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UniProtKB - Q5SU94 (Q5SU94_MOUSE)
Protein
Vascular endothelial growth factor receptor 3
Gene
Flt4
Organism
Mus musculus (Mouse)
Status
Functioni
Catalytic activityi
- EC:2.7.10.1ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 879 | ATPPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- growth factor binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- protein phosphatase binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- vascular endothelial growth factor-activated receptor activity Source: Ensembl
GO - Biological processi
- angiogenesis Source: UniProtKB-KW
- lymphangiogenesis Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- positive regulation of endothelial cell migration Source: Ensembl
- positive regulation of endothelial cell proliferation Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: Ensembl
- positive regulation of JNK cascade Source: Ensembl
- positive regulation of protein kinase C signaling Source: Ensembl
- positive regulation of protein phosphorylation Source: Ensembl
- positive regulation of vascular endothelial growth factor production Source: Ensembl
- protein autophosphorylation Source: Ensembl
- vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Keywordsi
Molecular function | Kinase, ReceptorUniRule annotationARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Biological process | AngiogenesisARBA annotation |
Ligand | ATP-bindingPROSITE-ProRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Vascular endothelial growth factor receptor 3ARBA annotation (EC:2.7.10.1ARBA annotation) |
Gene namesi | Name:Flt4Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:95561, Flt4 |
VEuPathDBi | HostDB:ENSMUSG00000020357 |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Nucleus
- Nucleus ARBA annotation
Other locations
- Membrane UniRule annotationARBA annotation; Single-pass type I membrane protein UniRule annotationARBA annotation
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleoplasm Source: Ensembl
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Other locations
- receptor complex Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 776 – 798 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5014309960 | 25 – 1363 | Vascular endothelial growth factor receptor 3Sequence analysisAdd BLAST | 1339 |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000020357, Expressed in endothelial cell of lymphatic vessel and 252 other tissues |
Interactioni
GO - Molecular functioni
- growth factor binding Source: Ensembl
- protein homodimerization activity Source: Ensembl
- protein phosphatase binding Source: Ensembl
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 230 – 326 | Ig-likeInterPro annotationAdd BLAST | 97 | |
Domaini | 331 – 415 | Ig-likeInterPro annotationAdd BLAST | 85 | |
Domaini | 422 – 552 | Ig-likeInterPro annotationAdd BLAST | 131 | |
Domaini | 555 – 671 | Ig-likeInterPro annotationAdd BLAST | 117 | |
Domaini | 678 – 764 | Ig-likeInterPro annotationAdd BLAST | 87 | |
Domaini | 845 – 1173 | Protein kinaseInterPro annotationAdd BLAST | 329 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1288 – 1330 | DisorderedSequence analysisAdd BLAST | 43 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.UniRule annotation
Keywords - Domaini
Immunoglobulin domainUniRule annotationARBA annotation, RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
HOGENOMi | CLU_000288_49_4_1 |
OMAi | RPYCKRL |
OrthoDBi | 236292at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS IPR041348, VEGFR-2_TMD IPR009137, VEGFR3_rcpt |
PANTHERi | PTHR24416:SF562, PTHR24416:SF562, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF17988, VEGFR-2_TMD, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 6 hits SM00408, IGc2, 4 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5SU94-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPGAALNLR LWLCLGLLQG LANGYSMTPP TLNITEDSYV IDTGDSLSIS
60 70 80 90 100
CRGQHPLEWT WPGAQEVLTT GGKDSEDTRV VHDCEGTEAR PYCKVLLLAQ
110 120 130 140 150
THANNTGSYH CYYKYIKARI EGTTAASTYV FVRDFKHPFI NKPDTLLVNR
160 170 180 190 200
KDSMWVPCLV SIPGLNITLR SQSSALHPDG QEVLWDDRRG MRVPTQLLRD
210 220 230 240 250
ALYLQCETTW GDQNFLSNLF VVHITGNELY DIQLYPKKSM ELLVGEKLVL
260 270 280 290 300
NCTVWAEFDS GVTFDWDYPG KQAERAKWVP ERRSQQTHTE LSSILTIHNV
310 320 330 340 350
SQNDLGPYVC EANNGIQRFR ESTEVIVHEK PFISVEWLKG PVLEATAGDE
360 370 380 390 400
LVKLPVKLAA YPPPEFQWYK DRKAVTGRHN PHALVLKEVT EASAGVYTLA
410 420 430 440 450
LWNSAAGLRQ NISLELVVNV PPHIHEKEAS SPSIYSRHSR QTLTCTAYGV
460 470 480 490 500
PQPLSVQWHW RPWTPCKTFA QRSLRRRQQR DGMPQCRDWK EVTTQDAVNP
510 520 530 540 550
IESLDSWTEF VEGKNKTVSK LVIQDANVSA MYKCVVVNKV GQDERLIYFY
560 570 580 590 600
VTTIPDGFSI ESEPSEDPLE GQSVRLSCRA DNYTYEHLRW YRLNLSTLHD
610 620 630 640 650
AQGNPLLLDC KNVHLFATPL EANLEEAEPG ARHATLSLNI PRVAPEDEGD
660 670 680 690 700
YVCEVQDRRS QDKHCHKKYL SVQALEAPRL TQNLTDLLVN VSDSLEMRCP
710 720 730 740 750
VAGAHVPSIV WYKDERLLEK ESGIDLADSN QRLSIQRVRE EDAGRYLCSV
760 770 780 790 800
CNAKGCVNSS ASVAVEGSED KGSMEIVILI GTGVIAVFFW VLLLLIFCNM
810 820 830 840 850
KRPAHADIKT GYLSIIMDPG EVPLEEQCEY LSYDASQWEF PRERLHLGRV
860 870 880 890 900
LGHGAFGKVV EASAFGINKG SSCDTVAVKM LKEGATASEH RALMSELKIL
910 920 930 940 950
IHIGNHLNVV NLLGACTKPN GPLMVIVEFC KYGNLSNFLR VKRDTFNPYA
960 970 980 990 1000
EKSPEQRRRF RAMVEGAKAD RRRPGSSDRA LFTRFLMGKG SARRAPLVQE
1010 1020 1030 1040 1050
AEDLWLSPLT MEDLVCYSFQ VARGMEFLAS RKCIHRDLAA RNILLSESDI
1060 1070 1080 1090 1100
VKICDFGLAR DIYKDPDYVR KGSARLPLKW MAPESIFDKV YTTQSDVWSF
1110 1120 1130 1140 1150
GVLLWEIFSL GASPYPGVQI NEEFCQRLKD GTRMRAPELA TPAIRHIMQS
1160 1170 1180 1190 1200
CWSGDPKARP AFSDLVEILG DLLQGGGWQE EEEERMALHS SQSSEEDGFM
1210 1220 1230 1240 1250
QASTTALHIT EADADDSPPS MHCHSLAARY YNCVSFPGRL ARGTKTPGSS
1260 1270 1280 1290 1300
RMKTFEELPM TPTTYKASMD NQTDSGMVLA SEEFEELESR HRPEGSFSCK
1310 1320 1330 1340 1350
GPGQHMDIPR GHPDPQGRRR RPTQGAQGGK VFYNNEYGEV SQPCTEGDCC
1360
PSAGSTFFAD SSY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC138346 mRNA Translation: AAI38347.1 BC138348 mRNA Translation: AAI38349.1 |
RefSeqi | NP_032055.1, NM_008029.3 |
Genome annotation databases
GeneIDi | 14257 |
KEGGi | mmu:14257 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC138346 mRNA Translation: AAI38347.1 BC138348 mRNA Translation: AAI38349.1 |
RefSeqi | NP_032055.1, NM_008029.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
Antibodypediai | 3429, 1065 antibodies from 45 providers |
DNASUi | 14257 |
Genome annotation databases
GeneIDi | 14257 |
KEGGi | mmu:14257 |
Organism-specific databases
CTDi | 2324 |
MGIi | MGI:95561, Flt4 |
VEuPathDBi | HostDB:ENSMUSG00000020357 |
Phylogenomic databases
HOGENOMi | CLU_000288_49_4_1 |
OMAi | RPYCKRL |
OrthoDBi | 236292at2759 |
Miscellaneous databases
BioGRID-ORCSi | 14257, 4 hits in 68 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020357, Expressed in endothelial cell of lymphatic vessel and 252 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS IPR041348, VEGFR-2_TMD IPR009137, VEGFR3_rcpt |
PANTHERi | PTHR24416:SF562, PTHR24416:SF562, 1 hit |
Pfami | View protein in Pfam PF07679, I-set, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit PF17988, VEGFR-2_TMD, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 6 hits SM00408, IGc2, 4 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 5 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 5 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5SU94_MOUSE | |
Accessioni | Q5SU94Primary (citable) accession number: Q5SU94 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | January 19, 2022 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |