UniProtKB - Q5SVL2 (Q5SVL2_HUMAN)
Protein
Submitted name:
Caspase-7
Gene
CASP7
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Thiol proteaseARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Caspase-7Imported |
Gene namesi | Name:CASP7Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1508, CASP7 |
VEuPathDBi | HostDB:ENSG00000165806.19 |
PTM / Processingi
Keywords - PTMi
ZymogenARBA annotationProteomic databases
MaxQBi | Q5SVL2 |
PeptideAtlasi | Q5SVL2 |
ProteomicsDBi | 63946 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165806, Expressed in colonic mucosa and 224 other tissues |
ExpressionAtlasi | Q5SVL2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 66 – 190 | CASPASE_P20InterPro annotationAdd BLAST | 125 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 30 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | AcidicSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the peptidase C14A family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000153232 |
HOGENOMi | CLU_036904_3_1_1 |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR015471, Casp3/7 IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR002398, Pept_C14 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit PTHR10454:SF31, PTHR10454:SF31, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00115, CASc, 1 hit |
SUPFAMi | SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50208, CASPASE_P20, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q5SVL2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADDQGCIEE QGVEDSANED SVDAKPDRSS FVPSLFSKKK KNVTMRSIKT
60 70 80 90 100
TRDRVPTYQY NMNFEKLGKC IIINNKNFDK VTGMGVRNGT DKDAEALFKC
110 120 130 140 150
FRSLGFDVIV YNDCSCAKMQ DLLKKASEED HTNAACFACI LLSHGEENVI
160 170 180 190 200
YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL FFIQACRGTE LDDGIQADSG
210 220
PINDTDANPR YKIPVEADFL FA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP55210 | CASP7_HUMAN | Caspase-7 | CASP7 MCH3 | 303 | Annotation score: | ||
A0A0A0MRL7 | A0A0A0MRL7_HUMAN | Caspase-7 | CASP7 | 388 | Annotation score: | ||
A0A5F9ZHZ6 | A0A5F9ZHZ6_HUMAN | Caspase-7 | CASP7 | 302 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 222 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL592546 Genomic DNA No translation available. AL627395 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000429617; ENSP00000400094; ENSG00000165806 |
UCSCi | uc057wbr.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL592546 Genomic DNA No translation available. AL627395 Genomic DNA No translation available. |
3D structure databases
SMRi | Q5SVL2 |
ModBasei | Search... |
Proteomic databases
MaxQBi | Q5SVL2 |
PeptideAtlasi | Q5SVL2 |
ProteomicsDBi | 63946 |
Protocols and materials databases
Antibodypediai | 18528, 1028 antibodies |
Genome annotation databases
Ensembli | ENST00000429617; ENSP00000400094; ENSG00000165806 |
UCSCi | uc057wbr.1, human |
Organism-specific databases
HGNCi | HGNC:1508, CASP7 |
OpenTargetsi | ENSG00000165806 |
VEuPathDBi | HostDB:ENSG00000165806.19 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153232 |
HOGENOMi | CLU_036904_3_1_1 |
Miscellaneous databases
ChiTaRSi | CASP7, human |
Gene expression databases
Bgeei | ENSG00000165806, Expressed in colonic mucosa and 224 other tissues |
ExpressionAtlasi | Q5SVL2, baseline and differential |
Family and domain databases
CDDi | cd00032, CASc, 1 hit |
InterProi | View protein in InterPro IPR015471, Casp3/7 IPR029030, Caspase-like_dom_sf IPR033139, Caspase_cys_AS IPR016129, Caspase_his_AS IPR002398, Pept_C14 IPR001309, Pept_C14_p20 IPR015917, Pept_C14A |
PANTHERi | PTHR10454, PTHR10454, 1 hit PTHR10454:SF31, PTHR10454:SF31, 1 hit |
PRINTSi | PR00376, IL1BCENZYME |
SMARTi | View protein in SMART SM00115, CASc, 1 hit |
SUPFAMi | SSF52129, SSF52129, 1 hit |
PROSITEi | View protein in PROSITE PS01122, CASPASE_CYS, 1 hit PS01121, CASPASE_HIS, 1 hit PS50208, CASPASE_P20, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5SVL2_HUMAN | |
Accessioni | Q5SVL2Primary (citable) accession number: Q5SVL2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 21, 2004 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 10, 2021 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |