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Entry version 158 (07 Oct 2020)
Sequence version 1 (10 May 2005)
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Protein
Submitted name:

HLA class I histocompatibility antigen

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HLA class I histocompatibility antigenImported
Submitted name:
HLA class I histocompatibility antigen A alpha chainImported
Submitted name:
HLA class I histocompatibility antigen, A alpha chainImported
Submitted name:
MHC class I antigenImported
Submitted name:
MHC class I proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-AImported
Synonyms:HLAImported, HLA-A*0101Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4931, HLA-A

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei308 – 332HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509802125 – 365Sequence analysisAdd BLAST341

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5SUL5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q5SUL5, 10 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5SUL5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini209 – 295Ig-likeInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni339 – 365DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi341 – 359PolarSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation

Keywords - Domaini

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K06751

Database of Orthologous Groups

More...
OrthoDBi
1390181at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.30.500.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR011161, MHC_I-like_Ag-recog
IPR037055, MHC_I-like_Ag-recog_sf
IPR011162, MHC_I/II-like_Ag-recog
IPR001039, MHC_I_a_a1/a2
IPR010579, MHC_I_a_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654, C1-set, 1 hit
PF00129, MHC_I, 1 hit
PF06623, MHC_I_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01638, MHCCLASSI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407, IGc1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 31 potential isoforms that are computationally mapped.Show allAlign All

Q5SUL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA
110 120 130 140 150
NLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAVHAAEQR RVYLEGRCVD GLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,846
Last modified:May 10, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8667AFF3F06C4932
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 31 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P04439HLAA_HUMAN
HLA class I histocompatibility anti...
HLA-A HLAA
365Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q53Z42Q53Z42_HUMAN
HLA class I antigen
HLA-A HLA
365Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SPM2Q5SPM2_HUMAN
HLA class I heavy chain
HLA-A HLA, HLA-A26
365Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T913A0A140T913_HUMAN
HLA class I histocompatibility anti...
HLA-A
371Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0UXQ0B0UXQ0_HUMAN
HLA class I histocompatibility anti...
HLA-A HLA
365Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5RJ27Q5RJ27_HUMAN
HLA class I histocompatibility anti...
HLA-A HLA
365Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SRN5Q5SRN5_HUMAN
HLA class I histocompatibility anti...
HLA-A
371Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9X5A0A140T9X5_HUMAN
HLA class I histocompatibility anti...
HLA-A
371Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T8Y4A0A140T8Y4_HUMAN
HLA class I histocompatibility anti...
HLA-A
371Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPD3A0A0G2JPD3_HUMAN
HLA class I histocompatibility anti...
HLA-A
394Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL645935 Genomic DNA No translation available.
AL671561 Genomic DNA No translation available.
CR759913 Genomic DNA No translation available.
CR759943 Genomic DNA No translation available.
CR759960 Genomic DNA No translation available.
CT009496 Genomic DNA No translation available.
AY973959 Genomic DNA Translation: AAX94768.1
EU445470 Genomic DNA Translation: ACA34990.1
GU812295 Genomic DNA Translation: ADE80886.1
KU528597 Genomic DNA Translation: ALZ40812.1
KX621301 Genomic DNA Translation: AOE46675.1
KX621306 Genomic DNA Translation: AOE46680.1
KX621307 Genomic DNA Translation: AOE46681.1
KY235390 Genomic DNA Translation: ASA47538.1
KY235393 Genomic DNA Translation: ASA47541.1
KY350872 Genomic DNA Translation: ASA47555.1
MF382100 Genomic DNA Translation: AST08336.1
KY419425 Genomic DNA Translation: ASU50316.1
KY419426 Genomic DNA Translation: ASU50317.1
KY419427 Genomic DNA Translation: ASU50318.1
MF474215 Genomic DNA Translation: ASU61665.1
MG372847 Genomic DNA Translation: AUL81602.1
MG584011 Genomic DNA Translation: AUQ33071.1
MG701434 Genomic DNA Translation: AUQ33114.1
MG701457 Genomic DNA Translation: AUQ33137.1
MG724752 Genomic DNA Translation: AUQ33157.1
MG724778 Genomic DNA Translation: AUQ33182.1
MG724789 Genomic DNA Translation: AUQ33193.1
MG724791 Genomic DNA Translation: AUQ33195.1
MG724808 Genomic DNA Translation: AUQ33212.1
MG769698 Genomic DNA Translation: AUQ33253.1
MG779945 Genomic DNA Translation: AVE16194.1
MF069193 Genomic DNA Translation: AWB14519.1
MH179253 Genomic DNA Translation: AWK57491.1
MH173418 Genomic DNA Translation: AWM62177.1
MH215810 Genomic DNA Translation: AWM62304.1
MH347523 Genomic DNA Translation: AWM62322.1
MH347539 Genomic DNA Translation: AWM62337.1
MH347561 Genomic DNA Translation: AWM62359.1
MH721215 Genomic DNA Translation: AXN55439.1
MH045578 Genomic DNA Translation: AZA04796.1
MH758800 Genomic DNA Translation: AZL48304.1
MH758810 Genomic DNA Translation: AZL48312.1
MH802058 Genomic DNA Translation: AZL48329.1
MH924864 Genomic DNA Translation: AZL48377.1
MH973872 Genomic DNA Translation: AZL48406.1
MK032348 Genomic DNA Translation: AZL48481.1
MK032357 Genomic DNA Translation: AZL48490.1
MK032368 Genomic DNA Translation: AZL48501.1
MK032373 Genomic DNA Translation: AZL48504.1
MH043602 Genomic DNA Translation: AZM68784.1
MH939273 Genomic DNA Translation: AZM68873.1
MK225381 Genomic DNA Translation: AZU89800.1
MK300267 Genomic DNA Translation: AZU89862.1
MK300286 Genomic DNA Translation: AZU89881.1
MK336288 Genomic DNA Translation: AZU89930.1
AB774950 Genomic DNA Translation: BAN59796.1
LC257682 Genomic DNA Translation: BBD34000.1
LC326108 Genomic DNA Translation: BBD74344.1
AJ278305 Genomic DNA Translation: CAB93537.1
AJ538348 Genomic DNA Translation: CAD61867.1
HG794373 Genomic DNA Translation: CDK41182.1
LN994715 Genomic DNA Translation: CUV66767.1
LN994725 Genomic DNA Translation: CUV66777.1
LN994749 Genomic DNA Translation: CUV66801.1
LN999564 Genomic DNA Translation: CUX90957.1
LN999604 Genomic DNA Translation: CUX90997.1
MH269331 Genomic DNA Translation: QAX33591.1
MH269332 Genomic DNA Translation: QAX33592.1
MH285865 Genomic DNA Translation: QAY29286.1
MK394240 Genomic DNA Translation: QBM15266.1
MK394316 Genomic DNA Translation: QBM15342.1
MK394319 Genomic DNA Translation: QBM15345.1
MK394324 Genomic DNA Translation: QBM15350.1
MK532630 Genomic DNA Translation: QBM15406.1
MK843977 Genomic DNA Translation: QCQ67031.1
MK920321 Genomic DNA Translation: QCQ67064.1
MK805531 Genomic DNA Translation: QDA01910.1
MK814894 Genomic DNA Translation: QDC33449.1
MK279523 Genomic DNA Translation: QDC33588.1
MK938088 Genomic DNA Translation: QDK61685.1
MK938096 Genomic DNA Translation: QDK61693.1
MK938099 Genomic DNA Translation: QDK61696.1
MK938106 Genomic DNA Translation: QDK61703.1
MK938115 Genomic DNA Translation: QDK61712.1
MK938141 Genomic DNA Translation: QDK61737.1
MK938160 Genomic DNA Translation: QDK61755.1
MK938162 Genomic DNA Translation: QDK61757.1
MK938163 Genomic DNA Translation: QDK61758.1
MK954870 Genomic DNA Translation: QDK61801.1
MK954884 Genomic DNA Translation: QDK61815.1
MK954936 Genomic DNA Translation: QDK61867.1
MK954957 Genomic DNA Translation: QDK61888.1
MK954973 Genomic DNA Translation: QDK61903.1
MK954995 Genomic DNA Translation: QDK61925.1
MK955000 Genomic DNA Translation: QDK61930.1
MK955001 Genomic DNA Translation: QDK61931.1
MK955021 Genomic DNA Translation: QDK61951.1
MK955033 Genomic DNA Translation: QDK61963.1
MK955037 Genomic DNA Translation: QDK61967.1
MK955049 Genomic DNA Translation: QDK61979.1
MK955086 Genomic DNA Translation: QDK62015.1
MK955090 Genomic DNA Translation: QDK62018.1
MK955093 Genomic DNA Translation: QDK62021.1
MK955102 Genomic DNA Translation: QDK62030.1
MK955104 Genomic DNA Translation: QDK62032.1
MK955117 Genomic DNA Translation: QDK62045.1
MK955120 Genomic DNA Translation: QDK62048.1
MK955129 Genomic DNA Translation: QDK62057.1
MN015827 Genomic DNA Translation: QDK62075.1
MN015842 Genomic DNA Translation: QDK62090.1
MN015855 Genomic DNA Translation: QDK62103.1
MN015859 Genomic DNA Translation: QDK62107.1
MN015862 Genomic DNA Translation: QDK62110.1
MN015867 Genomic DNA Translation: QDK62115.1
MN015911 Genomic DNA Translation: QDK62159.1
MN015912 Genomic DNA Translation: QDK62160.1
MN015936 Genomic DNA Translation: QDK62184.1
MN015944 Genomic DNA Translation: QDK62192.1
MN015949 Genomic DNA Translation: QDK62197.1
MN015962 Genomic DNA Translation: QDK62210.1
MN015985 Genomic DNA Translation: QDK62233.1
MN015994 Genomic DNA Translation: QDK62242.1
MN016018 Genomic DNA Translation: QDK62266.1
MN016042 Genomic DNA Translation: QDK62290.1
MN016058 Genomic DNA Translation: QDK62306.1
MN075170 Genomic DNA Translation: QDK62403.1
MN075174 Genomic DNA Translation: QDK62407.1
MN136781 Genomic DNA Translation: QDK62437.1
MN166910 Genomic DNA Translation: QEQ28461.1
MN166911 Genomic DNA Translation: QEQ28462.1
MN178562 Genomic DNA Translation: QEQ28465.1
MN380570 Genomic DNA Translation: QEQ28488.1
MK953610 Genomic DNA Translation: QGN03553.1
MN176142 Genomic DNA Translation: QGY93928.1
MN402709 Genomic DNA Translation: QGZ98368.1
MN894573 Genomic DNA Translation: QHD25647.1
MN461480 Genomic DNA Translation: QHQ98799.1
MN461481 Genomic DNA Translation: QHQ98800.1
MN461482 Genomic DNA Translation: QHQ98801.1
MN154468 Genomic DNA Translation: QIA58912.1
MT113481 Genomic DNA Translation: QIJ96583.1
LT575515 Genomic DNA Translation: SBL08149.1
LT575612 Genomic DNA Translation: SBL08864.1
LT599170 Genomic DNA Translation: SBW38391.1
LT604086 Genomic DNA Translation: SCB63957.1
LT627704 Genomic DNA Translation: SFV42133.1
LT795516 Genomic DNA Translation: SJX71916.1
LT906371 Genomic DNA Translation: SNU78106.1
LT962590 Genomic DNA Translation: SOQ60061.1
LT963195 Genomic DNA Translation: SOR74739.1
LT963205 Genomic DNA Translation: SOR74749.1
LT963235 Genomic DNA Translation: SOR74779.1
LT963296 Genomic DNA Translation: SOR74840.1
LT986532 Genomic DNA Translation: SPF82205.1
LT986548 Genomic DNA Translation: SPF82221.1
LS398154 Genomic DNA Translation: SPQ44283.1
LS398167 Genomic DNA Translation: SPQ44296.1
LS398199 Genomic DNA Translation: SPQ44328.1
LS398201 Genomic DNA Translation: SPQ44330.1
LR027004 Genomic DNA Translation: VCU43044.1
LR027046 Genomic DNA Translation: VCU43086.1

NCBI Reference Sequences

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RefSeqi
NP_001229687.1, NM_001242758.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000431930; ENSP00000406366; ENSG00000229215
ENST00000443552; ENSP00000404678; ENSG00000224320
ENST00000549869; ENSP00000447635; ENSG00000224320
ENST00000552193; ENSP00000447614; ENSG00000229215

Database of genes from NCBI RefSeq genomes

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GeneIDi
3105

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3105

UCSC genome browser

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UCSCi
uc011ejq.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645935 Genomic DNA No translation available.
AL671561 Genomic DNA No translation available.
CR759913 Genomic DNA No translation available.
CR759943 Genomic DNA No translation available.
CR759960 Genomic DNA No translation available.
CT009496 Genomic DNA No translation available.
AY973959 Genomic DNA Translation: AAX94768.1
EU445470 Genomic DNA Translation: ACA34990.1
GU812295 Genomic DNA Translation: ADE80886.1
KU528597 Genomic DNA Translation: ALZ40812.1
KX621301 Genomic DNA Translation: AOE46675.1
KX621306 Genomic DNA Translation: AOE46680.1
KX621307 Genomic DNA Translation: AOE46681.1
KY235390 Genomic DNA Translation: ASA47538.1
KY235393 Genomic DNA Translation: ASA47541.1
KY350872 Genomic DNA Translation: ASA47555.1
MF382100 Genomic DNA Translation: AST08336.1
KY419425 Genomic DNA Translation: ASU50316.1
KY419426 Genomic DNA Translation: ASU50317.1
KY419427 Genomic DNA Translation: ASU50318.1
MF474215 Genomic DNA Translation: ASU61665.1
MG372847 Genomic DNA Translation: AUL81602.1
MG584011 Genomic DNA Translation: AUQ33071.1
MG701434 Genomic DNA Translation: AUQ33114.1
MG701457 Genomic DNA Translation: AUQ33137.1
MG724752 Genomic DNA Translation: AUQ33157.1
MG724778 Genomic DNA Translation: AUQ33182.1
MG724789 Genomic DNA Translation: AUQ33193.1
MG724791 Genomic DNA Translation: AUQ33195.1
MG724808 Genomic DNA Translation: AUQ33212.1
MG769698 Genomic DNA Translation: AUQ33253.1
MG779945 Genomic DNA Translation: AVE16194.1
MF069193 Genomic DNA Translation: AWB14519.1
MH179253 Genomic DNA Translation: AWK57491.1
MH173418 Genomic DNA Translation: AWM62177.1
MH215810 Genomic DNA Translation: AWM62304.1
MH347523 Genomic DNA Translation: AWM62322.1
MH347539 Genomic DNA Translation: AWM62337.1
MH347561 Genomic DNA Translation: AWM62359.1
MH721215 Genomic DNA Translation: AXN55439.1
MH045578 Genomic DNA Translation: AZA04796.1
MH758800 Genomic DNA Translation: AZL48304.1
MH758810 Genomic DNA Translation: AZL48312.1
MH802058 Genomic DNA Translation: AZL48329.1
MH924864 Genomic DNA Translation: AZL48377.1
MH973872 Genomic DNA Translation: AZL48406.1
MK032348 Genomic DNA Translation: AZL48481.1
MK032357 Genomic DNA Translation: AZL48490.1
MK032368 Genomic DNA Translation: AZL48501.1
MK032373 Genomic DNA Translation: AZL48504.1
MH043602 Genomic DNA Translation: AZM68784.1
MH939273 Genomic DNA Translation: AZM68873.1
MK225381 Genomic DNA Translation: AZU89800.1
MK300267 Genomic DNA Translation: AZU89862.1
MK300286 Genomic DNA Translation: AZU89881.1
MK336288 Genomic DNA Translation: AZU89930.1
AB774950 Genomic DNA Translation: BAN59796.1
LC257682 Genomic DNA Translation: BBD34000.1
LC326108 Genomic DNA Translation: BBD74344.1
AJ278305 Genomic DNA Translation: CAB93537.1
AJ538348 Genomic DNA Translation: CAD61867.1
HG794373 Genomic DNA Translation: CDK41182.1
LN994715 Genomic DNA Translation: CUV66767.1
LN994725 Genomic DNA Translation: CUV66777.1
LN994749 Genomic DNA Translation: CUV66801.1
LN999564 Genomic DNA Translation: CUX90957.1
LN999604 Genomic DNA Translation: CUX90997.1
MH269331 Genomic DNA Translation: QAX33591.1
MH269332 Genomic DNA Translation: QAX33592.1
MH285865 Genomic DNA Translation: QAY29286.1
MK394240 Genomic DNA Translation: QBM15266.1
MK394316 Genomic DNA Translation: QBM15342.1
MK394319 Genomic DNA Translation: QBM15345.1
MK394324 Genomic DNA Translation: QBM15350.1
MK532630 Genomic DNA Translation: QBM15406.1
MK843977 Genomic DNA Translation: QCQ67031.1
MK920321 Genomic DNA Translation: QCQ67064.1
MK805531 Genomic DNA Translation: QDA01910.1
MK814894 Genomic DNA Translation: QDC33449.1
MK279523 Genomic DNA Translation: QDC33588.1
MK938088 Genomic DNA Translation: QDK61685.1
MK938096 Genomic DNA Translation: QDK61693.1
MK938099 Genomic DNA Translation: QDK61696.1
MK938106 Genomic DNA Translation: QDK61703.1
MK938115 Genomic DNA Translation: QDK61712.1
MK938141 Genomic DNA Translation: QDK61737.1
MK938160 Genomic DNA Translation: QDK61755.1
MK938162 Genomic DNA Translation: QDK61757.1
MK938163 Genomic DNA Translation: QDK61758.1
MK954870 Genomic DNA Translation: QDK61801.1
MK954884 Genomic DNA Translation: QDK61815.1
MK954936 Genomic DNA Translation: QDK61867.1
MK954957 Genomic DNA Translation: QDK61888.1
MK954973 Genomic DNA Translation: QDK61903.1
MK954995 Genomic DNA Translation: QDK61925.1
MK955000 Genomic DNA Translation: QDK61930.1
MK955001 Genomic DNA Translation: QDK61931.1
MK955021 Genomic DNA Translation: QDK61951.1
MK955033 Genomic DNA Translation: QDK61963.1
MK955037 Genomic DNA Translation: QDK61967.1
MK955049 Genomic DNA Translation: QDK61979.1
MK955086 Genomic DNA Translation: QDK62015.1
MK955090 Genomic DNA Translation: QDK62018.1
MK955093 Genomic DNA Translation: QDK62021.1
MK955102 Genomic DNA Translation: QDK62030.1
MK955104 Genomic DNA Translation: QDK62032.1
MK955117 Genomic DNA Translation: QDK62045.1
MK955120 Genomic DNA Translation: QDK62048.1
MK955129 Genomic DNA Translation: QDK62057.1
MN015827 Genomic DNA Translation: QDK62075.1
MN015842 Genomic DNA Translation: QDK62090.1
MN015855 Genomic DNA Translation: QDK62103.1
MN015859 Genomic DNA Translation: QDK62107.1
MN015862 Genomic DNA Translation: QDK62110.1
MN015867 Genomic DNA Translation: QDK62115.1
MN015911 Genomic DNA Translation: QDK62159.1
MN015912 Genomic DNA Translation: QDK62160.1
MN015936 Genomic DNA Translation: QDK62184.1
MN015944 Genomic DNA Translation: QDK62192.1
MN015949 Genomic DNA Translation: QDK62197.1
MN015962 Genomic DNA Translation: QDK62210.1
MN015985 Genomic DNA Translation: QDK62233.1
MN015994 Genomic DNA Translation: QDK62242.1
MN016018 Genomic DNA Translation: QDK62266.1
MN016042 Genomic DNA Translation: QDK62290.1
MN016058 Genomic DNA Translation: QDK62306.1
MN075170 Genomic DNA Translation: QDK62403.1
MN075174 Genomic DNA Translation: QDK62407.1
MN136781 Genomic DNA Translation: QDK62437.1
MN166910 Genomic DNA Translation: QEQ28461.1
MN166911 Genomic DNA Translation: QEQ28462.1
MN178562 Genomic DNA Translation: QEQ28465.1
MN380570 Genomic DNA Translation: QEQ28488.1
MK953610 Genomic DNA Translation: QGN03553.1
MN176142 Genomic DNA Translation: QGY93928.1
MN402709 Genomic DNA Translation: QGZ98368.1
MN894573 Genomic DNA Translation: QHD25647.1
MN461480 Genomic DNA Translation: QHQ98799.1
MN461481 Genomic DNA Translation: QHQ98800.1
MN461482 Genomic DNA Translation: QHQ98801.1
MN154468 Genomic DNA Translation: QIA58912.1
MT113481 Genomic DNA Translation: QIJ96583.1
LT575515 Genomic DNA Translation: SBL08149.1
LT575612 Genomic DNA Translation: SBL08864.1
LT599170 Genomic DNA Translation: SBW38391.1
LT604086 Genomic DNA Translation: SCB63957.1
LT627704 Genomic DNA Translation: SFV42133.1
LT795516 Genomic DNA Translation: SJX71916.1
LT906371 Genomic DNA Translation: SNU78106.1
LT962590 Genomic DNA Translation: SOQ60061.1
LT963195 Genomic DNA Translation: SOR74739.1
LT963205 Genomic DNA Translation: SOR74749.1
LT963235 Genomic DNA Translation: SOR74779.1
LT963296 Genomic DNA Translation: SOR74840.1
LT986532 Genomic DNA Translation: SPF82205.1
LT986548 Genomic DNA Translation: SPF82221.1
LS398154 Genomic DNA Translation: SPQ44283.1
LS398167 Genomic DNA Translation: SPQ44296.1
LS398199 Genomic DNA Translation: SPQ44328.1
LS398201 Genomic DNA Translation: SPQ44330.1
LR027004 Genomic DNA Translation: VCU43044.1
LR027046 Genomic DNA Translation: VCU43086.1
RefSeqiNP_001229687.1, NM_001242758.1

3D structure databases

SMRiQ5SUL5
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ5SUL5, 10 interactors

Proteomic databases

MaxQBiQ5SUL5

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3105

Genome annotation databases

EnsembliENST00000431930; ENSP00000406366; ENSG00000229215
ENST00000443552; ENSP00000404678; ENSG00000224320
ENST00000549869; ENSP00000447635; ENSG00000224320
ENST00000552193; ENSP00000447614; ENSG00000229215
GeneIDi3105
KEGGihsa:3105
UCSCiuc011ejq.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3105
HGNCiHGNC:4931, HLA-A

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

KOiK06751
OrthoDBi1390181at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3105, 17 hits in 853 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HLA-A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3105

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR011161, MHC_I-like_Ag-recog
IPR037055, MHC_I-like_Ag-recog_sf
IPR011162, MHC_I/II-like_Ag-recog
IPR001039, MHC_I_a_a1/a2
IPR010579, MHC_I_a_C
PfamiView protein in Pfam
PF07654, C1-set, 1 hit
PF00129, MHC_I, 1 hit
PF06623, MHC_I_C, 1 hit
PRINTSiPR01638, MHCCLASSI
SMARTiView protein in SMART
SM00407, IGc1, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5SUL5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SUL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 7, 2020
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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