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Protein
Submitted name:

MHC class I antigen

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I antigenImported
Gene namesi
Name:HLA-AImported
Synonyms:HLAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei308 – 332HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501509802125 – 365Sequence analysisAdd BLAST341

Keywords - PTMi

Disulfide bondSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-likeInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
HOVERGENiHBG016709
KOiK06751

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5SUL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQKME PRAPWIEQEG PEYWDQETRN MKAHSQTDRA
110 120 130 140 150
NLGTLRGYYN QSEDGSHTIQ IMYGCDVGPD GRFLRGYRQD AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DMAAQITKRK WEAVHAAEQR RVYLEGRCVD GLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL
310 320 330 340 350
SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS
360
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,846
Last modified:May 10, 2005 - v1
Checksum:i8667AFF3F06C4932
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY973959 Genomic DNA Translation: AAX94768.1
EU445470 Genomic DNA Translation: ACA34990.1
GU812295 Genomic DNA Translation: ADE80886.1
KU528597 Genomic DNA Translation: ALZ40812.1
KY235390 Genomic DNA Translation: ASA47538.1
KY235393 Genomic DNA Translation: ASA47541.1
KY350872 Genomic DNA Translation: ASA47555.1
MF382100 Genomic DNA Translation: AST08336.1
KY419425 Genomic DNA Translation: ASU50316.1
KY419426 Genomic DNA Translation: ASU50317.1
KY419427 Genomic DNA Translation: ASU50318.1
MF474215 Genomic DNA Translation: ASU61665.1
MG372847 Genomic DNA Translation: AUL81602.1
MG779945 Genomic DNA Translation: AVE16194.1
MF069193 Genomic DNA Translation: AWB14519.1
MH179253 Genomic DNA Translation: AWK57491.1
AB774950 Genomic DNA Translation: BAN59796.1
LC326108 Genomic DNA Translation: BBD74344.1
AJ538348 Genomic DNA Translation: CAD61867.1
HG794373 Genomic DNA Translation: CDK41182.1
LN994715 Genomic DNA Translation: CUV66767.1
LN994725 Genomic DNA Translation: CUV66777.1
LN994749 Genomic DNA Translation: CUV66801.1
LN999564 Genomic DNA Translation: CUX90957.1
LN999604 Genomic DNA Translation: CUX90997.1
LT575515 Genomic DNA Translation: SBL08149.1
LT575612 Genomic DNA Translation: SBL08864.1
LT599170 Genomic DNA Translation: SBW38391.1
LT604086 Genomic DNA Translation: SCB63957.1
LT627704 Genomic DNA Translation: SFV42133.1
LT795516 Genomic DNA Translation: SJX71916.1
LT906371 Genomic DNA Translation: SNU78106.1
LT963195 Genomic DNA Translation: SOR74739.1
LT963205 Genomic DNA Translation: SOR74749.1
LT963235 Genomic DNA Translation: SOR74779.1
LT963296 Genomic DNA Translation: SOR74840.1
LT971266 Genomic DNA Translation: SOX29907.1
LT971269 Genomic DNA Translation: SOX29910.1
LT971288 Genomic DNA Translation: SOX29929.1
LT971289 Genomic DNA Translation: SOX29930.1
LT971314 Genomic DNA Translation: SOX29961.1
LT971316 Genomic DNA Translation: SOX29963.1
LT972128 Genomic DNA Translation: SOX30044.1
LT972133 Genomic DNA Translation: SOX30049.1
LT972137 Genomic DNA Translation: SOX30053.1
LT972159 Genomic DNA Translation: SOX30075.1
LT972160 Genomic DNA Translation: SOX30076.1
LT972161 Genomic DNA Translation: SOX30077.1
LT986532 Genomic DNA Translation: SPF82205.1
LT986548 Genomic DNA Translation: SPF82221.1
LS398154 Genomic DNA Translation: SPQ44283.1
LS398167 Genomic DNA Translation: SPQ44296.1
LS398199 Genomic DNA Translation: SPQ44328.1
LS398201 Genomic DNA Translation: SPQ44330.1
RefSeqiNP_001229687.1, NM_001242758.1
UniGeneiHs.181244
Hs.713441

Genome annotation databases

GeneIDi3105
KEGGihsa:3105
UCSCiuc011ejq.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY973959 Genomic DNA Translation: AAX94768.1
EU445470 Genomic DNA Translation: ACA34990.1
GU812295 Genomic DNA Translation: ADE80886.1
KU528597 Genomic DNA Translation: ALZ40812.1
KY235390 Genomic DNA Translation: ASA47538.1
KY235393 Genomic DNA Translation: ASA47541.1
KY350872 Genomic DNA Translation: ASA47555.1
MF382100 Genomic DNA Translation: AST08336.1
KY419425 Genomic DNA Translation: ASU50316.1
KY419426 Genomic DNA Translation: ASU50317.1
KY419427 Genomic DNA Translation: ASU50318.1
MF474215 Genomic DNA Translation: ASU61665.1
MG372847 Genomic DNA Translation: AUL81602.1
MG779945 Genomic DNA Translation: AVE16194.1
MF069193 Genomic DNA Translation: AWB14519.1
MH179253 Genomic DNA Translation: AWK57491.1
AB774950 Genomic DNA Translation: BAN59796.1
LC326108 Genomic DNA Translation: BBD74344.1
AJ538348 Genomic DNA Translation: CAD61867.1
HG794373 Genomic DNA Translation: CDK41182.1
LN994715 Genomic DNA Translation: CUV66767.1
LN994725 Genomic DNA Translation: CUV66777.1
LN994749 Genomic DNA Translation: CUV66801.1
LN999564 Genomic DNA Translation: CUX90957.1
LN999604 Genomic DNA Translation: CUX90997.1
LT575515 Genomic DNA Translation: SBL08149.1
LT575612 Genomic DNA Translation: SBL08864.1
LT599170 Genomic DNA Translation: SBW38391.1
LT604086 Genomic DNA Translation: SCB63957.1
LT627704 Genomic DNA Translation: SFV42133.1
LT795516 Genomic DNA Translation: SJX71916.1
LT906371 Genomic DNA Translation: SNU78106.1
LT963195 Genomic DNA Translation: SOR74739.1
LT963205 Genomic DNA Translation: SOR74749.1
LT963235 Genomic DNA Translation: SOR74779.1
LT963296 Genomic DNA Translation: SOR74840.1
LT971266 Genomic DNA Translation: SOX29907.1
LT971269 Genomic DNA Translation: SOX29910.1
LT971288 Genomic DNA Translation: SOX29929.1
LT971289 Genomic DNA Translation: SOX29930.1
LT971314 Genomic DNA Translation: SOX29961.1
LT971316 Genomic DNA Translation: SOX29963.1
LT972128 Genomic DNA Translation: SOX30044.1
LT972133 Genomic DNA Translation: SOX30049.1
LT972137 Genomic DNA Translation: SOX30053.1
LT972159 Genomic DNA Translation: SOX30075.1
LT972160 Genomic DNA Translation: SOX30076.1
LT972161 Genomic DNA Translation: SOX30077.1
LT986532 Genomic DNA Translation: SPF82205.1
LT986548 Genomic DNA Translation: SPF82221.1
LS398154 Genomic DNA Translation: SPQ44283.1
LS398167 Genomic DNA Translation: SPQ44296.1
LS398199 Genomic DNA Translation: SPQ44328.1
LS398201 Genomic DNA Translation: SPQ44330.1
RefSeqiNP_001229687.1, NM_001242758.1
UniGeneiHs.181244
Hs.713441

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi3105
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3105
KEGGihsa:3105
UCSCiuc011ejq.2 human

Organism-specific databases

CTDi3105
H-InvDBiHIX0165925
HIX0166103

Phylogenomic databases

eggNOGiENOG410II5V Eukaryota
ENOG4111K8F LUCA
HOVERGENiHBG016709
KOiK06751

Miscellaneous databases

ChiTaRSiHLA-A human
GenomeRNAii3105

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
IPR010579 MHC_I_a_C
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PF06623 MHC_I_C, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5SUL5_HUMAN
AccessioniPrimary (citable) accession number: Q5SUL5
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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