UniProtKB - Q5STP9 (Q5STP9_HUMAN)
Protein
Submitted name:
Retinoid X nuclear receptor beta
Gene
RXRB
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- steroid hormone receptor activity Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationImportedARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Retinoid X nuclear receptor betaImportedSubmitted name: Retinoid X receptor beta isoform 1ImportedSubmitted name: Retinoid X receptor, betaImported |
Gene namesi | Name:RXRBImported Synonyms:NR2B2Imported ORF Names:hCG_2042227Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000204231.10 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000204231, Expressed in left lobe of thyroid gland and 236 other tissues |
ExpressionAtlasi | Q5STP9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 202 – 277 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 296 – 529 | NR LBDInterPro annotationAdd BLAST | 234 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 36 – 181 | DisorderedSequence analysisAdd BLAST | 146 | |
Regioni | 276 – 299 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 313 – 336 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 89 – 133 | Pro-richSequence analysisAdd BLAST | 45 | |
Compositional biasi | 141 – 155 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 156 – 170 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 276 – 292 | PolyampholyteSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the nuclear hormone receptor family.UniRule annotation
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_007368_5_4_1 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5STP9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSWAARPPFL PQRHAAGQCG PVGVRKEMHC GVASRWRRRR PWLDPAAAAA
60 70 80 90 100
AAVAGGEQQT PEPEPGEAGR DGMGDSGRDS RSPDSSSPNP LPQGVPPPSP
110 120 130 140 150
PGPPLPPSTA PSLGGSGAPP PPPMPPPPLG SPFPVISSSM GSPGLPPPAP
160 170 180 190 200
PGFSGPVSSP QINSTVSLPG GGSGPPEDVK PPVLGVRGLH CPPPPGGPGA
210 220 230 240 250
GKRLCAICGD RSSGKHYGVY SCEGCKGFFK RTIRKDLTYS CRDNKDCTVD
260 270 280 290 300
KRQRNRCQYC RYQKCLATGM KREAVQEERQ RGKDKDGDGE GAGGAPEEMP
310 320 330 340 350
VDRILEAELA VEQKSDQGVE GPGGTGGSGS SPNDPVTNIC QAADKQLFTL
360 370 380 390 400
VEWAKRIPHF SSLPLDDQVI LLRAGWNELL IASFSHRSID VRDGILLATG
410 420 430 440 450
LHVHRNSAHS AGVGAIFDRV LTELVSKMRD MRMDKTELGC LRAIILFNPD
460 470 480 490 500
AKGLSNPSEV EVLREKVYAS LETYCKQKYP EQQGRFAKLL LRLPALRSIG
510 520 530
LKCLEHLFFF KLIGDTPIDT FLMEMLEAPH QLA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007280 mRNA Translation: AAP35944.1 HQ692844 mRNA Translation: ADZ17355.1 KU178313 mRNA Translation: ALQ33771.1 CH471081 Genomic DNA Translation: EAX03679.1 |
RefSeqi | NP_068811.1, NM_021976.4 |
Genome annotation databases
GeneIDi | 6257 |
KEGGi | hsa:6257 |
UCSCi | uc003odb.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT007280 mRNA Translation: AAP35944.1 HQ692844 mRNA Translation: ADZ17355.1 KU178313 mRNA Translation: ALQ33771.1 CH471081 Genomic DNA Translation: EAX03679.1 |
RefSeqi | NP_068811.1, NM_021976.4 |
3D structure databases
SMRi | Q5STP9 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q5STP9 |
Proteomic databases
MaxQBi | Q5STP9 |
Protocols and materials databases
Antibodypediai | 28936, 335 antibodies |
DNASUi | 6257 |
Genome annotation databases
GeneIDi | 6257 |
KEGGi | hsa:6257 |
UCSCi | uc003odb.5, human |
Organism-specific databases
CTDi | 6257 |
PharmGKBi | PA34891 |
VEuPathDBi | HostDB:ENSG00000204231.10 |
Phylogenomic databases
HOGENOMi | CLU_007368_5_4_1 |
Miscellaneous databases
BioGRID-ORCSi | 6257, 23 hits in 1018 CRISPR screens |
ChiTaRSi | RXRB, human |
GenomeRNAii | 6257 |
Gene expression databases
Bgeei | ENSG00000204231, Expressed in left lobe of thyroid gland and 236 other tissues |
ExpressionAtlasi | Q5STP9, baseline and differential |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5STP9_HUMAN | |
Accessioni | Q5STP9Primary (citable) accession number: Q5STP9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |