyltransferase binding to ORC11 Publication
Lysine acetyltransferase 7
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
Short name:
MYST-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Kat7Imported
Synonyms:Hbo11 Publication, Myst2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2182799, Kat7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethality caused by a strong reduction of histone H3 'Lys-14' acetylation (H3K14ac) (PubMed:21149574). Development is arrested at the 10-somite stage (PubMed:21149574). Blood vessels, mesenchyme, and somites are disorganized (PubMed:21149574). No defects in DNA replication or cell proliferation are observed (PubMed:21149574). Conditional mice lacking Kat7 in thymocytes display normal alpha-beta T-cells but show impaired development of peripheral CD4+ or CD8+ T-cells (PubMed:27733580).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000515701 – 613Histone acetyltransferase KAT7Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphoserineBy similarity1
Modified residuei52PhosphoserineCombined sources1
Modified residuei55PhosphoserineBy similarity1
Modified residuei59PhosphoserineCombined sources1
Modified residuei66PhosphoserineBy similarity1
Modified residuei87PhosphothreonineCombined sources1
Modified residuei90PhosphothreonineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei106PhosphothreonineCombined sources1
Modified residuei113PhosphoserineBy similarity1
Modified residuei126PhosphoserineCombined sources1
Modified residuei130PhosphothreonineCombined sources1
Modified residuei160PhosphoserineBy similarity1
Modified residuei164PhosphoserineBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei180PhosphoserineBy similarity1
Modified residuei201N6-acetyllysineCombined sources1
Modified residuei279N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki325Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki340Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei434N6-acetyllysine; by autocatalysisBy similarity1
Modified residuei508PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-52 and Ser-55 by ATR in response to DNA damage, promoting its ubiquitination by the CRL4(DDB2) complex and subsequent degradation. Phosphorylation at Ser-52 and Ser-55 by ATR in response to ultraviolet-induced DNA, promotes localization to DNA damage sites. Phosphorylation at Ser-59 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-87 and Thr-90 by CDK1 (By similarity). Phosphorylated by MAP2K1, which accelerates its degradation (PubMed:23319590).By similarity1 Publication
Ubiquitinated at Lys-340, leading to proteasomal degradation. Ubiquitinated by the CRL4(DDB2) complex following phosphorylation by ATR, leading to its subsequent degradation.By similarity
Autoacetylation at Lys-434 is required for proper function.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5SVQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SVQ0

PeptideAtlas

More...
PeptideAtlasi
Q5SVQ0

PRoteomics IDEntifications database

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PRIDEi
Q5SVQ0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SVQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SVQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in adult tissues.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed ubiquitously in the embryonic and extraembryonic tissues (PubMed:21149574). High levels are present in the chorionic plate (E8.5 and E9.5) as well as in and around the foregut and hindgut regions (E9.5) (PubMed:21149574).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038909, Expressed in spermatocyte and 310 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5SVQ0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5SVQ0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING4 or ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4 (PubMed:21753189, PubMed:31827282).

Interacts with MCM2 and ORC1 (By similarity).

Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone (By similarity).

Interacts with CDT1 (By similarity).

Interacts with MAP2K1 and CUL1 (PubMed:23319590).

Interacts with p53/TP53; leading to inhibit histone acetyltransferase activity (By similarity).

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
229849, 6 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-794, HBO1-4.1 histone acetyltransferase complex
CPX-795, HBO1-4.2 histone acetyltransferase complex
CPX-796, HBO1-4.3 histone acetyltransferase complex
CPX-797, HBO1-5.1 histone acetyltransferase complex
CPX-798, HBO1-5.2 histone acetyltransferase complex
CPX-799, HBO1-5.3 histone acetyltransferase complex

Protein interaction database and analysis system

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IntActi
Q5SVQ0, 2 interactors

Molecular INTeraction database

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MINTi
Q5SVQ0

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q5SVQ0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5SVQ0

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini334 – 609MYST-type HATPROSITE-ProRule annotationAdd BLAST276

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni477 – 479acetyl-CoA bindingBy similarity3
Regioni485 – 490acetyl-CoA bindingBy similarity6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 59Ser-richAdd BLAST48

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C2HC MYST-type zinc finger is required for interaction with MCM2 and ORC1.By similarity
The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri178 – 221CCHHC-typePROSITE-ProRule annotationAdd BLAST44
Zinc fingeri367 – 392C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000157744

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_011815_6_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5SVQ0

Identification of Orthologs from Complete Genome Data

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OMAi
XVRAQSR

Database of Orthologous Groups

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OrthoDBi
629545at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5SVQ0

TreeFam database of animal gene trees

More...
TreeFami
TF317619

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR002717, HAT_MYST-type
IPR036388, WH-like_DNA-bd_sf
IPR040706, Zf-MYST
IPR002515, Znf_C2H2C
IPR036060, Znf_C2H2C_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF01853, MOZ_SAS, 1 hit
PF01530, zf-C2HC, 1 hit
PF17772, zf-MYST, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF103637, SSF103637, 1 hit
SSF55729, SSF55729, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51726, MYST_HAT, 1 hit
PS51802, ZF_CCHHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SVQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAIGVVKRNA GSSSDGTEDS DFSTDLEHTD SSESDGTSRR SARVTRSSAR
60 70 80 90 100
LSQSSQDSSP VRNLPSFGTE EPAYSTRRVT RSQQQPTPVT PKKYPLRQTR
110 120 130 140 150
SSGSETEQVV DFSDRETKNT ADHDESPPRT PTGNAPSSES DIDISSPNVS
160 170 180 190 200
HDESIAKDMS LKDSGSDLSH RPKRRRFHES YNFNMKCPTP GCNSLGHLTG
210 220 230 240 250
KHERHFSISG CPLYHNLSAD ECKVRAQSRD KQIEERMLSH RQDDNNRHAT
260 270 280 290 300
RHQAPTERQL RYKEKVAELR KKRNSGLSKE QKEKYMEHRQ TYGNTREPLL
310 320 330 340 350
ENLTSEYDLD LFRRAQARAS EDLEKLRLQG QITEGSNMIK TIAFGRYELD
360 370 380 390 400
TWYHSPYPEE YARLGRLYMC EFCLKYMKSQ TILRRHMAKC VWKHPPGDEI
410 420 430 440 450
YRKGSISVFE VDGKKNKIYC QNLCLLAKLF LDHKTLYYDV EPFLFYVMTE
460 470 480 490 500
ADNTGCHLIG YFSKEKNSFL NYNVSCILTM PQYMRQGYGK MLIDFSYLLS
510 520 530 540 550
KVEEKVGSPE RPLSDLGLIS YRSYWKEVLL RYLHNFQGKE ISIKEISQET
560 570 580 590 600
AVNPVDIVST LQALQMLKYW KGKHLVLKRQ DLIDEWIAKE AKRSNSNKTM
610
DPSCLKWTPP KGT
Length:613
Mass (Da):70,641
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7D6F05EE90A7134E
GO
Isoform 2 (identifier: Q5SVQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     224-253: Missing.

Show »
Length:583
Mass (Da):66,946
Checksum:i3F76E885AA985114
GO
Isoform 3 (identifier: Q5SVQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAIGVV → MPRR

Show »
Length:611
Mass (Da):70,611
Checksum:i769DE7C4F03762D9
GO
Isoform 4 (identifier: Q5SVQ0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAIGVV → MPRR
     224-253: Missing.

Show »
Length:581
Mass (Da):66,916
Checksum:i3F06E4C3E47EFBA3
GO
Isoform 5 (identifier: Q5SVQ0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MAIGVV → MPRR
     57-115: Missing.
     224-253: Missing.

Show »
Length:522
Mass (Da):60,251
Checksum:iA3625C7287230759
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6S4B9F6S4B9_MOUSE
Histone acetyltransferase
Kat7 Myst2
150Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti429L → P in AAH57102 (PubMed:15489334).Curated1
Sequence conflicti545 – 548EISQ → GPDR in CAI24805 (PubMed:19468303).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0145821 – 6MAIGVV → MPRR in isoform 3, isoform 4 and isoform 5. 1 Publication6
Alternative sequenceiVSP_01458357 – 115Missing in isoform 5. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_014584224 – 253Missing in isoform 2, isoform 4 and isoform 5. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL627222 Genomic DNA Translation: CAI24800.1
AL627222 Genomic DNA Translation: CAI24801.1
AL627222 Genomic DNA Translation: CAI24802.1
AL627222 Genomic DNA Translation: CAI24803.1
AL627222 Genomic DNA Translation: CAI24804.1
AL627222 Genomic DNA Translation: CAI24805.1
BC057102 mRNA Translation: AAH57102.1
BC048904 mRNA Translation: AAH48904.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25275.1 [Q5SVQ0-5]
CCDS56798.1 [Q5SVQ0-4]
CCDS56799.1 [Q5SVQ0-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001181933.1, NM_001195004.1 [Q5SVQ0-4]
NP_808287.1, NM_177619.3 [Q5SVQ0-5]
XP_006533076.1, XM_006533013.3 [Q5SVQ0-1]
XP_006533077.1, XM_006533014.3 [Q5SVQ0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000072621; ENSMUSP00000072416; ENSMUSG00000038909 [Q5SVQ0-2]
ENSMUST00000092766; ENSMUSP00000090441; ENSMUSG00000038909 [Q5SVQ0-1]
ENSMUST00000103159; ENSMUSP00000099448; ENSMUSG00000038909 [Q5SVQ0-5]
ENSMUST00000107733; ENSMUSP00000103361; ENSMUSG00000038909 [Q5SVQ0-4]
ENSMUST00000107734; ENSMUSP00000103362; ENSMUSG00000038909 [Q5SVQ0-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
217127

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:217127

UCSC genome browser

More...
UCSCi
uc007lad.2, mouse [Q5SVQ0-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL627222 Genomic DNA Translation: CAI24800.1
AL627222 Genomic DNA Translation: CAI24801.1
AL627222 Genomic DNA Translation: CAI24802.1
AL627222 Genomic DNA Translation: CAI24803.1
AL627222 Genomic DNA Translation: CAI24804.1
AL627222 Genomic DNA Translation: CAI24805.1
BC057102 mRNA Translation: AAH57102.1
BC048904 mRNA Translation: AAH48904.1
CCDSiCCDS25275.1 [Q5SVQ0-5]
CCDS56798.1 [Q5SVQ0-4]
CCDS56799.1 [Q5SVQ0-3]
RefSeqiNP_001181933.1, NM_001195004.1 [Q5SVQ0-4]
NP_808287.1, NM_177619.3 [Q5SVQ0-5]
XP_006533076.1, XM_006533013.3 [Q5SVQ0-1]
XP_006533077.1, XM_006533014.3 [Q5SVQ0-2]

3D structure databases

SMRiQ5SVQ0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi229849, 6 interactors
ComplexPortaliCPX-794, HBO1-4.1 histone acetyltransferase complex
CPX-795, HBO1-4.2 histone acetyltransferase complex
CPX-796, HBO1-4.3 histone acetyltransferase complex
CPX-797, HBO1-5.1 histone acetyltransferase complex
CPX-798, HBO1-5.2 histone acetyltransferase complex
CPX-799, HBO1-5.3 histone acetyltransferase complex
IntActiQ5SVQ0, 2 interactors
MINTiQ5SVQ0

PTM databases

iPTMnetiQ5SVQ0
PhosphoSitePlusiQ5SVQ0

Proteomic databases

jPOSTiQ5SVQ0
PaxDbiQ5SVQ0
PeptideAtlasiQ5SVQ0
PRIDEiQ5SVQ0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
17983, 354 antibodies

Genome annotation databases

EnsembliENSMUST00000072621; ENSMUSP00000072416; ENSMUSG00000038909 [Q5SVQ0-2]
ENSMUST00000092766; ENSMUSP00000090441; ENSMUSG00000038909 [Q5SVQ0-1]
ENSMUST00000103159; ENSMUSP00000099448; ENSMUSG00000038909 [Q5SVQ0-5]
ENSMUST00000107733; ENSMUSP00000103361; ENSMUSG00000038909 [Q5SVQ0-4]
ENSMUST00000107734; ENSMUSP00000103362; ENSMUSG00000038909 [Q5SVQ0-3]
GeneIDi217127
KEGGimmu:217127
UCSCiuc007lad.2, mouse [Q5SVQ0-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11143
MGIiMGI:2182799, Kat7

Phylogenomic databases

GeneTreeiENSGT00940000157744
HOGENOMiCLU_011815_6_1_1
InParanoidiQ5SVQ0
OMAiXVRAQSR
OrthoDBi629545at2759
PhylomeDBiQ5SVQ0
TreeFamiTF317619

Enzyme and pathway databases

ReactomeiR-MMU-3214847, HATs acetylate histones

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
217127, 5 hits in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Kat7, mouse

Protein Ontology

More...
PROi
PR:Q5SVQ0
RNActiQ5SVQ0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038909, Expressed in spermatocyte and 310 other tissues
ExpressionAtlasiQ5SVQ0, baseline and differential
GenevisibleiQ5SVQ0, MM

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016181, Acyl_CoA_acyltransferase
IPR002717, HAT_MYST-type
IPR036388, WH-like_DNA-bd_sf
IPR040706, Zf-MYST
IPR002515, Znf_C2H2C
IPR036060, Znf_C2H2C_sf
PfamiView protein in Pfam
PF01853, MOZ_SAS, 1 hit
PF01530, zf-C2HC, 1 hit
PF17772, zf-MYST, 1 hit
SUPFAMiSSF103637, SSF103637, 1 hit
SSF55729, SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51726, MYST_HAT, 1 hit
PS51802, ZF_CCHHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKAT7_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SVQ0
Secondary accession number(s): Q5SVQ1
, Q5SVQ2, Q5SVQ3, Q5SVQ7, Q6PGC6, Q80Y65
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 21, 2004
Last modified: December 2, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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