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Entry version 128 (26 Feb 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Proteasome activator complex subunit 4

Gene

Psme4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, DNA damage, DNA repair, Spermatogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1169091 Activation of NF-kappaB in B cells
R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-195253 Degradation of beta-catenin by the destruction complex
R-MMU-202424 Downstream TCR signaling
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-MMU-350562 Regulation of ornithine decarboxylase (ODC)
R-MMU-382556 ABC-family proteins mediated transport
R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-4608870 Asymmetric localization of PCP proteins
R-MMU-4641257 Degradation of AXIN
R-MMU-4641258 Degradation of DVL
R-MMU-5358346 Hedgehog ligand biogenesis
R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-5610780 Degradation of GLI1 by the proteasome
R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome
R-MMU-5632684 Hedgehog 'on' state
R-MMU-5658442 Regulation of RAS by GAPs
R-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676590 NIK-->noncanonical NF-kB signaling
R-MMU-5687128 MAPK6/MAPK4 signaling
R-MMU-5689603 UCH proteinases
R-MMU-5689880 Ub-specific processing proteases
R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex
R-MMU-68949 Orc1 removal from chromatin
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69481 G2/M Checkpoints
R-MMU-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-MMU-75815 Ubiquitin-dependent degradation of Cyclin D
R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8948751 Regulation of PTEN stability and activity
R-MMU-8951664 Neddylation
R-MMU-9020702 Interleukin-1 signaling
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proteasome activator complex subunit 4
Alternative name(s):
Proteasome activator PA200
Protein TEMO
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Psme4
Synonyms:Kiaa0077
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2143994 Psme4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice are viable and show no obvious developmental abnormalities. They have reduced male fertility due to defects in spermatogenesis in meiotic spermatocytes and during the maturation of postmeiotic haploid spermatids. Testes are defective in core histone replacement.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002807191 – 1843Proteasome activator complex subunit 4Add BLAST1843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1121PhosphoserineBy similarity1
Modified residuei1614PhosphoserineBy similarity1
Modified residuei1746PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5SSW2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5SSW2

PeptideAtlas

More...
PeptideAtlasi
Q5SSW2

PRoteomics IDEntifications database

More...
PRIDEi
Q5SSW2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5SSW2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5SSW2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5SSW2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed. Present in heart (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040850 Expressed in blood and 296 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5SSW2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5SSW2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with the 20S and 26S proteasomes.

Component of the spermatoproteasome, a form of the proteasome specifically found in testis.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
222113, 1 interactor

Protein interaction database and analysis system

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IntActi
Q5SSW2, 5 interactors

Molecular INTeraction database

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MINTi
Q5SSW2

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000045460

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5SSW2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5SSW2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati475 – 519HEAT 1Add BLAST45
Repeati998 – 1037HEAT 2Add BLAST40
Repeati1179 – 1217HEAT 3Add BLAST39
Repeati1354 – 1392HEAT 4Add BLAST39
Repeati1636 – 1674HEAT 5Add BLAST39
Repeati1680 – 1718HEAT 6Add BLAST39

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1650 – 1738Bromodomain-like (BRDL)By similarityAdd BLAST89

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BLM10 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1851 Eukaryota
ENOG410XP7J LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011433

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000772_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5SSW2

KEGG Orthology (KO)

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KOi
K06699

Identification of Orthologs from Complete Genome Data

More...
OMAi
GKDWSDE

Database of Orthologous Groups

More...
OrthoDBi
83617at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5SSW2

TreeFam database of animal gene trees

More...
TreeFami
TF106237

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR032430 Blm10_mid
IPR035309 PSME4
IPR021843 PSME4_C

The PANTHER Classification System

More...
PANTHERi
PTHR32170 PTHR32170, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16507 BLM10_mid, 1 hit
PF11919 DUF3437, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5SSW2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAPERAGGG EPPEPGGRPV LGPRAFVPQK EIVYNKLLPY AERLDAESDL
60 70 80 90 100
QLAQIKSNLG RAVQLQELWP GGLFWTRKLS TYIRLYGRKF SKEDHVLFIK
110 120 130 140 150
LLYELVSIPK LEISMMQGFA RLLINLLKKK ELLSRDDLEL PWRPLYDLVE
160 170 180 190 200
RILYSKTEHL RLNSFPNSIE NVLKTLVKSC RPYFPADSTA EMLEEWRPLM
210 220 230 240 250
CPFDVTMQKA ISYFEIFLPT SLPPELHHKG FKLWFDELIG LWVSVQNLPQ
260 270 280 290 300
WEGQLVNLFA RLATDNIGYI DWDPYVPKIF TRILRSLNLP VGSSQVLVPR
310 320 330 340 350
FLTNAYDIGH AVIWITAMMG GPSKLVQKHL AGLFNSITSF YHPSNNGRWL
360 370 380 390 400
NKLMKLLQRL PNSVVRRLHR ERFKKPSWLT PVPESHKLTD EDVTDFVQCI
410 420 430 440 450
IQPVLLAMFS KTGSLEAAQA LQNLALMRPE LVIPPVLERT YPALETLTEP
460 470 480 490 500
HQLTATLNCV IGVARSLVSG SKWFPEGPTH MLPLLMRALP GVDPNDFSKC
510 520 530 540 550
MITFQFIGTF STLVPLVDCS SVLQERNDLT EIEKELCSAT AEFEDFVLQF
560 570 580 590 600
MDRCFGLIES STLEQTREET ETEKMTHLES LVELGLSSTF STILTQCSKD
610 620 630 640 650
IFMVALQKVF NFSVSHIFET RVAGRMVADM CRAAVKCCPE ESLKLFVPHC
660 670 680 690 700
YGVITQLTMN DDVLNEEELD KELLWNLQLL SEITRVDGKK LLLYREQLVK
710 720 730 740 750
ILQRTLHLTC KQGYTLSCNL LHHLLRSTTL IYPTEYCSVP GGFNKPPSEY
760 770 780 790 800
FPVKDWGKPG DLWNLGIQWH VPSSEEVSFA FYLLDSFLQP ELIKLQCCGD
810 820 830 840 850
GELEMSRDDI LQSLTIVHSC LIGSGNLLPP LKGEAVTNLV PSMVSLEETK
860 870 880 890 900
LYTGLEHDLS RENYREVIAS VIRKLLSHIL DNSEDDTKSL FLIIKIIGDL
910 920 930 940 950
LHFQGSHKHE FDSRWKSFNL VKKSMENRLH GKKQHIRALL IDRVMLQHEL
960 970 980 990 1000
RTLTVEGCEY KKIHQDMIRD LLRLSTSSYS QVRNKAQQTF FAALGAYNFC
1010 1020 1030 1040 1050
CRDIIPLVLE FLRPDRKDVT QQQFKGALYC LLGNHSGVCL ANLHDWDCIV
1060 1070 1080 1090 1100
QTWPALVSSG LSQAMSLEKP SIVRLFDDLA EKIHRQYETI GLDFTIPKSC
1110 1120 1130 1140 1150
AAIAELLQQS KNPSISQTLL SPEKIKEGQK RQQDKNADAL RNYECLVNTL
1160 1170 1180 1190 1200
LDGVEQRNLP WKFEHIGIGL LSLLLRDDRV LPLRAIRFFV ENLNHDAIVV
1210 1220 1230 1240 1250
RKMAISAVAG ILKQLKRTHK KLTINPYEIS GCPKPTKILA GDRPDNHWLH
1260 1270 1280 1290 1300
YDSKNIPRTK KEWESSCFVE KTHWGYYNWP KNMVVYAGVE EQPKLGRSRE
1310 1320 1330 1340 1350
DMIEAEQIIY DRFSDPKFVE QLITFLSLED RKGRDKFSPR RFCLFKGIFR
1360 1370 1380 1390 1400
NFDDAFLPVL KPHLERLVAD SHESTQRCVA EIIAGLIRGS KHWTFEKVEK
1410 1420 1430 1440 1450
LWELLCPLLR TALSNMTVET YNDWGTCIAT SCESRDPRKL HWLFELLLES
1460 1470 1480 1490 1500
PLSGEGGSFV DACRLYVLQG GLAQQEWRVP ELLHRLLKYL EPKLTQVYKN
1510 1520 1530 1540 1550
VRERIGSVLT YIFMIDVSLP NTAPTTSPCI PEFTARVLEK LKPLTDVDEE
1560 1570 1580 1590 1600
IQNHVMEENG IGEEDERTQG IKLLKTILKW LMASAGRSFS TAVKEQLQLL
1610 1620 1630 1640 1650
PLFFKIAPVE NDNSYDELKR DAKLCLSLMS QGLLYPQQVP LILQVLSQTA
1660 1670 1680 1690 1700
RSSSWHARYT VLTYLQTMVF YNLFIFLNNE DAVKDIRWLI ICLLEDEQLE
1710 1720 1730 1740 1750
VREMAATTLS GLLQCNFLTM DSAMQIHFEQ LCKTKLPKKR KRDPGSVGDT
1760 1770 1780 1790 1800
IPSAELVKRH AGVLGLGACV LSSPYDVPTW MPQLLMNLSA HLNDPQPIEM
1810 1820 1830 1840
TVKKTLSNFR RTHHDNWQEH KQQFTDDQLL VLTDLLVSPC YYA
Length:1,843
Mass (Da):211,197
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i326FD7B3A070C502
GO
Isoform 2 (identifier: Q5SSW2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1703: Missing.

Show »
Length:140
Mass (Da):15,778
Checksum:i51711972B0FBF2CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6R7K9F6R7K9_MOUSE
Proteasome activator complex subuni...
Psme4
219Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5SSW0Q5SSW0_MOUSE
Proteasome activator complex subuni...
Psme4
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG09060 differs from that shown. Reason: Frameshift.Curated
The sequence BAC97859 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52L → Q in AAG09060 (Ref. 3) Curated1
Sequence conflicti316T → A in AAG09060 (Ref. 3) Curated1
Sequence conflicti392D → V in AAG09060 (Ref. 3) Curated1
Sequence conflicti433I → V in AAG09060 (Ref. 3) Curated1
Sequence conflicti470G → R in AAG09060 (Ref. 3) Curated1
Sequence conflicti478P → L in AAG09060 (Ref. 3) Curated1
Sequence conflicti482L → P in AAG09060 (Ref. 3) Curated1
Sequence conflicti542E → G in AAG09060 (Ref. 3) Curated1
Sequence conflicti622V → A in AAG09060 (Ref. 3) Curated1
Sequence conflicti651Y → C in AAG09060 (Ref. 3) Curated1
Sequence conflicti651Y → C in AAI41382 (PubMed:15489334).Curated1
Sequence conflicti1163F → S in AAG09060 (Ref. 3) Curated1
Sequence conflicti1181L → S in AAG09060 (Ref. 3) Curated1
Sequence conflicti1234K → R in AAG09060 (Ref. 3) Curated1
Sequence conflicti1234K → R in AAH31174 (PubMed:15489334).Curated1
Sequence conflicti1234K → R in AAI41382 (PubMed:15489334).Curated1
Sequence conflicti1238I → V in AAG09060 (Ref. 3) Curated1
Sequence conflicti1238I → V in AAH31174 (PubMed:15489334).Curated1
Sequence conflicti1238I → V in AAI41382 (PubMed:15489334).Curated1
Sequence conflicti1342F → S in AAG09060 (Ref. 3) Curated1
Sequence conflicti1404L → V in AAG09060 (Ref. 3) Curated1
Sequence conflicti1404L → V in AAH31174 (PubMed:15489334).Curated1
Sequence conflicti1404L → V in AAI41382 (PubMed:15489334).Curated1
Sequence conflicti1545T → P in AAG09060 (Ref. 3) Curated1
Sequence conflicti1782P → S in AAG09060 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0238801 – 1703Missing in isoform 2. 1 PublicationAdd BLAST1703

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK129049 mRNA Translation: BAC97859.1 Different initiation.
AL662891 Genomic DNA No translation available.
AF296169 mRNA Translation: AAG09060.1 Frameshift.
BC004575 mRNA Translation: AAH04575.1
BC031174 mRNA Translation: AAH31174.1
BC054364 mRNA Translation: AAH54364.1
BC141381 mRNA Translation: AAI41382.1
AK131932 mRNA Translation: BAE20881.1
AK169447 mRNA Translation: BAE41181.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS36124.1 [Q5SSW2-1]

NCBI Reference Sequences

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RefSeqi
NP_598774.2, NM_134013.3 [Q5SSW2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000041231; ENSMUSP00000045460; ENSMUSG00000040850 [Q5SSW2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
103554

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:103554

UCSC genome browser

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UCSCi
uc007ihx.1 mouse [Q5SSW2-1]
uc007iia.1 mouse [Q5SSW2-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129049 mRNA Translation: BAC97859.1 Different initiation.
AL662891 Genomic DNA No translation available.
AF296169 mRNA Translation: AAG09060.1 Frameshift.
BC004575 mRNA Translation: AAH04575.1
BC031174 mRNA Translation: AAH31174.1
BC054364 mRNA Translation: AAH54364.1
BC141381 mRNA Translation: AAI41382.1
AK131932 mRNA Translation: BAE20881.1
AK169447 mRNA Translation: BAE41181.1
CCDSiCCDS36124.1 [Q5SSW2-1]
RefSeqiNP_598774.2, NM_134013.3 [Q5SSW2-1]

3D structure databases

SMRiQ5SSW2
ModBaseiSearch...

Protein-protein interaction databases

BioGridi222113, 1 interactor
IntActiQ5SSW2, 5 interactors
MINTiQ5SSW2
STRINGi10090.ENSMUSP00000045460

PTM databases

iPTMnetiQ5SSW2
PhosphoSitePlusiQ5SSW2
SwissPalmiQ5SSW2

Proteomic databases

EPDiQ5SSW2
PaxDbiQ5SSW2
PeptideAtlasiQ5SSW2
PRIDEiQ5SSW2

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
103554

Genome annotation databases

EnsembliENSMUST00000041231; ENSMUSP00000045460; ENSMUSG00000040850 [Q5SSW2-1]
GeneIDi103554
KEGGimmu:103554
UCSCiuc007ihx.1 mouse [Q5SSW2-1]
uc007iia.1 mouse [Q5SSW2-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23198
MGIiMGI:2143994 Psme4

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG1851 Eukaryota
ENOG410XP7J LUCA
GeneTreeiENSGT00390000011433
HOGENOMiCLU_000772_2_0_1
InParanoidiQ5SSW2
KOiK06699
OMAiGKDWSDE
OrthoDBi83617at2759
PhylomeDBiQ5SSW2
TreeFamiTF106237

Enzyme and pathway databases

ReactomeiR-MMU-1169091 Activation of NF-kappaB in B cells
R-MMU-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-MMU-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-MMU-174154 APC/C:Cdc20 mediated degradation of Securin
R-MMU-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-MMU-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-MMU-195253 Degradation of beta-catenin by the destruction complex
R-MMU-202424 Downstream TCR signaling
R-MMU-2467813 Separation of Sister Chromatids
R-MMU-2871837 FCERI mediated NF-kB activation
R-MMU-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-MMU-350562 Regulation of ornithine decarboxylase (ODC)
R-MMU-382556 ABC-family proteins mediated transport
R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-4608870 Asymmetric localization of PCP proteins
R-MMU-4641257 Degradation of AXIN
R-MMU-4641258 Degradation of DVL
R-MMU-5358346 Hedgehog ligand biogenesis
R-MMU-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-MMU-5607764 CLEC7A (Dectin-1) signaling
R-MMU-5610780 Degradation of GLI1 by the proteasome
R-MMU-5610785 GLI3 is processed to GLI3R by the proteasome
R-MMU-5632684 Hedgehog 'on' state
R-MMU-5658442 Regulation of RAS by GAPs
R-MMU-5668541 TNFR2 non-canonical NF-kB pathway
R-MMU-5676590 NIK-->noncanonical NF-kB signaling
R-MMU-5687128 MAPK6/MAPK4 signaling
R-MMU-5689603 UCH proteinases
R-MMU-5689880 Ub-specific processing proteases
R-MMU-68827 CDT1 association with the CDC6:ORC:origin complex
R-MMU-68949 Orc1 removal from chromatin
R-MMU-69017 CDK-mediated phosphorylation and removal of Cdc6
R-MMU-69481 G2/M Checkpoints
R-MMU-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-MMU-75815 Ubiquitin-dependent degradation of Cyclin D
R-MMU-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-MMU-8948751 Regulation of PTEN stability and activity
R-MMU-8951664 Neddylation
R-MMU-9020702 Interleukin-1 signaling
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Psme4 mouse

Protein Ontology

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PROi
PR:Q5SSW2
RNActiQ5SSW2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040850 Expressed in blood and 296 other tissues
ExpressionAtlasiQ5SSW2 baseline and differential
GenevisibleiQ5SSW2 MM

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR032430 Blm10_mid
IPR035309 PSME4
IPR021843 PSME4_C
PANTHERiPTHR32170 PTHR32170, 1 hit
PfamiView protein in Pfam
PF16507 BLM10_mid, 1 hit
PF11919 DUF3437, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSME4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5SSW2
Secondary accession number(s): C4IXU5
, Q3TER7, Q3V2B7, Q6ZQJ7, Q7TMY9, Q8K0K0, Q99KM2, Q9ESY1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 21, 2004
Last modified: February 26, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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