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Protein

Ankyrin repeat domain-containing protein 40

Gene

Ankrd40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 40
Gene namesi
Name:Ankrd40
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1918702 Ankrd40

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443691 – 363Ankyrin repeat domain-containing protein 40Add BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei176PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5SUE8
PeptideAtlasiQ5SUE8
PRIDEiQ5SUE8

PTM databases

iPTMnetiQ5SUE8
PhosphoSitePlusiQ5SUE8

Expressioni

Gene expression databases

BgeeiENSMUSG00000020864 Expressed in 294 organ(s), highest expression level in heart
CleanExiMM_ANKRD40
ExpressionAtlasiQ5SUE8 baseline and differential
GenevisibleiQ5SUE8 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103448

Structurei

3D structure databases

ProteinModelPortaliQ5SUE8
SMRiQ5SUE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati9 – 38ANK 1Add BLAST30
Repeati43 – 72ANK 2Add BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 103Poly-Glu4
Compositional biasi144 – 242Pro-richAdd BLAST99

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IN88 Eukaryota
ENOG410XSX1 LUCA
GeneTreeiENSGT00390000007792
HOGENOMiHOG000294200
HOVERGENiHBG058022
InParanoidiQ5SUE8
OMAiEINGWTC
OrthoDBiEOG091G0X80
PhylomeDBiQ5SUE8
TreeFamiTF331472

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR039195 ANKRD40
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PANTHERiPTHR24192 PTHR24192, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SUE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSALLEQKEQ QERLREAAAL GDIREVQKLV ESGVDVNSQN EVNGWTCLHW
60 70 80 90 100
ACKRNHGQVV SYLLQSGADR EILTTKGEMP VQLTSRREIR KIMGVEEADE
110 120 130 140 150
EEEIPQLKKE SELPFVPNYL ANPAFPFIYT PAAEDSTQLQ NGGPSPPPVS
160 170 180 190 200
PPADSSPPLL PPTETPLLGA FPRDHSSLAL VQNGDISAPS AILRTPESTK
210 220 230 240 250
PGPVCQPPVS QNRSLFSVPS KPPVSLEPQN GTYAGPAPAF QPFFFTGAFP
260 270 280 290 300
FNMQELVLKV RIQNPSLREN DFIEIELDRQ ELTYQELLRV SCCELGVNPD
310 320 330 340 350
QVEKIRKLPN TLLRKDKDVA RLQDFQELEL VLMISDNNFL FRNAASTLTE
360
RPCYNRRASK LTY
Length:363
Mass (Da):40,560
Last modified:December 21, 2004 - v1
Checksum:i7F45DD06268FE157
GO
Isoform 2 (identifier: Q5SUE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-322: DKDVARL → KRCIHTD
     323-363: Missing.

Note: No experimental confirmation available.
Show »
Length:322
Mass (Da):35,765
Checksum:i42B28669FD0AA09B
GO
Isoform 3 (identifier: Q5SUE8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-324: DKDVARLQD → IKDEPRPWN
     325-363: Missing.

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):36,047
Checksum:iA5151F7730E2B90D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZC98B7ZC98_MOUSE
Ankyrin repeat domain-containing pr...
Ankrd40
68Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7Q → E in BAB30748 (PubMed:16141072).Curated1
Sequence conflicti11Q → E in BAB30748 (PubMed:16141072).Curated1
Sequence conflicti40N → K in BAB30748 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019554316 – 324DKDVARLQD → IKDEPRPWN in isoform 3. 1 Publication9
Alternative sequenceiVSP_019555316 – 322DKDVARL → KRCIHTD in isoform 2. 1 Publication7
Alternative sequenceiVSP_019556323 – 363Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_019557325 – 363Missing in isoform 3. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645965 Genomic DNA No translation available.
BC023133 mRNA Translation: AAH23133.1
AK017451 mRNA Translation: BAB30748.1
CCDSiCCDS25253.2 [Q5SUE8-1]
CCDS36283.1 [Q5SUE8-3]
RefSeqiNP_082075.2, NM_027799.2 [Q5SUE8-1]
NP_666136.1, NM_146024.1 [Q5SUE8-3]
UniGeneiMm.141054

Genome annotation databases

EnsembliENSMUST00000021227; ENSMUSP00000021227; ENSMUSG00000020864 [Q5SUE8-3]
ENSMUST00000051221; ENSMUSP00000061637; ENSMUSG00000020864 [Q5SUE8-2]
ENSMUST00000107818; ENSMUSP00000103448; ENSMUSG00000020864 [Q5SUE8-1]
GeneIDi71452
KEGGimmu:71452
UCSCiuc007kyk.1 mouse [Q5SUE8-3]
uc007kyl.1 mouse [Q5SUE8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL645965 Genomic DNA No translation available.
BC023133 mRNA Translation: AAH23133.1
AK017451 mRNA Translation: BAB30748.1
CCDSiCCDS25253.2 [Q5SUE8-1]
CCDS36283.1 [Q5SUE8-3]
RefSeqiNP_082075.2, NM_027799.2 [Q5SUE8-1]
NP_666136.1, NM_146024.1 [Q5SUE8-3]
UniGeneiMm.141054

3D structure databases

ProteinModelPortaliQ5SUE8
SMRiQ5SUE8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103448

PTM databases

iPTMnetiQ5SUE8
PhosphoSitePlusiQ5SUE8

Proteomic databases

PaxDbiQ5SUE8
PeptideAtlasiQ5SUE8
PRIDEiQ5SUE8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021227; ENSMUSP00000021227; ENSMUSG00000020864 [Q5SUE8-3]
ENSMUST00000051221; ENSMUSP00000061637; ENSMUSG00000020864 [Q5SUE8-2]
ENSMUST00000107818; ENSMUSP00000103448; ENSMUSG00000020864 [Q5SUE8-1]
GeneIDi71452
KEGGimmu:71452
UCSCiuc007kyk.1 mouse [Q5SUE8-3]
uc007kyl.1 mouse [Q5SUE8-1]

Organism-specific databases

CTDi91369
MGIiMGI:1918702 Ankrd40

Phylogenomic databases

eggNOGiENOG410IN88 Eukaryota
ENOG410XSX1 LUCA
GeneTreeiENSGT00390000007792
HOGENOMiHOG000294200
HOVERGENiHBG058022
InParanoidiQ5SUE8
OMAiEINGWTC
OrthoDBiEOG091G0X80
PhylomeDBiQ5SUE8
TreeFamiTF331472

Miscellaneous databases

ChiTaRSiAnkrd40 mouse
PROiPR:Q5SUE8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020864 Expressed in 294 organ(s), highest expression level in heart
CleanExiMM_ANKRD40
ExpressionAtlasiQ5SUE8 baseline and differential
GenevisibleiQ5SUE8 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR039195 ANKRD40
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PANTHERiPTHR24192 PTHR24192, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiANR40_MOUSE
AccessioniPrimary (citable) accession number: Q5SUE8
Secondary accession number(s): Q5SUF0, Q8R595, Q9CU71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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