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Protein
Submitted name:

Tumor necrosis factor-alpha

Gene

TNF

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor-alphaImported
Submitted name:
cDNA, FLJ95875, Homo sapiens tumor necrosis factor (TNF superfamily, member 2)(TNF), mRNAImported
Gene namesi
Name:TNFImported
Synonyms:TNFAImported, TNLG1FImported
ORF Names:hCG_43716Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000232810.3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei30 – 55HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane, SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA435

Expressioni

Gene expression databases

BgeeiENSG00000232810 Expressed in 89 organ(s), highest expression level in leukocyte
ExpressionAtlasiQ5STB3 baseline and differential

Interactioni

Subunit structurei

Homotrimer.SAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

SMRiQ5STB3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 233TNF_2InterPro annotationAdd BLAST145

Sequence similaritiesi

Belongs to the tumor necrosis factor family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410ISAN Eukaryota
ENOG410YQC4 LUCA
HOVERGENiHBG012516
KOiK03156
OMAiPWYEPIY
OrthoDBiEOG091G0HIG

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002959 TNF_alpha
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PANTHERiPTHR11471:SF23 PTHR11471:SF23, 1 hit
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01235 TNFALPHA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5STB3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL
60 70 80 90 100
LHFGVIGPQR EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG
110 120 130 140 150
QLQWLNRRAN ALLANGVELR DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV
160 170 180 190 200
LLTHTISRIA VSYQTKVNLL SAIKSPCQRE TPEGAEAKPW YEPIYLGGVF
210 220 230
QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL
Length:233
Mass (Da):25,644
Last modified:May 10, 2005 - v1
Checksum:i3DF90F96C9031FFE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ201306 mRNA Translation: ADV31546.2
KF887965 Genomic DNA Translation: AHJ25918.1
KF887966 Genomic DNA Translation: AHJ25919.1
KF887967 Genomic DNA Translation: AHJ25920.1
KF887968 Genomic DNA Translation: AHJ25921.1
KF887969 Genomic DNA Translation: AHJ25922.1
KF887970 Genomic DNA Translation: AHJ25923.1
KF887971 Genomic DNA Translation: AHJ25924.1
KF887972 Genomic DNA Translation: AHJ25925.1
KY500676 Genomic DNA Translation: AQY77148.1
KY500678 Genomic DNA Translation: AQY77150.1
AB202113 Genomic DNA Translation: BAE78639.1
AB103618 Genomic DNA Translation: BAF31279.1
AK314960 mRNA Translation: BAG37464.1
LN874317 mRNA Translation: CTQ86082.1
CH471081 Genomic DNA Translation: EAX03424.1
RefSeqiNP_000585.2, NM_000594.3
UniGeneiHs.241570

Genome annotation databases

GeneIDi7124
KEGGihsa:7124
UCSCiuc003nui.5 human

Similar proteinsi

Entry informationi

Entry nameiQ5STB3_HUMAN
AccessioniPrimary (citable) accession number: Q5STB3
Secondary accession number(s): E7DB75
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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