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Entry version 117 (16 Oct 2019)
Sequence version 1 (21 Dec 2004)
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Protein

Tensin-3

Gene

Tns3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration (By similarity). May be involved in cell migration and bone development.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8875513 MET interacts with TNS proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tensin-3
Alternative name(s):
Tensin-like SH2 domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tns3
Synonyms:Tens1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443012 Tns3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice display growth retardation and incomplete development of small intestine, lung, and bone. Postnatal lethality is detected in one third of the homozygous mutants.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002959161 – 1440Tensin-3Add BLAST1440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei332PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei440PhosphoserineBy similarity1
Modified residuei516PhosphoserineBy similarity1
Modified residuei571PhosphoserineCombined sources1
Modified residuei632PhosphothreonineBy similarity1
Modified residuei648PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Modified residuei769PhosphoserineCombined sources1
Modified residuei773PhosphotyrosineBy similarity1
Modified residuei804PhosphoserineBy similarity1
Modified residuei860PhosphoserineBy similarity1
Modified residuei894PhosphoserineCombined sources1
Modified residuei960PhosphoserineCombined sources1
Modified residuei1144PhosphoserineBy similarity1
Modified residuei1149PhosphoserineBy similarity1
Modified residuei1288PhosphoserineBy similarity1
Modified residuei1436PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5SSZ5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SSZ5

PeptideAtlas

More...
PeptideAtlasi
Q5SSZ5

PRoteomics IDEntifications database

More...
PRIDEi
Q5SSZ5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SSZ5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SSZ5

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5SSZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, heart, lung, liver, spleen, kidney, stomach, small intestine, skeletal muscle, skin, thymus, testis, uterus, placenta, aorta and trachea.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at 13.5 dpc in lung, liver, spleen, stomach, aorta, trachea, and perichondrium.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020422 Expressed in 256 organ(s), highest expression level in humerus cartilage element

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SSZ5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

EGF promotes the interaction with EGFR.

Interacts with PTK2/FAK1 and BCAR1. Tyrosine phosphorylation is critical for these interactions (By similarity).

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q5SSZ5, 2 interactors

Molecular INTeraction database

More...
MINTi
Q5SSZ5

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000020695

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 170Phosphatase tensin-typePROSITE-ProRule annotationAdd BLAST170
Domaini175 – 301C2 tensin-typePROSITE-ProRule annotationAdd BLAST127
Domaini1167 – 1277SH2PROSITE-ProRule annotationAdd BLAST111

Keywords - Domaini

SH2 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1930 Eukaryota
KOG2283 Eukaryota
COG2453 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156328

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060090

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SSZ5

KEGG Orthology (KO)

More...
KOi
K18080

Identification of Orthologs from Complete Genome Data

More...
OMAi
QMNKKAG

Database of Orthologous Groups

More...
OrthoDBi
172407at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SSZ5

TreeFam database of animal gene trees

More...
TreeFami
TF315996

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035012 Tensin-like_SH2
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5SSZ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDSHELDLT YVTERIIAVS FPASCSEESY LHSLQEVTRM LKCKHGDNYL
60 70 80 90 100
VLNLSEKRYD LTKLNPKIMD VGWPELHAPP LDKMCTICKA QESWLNNDPQ
110 120 130 140 150
HVVVIHCRGG KGRIGVVISS YMHFTNVSAS ADQALDRFAM KKFYDDKISA
160 170 180 190 200
LMEPSQKRYV QFLSGLLSGA MKMNTSPLFL HFVIMHGVPS FDTGGACRPF
210 220 230 240 250
LKLYQAMQPV YTSGIYNVGS ENPSRIRIAI EPAQLLKGDI MVKCYHKKFR
260 270 280 290 300
SATRDVIFRL QFHTGAVQGY GLLFGKEELD SACKDDRFPD YGKIELVFSA
310 320 330 340 350
TPEKIQGSEH LYSDQGVTVD YNTADPLIRW DSYENMSADG EVLHTQGPVD
360 370 380 390 400
GSLYAKVRKK SASDTGIPSS PQGMPATSSP DHGDHTLSVS SDSGHSTASA
410 420 430 440 450
RTDKTEERLT PGARRGLSPQ EKAELDQLLS GFGLEDSASS HKDMTDMRSK
460 470 480 490 500
YSGTRHVVPA QVHVNGDAAL KDRETDILDD EMPHHDLHSV DSLGTLSSSE
510 520 530 540 550
GPQSTHLGPF TCLKSSQNSL LSDGFGNGVA EDHNGVLSPD LGLGVDTLYD
560 570 580 590 600
RERMCGGREQ KPLQPLLRKP SAPTPVQAYG QSNYSTQTWV RQQQMVAAHQ
610 620 630 640 650
YSFASDGEAR LGSRSTVDNT GLAQPPPHIP VTPNRGASSR VAVQRGISNG
660 670 680 690 700
PNPPDTQQLC PGKALQPRFQ DDRVTNGVHQ EPNTGSSPGS PTLDIDQSIE
710 720 730 740 750
QLNRLILELD PTFEPIPTHL NALGISAVCP DGVGSGLRCS GRLDSVDGPG
760 770 780 790 800
RSPGRQGDDP IGGRLRKLSI GQYDNDAASQ VTFSKCGWGK AGVDPAPSLG
810 820 830 840 850
SFSSPEDIKE TVITAYPSDL NMIDGRIPNS KESSMCLTPS FPVSPETPYV
860 870 880 890 900
KTSPRYPPFS PPEPQLSSPA SLHKGREPRG CPEIISHTVG MSESPVGPKP
910 920 930 940 950
TMLRADMPAT PNFQQVFASS CTVSSNGPGQ RRESPPSAER QWVESSPKST
960 970 980 990 1000
LTLLGNSHPS ESPLGTHEFC SSGKDSPGLP CFQSSELQAS FHSHELSMSE
1010 1020 1030 1040 1050
PQGALPPAGS QTFLGFNTVT TATSVLPPGE DAGTLLVNSH GTSPAPGTPL
1060 1070 1080 1090 1100
LTTGAADNGF LPHNFLTVSP GASSHHSPGL QNQNVSLPGQ PPLPEKKRAS
1110 1120 1130 1140 1150
EGDRSLGSVS PSSSGFSSPH SGSTMSIPFP NVLPDFCKPS EVASPLPDSP
1160 1170 1180 1190 1200
NDKLVIVKFV QDTSKFWYKA DISREQAIAM LKDKAPGSFI VRDSHSFRGA
1210 1220 1230 1240 1250
YGLAMKVATP PPSVLHLNKK AGDLSNELVR HFLIECTPKG VRLKGCSNEP
1260 1270 1280 1290 1300
YFGSLTALVC QHSITPLALP CKLLIPERDP LEEIAENSPQ TAANSAAELL
1310 1320 1330 1340 1350
KQGAACNVWY LNSVEMESLT GHQAVQKALS MTLVQEPPPV STVVHFKVSA
1360 1370 1380 1390 1400
QGITLTDNQR KLFFRRHYPV SSVIFCALDP QDRKWIKDGP SSKVFGFVAR
1410 1420 1430 1440
KQGSATDNVC HLFAEHDPEQ PASAIVNFVS KVMIGSPKKI
Length:1,440
Mass (Da):155,589
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83A07D855EE0D463
GO
Isoform 2 (identifier: Q5SSZ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-890: Missing.

Note: No experimental confirmation available.
Show »
Length:550
Mass (Da):58,725
Checksum:i3A569B9A486B64EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti910T → A in BAE34356 (PubMed:16141072).Curated1
Sequence conflicti1025V → I in BAE34356 (PubMed:16141072).Curated1
Sequence conflicti1051L → M in BAE34356 (PubMed:16141072).Curated1
Sequence conflicti1067T → M in BAE34356 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0271281 – 890Missing in isoform 2. 1 PublicationAdd BLAST890

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK089717 mRNA Translation: BAC40948.1
AK158101 mRNA Translation: BAE34356.1
AL603845 Genomic DNA No translation available.
AL662881 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36109.1 [Q5SSZ5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001077056.1, NM_001083587.1 [Q5SSZ5-1]
XP_006514804.1, XM_006514741.2 [Q5SSZ5-1]
XP_011242030.1, XM_011243728.2 [Q5SSZ5-1]
XP_017170096.1, XM_017314607.1 [Q5SSZ5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000020695; ENSMUSP00000020695; ENSMUSG00000020422 [Q5SSZ5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
319939

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:319939

UCSC genome browser

More...
UCSCi
uc007hzj.1 mouse [Q5SSZ5-2]
uc007hzk.1 mouse [Q5SSZ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089717 mRNA Translation: BAC40948.1
AK158101 mRNA Translation: BAE34356.1
AL603845 Genomic DNA No translation available.
AL662881 Genomic DNA No translation available.
CCDSiCCDS36109.1 [Q5SSZ5-1]
RefSeqiNP_001077056.1, NM_001083587.1 [Q5SSZ5-1]
XP_006514804.1, XM_006514741.2 [Q5SSZ5-1]
XP_011242030.1, XM_011243728.2 [Q5SSZ5-1]
XP_017170096.1, XM_017314607.1 [Q5SSZ5-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ5SSZ5, 2 interactors
MINTiQ5SSZ5
STRINGi10090.ENSMUSP00000020695

PTM databases

iPTMnetiQ5SSZ5
PhosphoSitePlusiQ5SSZ5
SwissPalmiQ5SSZ5

Proteomic databases

jPOSTiQ5SSZ5
PaxDbiQ5SSZ5
PeptideAtlasiQ5SSZ5
PRIDEiQ5SSZ5

Genome annotation databases

EnsembliENSMUST00000020695; ENSMUSP00000020695; ENSMUSG00000020422 [Q5SSZ5-1]
GeneIDi319939
KEGGimmu:319939
UCSCiuc007hzj.1 mouse [Q5SSZ5-2]
uc007hzk.1 mouse [Q5SSZ5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64759
MGIiMGI:2443012 Tns3

Phylogenomic databases

eggNOGiKOG1930 Eukaryota
KOG2283 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00940000156328
HOGENOMiHOG000060090
InParanoidiQ5SSZ5
KOiK18080
OMAiQMNKKAG
OrthoDBi172407at2759
PhylomeDBiQ5SSZ5
TreeFamiTF315996

Enzyme and pathway databases

ReactomeiR-MMU-8875513 MET interacts with TNS proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tns3 mouse

Protein Ontology

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PROi
PR:Q5SSZ5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000020422 Expressed in 256 organ(s), highest expression level in humerus cartilage element
GenevisibleiQ5SSZ5 MM

Family and domain databases

CDDicd01213 PTB_tensin, 1 hit
cd09927 SH2_Tensin_like, 1 hit
Gene3Di2.30.29.30, 1 hit
3.30.505.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR013625 PTB
IPR006020 PTB/PI_dom
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR035012 Tensin-like_SH2
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR033929 Tensin_PTB
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF08416 PTB, 1 hit
PF10409 PTEN_C2, 1 hit
PF00017 SH2, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 1 hit
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTENS3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SSZ5
Secondary accession number(s): Q3TZ54, Q8BJA7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 21, 2004
Last modified: October 16, 2019
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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