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Protein
Submitted name:

Lymphotoxin alpha (TNF superfamily, member 1), isoform CRA_a

Gene

LTA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Lymphotoxin alpha (TNF superfamily, member 1), isoform CRA_aImported
Submitted name:
Tumor necrosis factor ligand 1EImported
Gene namesi
Name:LTAImported
Synonyms:TNLG1EImported
ORF Names:hCG_43681Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000226979.8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneSAAS annotation, SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30474

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_501430995335 – 205Sequence analysisAdd BLAST171

Expressioni

Gene expression databases

BgeeiENSG00000226979
ExpressionAtlasiQ5STV3 baseline and differential

Interactioni

Subunit structurei

Homotrimer.SAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ5STV3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 205TNF_2InterPro annotationAdd BLAST142

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IWT9 Eukaryota
ENOG410YQC4 LUCA
HOVERGENiHBG012516
KOiK05468
OMAiQYPFHVP
OrthoDBiEOG091G0HIG

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002960 TNF_beta
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01236 TNFBETA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5STV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPPERLFLP RVCGTTLHLL LLGLLLVLLP GAQGLPGVGL TPSAAQTARQ
60 70 80 90 100
HPKMHLAHST LKPAAHLIGD PSKQNSLLWR ANTDRAFLQD GFSLSNNSLL
110 120 130 140 150
VPTSGIYFVY SQVVFSGKAY SPKATSSPLY LAHEVQLFSS QYPFHVPLLS
160 170 180 190 200
SQKMVYPGLQ EPWLHSMYHG AAFQLTQGDQ LSTHTDGIPH LVLSPSTVFF

GAFAL
Length:205
Mass (Da):22,297
Last modified:May 10, 2005 - v1
Checksum:i1BBD5E7D496A3A82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KY500410 Genomic DNA Translation: AQY76897.1
AB088112 Genomic DNA Translation: BAC54943.1
AB103618 Genomic DNA Translation: BAF31278.1
LN874316 mRNA Translation: CTQ86081.1
CH471081 Genomic DNA Translation: EAX03422.1
CH471081 Genomic DNA Translation: EAX03423.1
RefSeqiNP_000586.2, NM_000595.3
NP_001153212.1, NM_001159740.2
XP_011512917.1, XM_011514615.2
XP_011512918.1, XM_011514616.2
XP_011512919.1, XM_011514617.2
XP_011512920.1, XM_011514618.1
UniGeneiHs.36

Genome annotation databases

GeneIDi4049
KEGGihsa:4049
UCSCiuc003nue.3 human

Similar proteinsi

Entry informationi

Entry nameiQ5STV3_HUMAN
AccessioniPrimary (citable) accession number: Q5STV3
Secondary accession number(s): Q5HYS4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: June 20, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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