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Protein

Rap1 GTPase-activating protein 2

Gene

Rap1gap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.By similarity

GO - Molecular functioni

  • GTPase activator activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-MMU-392517 Rap1 signalling

Names & Taxonomyi

Protein namesi
Recommended name:
Rap1 GTPase-activating protein 2
Short name:
Rap1GAP2
Alternative name(s):
GTPase-activating Rap/Ran-GAP domain-like protein 4
Gene namesi
Name:Rap1gap2
Synonyms:Garnl4, Kiaa1039, Rap1ga2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:3028623 Rap1gap2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127171 – 712Rap1 GTPase-activating protein 2Add BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1
Modified residuei30PhosphothreonineBy similarity1
Modified residuei488PhosphoserineCombined sources1
Modified residuei495PhosphoserineCombined sources1
Modified residuei525PhosphoserineBy similarity1
Modified residuei539PhosphoserineBy similarity1
Modified residuei545PhosphoserineBy similarity1
Modified residuei593PhosphoserineCombined sources1
Modified residuei594PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5SVL6
PeptideAtlasiQ5SVL6
PRIDEiQ5SVL6

PTM databases

iPTMnetiQ5SVL6
PhosphoSitePlusiQ5SVL6

Expressioni

Gene expression databases

BgeeiENSMUSG00000038807 Expressed in 207 organ(s), highest expression level in dorsal pancreas
CleanExiMM_GARNL4
ExpressionAtlasiQ5SVL6 baseline and differential
GenevisibleiQ5SVL6 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040180

Structurei

3D structure databases

ProteinModelPortaliQ5SVL6
SMRiQ5SVL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini229 – 445Rap-GAPPROSITE-ProRule annotationAdd BLAST217

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi553 – 709Ser-richAdd BLAST157

Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00760000119182
HOGENOMiHOG000231640
HOVERGENiHBG016371
InParanoidiQ5SVL6
KOiK17708
OMAiHNSVEVT
OrthoDBiEOG091G028T
PhylomeDBiQ5SVL6
TreeFamiTF318626

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
PROSITEiView protein in PROSITE
PS50085 RAPGAP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SVL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAGLKVKKQ ELANSSDVTL PDRPLSPPLT APPTMKSAEF FEMLEKMQGI
60 70 80 90 100
KLEEQRPGPQ KNKDDYIPYP SIDEVVEKGG PYPLIILPQF GGYWIEDPEN
110 120 130 140 150
VGTPTSLGSS VYEEEEEDSL SPNTFGYKLE CRGEARAYRR HFLGKDHLNF
160 170 180 190 200
YCTGSSLGNL ILSIKCEEAE GMEYLRIILR SKLKTVHERI PLAGLSKLPS
210 220 230 240 250
VPQIAKAFCD DAVGLKFNPV LYPKASQMIV SYDEHDVNNT FKFGVIYQKA
260 270 280 290 300
RQTLEEELFG NNEESPAFKE FLDLLGDTIT LQDFKGFRGG LDVTHGQTGV
310 320 330 340 350
ESVYTTFRDR EIMFHVSTKL PFTDGDTQQL QRKRHIGNDI VAIIFQEENT
360 370 380 390 400
PFVPDMIASN FLHAYIVVQA DNPGTETPSY KVSVTAREDV PAFGPPLPSP
410 420 430 440 450
PVFQKGAEFR EFLLTKLTNA ENACCKSDKF AKLEDRTRAA LLDNLHDELH
460 470 480 490 500
THTQVMLGMG PEEDKFENGG HGGFLESFKR AIRVRSHSME TMVGSQRKLH
510 520 530 540 550
GGNLPGSLSG GIVHNSMEVT KTTFSPPVAA ATAKNQSRSP IKRRSGLFPR
560 570 580 590 600
LHSGSEGQGD SRTRCDSASS TPKTPDGGHS SQEIKSETSS NPSSPEICPN
610 620 630 640 650
KEKPFIKLKE NGRANISRSS SSTSSFSSTA GEGEAMEECD SGSSQPSTTS
660 670 680 690 700
PFKQEVFAYS PSPSSESPSL GAAATPIIMS RSPTDAKSRN SPRSNLKFRF
710
DKLSHASSSA GH
Length:712
Mass (Da):78,254
Last modified:December 21, 2004 - v1
Checksum:i49FD87D1AF030A57
GO
Isoform 2 (identifier: Q5SVL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-194: Missing.
     195-206: LSKLPSVPQIAK → MVLDLCVFLPSQ

Note: No experimental confirmation available.
Show »
Length:518
Mass (Da):56,548
Checksum:i0616F5A7EE8B713E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A171EBK8A0A171EBK8_MOUSE
Rap1 GTPase-activating protein 2
Rap1gap2
758Annotation score:
Q5SUE5Q5SUE5_MOUSE
Rap1 GTPase-activating protein 2
Rap1gap2
90Annotation score:
A0A140LI95A0A140LI95_MOUSE
Rap1 GTPase-activating protein 2
Rap1gap2
173Annotation score:

Sequence cautioni

The sequence BAC65706 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAC65706 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0298901 – 194Missing in isoform 2. 1 PublicationAdd BLAST194
Alternative sequenceiVSP_029952195 – 206LSKLP…PQIAK → MVLDLCVFLPSQ in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645971, AL604065, AL627348 Genomic DNA Translation: CAI25407.1
AL604065, AL627348, AL645971 Genomic DNA Translation: CAI24516.1
AL627348, AL604065, AL645971 Genomic DNA Translation: CAI25645.1
BC107388 mRNA Translation: AAI07389.1
AK038834 mRNA Translation: BAE20542.1
AK122424 mRNA Translation: BAC65706.1 Sequence problems.
CCDSiCCDS25032.1 [Q5SVL6-1]
RefSeqiNP_001015046.1, NM_001015046.2 [Q5SVL6-1]
UniGeneiMm.425690

Genome annotation databases

EnsembliENSMUST00000102521; ENSMUSP00000099580; ENSMUSG00000038807 [Q5SVL6-1]
GeneIDi380711
KEGGimmu:380711
UCSCiuc007kbw.1 mouse [Q5SVL6-2]
uc007kbx.1 mouse [Q5SVL6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645971, AL604065, AL627348 Genomic DNA Translation: CAI25407.1
AL604065, AL627348, AL645971 Genomic DNA Translation: CAI24516.1
AL627348, AL604065, AL645971 Genomic DNA Translation: CAI25645.1
BC107388 mRNA Translation: AAI07389.1
AK038834 mRNA Translation: BAE20542.1
AK122424 mRNA Translation: BAC65706.1 Sequence problems.
CCDSiCCDS25032.1 [Q5SVL6-1]
RefSeqiNP_001015046.1, NM_001015046.2 [Q5SVL6-1]
UniGeneiMm.425690

3D structure databases

ProteinModelPortaliQ5SVL6
SMRiQ5SVL6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000040180

PTM databases

iPTMnetiQ5SVL6
PhosphoSitePlusiQ5SVL6

Proteomic databases

PaxDbiQ5SVL6
PeptideAtlasiQ5SVL6
PRIDEiQ5SVL6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102521; ENSMUSP00000099580; ENSMUSG00000038807 [Q5SVL6-1]
GeneIDi380711
KEGGimmu:380711
UCSCiuc007kbw.1 mouse [Q5SVL6-2]
uc007kbx.1 mouse [Q5SVL6-1]

Organism-specific databases

CTDi23108
MGIiMGI:3028623 Rap1gap2
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3686 Eukaryota
ENOG410XTIX LUCA
GeneTreeiENSGT00760000119182
HOGENOMiHOG000231640
HOVERGENiHBG016371
InParanoidiQ5SVL6
KOiK17708
OMAiHNSVEVT
OrthoDBiEOG091G028T
PhylomeDBiQ5SVL6
TreeFamiTF318626

Enzyme and pathway databases

ReactomeiR-MMU-392517 Rap1 signalling

Miscellaneous databases

ChiTaRSiRap1gap2 mouse
PROiPR:Q5SVL6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038807 Expressed in 207 organ(s), highest expression level in dorsal pancreas
CleanExiMM_GARNL4
ExpressionAtlasiQ5SVL6 baseline and differential
GenevisibleiQ5SVL6 MM

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
PROSITEiView protein in PROSITE
PS50085 RAPGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPGP2_MOUSE
AccessioniPrimary (citable) accession number: Q5SVL6
Secondary accession number(s): Q3KNA3, Q3V3L0, Q80TL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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