CASP7

Functionⁱ

GO - Molecular functionⁱ

cysteine-type endopeptidase activity Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Thiol proteaseSAAS annotation

Molecular function

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Caspase-7Imported
Gene namesⁱ	Name:CASP7Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165806.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1508 CASP7

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000165806

OpenTargetsⁱ

ENSG00000165806

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5SVL2
PeptideAtlas More...PeptideAtlasⁱ	Q5SVL2
PRIDEⁱ	Q5SVL2

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000165806
ExpressionAtlasⁱ	Q5SVL2 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5SVL2
SMRⁱ	Q5SVL2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	66 – 190	CASPASE_P20InterPro annotationAdd BLAST		125

Sequence similaritiesⁱ

Belongs to the peptidase C14A family.SAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3573 Eukaryota ENOG410ZQIE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118912
HOGENOMⁱ	HOG000231878
HOVERGENⁱ	HBG050802

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032 CASc, 1 hit
InterProⁱ	View protein in InterPro IPR015471 Casp3/7 IPR029030 Caspase-like_dom_sf IPR033139 Caspase_cys_AS IPR016129 Caspase_his_AS IPR001309 Pept_C14_p20 IPR015917 Pept_C14A
PANTHERⁱ	PTHR10454:SF31 PTHR10454:SF31, 1 hit
PRINTSⁱ	PR00376 IL1BCENZYME
SMARTⁱ	View protein in SMART SM00115 CASc, 1 hit
SUPFAMⁱ	SSF52129 SSF52129, 1 hit
PROSITEⁱ	View protein in PROSITE PS01122 CASPASE_CYS, 1 hit PS01121 CASPASE_HIS, 1 hit PS50208 CASPASE_P20, 1 hit

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q5SVL2-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADDQGCIEE QGVEDSANED SVDAKPDRSS FVPSLFSKKK KNVTMRSIKT 
        60         70         80         90        100
TRDRVPTYQY NMNFEKLGKC IIINNKNFDK VTGMGVRNGT DKDAEALFKC 
       110        120        130        140        150
FRSLGFDVIV YNDCSCAKMQ DLLKKASEED HTNAACFACI LLSHGEENVI 
       160        170        180        190        200
YGKDGVTPIK DLTAHFRGDR CKTLLEKPKL FFIQACRGTE LDDGIQADSG 
       210        220 
PINDTDANPR YKIPVEADFL FA

Length:222

Mass (Da):24,790

Last modified:December 21, 2004 - v1

Checksum:ⁱ752B053E5870BB91

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	222	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL592546 Genomic DNA No translation available. AL627395 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL592546 Genomic DNA No translation available.
AL627395 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000429617; ENSP00000400094; ENSG00000165806
UCSC genome browser More...UCSCⁱ	uc057wbr.1 human

Protein	Similar proteins		Species	Score	Length
Q5SVL2	CASP7 isoform 4		PANTR		336
Caspase 7		PANPA		336
UPI000175400F		HUMAN		173
CASP7 isoform 5		PANTR		303
UPI0007AC51EE		HUMAN		198
+2

Protein	Similar proteins		Species	Score	Length
Q5SVL2	Caspase-7	)	HUMAN		303
Caspase 7		COLAP		337
Caspase 7		PAPAN		336
Caspase 7		GORGO		336
Caspase 7		RHIBE		336
+23

Protein	Similar proteins		Species	Score	Length
Q5SVL2	Caspase-7	)	HUMAN		303
Caspase 7		COLAP		337
Caspase 7		RHIBE		336
CASP7 isoform 4		PONAB		336
Uncharacterized protein		RHIRO		336
+187

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL592546 Genomic DNA No translation available. AL627395 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL592546 Genomic DNA No translation available.
AL627395 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	Q5SVL2
SMRⁱ	Q5SVL2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5SVL2
PeptideAtlas More...PeptideAtlasⁱ	Q5SVL2
PRIDEⁱ	Q5SVL2

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000429617; ENSP00000400094; ENSG00000165806
UCSC genome browser More...UCSCⁱ	uc057wbr.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000165806.19
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1508 CASP7
Open Targets More...OpenTargetsⁱ	ENSG00000165806
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3573 Eukaryota ENOG410ZQIE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118912
HOGENOMⁱ	HOG000231878
HOVERGENⁱ	HBG050802

Miscellaneous databases

ChiTaRSⁱ	CASP7 human

ChiTaRSⁱ

CASP7 human

Gene expression databases

Bgeeⁱ	ENSG00000165806
ExpressionAtlasⁱ	Q5SVL2 baseline and differential

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00032 CASc, 1 hit
InterProⁱ	View protein in InterPro IPR015471 Casp3/7 IPR029030 Caspase-like_dom_sf IPR033139 Caspase_cys_AS IPR016129 Caspase_his_AS IPR001309 Pept_C14_p20 IPR015917 Pept_C14A
PANTHERⁱ	PTHR10454:SF31 PTHR10454:SF31, 1 hit
PRINTSⁱ	PR00376 IL1BCENZYME
SMARTⁱ	View protein in SMART SM00115 CASc, 1 hit
SUPFAMⁱ	SSF52129 SSF52129, 1 hit
PROSITEⁱ	View protein in PROSITE PS01122 CASPASE_CYS, 1 hit PS01121 CASPASE_HIS, 1 hit PS50208 CASPASE_P20, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5SVL2_HUMAN
Accessionⁱ	Q5SVL2Primary (citable) accession number: Q5SVL2
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 21, 2004
	Last sequence update:	December 21, 2004
	Last modified:	July 18, 2018
	This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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Supporting data

UniProtKB - Q5SVL2 (Q5SVL2_HUMAN)

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Caspase-7

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ