UniProtKB - Q5SV01 (Q5SV01_MOUSE)
Protein
Interleukin-5
Gene
Il5
Organism
Mus musculus (Mouse)
Status
Functioni
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.UniRule annotationARBA annotation
GO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- growth factor activity Source: UniProtKB-KW
- interleukin-5 receptor binding Source: Ensembl
GO - Biological processi
- cytokine-mediated signaling pathway Source: Ensembl
- immune response Source: UniProtKB-UniRule
- inflammatory response Source: Ensembl
- positive regulation of B cell proliferation Source: Ensembl
- positive regulation of eosinophil differentiation Source: Ensembl
- positive regulation of podosome assembly Source: Ensembl
- positive regulation of receptor signaling pathway via JAK-STAT Source: Ensembl
Keywordsi
Molecular function | CytokineUniRule annotation, Growth factorUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-5UniRule annotationAlternative name(s): Eosinophil differentiation factorUniRule annotation |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:96557, Il5 |
Subcellular locationi
Extracellular region or secreted
- Secreted UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular space Source: UniProtKB-UniRule
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | UniRule annotationAdd BLAST | 20 | |
ChainiPRO_5014205901 | 21 – 133 | Interleukin-5UniRule annotationAdd BLAST | 113 |
Keywords - PTMi
Disulfide bondUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000036117, Expressed in retina and 40 other tissues |
ExpressionAtlasi | Q5SV01, baseline and differential |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
UniRule annotationARBA annotationGO - Molecular functioni
- cytokine activity Source: UniProtKB-KW
- growth factor activity Source: UniProtKB-KW
- interleukin-5 receptor binding Source: Ensembl
Chemistry databases
BindingDBi | Q5SV01 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalUniRule annotationPhylogenomic databases
HOGENOMi | CLU_156269_0_0_1 |
OMAi | NTEWTME |
OrthoDBi | 1469027at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000186, IL-5 |
Pfami | View protein in Pfam PF02025, IL5, 1 hit |
PRINTSi | PR00432, INTERLEUKIN5 |
SUPFAMi | SSF47266, SSF47266, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5SV01-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRMLLHLSV LTLSCVWATA MEIPMSTVVK ETLTQLSAHR ALLTSNETMR
60 70 80 90 100
LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ
110 120 130
KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC125366 mRNA Translation: AAI25367.1 BC132066 mRNA Translation: AAI32067.1 |
RefSeqi | NP_034688.1, NM_010558.1 |
Genome annotation databases
GeneIDi | 16191 |
KEGGi | mmu:16191 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC125366 mRNA Translation: AAI25367.1 BC132066 mRNA Translation: AAI32067.1 |
RefSeqi | NP_034688.1, NM_010558.1 |
3D structure databases
SMRi | Q5SV01 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q5SV01 |
Protocols and materials databases
Antibodypediai | 4146, 742 antibodies |
Genome annotation databases
GeneIDi | 16191 |
KEGGi | mmu:16191 |
Organism-specific databases
CTDi | 3567 |
MGIi | MGI:96557, Il5 |
Phylogenomic databases
HOGENOMi | CLU_156269_0_0_1 |
OMAi | NTEWTME |
OrthoDBi | 1469027at2759 |
Miscellaneous databases
BioGRID-ORCSi | 16191, 2 hits in 18 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000036117, Expressed in retina and 40 other tissues |
ExpressionAtlasi | Q5SV01, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000186, IL-5 |
Pfami | View protein in Pfam PF02025, IL5, 1 hit |
PRINTSi | PR00432, INTERLEUKIN5 |
SUPFAMi | SSF47266, SSF47266, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5SV01_MOUSE | |
Accessioni | Q5SV01Primary (citable) accession number: Q5SV01 Secondary accession number(s): Q05A89 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 21, 2004 |
Last sequence update: | February 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |